Flumatinib (mesylate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flumatinib (mesylate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flumatinib (mesylate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.242859
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.122367
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.115683
HILPDA hypoxia inducible lipid droplet-associated 0.101901
MYH9 myosin, heavy chain 9, non-muscle 0.088804
HSPA8 heat shock 70kDa protein 8 0.0863038
AREG amphiregulin 0.0844511
KMT2C lysine (K)-specific methyltransferase 2C 0.0736932
PTMA prothymosin, alpha 0.0709356
NUP58 nucleoporin 58 0.069557
ITPRID2 ITPR interacting domain containing 2 0.0695442
ANXA1 annexin A1 0.0691803
GARS1 glycyl-tRNA synthetase 1 0.0676053
KDM3A lysine (K)-specific demethylase 3A 0.0667646
DSCAM Down syndrome cell adhesion molecule 0.0655427
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0632641
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0612188
KDM6A lysine (K)-specific demethylase 6A 0.0596741
DSPP dentin sialophosphoprotein 0.0593859
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0579474
ZNF292 zinc finger protein 292 0.0551378
ANKRD11 ankyrin repeat domain 11 0.0535166
WAC WW domain containing adaptor with coiled-coil 0.0525802
DDIT4 DNA-damage-inducible transcript 4 0.0525183
IER3 immediate early response 3 0.0516864
FMNL2 formin-like 2 0.0512886
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.051279
RBM39 RNA binding motif protein 39 0.051214
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.051104
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0508415
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0498509
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0496847
AHNAK AHNAK nucleoprotein 0.0494641
ESYT2 extended synaptotagmin-like protein 2 0.0486278
NAMPT nicotinamide phosphoribosyltransferase 0.0479637
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0476837
RAB1A RAB1A, member RAS oncogene family 0.0475772
CDC73 cell division cycle 73 0.0474494
NCKAP1 NCK-associated protein 1 0.0465831
RPL3 ribosomal protein L3 0.0465423
PUM1 pumilio RNA-binding family member 1 0.0464724
FXR1 fragile X mental retardation, autosomal homolog 1 0.0461524
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0457482
PGK1 phosphoglycerate kinase 1 0.0452289
NAP1L1 nucleosome assembly protein 1-like 1 0.044907
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0448493
EREG epiregulin 0.0444289
KMT2E lysine (K)-specific methyltransferase 2E 0.0441815
RREB1 ras responsive element binding protein 1 0.0439339
CAMTA1 calmodulin binding transcription activator 1 0.0438553
PDIA3 protein disulfide isomerase family A, member 3 0.0434479
COPB1 coatomer protein complex, subunit beta 1 0.0432754
TFRC transferrin receptor 0.0426835
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0422059
USP9X ubiquitin specific peptidase 9, X-linked 0.0420244
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.041733
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0416194
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0412046
TRA2A transformer 2 alpha homolog (Drosophila) 0.0409124
ANKRD10 ankyrin repeat domain 10 0.0402223
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0391527
LAMB3 laminin, beta 3 0.0390968
IPO7 importin 7 0.0386139
RCOR1 REST corepressor 1 0.038455
PDE4B phosphodiesterase 4B, cAMP-specific 0.0378181
RLF rearranged L-myc fusion 0.0373771
PUM2 pumilio RNA-binding family member 2 0.0371962
PRRC2C proline-rich coiled-coil 2C 0.0371189
TFG TRK-fused gene 0.0368849
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0364325
RNF145 ring finger protein 145 0.0363953
OXSR1 oxidative stress responsive 1 0.03638
SNX9 sorting nexin 9 0.0363545
MYO5B myosin VB 0.036206
XPO1 exportin 1 0.0358132
COPA coatomer protein complex, subunit alpha 0.0355842
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0352951
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0352423
OGA O-GlcNAcase 0.0351765
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0348854
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0346734
CCNY cyclin Y 0.0343246
MARS1 methionyl-tRNA synthetase 1 0.0342655
TSC22D2 TSC22 domain family, member 2 0.0339426
EPS8 epidermal growth factor receptor pathway substrate 8 0.033741
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.033553
H1-4 H1.4 linker histone, cluster member 0.0333956
CPOX coproporphyrinogen oxidase 0.0333241
TOP2B topoisomerase (DNA) II beta 180kDa 0.0330435
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0329943
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0325953
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0323668
ANLN anillin, actin binding protein 0.0322822
RSRC2 arginine/serine-rich coiled-coil 2 0.0321242
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0319311
COG5 component of oligomeric golgi complex 5 0.0317667
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0317049
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0315329
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0311177
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.031113

decreased expression

Symbol Name Standardized Value
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.107202
CD36 CD36 molecule (thrombospondin receptor) -0.0984824
EGR1 early growth response 1 -0.0837363
HMGA2 high mobility group AT-hook 2 -0.0790402
HMGA1 high mobility group AT-hook 1 -0.0701424
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0691755
RPL35A ribosomal protein L35a -0.0688366
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0680923
LOC112694756 uncharaterized LOC112694756 -0.0617928
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0600427
TXNRD1 thioredoxin reductase 1 -0.0526208
FERMT1 fermitin family member 1 -0.0513264
RPS6 ribosomal protein S6 -0.0493995
FTH1 ferritin, heavy polypeptide 1 -0.0492039
RBM25 RNA binding motif protein 25 -0.0424705
RAD51B RAD51 paralog B -0.0422656
ACTG1 actin gamma 1 -0.0420388
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0391013
ITPKC inositol-trisphosphate 3-kinase C -0.0385922
RPS8 ribosomal protein S8 -0.0336343
POTEF POTE ankyrin domain family, member F -0.0332168
LAMC2 laminin, gamma 2 -0.0312551
LOC102724023 ES1 protein homolog, mitochondrial -0.030454
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0300869
MTUS1 microtubule associated tumor suppressor 1 -0.0299885
PERP PERP, TP53 apoptosis effector -0.0291789
S100A6 S100 calcium binding protein A6 -0.0287822
RPLP1 ribosomal protein, large, P1 -0.0287717
RPS24 ribosomal protein S24 -0.0286387
GCLC glutamate-cysteine ligase, catalytic subunit -0.0271242
RPL5 ribosomal protein L5 -0.0269273
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0258679
BPTF bromodomain PHD finger transcription factor -0.0257113
PTEN phosphatase and tensin homolog -0.0253885
KLK10 kallikrein-related peptidase 10 -0.0238887
TNS3 tensin 3 -0.0238089
EGFR epidermal growth factor receptor -0.0235698
NTSR1 neurotensin receptor 1 (high affinity) -0.0230881
BAMBI BMP and activin membrane-bound inhibitor -0.022852
SKAP1 src kinase associated phosphoprotein 1 -0.0227076
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0224079
PTPRK protein tyrosine phosphatase, receptor type, K -0.022289
SH3D19 SH3 domain containing 19 -0.0218898
FOSL1 FOS-like antigen 1 -0.0217245
BMAL2 basic helix-loop-helix ARNT like 2 -0.0217079
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0214573
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0214451
ZNRF3 zinc and ring finger 3 -0.0213229
RNF43 ring finger protein 43 -0.0208855
RPLP2 ribosomal protein, large, P2 -0.0205896
HMGB1 high mobility group box 1 -0.0204141
ACTN4 actinin, alpha 4 -0.0203787
RPL26 ribosomal protein L26 -0.0202446
BCL2L1 BCL2-like 1 -0.020128
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0200254
RPS4X ribosomal protein S4, X-linked -0.0199667
RPS21 ribosomal protein S21 -0.0199496
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0199339
PDE4D phosphodiesterase 4D, cAMP-specific -0.0199191
FHL2 four and a half LIM domains 2 -0.0198605
THSD4 thrombospondin, type I, domain containing 4 -0.0194071
RPL9 ribosomal protein L9 -0.018908
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0184463
ZFP36 ZFP36 ring finger protein -0.0184419
IGFBP3 insulin-like growth factor binding protein 3 -0.0180789
TMSB10 thymosin beta 10 -0.0177664
BMP4 bone morphogenetic protein 4 -0.0176041
TOP1 topoisomerase (DNA) I -0.0175396
LMO7 LIM domain 7 -0.0175005
RACK1 receptor for activated C kinase 1 -0.017481
RPL38 ribosomal protein L38 -0.0174566
PHF14 PHD finger protein 14 -0.0173879
RUNX2 runt-related transcription factor 2 -0.0172735
ATP5F1B ATP synthase F1 subunit beta -0.01725
WDR70 WD repeat domain 70 -0.017237
RPL30 ribosomal protein L30 -0.0171857
RPS28 ribosomal protein S28 -0.0170767
RPS14 ribosomal protein S14 -0.0170097
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0169412
RPS17 ribosomal protein S17 -0.0164947
CLYBL citrate lyase beta like -0.016398
EVA1C eva-1 homolog C (C. elegans) -0.0163577
DOCK5 dedicator of cytokinesis 5 -0.016203
CLASP2 cytoplasmic linker associated protein 2 -0.0158541
SPATA13 spermatogenesis associated 13 -0.0158333
KIAA0040 KIAA0040 -0.0157162
CDCP1 CUB domain containing protein 1 -0.0156741
PATJ PATJ crumbs cell polarity complex component -0.0155743
MTAP methylthioadenosine phosphorylase -0.0154771
RPL36 ribosomal protein L36 -0.0154388
TBCA tubulin folding cofactor A -0.0153382
FHIT fragile histidine triad -0.0152815
LAMA4 laminin, alpha 4 -0.0152011
FRMD5 FERM domain containing 5 -0.0151901
NT5DC3 5'-nucleotidase domain containing 3 -0.0151384
ATXN7L1 ataxin 7-like 1 -0.0150187
FAM3C family with sequence similarity 3, member C -0.0150181
EMP1 epithelial membrane protein 1 -0.014979
BTBD9 BTB (POZ) domain containing 9 -0.0149099
CCSER1 coiled-coil serine-rich protein 1 -0.0148763