| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Flutamide perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Flutamide_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.423003 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.324242 |
| APOB | apolipoprotein B | 0.233372 |
| FN1 | fibronectin 1 | 0.126062 |
| MT2A | metallothionein 2A | 0.114616 |
| C3 | complement component 3 | 0.103637 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.076124 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0633244 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0622594 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0620491 |
| GPC3 | glypican 3 | 0.05975 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0592409 |
| TF | transferrin | 0.0591006 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0578091 |
| SLC38A2 | solute carrier family 38, member 2 | 0.057709 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0568213 |
| TRIM26 | tripartite motif containing 26 | 0.0549044 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.04947 |
| APOA2 | apolipoprotein A-II | 0.0452459 |
| RPL11 | ribosomal protein L11 | 0.0439619 |
| FTL | ferritin, light polypeptide | 0.0435035 |
| RPS12 | ribosomal protein S12 | 0.0425519 |
| DSPP | dentin sialophosphoprotein | 0.0421811 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0417343 |
| A2M | alpha-2-macroglobulin | 0.0395623 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0382713 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0380839 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0379037 |
| RPLP0 | ribosomal protein, large, P0 | 0.0355156 |
| ENO1 | enolase 1, (alpha) | 0.0340668 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0339689 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0337993 |
| KIF5B | kinesin family member 5B | 0.0330901 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0327007 |
| CFB | complement factor B | 0.0324435 |
| RPS6 | ribosomal protein S6 | 0.0320771 |
| ITGAV | integrin, alpha V | 0.032025 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0316781 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0314729 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0311458 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0311188 |
| MRTFA | myocardin related transcription factor A | 0.0310988 |
| RPL35A | ribosomal protein L35a | 0.0310113 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0299115 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0298439 |
| AFDN | afadin, adherens junction formation factor | 0.029694 |
| VCL | vinculin | 0.0290493 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0284999 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0284636 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0283431 |
| MBNL3 | muscleblind-like splicing regulator 3 | 0.0274798 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0274504 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.027338 |
| BCL2L1 | BCL2-like 1 | 0.0272505 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0259982 |
| RPS8 | ribosomal protein S8 | 0.0255763 |
| CPE | carboxypeptidase E | 0.0255152 |
| APOE | apolipoprotein E | 0.0253519 |
| RACK1 | receptor for activated C kinase 1 | 0.0249215 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.024465 |
| LDHA | lactate dehydrogenase A | 0.0244255 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0242634 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0240799 |
| PCBP2 | poly(rC) binding protein 2 | 0.0237534 |
| RPS19 | ribosomal protein S19 | 0.0237092 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0229616 |
| FAT1 | FAT atypical cadherin 1 | 0.0228335 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0228012 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0226179 |
| SFTPA2 | surfactant protein A2 | 0.022489 |
| PEG10 | paternally expressed 10 | 0.0224393 |
| GDF15 | growth differentiation factor 15 | 0.0224272 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0223009 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0221357 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0214154 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0212221 |
| RPL23 | ribosomal protein L23 | 0.0212194 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0210134 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.020941 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.020939 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0205613 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.020509 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0204527 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0204516 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0199827 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0198629 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0192999 |
| JMJD1C | jumonji domain containing 1C | 0.0192138 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0186825 |
| FOXO1 | forkhead box O1 | 0.0186583 |
| TMEM123 | transmembrane protein 123 | 0.0186194 |
| RPL37A | ribosomal protein L37a | 0.0183163 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0183009 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | 0.0180542 |
| RPL9 | ribosomal protein L9 | 0.0178502 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0178318 |
| PEG3 | paternally expressed 3 | 0.0178304 |
| RPS23 | ribosomal protein S23 | 0.0177325 |
| RPLP1 | ribosomal protein, large, P1 | 0.0175047 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0174263 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.116986 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0896586 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0644636 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0552855 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0506063 |
| INTS6 | integrator complex subunit 6 | -0.0448303 |
| GPC6 | glypican 6 | -0.0435465 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0392185 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0391632 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0372889 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0362724 |
| PDLIM5 | PDZ and LIM domain 5 | -0.036092 |
| ASPH | aspartate beta-hydroxylase | -0.0347571 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0305476 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0286515 |
| ATP10A | ATPase, class V, type 10A | -0.028348 |
| ATXN1 | ataxin 1 | -0.0268917 |
| DTNA | dystrobrevin, alpha | -0.0267733 |
| FMNL2 | formin-like 2 | -0.026065 |
| GK | glycerol kinase | -0.0259659 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0253941 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0253283 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0237601 |
| KIAA1217 | KIAA1217 | -0.0236162 |
| RIGI | RNA sensor RIG-I | -0.0233804 |
| RNF213 | ring finger protein 213 | -0.0231045 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0230424 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0228857 |
| PLXDC2 | plexin domain containing 2 | -0.0221288 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0219915 |
| FLNB | filamin B, beta | -0.0212692 |
| RAD51B | RAD51 paralog B | -0.0212672 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.021259 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0206776 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.020222 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0201717 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0200711 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0194767 |
| MYO1E | myosin IE | -0.0192865 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0191357 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0190442 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0190067 |
| SQSTM1 | sequestosome 1 | -0.0181875 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0181451 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0179846 |
| NHSL1 | NHS-like 1 | -0.0176062 |
| NABP1 | nucleic acid binding protein 1 | -0.0171952 |
| GOLGB1 | golgin B1 | -0.0171836 |
| HPCAL1 | hippocalcin-like 1 | -0.0171463 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0163313 |
| HDAC4 | histone deacetylase 4 | -0.0163054 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0160861 |
| HOMER1 | homer scaffolding protein 1 | -0.0157236 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0155094 |
| EHBP1 | EH domain binding protein 1 | -0.0154111 |
| FAM107B | family with sequence similarity 107, member B | -0.0153575 |
| MX2 | MX dynamin-like GTPase 2 | -0.0151517 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0151011 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0148883 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0148484 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0147036 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0144302 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0143685 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0143295 |
| FKTN | fukutin | -0.0142541 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0141417 |
| AHNAK | AHNAK nucleoprotein | -0.0141255 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0139166 |
| COL27A1 | collagen, type XXVII, alpha 1 | -0.0137609 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0136094 |
| FRMD5 | FERM domain containing 5 | -0.0135665 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0135544 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0134117 |
| PARD3 | par-3 family cell polarity regulator | -0.0133871 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.01338 |
| TMSB10 | thymosin beta 10 | -0.01327 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0132633 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0129016 |
| RCC1 | regulator of chromosome condensation 1 | -0.0128436 |
| STK17A | serine/threonine kinase 17a | -0.0127278 |
| CLIC4 | chloride intracellular channel 4 | -0.0126751 |
| CP | ceruloplasmin (ferroxidase) | -0.0126299 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.012584 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0125126 |
| TNS3 | tensin 3 | -0.0124812 |
| PLIN2 | perilipin 2 | -0.0124638 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0124471 |
| PALLD | palladin, cytoskeletal associated protein | -0.01244 |
| PMM2 | phosphomannomutase 2 | -0.0121676 |
| TNS1 | tensin 1 | -0.0120427 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0120252 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0119217 |
| HM13 | histocompatibility (minor) 13 | -0.0118263 |
| PRDM2 | PR domain containing 2, with ZNF domain | -0.0115497 |
| FAM13A | family with sequence similarity 13, member A | -0.0115492 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.011502 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0113888 |
| CANX | calnexin | -0.011337 |
| LMO7 | LIM domain 7 | -0.0113048 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0112992 |
