Flutamide_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flutamide perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flutamide_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.449462
AKAP12 A kinase (PRKA) anchor protein 12 0.0643548
SOS1 son of sevenless homolog 1 (Drosophila) 0.0613936
PLAT plasminogen activator, tissue 0.0527874
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0522668
FAM13A family with sequence similarity 13, member A 0.0521317
EEF2 eukaryotic translation elongation factor 2 0.0451735
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.044251
SLITRK6 SLIT and NTRK-like family, member 6 0.0420425
WDR45B WD repeat domain 45B 0.0416552
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0415927
MEIS2 Meis homeobox 2 0.0412739
DST dystonin 0.0386337
FNBP1 formin binding protein 1 0.038586
ZNF292 zinc finger protein 292 0.0372452
MEF2A myocyte enhancer factor 2A 0.0353893
NFE2L1 nuclear factor, erythroid 2-like 1 0.0345046
STC1 stanniocalcin 1 0.0325798
DDIT4 DNA-damage-inducible transcript 4 0.0323747
MAP1B microtubule-associated protein 1B 0.0299141
GDF15 growth differentiation factor 15 0.0290532
LIMCH1 LIM and calponin homology domains 1 0.0274126
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0273331
PGK1 phosphoglycerate kinase 1 0.0269251
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0263515
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0262233
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0257367
HELZ helicase with zinc finger 0.0256331
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0253085
NDRG1 N-myc downstream regulated 1 0.0250586
RGS4 regulator of G-protein signaling 4 0.024598
ZBTB20 zinc finger and BTB domain containing 20 0.0242859
PTPRD protein tyrosine phosphatase, receptor type, D 0.0242244
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0238379
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0232946
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0230302
CD36 CD36 molecule (thrombospondin receptor) 0.0228246
FTH1 ferritin, heavy polypeptide 1 0.022392
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0220962
ITPRID2 ITPR interacting domain containing 2 0.0220501
TOB1 transducer of ERBB2, 1 0.0218312
MTUS1 microtubule associated tumor suppressor 1 0.0211457
FMN1 formin 1 0.020987
PCBP3 poly(rC) binding protein 3 0.0207828
ARRDC3 arrestin domain containing 3 0.0207338
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0207014
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0205266
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0205154
IGFBP4 insulin-like growth factor binding protein 4 0.0204714
YTHDC1 YTH domain containing 1 0.0202085
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0199115
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0196809
ZMIZ1 zinc finger, MIZ-type containing 1 0.0196074
TPR translocated promoter region, nuclear basket protein 0.0192493
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0191926
COL3A1 collagen, type III, alpha 1 0.0187041
MMP2 matrix metallopeptidase 2 0.0186519
ZFC3H1 zinc finger, C3H1-type containing 0.0184527
FNIP1 folliculin interacting protein 1 0.0181926
PPARG peroxisome proliferator-activated receptor gamma 0.0181471
AMOTL1 angiomotin like 1 0.0180514
HAND2 heart and neural crest derivatives expressed 2 0.0179339
NUP58 nucleoporin 58 0.0179186
UBAP2L ubiquitin associated protein 2-like 0.0178055
CSDE1 cold shock domain containing E1, RNA-binding 0.0177516
SSH1 slingshot protein phosphatase 1 0.0175128
HILPDA hypoxia inducible lipid droplet-associated 0.0173456
PTEN phosphatase and tensin homolog 0.0167282
LIFR leukemia inhibitory factor receptor alpha 0.0167179
ARHGAP5 Rho GTPase activating protein 5 0.016652
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0165625
ITGA1 integrin, alpha 1 0.0165271
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0164365
CERK ceramide kinase 0.0161416
ARHGAP9 Rho GTPase activating protein 9 0.0161362
ZNF148 zinc finger protein 148 0.0161251
MBNL2 muscleblind-like splicing regulator 2 0.0158944
YEATS2 YEATS domain containing 2 0.0158448
BTG1 B-cell translocation gene 1, anti-proliferative 0.0158283
DAND5 DAN domain family member 5, BMP antagonist 0.0156513
NKTR natural killer cell triggering receptor 0.0156113
SLC38A1 solute carrier family 38, member 1 0.0155521
RAB30 RAB30, member RAS oncogene family 0.0154274
KIF5B kinesin family member 5B 0.0154231
ADGRG6 adhesion G protein-coupled receptor G6 0.0153731
SOX9 SRY (sex determining region Y)-box 9 0.0152708
PRPF3 pre-mRNA processing factor 3 0.0152507
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0151332
EPHA3 EPH receptor A3 0.0150444
CAB39 calcium binding protein 39 0.0149651
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0148812
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0148123
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0146571
PSD3 pleckstrin and Sec7 domain containing 3 0.0146028
CLTC clathrin, heavy chain (Hc) 0.0145987
RNF145 ring finger protein 145 0.0145979
CD46 CD46 molecule, complement regulatory protein 0.0145593
PCDH9 protocadherin 9 0.0143691
UBA6 ubiquitin-like modifier activating enzyme 6 0.0143286
TMED2 transmembrane emp24 domain trafficking protein 2 0.014313

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.102949
PTMA prothymosin, alpha -0.0930436
VCL vinculin -0.0904255
NALF1 NALCN channel auxiliary factor 1 -0.0895426
RPL23 ribosomal protein L23 -0.0577931
EXT1 exostosin glycosyltransferase 1 -0.0570118
NRG1 neuregulin 1 -0.0559297
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0494362
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0493289
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0484741
RPS6 ribosomal protein S6 -0.0483204
THSD4 thrombospondin, type I, domain containing 4 -0.0475522
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.047128
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0468587
RPL38 ribosomal protein L38 -0.0461849
TPT1 tumor protein, translationally-controlled 1 -0.0449442
TMSB10 thymosin beta 10 -0.0420781
ZSWIM6 zinc finger, SWIM-type containing 6 -0.041661
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0406421
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0403014
RPL34 ribosomal protein L34 -0.0389384
RPL19 ribosomal protein L19 -0.0381935
RPLP1 ribosomal protein, large, P1 -0.0379197
TPM1 tropomyosin 1 (alpha) -0.0374239
LPIN1 lipin 1 -0.0372626
PRKCA protein kinase C, alpha -0.0369558
ZNF804A zinc finger protein 804A -0.0363175
NPAS2 neuronal PAS domain protein 2 -0.0350627
LPP LIM domain containing preferred translocation partner in lipoma -0.0343565
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0340424
ZFAND3 zinc finger, AN1-type domain 3 -0.0324155
RPS24 ribosomal protein S24 -0.0316707
AK1 adenylate kinase 1 -0.0310398
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0282797
RPL26 ribosomal protein L26 -0.0281554
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0279806
ACTG1 actin gamma 1 -0.027913
BCAS3 breast carcinoma amplified sequence 3 -0.0277855
MSI2 musashi RNA-binding protein 2 -0.0272444
EXOC4 exocyst complex component 4 -0.0270327
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0263078
COL1A1 collagen, type I, alpha 1 -0.0257479
TRPS1 trichorhinophalangeal syndrome I -0.0256084
FRMD4A FERM domain containing 4A -0.0253636
MED13 mediator complex subunit 13 -0.0252832
CDK12 cyclin-dependent kinase 12 -0.0252115
RPL31 ribosomal protein L31 -0.0250372
HDLBP high density lipoprotein binding protein -0.0250046
CEMIP cell migration inducing protein, hyaluronan binding -0.0249993
INTS6 integrator complex subunit 6 -0.0247934
RPS19 ribosomal protein S19 -0.0246103
RBM39 RNA binding motif protein 39 -0.0241745
H3-3B H3.3 histone B -0.0233348
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0232636
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0231414
RPS25 ribosomal protein S25 -0.0229026
UNC5C unc-5 homolog C (C. elegans) -0.0227224
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0223937
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0223868
DLG1 discs, large homolog 1 (Drosophila) -0.0222686
GREM2 gremlin 2, DAN family BMP antagonist -0.0221474
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0221343
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0218101
DACH2 dachshund family transcription factor 2 -0.0214151
IER3 immediate early response 3 -0.021311
RBM25 RNA binding motif protein 25 -0.021237
EFNA5 ephrin-A5 -0.0210188
RPL35A ribosomal protein L35a -0.0208502
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0207558
CUX1 cut-like homeobox 1 -0.0206219
CNTN4 contactin 4 -0.0204192
RPL36 ribosomal protein L36 -0.020378
DSTN destrin (actin depolymerizing factor) -0.0199282
VMP1 vacuole membrane protein 1 -0.0198585
RPS11 ribosomal protein S11 -0.0198268
SAMD4A sterile alpha motif domain containing 4A -0.0195631
MYH9 myosin, heavy chain 9, non-muscle -0.0195233
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0193501
ZNF609 zinc finger protein 609 -0.019155
ASPH aspartate beta-hydroxylase -0.0191107
RPS23 ribosomal protein S23 -0.0190714
MAML2 mastermind-like 2 (Drosophila) -0.0189045
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0188904
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0187886
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0187825
ATXN1 ataxin 1 -0.0186623
EGFR epidermal growth factor receptor -0.0186585
RPL12 ribosomal protein L12 -0.0186561
RPS8 ribosomal protein S8 -0.0185876
MCL1 myeloid cell leukemia 1 -0.0183915
ARID4B AT rich interactive domain 4B (RBP1-like) -0.018197
SMAD3 SMAD family member 3 -0.0179833
SRPK2 SRSF protein kinase 2 -0.0177105
SEPTIN7 septin 7 -0.0175691
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0175191
IGF1R insulin-like growth factor 1 receptor -0.0174088
RPL9 ribosomal protein L9 -0.01737
PDZRN3 PDZ domain containing ring finger 3 -0.0173221
UBE2B ubiquitin-conjugating enzyme E2B -0.0171447
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0170898