Flutamide_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flutamide perturbation in A-427 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Flutamide_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.198405
AREG amphiregulin 0.159903
PDE4D phosphodiesterase 4D, cAMP-specific 0.0820384
ANKRD12 ankyrin repeat domain 12 0.0677128
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0556343
EEF2 eukaryotic translation elongation factor 2 0.0519949
TXNRD1 thioredoxin reductase 1 0.0505853
ZBTB20 zinc finger and BTB domain containing 20 0.0500359
SLC38A2 solute carrier family 38, member 2 0.0480961
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.044839
TMEM41B transmembrane protein 41B 0.0426898
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0424583
NCEH1 neutral cholesterol ester hydrolase 1 0.0356811
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0318805
PDE4B phosphodiesterase 4B, cAMP-specific 0.0309315
RTN4 reticulon 4 0.0293992
ERRFI1 ERBB receptor feedback inhibitor 1 0.0293494
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0263005
KLF6 Kruppel-like factor 6 0.0262957
MTAP methylthioadenosine phosphorylase 0.0254339
MKI67 marker of proliferation Ki-67 0.0252015
ATP11A ATPase, class VI, type 11A 0.024185
VCL vinculin 0.0233457
CEP95 centrosomal protein 95kDa 0.0226455
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0219943
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0217503
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0215585
BRWD3 bromodomain and WD repeat domain containing 3 0.0211791
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.021129
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0211008
RPL12 ribosomal protein L12 0.0209569
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0207023
RPL37 ribosomal protein L37 0.0203757
NRXN3 neurexin 3 0.0200756
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0190804
ARL5B ADP-ribosylation factor-like 5B 0.0187056
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0183176
GOLT1A golgi transport 1A 0.018291
ZFYVE16 zinc finger, FYVE domain containing 16 0.0181906
ADGRG6 adhesion G protein-coupled receptor G6 0.0179461
EDN1 endothelin 1 0.0178357
NEK7 NIMA-related kinase 7 0.0178284
FTH1 ferritin, heavy polypeptide 1 0.0171609
RB1CC1 RB1-inducible coiled-coil 1 0.0170272
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 0.0167427
RPLP0 ribosomal protein, large, P0 0.0166379
TIGAR TP53 induced glycolysis regulatory phosphatase 0.0165849
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0165448
TM4SF1 transmembrane 4 L six family member 1 0.0165447
FGF20 fibroblast growth factor 20 0.016461
NFE2L1 nuclear factor, erythroid 2-like 1 0.0161956
XPOT exportin, tRNA 0.0161934
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0158475
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0157345
PCDH18 protocadherin 18 0.0157117
PAX6 paired box 6 0.0154534
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0154523
ITSN2 intersectin 2 0.0153705
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0153202
CDK19 cyclin-dependent kinase 19 0.0153094
JMJD1C jumonji domain containing 1C 0.0148706
CLDN1 claudin 1 0.0147206
COG5 component of oligomeric golgi complex 5 0.0144452
KIF5B kinesin family member 5B 0.0137738
BTBD10 BTB (POZ) domain containing 10 0.0136964
RACK1 receptor for activated C kinase 1 0.0136958
OXR1 oxidation resistance 1 0.0136923
KIAA1328 KIAA1328 0.0136625
TGIF1 TGFB-induced factor homeobox 1 0.01361
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0135884
TWF1 twinfilin actin binding protein 1 0.0135544
PFN1 profilin 1 0.0134609
THUMPD2 THUMP domain containing 2 0.0134277
SESN2 sestrin 2 0.0133697
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0132942
LMO7 LIM domain 7 0.013243
SPRED1 sprouty-related, EVH1 domain containing 1 0.013208
CXADR coxsackie virus and adenovirus receptor 0.0131138
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0130985
EIF1 eukaryotic translation initiation factor 1 0.0130028
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0130026
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0128047
GPR180 G protein-coupled receptor 180 0.0127085
SEPHS2 selenophosphate synthetase 2 0.0127021
SP3 Sp3 transcription factor 0.0126925
MACROD2 MACRO domain containing 2 0.0125961
SCAMP1 secretory carrier membrane protein 1 0.0125279
DLC1 DLC1 Rho GTPase activating protein 0.0125146
WDR41 WD repeat domain 41 0.0124946
PRKN parkin RBR E3 ubiquitin protein ligase 0.0124637
MEF2C myocyte enhancer factor 2C 0.0123582
SLC49A4 solute carrier family 49 member 4 0.0122262
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.012184
NIPSNAP2 nipsnap homolog 2 0.012153
EPS15 epidermal growth factor receptor pathway substrate 15 0.0121425
MAP1B microtubule-associated protein 1B 0.0121214
GPR15 G protein-coupled receptor 15 0.0120827
SPRED2 sprouty-related, EVH1 domain containing 2 0.0120494
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0119883
BARD1 BRCA1 associated RING domain 1 0.0119602

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.171047
NLGN1 neuroligin 1 -0.159975
PTMA prothymosin, alpha -0.129591
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.099734
TMSB10 thymosin beta 10 -0.093366
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.086916
HMGA2 high mobility group AT-hook 2 -0.0849421
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0818391
NAP1L1 nucleosome assembly protein 1-like 1 -0.0697444
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0662194
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0648876
ZFAND3 zinc finger, AN1-type domain 3 -0.0587549
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0570958
USP34 ubiquitin specific peptidase 34 -0.0564802
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0558714
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0554883
ACTG1 actin gamma 1 -0.0537372
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0533201
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0466555
EHBP1 EH domain binding protein 1 -0.0457503
TRIO trio Rho guanine nucleotide exchange factor -0.0453983
RAB7A RAB7A, member RAS oncogene family -0.0450609
ADIPOR2 adiponectin receptor 2 -0.0421188
SYT1 synaptotagmin I -0.0419695
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0415448
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.041394
RASAL2 RAS protein activator like 2 -0.0411224
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0410198
NHSL1 NHS-like 1 -0.0408146
AKAP12 A kinase (PRKA) anchor protein 12 -0.0398623
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0397359
MACF1 microtubule-actin crosslinking factor 1 -0.0396294
CANX calnexin -0.0386752
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0377496
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0375769
RPS3 ribosomal protein S3 -0.0365479
PA2G4 proliferation-associated 2G4, 38kDa -0.0352252
RERE arginine-glutamic acid dipeptide (RE) repeats -0.034465
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0339611
AHNAK AHNAK nucleoprotein -0.0339544
DEK DEK proto-oncogene -0.0329295
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0325717
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0322741
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0320606
CALR calreticulin -0.0317021
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0313133
DST dystonin -0.0312709
U2SURP U2 snRNP-associated SURP domain containing -0.0311073
KDM2A lysine (K)-specific demethylase 2A -0.0309472
INTS6 integrator complex subunit 6 -0.0307546
FNDC3B fibronectin type III domain containing 3B -0.0302527
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.030143
AFF4 AF4/FMR2 family, member 4 -0.0300008
HMGB1 high mobility group box 1 -0.0299462
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.029673
ZCCHC7 zinc finger, CCHC domain containing 7 -0.029416
BIRC3 baculoviral IAP repeat containing 3 -0.029055
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0290373
KMT2E lysine (K)-specific methyltransferase 2E -0.0288149
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0287222
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0287211
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0286971
SLC38A1 solute carrier family 38, member 1 -0.0286186
PCDH7 protocadherin 7 -0.0285113
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0280749
MAP4 microtubule-associated protein 4 -0.0280567
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0275248
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0275073
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0273536
FUS FUS RNA binding protein -0.0272864
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0271002
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0270821
PTK2 protein tyrosine kinase 2 -0.0267546
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0267488
HSPA4 heat shock 70kDa protein 4 -0.0266522
ENO1 enolase 1, (alpha) -0.0266239
SPDYA speedy/RINGO cell cycle regulator family member A -0.0264378
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0263966
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0263288
ASXL1 additional sex combs like transcriptional regulator 1 -0.0261504
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0258851
YAP1 Yes-associated protein 1 -0.0256038
TBC1D5 TBC1 domain family, member 5 -0.0255045
CELF2 CUGBP, Elav-like family member 2 -0.025421
RLF rearranged L-myc fusion -0.0250659
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0247482
H1-0 H1.0 linker histone -0.0247412
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0246949
TFRC transferrin receptor -0.0245808
PTMS parathymosin -0.0244975
PDIA6 protein disulfide isomerase family A, member 6 -0.0243635
WAC WW domain containing adaptor with coiled-coil -0.0242887
HDGF hepatoma-derived growth factor -0.0242602
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0241576
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0240794
CUX1 cut-like homeobox 1 -0.0240057
RBM25 RNA binding motif protein 25 -0.0237959
CHD4 chromodomain helicase DNA binding protein 4 -0.0236606
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0233418
KDM4C lysine (K)-specific demethylase 4C -0.0233328