Flumatinib (mesylate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flumatinib (mesylate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flumatinib (mesylate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.15086
NAMPT nicotinamide phosphoribosyltransferase 0.138012
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.126561
TRIO trio Rho guanine nucleotide exchange factor 0.10196
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0952526
MYH9 myosin, heavy chain 9, non-muscle 0.0884326
FAM13A family with sequence similarity 13, member A 0.0867423
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0849041
PRELID2 PRELI domain containing 2 0.0731006
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0689157
FNDC3B fibronectin type III domain containing 3B 0.0656836
AHR aryl hydrocarbon receptor 0.0614484
NDRG1 N-myc downstream regulated 1 0.0571188
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0565838
HILPDA hypoxia inducible lipid droplet-associated 0.0562025
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0555201
ERRFI1 ERBB receptor feedback inhibitor 1 0.0520526
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0484888
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0483414
RNF145 ring finger protein 145 0.0471488
CD109 CD109 molecule 0.0467298
MKI67 marker of proliferation Ki-67 0.0426391
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.041153
SFXN1 sideroflexin 1 0.0410882
ZNF292 zinc finger protein 292 0.0407627
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0397472
EYA1 EYA transcriptional coactivator and phosphatase 1 0.039613
UGCG UDP-glucose ceramide glucosyltransferase 0.0393902
PGK1 phosphoglycerate kinase 1 0.0387645
RAB8B RAB8B, member RAS oncogene family 0.0375106
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0366343
MXI1 MAX interactor 1, dimerization protein 0.0351425
NAP1L1 nucleosome assembly protein 1-like 1 0.0350081
PLIN2 perilipin 2 0.034491
FBXL5 F-box and leucine-rich repeat protein 5 0.0344223
CENPF centromere protein F, 350/400kDa 0.0343935
ANLN anillin, actin binding protein 0.0322898
HELZ helicase with zinc finger 0.0322106
KDM3A lysine (K)-specific demethylase 3A 0.0321996
WAC WW domain containing adaptor with coiled-coil 0.0321462
RNF24 ring finger protein 24 0.0318016
UBA6 ubiquitin-like modifier activating enzyme 6 0.0316082
VCL vinculin 0.0311144
TMSB4X thymosin beta 4, X-linked 0.0310659
ELL2 elongation factor, RNA polymerase II, 2 0.0308365
KIF5B kinesin family member 5B 0.0308196
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0305303
KMT2C lysine (K)-specific methyltransferase 2C 0.0304292
SEPTIN7 septin 7 0.0303808
CDC73 cell division cycle 73 0.0299393
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0298941
PTK2 protein tyrosine kinase 2 0.0296996
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.029644
ANXA5 annexin A5 0.0295964
MIS18BP1 MIS18 binding protein 1 0.0293755
SEC23A Sec23 homolog A (S. cerevisiae) 0.0290323
RPS2 ribosomal protein S2 0.0287178
CEP350 centrosomal protein 350kDa 0.0283862
TPR translocated promoter region, nuclear basket protein 0.0282942
LPP LIM domain containing preferred translocation partner in lipoma 0.0280612
STC2 stanniocalcin 2 0.0278408
CD46 CD46 molecule, complement regulatory protein 0.0275026
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0274979
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0272707
SP3 Sp3 transcription factor 0.027224
SPAG9 sperm associated antigen 9 0.0271424
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0270229
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0269876
DST dystonin 0.0268944
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0265731
NUP58 nucleoporin 58 0.0264097
YEATS2 YEATS domain containing 2 0.026385
GPC6 glypican 6 0.0262391
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0259594
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0256467
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0253149
EPS8 epidermal growth factor receptor pathway substrate 8 0.0253066
MACF1 microtubule-actin crosslinking factor 1 0.025043
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0249963
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0248645
PNISR PNN-interacting serine/arginine-rich protein 0.0247223
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0246785
TPD52 tumor protein D52 0.0246627
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0246324
BIRC3 baculoviral IAP repeat containing 3 0.0245302
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0242656
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0238406
PUM2 pumilio RNA-binding family member 2 0.0237077
WDR26 WD repeat domain 26 0.0236119
DENND5B DENN/MADD domain containing 5B 0.0234782
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0234611
USP12 ubiquitin specific peptidase 12 0.0231674
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0231369
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0231253
AFDN afadin, adherens junction formation factor 0.0228195
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0228159
DDIT4 DNA-damage-inducible transcript 4 0.0227935
WDR33 WD repeat domain 33 0.0226549
RICTOR RPTOR independent companion of MTOR, complex 2 0.0226527
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0225238

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.43282
UBC ubiquitin C -0.136556
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.125108
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.123195
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.115691
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0929028
FTH1 ferritin, heavy polypeptide 1 -0.0895132
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0743147
RPS27A ribosomal protein S27a -0.0738394
TMSB10 thymosin beta 10 -0.0685688
EXT1 exostosin glycosyltransferase 1 -0.0674666
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0657006
CANX calnexin -0.065548
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0653345
SQSTM1 sequestosome 1 -0.0590038
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0580335
LOC112694756 uncharaterized LOC112694756 -0.0569478
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0566483
S100A6 S100 calcium binding protein A6 -0.0505883
LMNA lamin A/C -0.0499815
SYT1 synaptotagmin I -0.0485456
FTL ferritin, light polypeptide -0.0480193
ANKRD28 ankyrin repeat domain 28 -0.0473332
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0464884
CALU calumenin -0.0439568
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0418808
LOC102724023 ES1 protein homolog, mitochondrial -0.0415863
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0397169
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0389917
TXNRD1 thioredoxin reductase 1 -0.0355804
EGR1 early growth response 1 -0.0348426
PTMA prothymosin, alpha -0.0345481
EMP1 epithelial membrane protein 1 -0.0343802
PDE4D phosphodiesterase 4D, cAMP-specific -0.0342119
HLA-B major histocompatibility complex, class I, B -0.034003
ENO2 enolase 2 (gamma, neuronal) -0.0334918
KRT81 keratin 81, type II -0.0332552
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0330911
TXNIP thioredoxin interacting protein -0.0329161
MCL1 myeloid cell leukemia 1 -0.0324696
ACBD3 acyl-CoA binding domain containing 3 -0.0324366
POTEF POTE ankyrin domain family, member F -0.0323178
PCBP2 poly(rC) binding protein 2 -0.0317119
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0303923
FUS FUS RNA binding protein -0.0301269
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0300667
TPT1 tumor protein, translationally-controlled 1 -0.0297006
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0285846
RPS6 ribosomal protein S6 -0.0276872
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0276778
SPDYA speedy/RINGO cell cycle regulator family member A -0.0274728
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0274074
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0273932
SVIL supervillin -0.0269415
HM13 histocompatibility (minor) 13 -0.0268833
RPL23 ribosomal protein L23 -0.0265273
SIRT1 sirtuin 1 -0.0263534
HDLBP high density lipoprotein binding protein -0.026335
IER3 immediate early response 3 -0.0258434
FBN1 fibrillin 1 -0.0255429
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0253375
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0253259
AHRR aryl-hydrocarbon receptor repressor -0.0251823
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0251741
ATF6 activating transcription factor 6 -0.0249147
AEBP2 AE binding protein 2 -0.0247901
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0246345
INTS6 integrator complex subunit 6 -0.0244131
H1-0 H1.0 linker histone -0.0243492
MON2 MON2 homolog (S. cerevisiae) -0.0241696
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0241497
EZR ezrin -0.0240982
ATF3 activating transcription factor 3 -0.0238798
SEC31A SEC31 homolog A (S. cerevisiae) -0.0238245
ZMYND8 zinc finger, MYND-type containing 8 -0.0231416
NRG1 neuregulin 1 -0.0230337
AHI1 Abelson helper integration site 1 -0.0229839
NRP1 neuropilin 1 -0.0229166
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0228926
CCDC138 coiled-coil domain containing 138 -0.0228668
BRD2 bromodomain containing 2 -0.0228528
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0223969
RPL28 ribosomal protein L28 -0.0219919
NTN4 netrin 4 -0.0215336
BLZF1 basic leucine zipper nuclear factor 1 -0.0215002
RHOA ras homolog family member A -0.0214697
THBS1 thrombospondin 1 -0.021142
RPS5 ribosomal protein S5 -0.0211038
GOLGB1 golgin B1 -0.0208465
UGDH UDP-glucose 6-dehydrogenase -0.0207808
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -0.0206289
KSR1 kinase suppressor of ras 1 -0.0204873
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0199794
BICD1 bicaudal D homolog 1 (Drosophila) -0.0199741
RPS21 ribosomal protein S21 -0.0197718
JUN jun proto-oncogene -0.0195626
RAB31 RAB31, member RAS oncogene family -0.0195365
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0190188
ATP5F1B ATP synthase F1 subunit beta -0.0190047
CUX1 cut-like homeobox 1 -0.0189707