Flutamide_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flutamide perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Flutamide_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MACC1 metastasis associated in colon cancer 1 0.0954629
NDRG1 N-myc downstream regulated 1 0.077072
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0750019
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0696859
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0626773
ERBIN erbb2 interacting protein 0.0618529
SPTBN1 spectrin, beta, non-erythrocytic 1 0.056568
DSCAM Down syndrome cell adhesion molecule 0.0549458
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0543245
STK24 serine/threonine kinase 24 0.0512918
PTBP3 polypyrimidine tract binding protein 3 0.0494326
ZMYND8 zinc finger, MYND-type containing 8 0.0412142
EPS8 epidermal growth factor receptor pathway substrate 8 0.0410685
ZNF292 zinc finger protein 292 0.0410108
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0408306
LIMA1 LIM domain and actin binding 1 0.0396058
PADI1 peptidyl arginine deiminase, type I 0.0390877
TXNIP thioredoxin interacting protein 0.037887
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0365193
RNF149 ring finger protein 149 0.0354519
MYO1E myosin IE 0.0349033
PGK1 phosphoglycerate kinase 1 0.0339177
ERRFI1 ERBB receptor feedback inhibitor 1 0.0336664
FHL2 four and a half LIM domains 2 0.0334976
KMT2E lysine (K)-specific methyltransferase 2E 0.033213
TMEM62 transmembrane protein 62 0.0327857
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0327268
FAT1 FAT atypical cadherin 1 0.0324035
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0317728
SRRM2 serine/arginine repetitive matrix 2 0.031623
OARD1 O-acyl-ADP-ribose deacylase 1 0.0308205
NCKAP5 NCK-associated protein 5 0.0307772
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0304471
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0303565
USP54 ubiquitin specific peptidase 54 0.0300812
ARGLU1 arginine and glutamate rich 1 0.0299247
IFNGR1 interferon gamma receptor 1 0.0297583
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0295057
VCL vinculin 0.0294326
OCLN occludin 0.0290509
KLF5 Kruppel-like factor 5 (intestinal) 0.0285123
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0284416
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0283482
RAD51B RAD51 paralog B 0.0278834
NRIP1 nuclear receptor interacting protein 1 0.0277753
BTBD9 BTB (POZ) domain containing 9 0.0277491
STS steroid sulfatase (microsomal), isozyme S 0.0274093
SYNE2 spectrin repeat containing, nuclear envelope 2 0.027016
PRELID2 PRELI domain containing 2 0.0269372
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0269067
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0264786
KLF3 Kruppel-like factor 3 (basic) 0.0262988
ARRDC3 arrestin domain containing 3 0.0261221
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0258993
KIF16B kinesin family member 16B 0.0258864
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0257589
TMEM51 transmembrane protein 51 0.025608
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.025413
ARHGAP5 Rho GTPase activating protein 5 0.0250958
AKAP13 A kinase (PRKA) anchor protein 13 0.0248716
ADAM10 ADAM metallopeptidase domain 10 0.0244824
LDHA lactate dehydrogenase A 0.0241535
RAB6A RAB6A, member RAS oncogene family 0.0240362
ITCH itchy E3 ubiquitin protein ligase 0.0238352
PLAUR plasminogen activator, urokinase receptor 0.0238333
ANKRD17 ankyrin repeat domain 17 0.023536
CD46 CD46 molecule, complement regulatory protein 0.0235123
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0232815
LURAP1L leucine rich adaptor protein 1-like 0.0232234
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0230957
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0229723
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0229629
COG6 component of oligomeric golgi complex 6 0.0225329
PTEN phosphatase and tensin homolog 0.0223047
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0222185
WDR26 WD repeat domain 26 0.0220591
UGCG UDP-glucose ceramide glucosyltransferase 0.0219762
MBNL1 muscleblind-like splicing regulator 1 0.0217599
ZNF148 zinc finger protein 148 0.0216979
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0216694
RBM26 RNA binding motif protein 26 0.0216568
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0215444
MBNL2 muscleblind-like splicing regulator 2 0.0215069
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0213228
CD68 CD68 molecule 0.0208019
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0206899
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0206757
FRK fyn-related Src family tyrosine kinase 0.0206653
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0206612
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0203565
PIAS1 protein inhibitor of activated STAT, 1 0.0201351
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.0200995
CMIP c-Maf inducing protein 0.019738
NMU neuromedin U 0.0196628
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.019429
TNRC6B trinucleotide repeat containing 6B 0.0193748
AKAP9 A kinase (PRKA) anchor protein 9 0.0193465
EHF ets homologous factor 0.0192732
KLF6 Kruppel-like factor 6 0.0191609
ZDHHC20 zinc finger, DHHC-type containing 20 0.0190793

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.145518
TPT1 tumor protein, translationally-controlled 1 -0.141457
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108446
GMDS GDP-mannose 4,6-dehydratase -0.0817094
SQSTM1 sequestosome 1 -0.0744568
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0723308
IRF1 interferon regulatory factor 1 -0.0699964
LMO7 LIM domain 7 -0.0632954
PTMA prothymosin, alpha -0.0578634
GCLC glutamate-cysteine ligase, catalytic subunit -0.0525963
EZR ezrin -0.0522434
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0512138
MX1 MX dynamin-like GTPase 1 -0.0511011
RPS6 ribosomal protein S6 -0.0484028
LCN2 lipocalin 2 -0.0470824
H1-0 H1.0 linker histone -0.0468294
RRBP1 ribosome binding protein 1 -0.0465145
INTS6 integrator complex subunit 6 -0.046159
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0447729
RIGI RNA sensor RIG-I -0.0445904
MX2 MX dynamin-like GTPase 2 -0.0422229
PERP PERP, TP53 apoptosis effector -0.041594
AHNAK AHNAK nucleoprotein -0.0403766
GOLGB1 golgin B1 -0.0385856
HDLBP high density lipoprotein binding protein -0.0381977
UGDH UDP-glucose 6-dehydrogenase -0.0364971
SP100 SP100 nuclear antigen -0.0358571
CANX calnexin -0.0356175
STAT1 signal transducer and activator of transcription 1, 91kDa -0.035455
SDC4 syndecan 4 -0.0353152
EPHB2 EPH receptor B2 -0.0330903
ARHGAP26 Rho GTPase activating protein 26 -0.0328697
AGR2 anterior gradient 2 -0.0319433
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0317766
RPL19 ribosomal protein L19 -0.0315761
MORF4L2 mortality factor 4 like 2 -0.0313798
MSI2 musashi RNA-binding protein 2 -0.0306955
AHI1 Abelson helper integration site 1 -0.0306098
RPL34 ribosomal protein L34 -0.0305244
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0303506
ZSWIM6 zinc finger, SWIM-type containing 6 -0.029994
XAF1 XIAP associated factor 1 -0.0296394
S100A10 S100 calcium binding protein A10 -0.0285035
ITGA6 integrin, alpha 6 -0.0274774
RPLP1 ribosomal protein, large, P1 -0.026913
HMGB1 high mobility group box 1 -0.0268522
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0266626
HLA-C major histocompatibility complex, class I, C -0.0258165
FUS FUS RNA binding protein -0.025093
RPS24 ribosomal protein S24 -0.0246597
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0245818
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0245154
PKM pyruvate kinase, muscle -0.0242271
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0238298
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0237681
TXNRD1 thioredoxin reductase 1 -0.0237316
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0236853
RPL12 ribosomal protein L12 -0.0232993
RPL38 ribosomal protein L38 -0.0228527
VDAC1 voltage-dependent anion channel 1 -0.022694
CATSPERB catsper channel auxiliary subunit beta -0.0225621
GLO1 glyoxalase I -0.0224786
S100A6 S100 calcium binding protein A6 -0.0219942
LAMA4 laminin, alpha 4 -0.0215572
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0209257
UBC ubiquitin C -0.0209107
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0208873
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0208089
RPL7L1 ribosomal protein L7-like 1 -0.0206711
IER3 immediate early response 3 -0.0205937
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0205514
PLSCR1 phospholipid scramblase 1 -0.0203292
RUNX1 runt-related transcription factor 1 -0.0198623
UFM1 ubiquitin-fold modifier 1 -0.0198495
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0196827
H3-3B H3.3 histone B -0.0196721
SLC38A2 solute carrier family 38, member 2 -0.0196371
DEK DEK proto-oncogene -0.0195996
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.019536
EGR1 early growth response 1 -0.0194013
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0192905
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0191059
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0188386
ACTG1 actin gamma 1 -0.0188211
RPL31 ribosomal protein L31 -0.0187511
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0187375
MCL1 myeloid cell leukemia 1 -0.0185458
NPSR1 neuropeptide S receptor 1 -0.0184999
RPL32 ribosomal protein L32 -0.0183135
KRT8 keratin 8, type II -0.0182548
RAB1A RAB1A, member RAS oncogene family -0.0181971
FTL ferritin, light polypeptide -0.0180379
EIF1 eukaryotic translation initiation factor 1 -0.0178754
RPL23 ribosomal protein L23 -0.0178591
TMCO3 transmembrane and coiled-coil domains 3 -0.017821
SENP5 SUMO1/sentrin specific peptidase 5 -0.0175453
NCOA7 nuclear receptor coactivator 7 -0.0174709
IARS1 isoleucyl-tRNA synthetase 1 -0.0173195
ANXA2 annexin A2 -0.017286
TMSB10 thymosin beta 10 -0.0172037