Flumatinib (mesylate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flumatinib (mesylate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flumatinib (mesylate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.112685
ZNF292 zinc finger protein 292 0.0955176
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0941812
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.086117
EEF2 eukaryotic translation elongation factor 2 0.0849629
ECT2 epithelial cell transforming 2 0.0805069
HDAC9 histone deacetylase 9 0.0753489
KDM3A lysine (K)-specific demethylase 3A 0.0733753
NAMPT nicotinamide phosphoribosyltransferase 0.073119
KMT2E lysine (K)-specific methyltransferase 2E 0.0712839
NUP58 nucleoporin 58 0.0655346
DSCAM Down syndrome cell adhesion molecule 0.065347
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0636124
PGK1 phosphoglycerate kinase 1 0.0623982
SSBP2 single-stranded DNA binding protein 2 0.0622215
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.057942
ZEB1 zinc finger E-box binding homeobox 1 0.0574208
FLNB filamin B, beta 0.0573605
NCKAP1 NCK-associated protein 1 0.0538103
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0529992
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0519895
RPL3 ribosomal protein L3 0.0515979
CDC73 cell division cycle 73 0.0506928
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0496117
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0495487
TFG TRK-fused gene 0.0492476
RNF145 ring finger protein 145 0.0489283
GOLGA4 golgin A4 0.0487811
SRRM2 serine/arginine repetitive matrix 2 0.0481121
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0475281
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0453854
CAMTA1 calmodulin binding transcription activator 1 0.0451089
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0439096
QKI QKI, KH domain containing, RNA binding 0.0430438
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0430286
PDGFC platelet derived growth factor C 0.0428323
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0412292
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0393839
EZR ezrin 0.0378262
PUM2 pumilio RNA-binding family member 2 0.0377246
NBAS neuroblastoma amplified sequence 0.037564
XPO1 exportin 1 0.0375447
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.037229
SET SET nuclear proto-oncogene 0.0368001
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0367239
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0364139
PYGB phosphorylase, glycogen; brain 0.036139
PICALM phosphatidylinositol binding clathrin assembly protein 0.0360453
WAC WW domain containing adaptor with coiled-coil 0.0359878
PRELID2 PRELI domain containing 2 0.03597
RPS2 ribosomal protein S2 0.035637
UBA6 ubiquitin-like modifier activating enzyme 6 0.0352669
KDM6A lysine (K)-specific demethylase 6A 0.0346584
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0338493
PDS5B PDS5 cohesin associated factor B 0.0337452
EVI5 ecotropic viral integration site 5 0.0333829
LPP LIM domain containing preferred translocation partner in lipoma 0.0331987
PTBP2 polypyrimidine tract binding protein 2 0.0328937
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0324751
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0320465
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0316086
KMT2C lysine (K)-specific methyltransferase 2C 0.0315814
HELZ helicase with zinc finger 0.0310939
MATR3 matrin 3 0.0310615
CENPF centromere protein F, 350/400kDa 0.0308145
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0307684
RAB6A RAB6A, member RAS oncogene family 0.0307138
ZMYM2 zinc finger, MYM-type 2 0.0306139
ELP2 elongator acetyltransferase complex subunit 2 0.0293703
TMEM41B transmembrane protein 41B 0.0290458
RAD23B RAD23 homolog B (S. cerevisiae) 0.0290275
CCNL1 cyclin L1 0.0287091
FAM13A family with sequence similarity 13, member A 0.028667
ELOVL5 ELOVL fatty acid elongase 5 0.0286509
TOP2B topoisomerase (DNA) II beta 180kDa 0.0284486
CASC3 cancer susceptibility candidate 3 0.0283878
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0283237
BIRC6 baculoviral IAP repeat containing 6 0.028262
AKAP9 A kinase (PRKA) anchor protein 9 0.0282043
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0281917
TPR translocated promoter region, nuclear basket protein 0.0279328
COPA coatomer protein complex, subunit alpha 0.0278391
ASXL1 additional sex combs like transcriptional regulator 1 0.0277953
ZNF608 zinc finger protein 608 0.027773
PNISR PNN-interacting serine/arginine-rich protein 0.0276537
ADAM9 ADAM metallopeptidase domain 9 0.0276531
ANKRD36 ankyrin repeat domain 36 0.0276061
DAPK3 death-associated protein kinase 3 0.0276001
FAT1 FAT atypical cadherin 1 0.027519
TMF1 TATA element modulatory factor 1 0.0274627
MXI1 MAX interactor 1, dimerization protein 0.0274328
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0271541
BRWD1 bromodomain and WD repeat domain containing 1 0.0270736
RBM33 RNA binding motif protein 33 0.027073
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0270493
MYOF myoferlin 0.0269787
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0269739
HMGB2 high mobility group box 2 0.0268091
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0268016
FUBP1 far upstream element (FUSE) binding protein 1 0.0266597

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.353547
AHNAK AHNAK nucleoprotein -0.116394
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0976568
VCL vinculin -0.0955142
RPS6 ribosomal protein S6 -0.0910824
TPT1 tumor protein, translationally-controlled 1 -0.0866025
FOXP1 forkhead box P1 -0.0793301
BMP10 bone morphogenetic protein 10 -0.0687941
PTMA prothymosin, alpha -0.0638487
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0633097
PKM pyruvate kinase, muscle -0.0630716
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0614924
RPL35A ribosomal protein L35a -0.0495605
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0482247
NBEA neurobeachin -0.0475649
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0469404
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0445063
ZMYND8 zinc finger, MYND-type containing 8 -0.0443572
RPLP0 ribosomal protein, large, P0 -0.0436018
RPLP1 ribosomal protein, large, P1 -0.043034
PDE4D phosphodiesterase 4D, cAMP-specific -0.0429038
GLI3 GLI family zinc finger 3 -0.0424725
RPS23 ribosomal protein S23 -0.0417317
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0404444
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0393398
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0381744
RPS24 ribosomal protein S24 -0.0375121
TMSB10 thymosin beta 10 -0.0373939
RPL34 ribosomal protein L34 -0.0362626
HSPB1 heat shock 27kDa protein 1 -0.0356312
ACTG1 actin gamma 1 -0.0353185
RPL31 ribosomal protein L31 -0.0351238
RPL12 ribosomal protein L12 -0.0350731
BPTF bromodomain PHD finger transcription factor -0.0346841
TM4SF1 transmembrane 4 L six family member 1 -0.0346669
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.034549
POTEF POTE ankyrin domain family, member F -0.0337579
RPS19 ribosomal protein S19 -0.0335313
EGFR epidermal growth factor receptor -0.0329173
RPS13 ribosomal protein S13 -0.0325246
IFI16 interferon, gamma-inducible protein 16 -0.0324283
RPLP2 ribosomal protein, large, P2 -0.0316781
S100A10 S100 calcium binding protein A10 -0.0309744
RPL32 ribosomal protein L32 -0.0306084
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0304271
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0298809
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0290768
RPL19 ribosomal protein L19 -0.0289979
MYO5C myosin VC -0.0289541
RPS8 ribosomal protein S8 -0.0289394
PDE7B phosphodiesterase 7B -0.0281892
HDLBP high density lipoprotein binding protein -0.027809
RPS27A ribosomal protein S27a -0.0274527
LOC112694756 uncharaterized LOC112694756 -0.0273826
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0269063
S100A9 S100 calcium binding protein A9 -0.0267162
DOCK3 dedicator of cytokinesis 3 -0.0261509
IFI6 interferon, alpha-inducible protein 6 -0.025917
CUX1 cut-like homeobox 1 -0.0257856
OSMR oncostatin M receptor -0.0257117
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0253484
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0252765
S100A6 S100 calcium binding protein A6 -0.0249861
ARL4C ADP-ribosylation factor-like 4C -0.0246031
HMGB1 high mobility group box 1 -0.0245683
RPS11 ribosomal protein S11 -0.0245676
RPS21 ribosomal protein S21 -0.0244178
ZNF438 zinc finger protein 438 -0.0239804
GCLM glutamate-cysteine ligase, modifier subunit -0.0237857
MLIP muscular LMNA-interacting protein -0.0237582
S100A4 S100 calcium binding protein A4 -0.0236657
PRDX2 peroxiredoxin 2 -0.0235456
RPL28 ribosomal protein L28 -0.0234121
PRUNE2 prune homolog 2 (Drosophila) -0.0234033
RPL8 ribosomal protein L8 -0.0232283
BICD1 bicaudal D homolog 1 (Drosophila) -0.0226492
SP100 SP100 nuclear antigen -0.0225856
TBCA tubulin folding cofactor A -0.0225272
RPL27A ribosomal protein L27a -0.0224675
RPS14 ribosomal protein S14 -0.0224046
RPL13A ribosomal protein L13a -0.0220925
RPS16 ribosomal protein S16 -0.0220861
CCNI cyclin I -0.0219968
RPS25 ribosomal protein S25 -0.0219505
TTC28 tetratricopeptide repeat domain 28 -0.0216472
RPL38 ribosomal protein L38 -0.0215632
FTL ferritin, light polypeptide -0.0214922
RPS15 ribosomal protein S15 -0.0214812
ZNFX1 zinc finger, NFX1-type containing 1 -0.0213014
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.021256
IFITM3 interferon induced transmembrane protein 3 -0.0212269
ZBTB20 zinc finger and BTB domain containing 20 -0.0211249
RPL9 ribosomal protein L9 -0.0210866
MTDH metadherin -0.0210822
PTPRG protein tyrosine phosphatase, receptor type, G -0.0209111
TAS2R14 taste receptor, type 2, member 14 -0.0208335
RPL36 ribosomal protein L36 -0.0206188
RIGI RNA sensor RIG-I -0.0206038
DUSP6 dual specificity phosphatase 6 -0.0205602
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0202069