Flutamide_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flutamide perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flutamide_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.116131
TXNRD1 thioredoxin reductase 1 0.115011
EEF2 eukaryotic translation elongation factor 2 0.0943712
TM4SF1 transmembrane 4 L six family member 1 0.0919456
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0849925
RAI1 retinoic acid induced 1 0.0787454
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0644723
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0594516
VIM vimentin 0.0551025
SLC38A2 solute carrier family 38, member 2 0.0513347
MACF1 microtubule-actin crosslinking factor 1 0.050686
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0476603
EREG epiregulin 0.0445444
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0445235
YEATS2 YEATS domain containing 2 0.044479
USP34 ubiquitin specific peptidase 34 0.0441983
ARHGAP5 Rho GTPase activating protein 5 0.0440378
PGK1 phosphoglycerate kinase 1 0.0425881
SPAG9 sperm associated antigen 9 0.0414015
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0400176
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.03894
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0376216
TMEM41B transmembrane protein 41B 0.0374282
PYGL phosphorylase, glycogen, liver 0.0353469
HOOK2 hook microtubule-tethering protein 2 0.0351829
SPRY4 sprouty homolog 4 (Drosophila) 0.0336177
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0335782
MKI67 marker of proliferation Ki-67 0.033453
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0333974
KLF6 Kruppel-like factor 6 0.0333699
CSNK1A1 casein kinase 1, alpha 1 0.0329433
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0326549
KMT2E lysine (K)-specific methyltransferase 2E 0.0325969
ESYT2 extended synaptotagmin-like protein 2 0.0325383
ANGPTL4 angiopoietin-like 4 0.0314032
LOXL2 lysyl oxidase-like 2 0.0311954
WWTR1 WW domain containing transcription regulator 1 0.030925
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0303225
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0302871
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0288318
EZR ezrin 0.0287665
UPP1 uridine phosphorylase 1 0.0286398
NAV2 neuron navigator 2 0.0285716
ZEB1 zinc finger E-box binding homeobox 1 0.028511
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0282717
USP9X ubiquitin specific peptidase 9, X-linked 0.0282219
ADAM17 ADAM metallopeptidase domain 17 0.0282138
AFF4 AF4/FMR2 family, member 4 0.0281857
PSD3 pleckstrin and Sec7 domain containing 3 0.0274585
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0273743
SET SET nuclear proto-oncogene 0.0271373
BIRC3 baculoviral IAP repeat containing 3 0.0270896
LDHA lactate dehydrogenase A 0.026934
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0268965
ACTG1 actin gamma 1 0.0267421
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0267332
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0266566
ZMYND8 zinc finger, MYND-type containing 8 0.0264454
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0264261
FLNB filamin B, beta 0.0264257
CENPF centromere protein F, 350/400kDa 0.0260222
DPYSL2 dihydropyrimidinase-like 2 0.025991
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0259694
CLTC clathrin, heavy chain (Hc) 0.0258672
FNIP1 folliculin interacting protein 1 0.0256663
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0256599
CXCL8 chemokine (C-X-C motif) ligand 8 0.0253932
BCAR3 breast cancer anti-estrogen resistance 3 0.0252632
DOCK11 dedicator of cytokinesis 11 0.0251924
SEC24A SEC24 family member A 0.0248252
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0246254
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0244753
RTN4 reticulon 4 0.0244671
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0244375
TRIP12 thyroid hormone receptor interactor 12 0.0243775
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.023884
APP amyloid beta (A4) precursor protein 0.023804
CEP170 centrosomal protein 170kDa 0.02379
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0236661
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0234919
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0233745
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0228487
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0220225
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0219153
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0215205
CDK19 cyclin-dependent kinase 19 0.0214619
JMJD1C jumonji domain containing 1C 0.0210447
CANX calnexin 0.0209565
ARRDC3 arrestin domain containing 3 0.0208364
KIF5B kinesin family member 5B 0.020697
HDAC9 histone deacetylase 9 0.0203972
EMP1 epithelial membrane protein 1 0.0200999
MYH9 myosin, heavy chain 9, non-muscle 0.0200537
MBNL2 muscleblind-like splicing regulator 2 0.0198843
PODXL podocalyxin-like 0.0197292
TMED2 transmembrane emp24 domain trafficking protein 2 0.0193101
CAPN2 calpain 2, (m/II) large subunit 0.0192952
ADAM10 ADAM metallopeptidase domain 10 0.0192477
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0191772
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0190696

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0940738
TP63 tumor protein p63 -0.0640908
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0609863
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0602261
FTL ferritin, light polypeptide -0.056928
TMSB10 thymosin beta 10 -0.054842
CADM2 cell adhesion molecule 2 -0.0500954
POTEF POTE ankyrin domain family, member F -0.0445184
RPS6 ribosomal protein S6 -0.0425552
RPS8 ribosomal protein S8 -0.0357543
DPYD dihydropyrimidine dehydrogenase -0.0312442
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0308986
MT2A metallothionein 2A -0.0271991
RPS19 ribosomal protein S19 -0.0271684
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0268513
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0267746
RPL35A ribosomal protein L35a -0.0242617
WSB1 WD repeat and SOCS box containing 1 -0.0240951
YBX1 Y box binding protein 1 -0.0240092
SP100 SP100 nuclear antigen -0.0231793
RPL12 ribosomal protein L12 -0.0228763
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0221677
RPL28 ribosomal protein L28 -0.0220912
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0219907
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0207336
RPL19 ribosomal protein L19 -0.0201592
HLA-A major histocompatibility complex, class I, A -0.0197382
TXNIP thioredoxin interacting protein -0.0194256
RPLP1 ribosomal protein, large, P1 -0.0191379
HLA-B major histocompatibility complex, class I, B -0.0190728
TSC22D2 TSC22 domain family, member 2 -0.0187694
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0181818
B2M beta-2-microglobulin -0.0178534
RPLP2 ribosomal protein, large, P2 -0.0176114
RPL26 ribosomal protein L26 -0.0172496
RPS10 ribosomal protein S10 -0.0171039
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0170912
RPL36 ribosomal protein L36 -0.0166148
LOC102724023 ES1 protein homolog, mitochondrial -0.0164647
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.01627
INTS6 integrator complex subunit 6 -0.0160461
RPL34 ribosomal protein L34 -0.0158264
RPL31 ribosomal protein L31 -0.0153982
TNS3 tensin 3 -0.0153534
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0151615
PMP22 peripheral myelin protein 22 -0.0149866
RPL9 ribosomal protein L9 -0.0145222
BRD2 bromodomain containing 2 -0.0144855
RPL35 ribosomal protein L35 -0.0142866
RPS25 ribosomal protein S25 -0.014155
RAB7A RAB7A, member RAS oncogene family -0.0139673
DPH6 diphthamine biosynthesis 6 -0.0137577
IFIH1 interferon induced with helicase C domain 1 -0.0135708
RPS5 ribosomal protein S5 -0.013509
RPS23 ribosomal protein S23 -0.0133881
EPHA4 EPH receptor A4 -0.0133843
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0132711
TPI1 triosephosphate isomerase 1 -0.0132323
PLSCR1 phospholipid scramblase 1 -0.0131194
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0130159
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0129589
RPL8 ribosomal protein L8 -0.0126822
PKM pyruvate kinase, muscle -0.01262
S100A9 S100 calcium binding protein A9 -0.0124869
RPL23 ribosomal protein L23 -0.0123976
RPS24 ribosomal protein S24 -0.0122812
RPS16 ribosomal protein S16 -0.012083
RPS14 ribosomal protein S14 -0.012063
RPS12 ribosomal protein S12 -0.0117246
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0117198
TOP1 topoisomerase (DNA) I -0.011699
RPL11 ribosomal protein L11 -0.0116845
NEK10 NIMA-related kinase 10 -0.0116787
H1-0 H1.0 linker histone -0.0116507
ARID4B AT rich interactive domain 4B (RBP1-like) -0.011503
IFITM1 interferon induced transmembrane protein 1 -0.0114904
RPS15 ribosomal protein S15 -0.0113729
GNAS GNAS complex locus -0.0113466
TPT1 tumor protein, translationally-controlled 1 -0.0112661
RPS29 ribosomal protein S29 -0.0110971
RPL5 ribosomal protein L5 -0.0110553
ASTN2 astrotactin 2 -0.0110308
HMGB1 high mobility group box 1 -0.010966
RPL36A ribosomal protein L36a -0.0108642
COL5A2 collagen, type V, alpha 2 -0.0107494
RPS21 ribosomal protein S21 -0.0106188
SAMHD1 SAM domain and HD domain 1 -0.010604
RPL39 ribosomal protein L39 -0.0103549
ISG15 ISG15 ubiquitin-like modifier -0.0102089
RPS13 ribosomal protein S13 -0.0101452
RPS20 ribosomal protein S20 -0.0100667
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0100207
RPS11 ribosomal protein S11 -0.00991694
IFRD1 interferon-related developmental regulator 1 -0.00987804
SRSF3 serine/arginine-rich splicing factor 3 -0.00986857
NPR2 natriuretic peptide receptor 2 -0.00978869
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0096004
CFAP299 cilia and flagella associated protein 299 -0.00956567
NOP58 NOP58 ribonucleoprotein -0.00954554
DEK DEK proto-oncogene -0.0094563