Flumatinib (mesylate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flumatinib (mesylate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flumatinib (mesylate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.105909
VIM vimentin 0.0907328
ZNF292 zinc finger protein 292 0.0845651
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0839603
SET SET nuclear proto-oncogene 0.0781502
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0767693
NAP1L1 nucleosome assembly protein 1-like 1 0.0679766
RPL4 ribosomal protein L4 0.0634741
NAMPT nicotinamide phosphoribosyltransferase 0.061653
EEF2 eukaryotic translation elongation factor 2 0.0551994
PDE4D phosphodiesterase 4D, cAMP-specific 0.0548047
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0517002
RNF145 ring finger protein 145 0.0509556
CEP250 centrosomal protein 250kDa 0.0508583
HILPDA hypoxia inducible lipid droplet-associated 0.0507686
PDCD6IP programmed cell death 6 interacting protein 0.0496393
PHF21A PHD finger protein 21A 0.0487094
AKAP13 A kinase (PRKA) anchor protein 13 0.0485016
CHD1 chromodomain helicase DNA binding protein 1 0.0483944
ITCH itchy E3 ubiquitin protein ligase 0.0475967
ERRFI1 ERBB receptor feedback inhibitor 1 0.0474049
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0471261
CAPRIN2 caprin family member 2 0.0469178
CSNK1A1 casein kinase 1, alpha 1 0.0459104
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0457059
TPX2 TPX2, microtubule-associated 0.0450251
PTMA prothymosin, alpha 0.0447763
AKAP9 A kinase (PRKA) anchor protein 9 0.0446567
NUP58 nucleoporin 58 0.0444931
ECT2 epithelial cell transforming 2 0.0439209
FMNL2 formin-like 2 0.0430737
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0428818
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0424287
SEC23A Sec23 homolog A (S. cerevisiae) 0.0420348
NBAS neuroblastoma amplified sequence 0.0419598
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.041446
HOOK2 hook microtubule-tethering protein 2 0.0412772
MATR3 matrin 3 0.0402565
MSN moesin 0.0402523
TFG TRK-fused gene 0.0390723
CDCP1 CUB domain containing protein 1 0.0387395
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.038543
ARHGAP5 Rho GTPase activating protein 5 0.0379006
SETD5 SET domain containing 5 0.0375143
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0372173
BIRC3 baculoviral IAP repeat containing 3 0.0367817
RBM25 RNA binding motif protein 25 0.0367593
SRRM2 serine/arginine repetitive matrix 2 0.0366208
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0366106
RPS12 ribosomal protein S12 0.0359992
HMGB2 high mobility group box 2 0.0358747
RPS2 ribosomal protein S2 0.0358699
TOP2A topoisomerase (DNA) II alpha 170kDa 0.035697
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.035439
PKM pyruvate kinase, muscle 0.0354224
FLNA filamin A, alpha 0.0352834
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0350448
PBX3 pre-B-cell leukemia homeobox 3 0.0347145
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0346624
RPS17 ribosomal protein S17 0.034483
RAD23B RAD23 homolog B (S. cerevisiae) 0.0344614
RPL36 ribosomal protein L36 0.0343416
H1-4 H1.4 linker histone, cluster member 0.0340912
CEP170 centrosomal protein 170kDa 0.0339787
RSRC2 arginine/serine-rich coiled-coil 2 0.0339712
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0339561
MTMR2 myotubularin related protein 2 0.0337199
ZNF148 zinc finger protein 148 0.0336552
PRELID2 PRELI domain containing 2 0.0336501
MIS18BP1 MIS18 binding protein 1 0.0334731
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0332443
MAP2K1 mitogen-activated protein kinase kinase 1 0.0331771
SDC4 syndecan 4 0.0329905
PUM2 pumilio RNA-binding family member 2 0.032985
RICTOR RPTOR independent companion of MTOR, complex 2 0.0327705
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0326999
SEPTIN2 septin 2 0.0325922
HSPA8 heat shock 70kDa protein 8 0.0318819
TPM3 tropomyosin 3 0.0317447
PDS5B PDS5 cohesin associated factor B 0.0316121
THSD4 thrombospondin, type I, domain containing 4 0.0316038
SLFN11 schlafen family member 11 0.0315649
PNN pinin, desmosome associated protein 0.0313547
CALR calreticulin 0.0311039
KMT2E lysine (K)-specific methyltransferase 2E 0.030897
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0308188
UVRAG UV radiation resistance associated 0.0306433
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0304713
NCKAP1 NCK-associated protein 1 0.030372
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.030324
ANKRD28 ankyrin repeat domain 28 0.0302835
RPL26 ribosomal protein L26 0.0302468
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0302099
NUP153 nucleoporin 153kDa 0.0300274
SEPTIN7 septin 7 0.029986
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0297124
HIPK3 homeodomain interacting protein kinase 3 0.0295101
RBM26 RNA binding motif protein 26 0.0292671
RPL35 ribosomal protein L35 0.0292323
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0288979

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.339679
TPT1 tumor protein, translationally-controlled 1 -0.0931504
POTEF POTE ankyrin domain family, member F -0.0584315
IER3 immediate early response 3 -0.0558367
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0506192
SLC38A2 solute carrier family 38, member 2 -0.05048
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0501806
EGR1 early growth response 1 -0.0491687
FNDC3B fibronectin type III domain containing 3B -0.0487524
HMGA2 high mobility group AT-hook 2 -0.0485131
ANXA2 annexin A2 -0.0484124
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0483137
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0482633
LDHA lactate dehydrogenase A -0.0464701
NF1 neurofibromin 1 -0.045566
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0429698
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.042291
H3-3B H3.3 histone B -0.0411505
B2M beta-2-microglobulin -0.041045
FUS FUS RNA binding protein -0.0409625
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0405775
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0405139
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0401987
AK1 adenylate kinase 1 -0.0401614
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0399237
FTH1 ferritin, heavy polypeptide 1 -0.039428
RPLP1 ribosomal protein, large, P1 -0.0373072
SASH1 SAM and SH3 domain containing 1 -0.0372922
FMN1 formin 1 -0.0369488
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0365591
RIGI RNA sensor RIG-I -0.0365126
IL6ST interleukin 6 signal transducer -0.0352526
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0351517
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0348908
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0345374
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.034443
VCL vinculin -0.0336177
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0334563
SAMD4A sterile alpha motif domain containing 4A -0.0334
BTG1 B-cell translocation gene 1, anti-proliferative -0.0325158
ETF1 eukaryotic translation termination factor 1 -0.0323049
ZBTB20 zinc finger and BTB domain containing 20 -0.0321989
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0318655
OASL 2'-5'-oligoadenylate synthetase-like -0.0314059
GPC6 glypican 6 -0.0313126
PHF14 PHD finger protein 14 -0.03108
DPYD dihydropyrimidine dehydrogenase -0.0306269
ZC3H12C zinc finger CCCH-type containing 12C -0.0303926
IARS1 isoleucyl-tRNA synthetase 1 -0.0301262
S100A9 S100 calcium binding protein A9 -0.0297261
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0297004
ZBTB38 zinc finger and BTB domain containing 38 -0.0295173
SMC5 structural maintenance of chromosomes 5 -0.0293342
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0293065
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0292161
HLA-C major histocompatibility complex, class I, C -0.028838
PCNX4 pecanex 4 -0.0288172
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0286837
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0284532
AHNAK AHNAK nucleoprotein -0.0284003
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0272716
BCAR3 breast cancer anti-estrogen resistance 3 -0.0272705
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0271566
ATXN1 ataxin 1 -0.026924
S100A10 S100 calcium binding protein A10 -0.0269213
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0268447
UBB ubiquitin B -0.0268311
ASXL1 additional sex combs like transcriptional regulator 1 -0.0267589
NALCN sodium leak channel, non selective -0.0266411
EFNA5 ephrin-A5 -0.0266002
ATG12 autophagy related 12 -0.0265444
CYTH1 cytohesin 1 -0.0263625
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0263584
JUN jun proto-oncogene -0.0262705
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0255895
NCOR1 nuclear receptor corepressor 1 -0.0253827
PRR16 proline rich 16 -0.0253652
SCAMP1 secretory carrier membrane protein 1 -0.0250034
RPS29 ribosomal protein S29 -0.024824
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0247525
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.024649
SIK2 salt-inducible kinase 2 -0.0245751
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -0.0244631
INTS6 integrator complex subunit 6 -0.0242699
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0241198
RPL38 ribosomal protein L38 -0.0240694
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0240551
AHI1 Abelson helper integration site 1 -0.0240082
SOD2 superoxide dismutase 2, mitochondrial -0.0239883
PRSS23 protease, serine, 23 -0.023854
OSMR oncostatin M receptor -0.0237892
EVI5 ecotropic viral integration site 5 -0.0236649
SVIL supervillin -0.0233554
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0233386
HLA-B major histocompatibility complex, class I, B -0.0231507
PTPRK protein tyrosine phosphatase, receptor type, K -0.0228605
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0228579
CUX1 cut-like homeobox 1 -0.0228124
DEK DEK proto-oncogene -0.0228015
HDLBP high density lipoprotein binding protein -0.0227817