Flutamide_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flutamide perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flutamide_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0514885
TGM2 transglutaminase 2 0.0447571
MBNL1 muscleblind-like splicing regulator 1 0.0398896
INTS6 integrator complex subunit 6 0.0387461
FOXO1 forkhead box O1 0.0337636
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0321791
CEMIP cell migration inducing protein, hyaluronan binding 0.0312572
VCL vinculin 0.0299157
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0290888
ITGA6 integrin, alpha 6 0.0258466
EGR1 early growth response 1 0.0232437
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0218085
STC1 stanniocalcin 1 0.0214689
NECTIN1 nectin cell adhesion molecule 1 0.0211826
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0207881
CYB5R3 cytochrome b5 reductase 3 0.020457
POTEF POTE ankyrin domain family, member F 0.0201733
PLAT plasminogen activator, tissue 0.0200065
PCDH1 protocadherin 1 0.0198526
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0198275
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0194617
KRT6A keratin 6A, type II 0.0190022
LUZP1 leucine zipper protein 1 0.0184234
AKAP9 A kinase (PRKA) anchor protein 9 0.0182587
CLU clusterin 0.0181594
CAPRIN2 caprin family member 2 0.0181087
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0180456
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0179934
EPHA2 EPH receptor A2 0.0173832
NRG1 neuregulin 1 0.0173229
C1D C1D nuclear receptor corepressor 0.0167461
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0162143
PDLIM1 PDZ and LIM domain 1 0.0159898
CD44 CD44 molecule (Indian blood group) 0.0158922
RPS13 ribosomal protein S13 0.0157786
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0156611
ANKRD33B ankyrin repeat domain 33B 0.015466
SEPTIN9 septin 9 0.0153042
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0152579
BCL2L1 BCL2-like 1 0.0152425
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0151614
LIMA1 LIM domain and actin binding 1 0.0151069
NCEH1 neutral cholesterol ester hydrolase 1 0.014946
PLK2 polo-like kinase 2 0.0149321
FLNA filamin A, alpha 0.0148172
JAG1 jagged 1 0.0142015
APLP2 amyloid beta (A4) precursor-like protein 2 0.0141646
RPS23 ribosomal protein S23 0.0139632
MT1E metallothionein 1E 0.0137836
ARRDC3 arrestin domain containing 3 0.0131556
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0130976
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0130266
FRMD6 FERM domain containing 6 0.0127971
ITSN1 intersectin 1 (SH3 domain protein) 0.0124935
CD59 CD59 molecule, complement regulatory protein 0.0124818
MSN moesin 0.012386
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0123859
RIN2 Ras and Rab interactor 2 0.0123626
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0123557
DOCK5 dedicator of cytokinesis 5 0.0122106
MT2A metallothionein 2A 0.0121567
ANKH ANKH inorganic pyrophosphate transport regulator 0.0120806
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0120763
SOX7 SRY (sex determining region Y)-box 7 0.0120516
FTL ferritin, light polypeptide 0.0119381
TSC22D1 TSC22 domain family, member 1 0.0118558
RPS27 ribosomal protein S27 0.0116138
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0116079
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0115723
SLTM SAFB-like, transcription modulator 0.011437
USO1 USO1 vesicle transport factor 0.011303
BCL10 B-cell CLL/lymphoma 10 0.0112313
CTSD cathepsin D 0.0110666
GPR176 G protein-coupled receptor 176 0.0110405
KTN1 kinectin 1 (kinesin receptor) 0.0110277
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.011015
ENO2 enolase 2 (gamma, neuronal) 0.0109632
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0109484
PNISR PNN-interacting serine/arginine-rich protein 0.0108894
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0108295
S100A2 S100 calcium binding protein A2 0.0107768
SCFD1 sec1 family domain containing 1 0.0106155
COG6 component of oligomeric golgi complex 6 0.0104277
NLRP1 NLR family, pyrin domain containing 1 0.01036
IFITM3 interferon induced transmembrane protein 3 0.0102936
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0102863
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0102787
FNIP1 folliculin interacting protein 1 0.0100896
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.00998723
LOXL2 lysyl oxidase-like 2 0.00990188
SRRM2 serine/arginine repetitive matrix 2 0.00988794
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.00966492
MYO9A myosin IXA 0.0096567
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00951467
SKAP2 src kinase associated phosphoprotein 2 0.00947288
PKP2 plakophilin 2 0.00938554
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.00928988
PTEN phosphatase and tensin homolog 0.00928541
ANKRD12 ankyrin repeat domain 12 0.00924707
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.00919109

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.176167
TIMP3 TIMP metallopeptidase inhibitor 3 -0.150493
AHNAK AHNAK nucleoprotein -0.0857745
PDE4D phosphodiesterase 4D, cAMP-specific -0.0720497
LMO7 LIM domain 7 -0.0668083
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0662631
RAI14 retinoic acid induced 14 -0.0611017
DPYD dihydropyrimidine dehydrogenase -0.0554206
PTMA prothymosin, alpha -0.0513678
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0472344
TMSB4X thymosin beta 4, X-linked -0.0461531
TPT1 tumor protein, translationally-controlled 1 -0.0459884
ABI3BP ABI family, member 3 (NESH) binding protein -0.0415084
MTSS1 metastasis suppressor 1 -0.0385697
ZMYND8 zinc finger, MYND-type containing 8 -0.0379652
MACF1 microtubule-actin crosslinking factor 1 -0.0379373
SULF1 sulfatase 1 -0.0375942
ANXA1 annexin A1 -0.0369454
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.036695
PSD3 pleckstrin and Sec7 domain containing 3 -0.0366523
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0342822
RABGAP1L RAB GTPase activating protein 1-like -0.0339036
PALM2AKAP2 PALM2 and AKAP2 fusion -0.033569
RBM39 RNA binding motif protein 39 -0.0326345
ZNFX1 zinc finger, NFX1-type containing 1 -0.0318273
RIGI RNA sensor RIG-I -0.0310286
TXNRD1 thioredoxin reductase 1 -0.0293583
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0285183
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0283612
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0281118
GNAS GNAS complex locus -0.0280755
ANO1 anoctamin 1, calcium activated chloride channel -0.0275882
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0275667
RPS6 ribosomal protein S6 -0.026789
LAMC2 laminin, gamma 2 -0.0253844
WARS1 tryptophanyl-tRNA synthetase 1 -0.024746
PRRC2C proline-rich coiled-coil 2C -0.0246581
ASPH aspartate beta-hydroxylase -0.0245354
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0244893
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0244144
IFIH1 interferon induced with helicase C domain 1 -0.0241204
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0241148
H1-0 H1.0 linker histone -0.0240933
CAVIN1 caveolae associated protein 1 -0.0240112
KLF5 Kruppel-like factor 5 (intestinal) -0.0237484
LMNA lamin A/C -0.0233808
EXT1 exostosin glycosyltransferase 1 -0.0233032
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0231994
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0229787
SULF2 sulfatase 2 -0.0228011
CALB1 calbindin 1, 28kDa -0.0225669
ZEB1 zinc finger E-box binding homeobox 1 -0.0224153
PTK2 protein tyrosine kinase 2 -0.0224076
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.022364
FOXP1 forkhead box P1 -0.0221669
NAV2 neuron navigator 2 -0.0220043
HSPG2 heparan sulfate proteoglycan 2 -0.0219317
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.021698
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.021145
GRB10 growth factor receptor-bound protein 10 -0.0211426
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0211312
EMP1 epithelial membrane protein 1 -0.0210179
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0208435
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0206742
SP100 SP100 nuclear antigen -0.0206537
JMJD1C jumonji domain containing 1C -0.0205296
BZW1 basic leucine zipper and W2 domains 1 -0.0204415
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0203008
CANX calnexin -0.0202883
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0201236
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0199115
TMSB10 thymosin beta 10 -0.0194759
IFI44L interferon-induced protein 44-like -0.0194347
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0191741
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0191721
RASAL2 RAS protein activator like 2 -0.0191626
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0186678
SQSTM1 sequestosome 1 -0.018655
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0186062
SAMD9 sterile alpha motif domain containing 9 -0.0185917
HSPH1 heat shock 105kDa/110kDa protein 1 -0.01859
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0185347
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.018532
KMT2C lysine (K)-specific methyltransferase 2C -0.0183376
EZR ezrin -0.0182726
SMYD3 SET and MYND domain containing 3 -0.0180984
AOPEP aminopeptidase O (putative) -0.0178005
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0177694
ECPAS Ecm29 proteasome adaptor and scaffold -0.0177484
TOP1 topoisomerase (DNA) I -0.0177274
SLC35F3 solute carrier family 35, member F3 -0.0176378
RPLP1 ribosomal protein, large, P1 -0.0172432
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.017169
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0171581
FAF1 Fas (TNFRSF6) associated factor 1 -0.0171488
MECOM MDS1 and EVI1 complex locus -0.0171244
RSL1D1 ribosomal L1 domain containing 1 -0.0170659
TNS3 tensin 3 -0.0170331
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0169326
RRBP1 ribosome binding protein 1 -0.01693