Flutamide_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flutamide perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flutamide_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.164088
NDRG1 N-myc downstream regulated 1 0.159412
FN1 fibronectin 1 0.140265
NAMPT nicotinamide phosphoribosyltransferase 0.0730209
RNF145 ring finger protein 145 0.0699823
TSC22D2 TSC22 domain family, member 2 0.067289
UBA6 ubiquitin-like modifier activating enzyme 6 0.0658588
LAMC2 laminin, gamma 2 0.0637083
ELL2 elongation factor, RNA polymerase II, 2 0.0617368
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0573894
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0543725
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0542298
TFG TRK-fused gene 0.0539178
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0520865
MARCHF6 membrane associated ring-CH-type finger 6 0.0498891
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.049783
ASPH aspartate beta-hydroxylase 0.0482514
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0481495
EEF2 eukaryotic translation elongation factor 2 0.0475954
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0468854
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0465854
LAMB3 laminin, beta 3 0.0442492
KMT2E lysine (K)-specific methyltransferase 2E 0.0438362
HMGA1 high mobility group AT-hook 1 0.0428381
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0422281
RASA2 RAS p21 protein activator 2 0.0415304
NUP58 nucleoporin 58 0.0403757
NPEPPS aminopeptidase puromycin sensitive 0.0390583
CCNL1 cyclin L1 0.0387083
USP3 ubiquitin specific peptidase 3 0.0384629
YTHDC1 YTH domain containing 1 0.0382111
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0381964
NCKAP1 NCK-associated protein 1 0.0378892
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0376699
CALR calreticulin 0.0373559
UGCG UDP-glucose ceramide glucosyltransferase 0.0371307
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.036603
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0365149
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0362953
ADAM9 ADAM metallopeptidase domain 9 0.0360707
ARRDC3 arrestin domain containing 3 0.0353531
COPA coatomer protein complex, subunit alpha 0.0346698
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0334226
TACSTD2 tumor-associated calcium signal transducer 2 0.0332393
ANXA1 annexin A1 0.0324466
ATP13A3 ATPase type 13A3 0.032112
KLF6 Kruppel-like factor 6 0.0317603
FAM162A family with sequence similarity 162, member A 0.0315635
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0315098
MSMO1 methylsterol monooxygenase 1 0.0314703
RTN4 reticulon 4 0.0314553
CD46 CD46 molecule, complement regulatory protein 0.031192
S100A6 S100 calcium binding protein A6 0.0301922
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0301402
CDC73 cell division cycle 73 0.030065
RAD23B RAD23 homolog B (S. cerevisiae) 0.0298059
WAC WW domain containing adaptor with coiled-coil 0.0295458
CLDN4 claudin 4 0.0292042
POTEF POTE ankyrin domain family, member F 0.0289784
SEC23A Sec23 homolog A (S. cerevisiae) 0.0286965
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0285488
PRRC1 proline-rich coiled-coil 1 0.0285057
NEK7 NIMA-related kinase 7 0.0283761
SLMAP sarcolemma associated protein 0.0281625
MATR3 matrin 3 0.0281576
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.02811
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0277297
QKI QKI, KH domain containing, RNA binding 0.0270403
CPNE8 copine VIII 0.027023
FERMT2 fermitin family member 2 0.0268253
CDK17 cyclin-dependent kinase 17 0.026507
ABI1 abl-interactor 1 0.0263444
RIOK3 RIO kinase 3 0.0261626
PTBP2 polypyrimidine tract binding protein 2 0.0258005
MXD1 MAX dimerization protein 1 0.0256842
FAM13A family with sequence similarity 13, member A 0.0254822
PLAUR plasminogen activator, urokinase receptor 0.0254462
NRIP1 nuclear receptor interacting protein 1 0.0250893
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0250787
ANXA5 annexin A5 0.0250609
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0249729
FTH1 ferritin, heavy polypeptide 1 0.0248659
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0247857
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0244663
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0244524
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0244028
WTAP Wilms tumor 1 associated protein 0.024376
RAB6A RAB6A, member RAS oncogene family 0.0242007
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 0.0239344
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0237319
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0236971
MYO6 myosin VI 0.023638
KDM6A lysine (K)-specific demethylase 6A 0.0235799
FOXJ3 forkhead box J3 0.0235617
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0235171
MEF2A myocyte enhancer factor 2A 0.0234809
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0232751
EPS8 epidermal growth factor receptor pathway substrate 8 0.023275
BHLHE40 basic helix-loop-helix family, member e40 0.0231139
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0230277

decreased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A -0.176811
LPP LIM domain containing preferred translocation partner in lipoma -0.15113
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.133963
ZSWIM6 zinc finger, SWIM-type containing 6 -0.114566
PTMA prothymosin, alpha -0.113344
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0996859
AHNAK AHNAK nucleoprotein -0.0990376
LIMCH1 LIM and calponin homology domains 1 -0.0941216
EXT1 exostosin glycosyltransferase 1 -0.0901343
EFNA5 ephrin-A5 -0.0887877
NAV2 neuron navigator 2 -0.0861959
GOLGB1 golgin B1 -0.0809591
FBXO32 F-box protein 32 -0.0764274
SQSTM1 sequestosome 1 -0.0743645
CANX calnexin -0.066669
RAI14 retinoic acid induced 14 -0.0572933
IFI16 interferon, gamma-inducible protein 16 -0.0554833
VCL vinculin -0.0549105
ZBTB20 zinc finger and BTB domain containing 20 -0.0546497
ENO1 enolase 1, (alpha) -0.0532581
CCND1 cyclin D1 -0.0531363
RNF213 ring finger protein 213 -0.049737
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0464245
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0463887
MX2 MX dynamin-like GTPase 2 -0.0463452
PDLIM5 PDZ and LIM domain 5 -0.0461427
MX1 MX dynamin-like GTPase 1 -0.0459056
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0454576
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.044992
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0443536
STAT1 signal transducer and activator of transcription 1, 91kDa -0.043736
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0434949
SEC31A SEC31 homolog A (S. cerevisiae) -0.0433987
RPS6 ribosomal protein S6 -0.0433602
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0430518
PLSCR1 phospholipid scramblase 1 -0.0430104
TTC3 tetratricopeptide repeat domain 3 -0.0430001
ARHGAP20 Rho GTPase activating protein 20 -0.0427722
FNIP1 folliculin interacting protein 1 -0.042665
ALCAM activated leukocyte cell adhesion molecule -0.0424407
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0417855
ARHGAP5 Rho GTPase activating protein 5 -0.0415483
RIGI RNA sensor RIG-I -0.0412282
ETV6 ets variant 6 -0.0408207
TPM4 tropomyosin 4 -0.0400508
SP100 SP100 nuclear antigen -0.0399831
PGBD5 piggyBac transposable element derived 5 -0.0396587
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0396115
RBM47 RNA binding motif protein 47 -0.039511
MYO1E myosin IE -0.0390406
TMSB10 thymosin beta 10 -0.0389863
KRT7 keratin 7, type II -0.0386927
MAML2 mastermind-like 2 (Drosophila) -0.0385665
SMAD3 SMAD family member 3 -0.0385011
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0380915
DSPP dentin sialophosphoprotein -0.0380413
RPLP1 ribosomal protein, large, P1 -0.0380276
PALLD palladin, cytoskeletal associated protein -0.037837
RPL34 ribosomal protein L34 -0.037709
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0375388
RAD51B RAD51 paralog B -0.0372989
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0372464
IFIH1 interferon induced with helicase C domain 1 -0.0369788
KDM2A lysine (K)-specific demethylase 2A -0.0369646
LMNA lamin A/C -0.0362364
INTS6 integrator complex subunit 6 -0.036162
GRB10 growth factor receptor-bound protein 10 -0.0359586
RPL19 ribosomal protein L19 -0.0355865
MCL1 myeloid cell leukemia 1 -0.0349266
SVIL supervillin -0.0347402
HDLBP high density lipoprotein binding protein -0.0342119
H1-0 H1.0 linker histone -0.034151
CTBP2 C-terminal binding protein 2 -0.0334973
DST dystonin -0.0331369
FBXO34 F-box protein 34 -0.0330259
CUX1 cut-like homeobox 1 -0.0330005
SAMD12 sterile alpha motif domain containing 12 -0.0329118
SCFD1 sec1 family domain containing 1 -0.0327036
ATXN1 ataxin 1 -0.0326236
ISG15 ISG15 ubiquitin-like modifier -0.0323042
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0322937
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0315699
AHNAK2 AHNAK nucleoprotein 2 -0.0314529
PATJ PATJ crumbs cell polarity complex component -0.0312565
RRBP1 ribosome binding protein 1 -0.0312491
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0309912
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0304241
CDK13 cyclin-dependent kinase 13 -0.0302741
IFI27 interferon, alpha-inducible protein 27 -0.0297022
TAOK1 TAO kinase 1 -0.029673
PTPRK protein tyrosine phosphatase, receptor type, K -0.0295811
RPS24 ribosomal protein S24 -0.0295189
TBCA tubulin folding cofactor A -0.0293369
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0293108
PKM pyruvate kinase, muscle -0.0292229
RAB7A RAB7A, member RAS oncogene family -0.0291505
BPTF bromodomain PHD finger transcription factor -0.0291498
RPL5 ribosomal protein L5 -0.0289268
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.02873
AFF1 AF4/FMR2 family, member 1 -0.0286985