Flutamide_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flutamide perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flutamide_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.147887
PABPC1 poly(A) binding protein, cytoplasmic 1 0.106846
PEG10 paternally expressed 10 0.104102
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0806297
THBS1 thrombospondin 1 0.0714161
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0568723
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0502997
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0478464
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0462312
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0406523
GNAS GNAS complex locus 0.0398852
USP53 ubiquitin specific peptidase 53 0.0398475
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0389743
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0384268
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0379283
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0378366
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0335642
PDIA6 protein disulfide isomerase family A, member 6 0.0333079
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0332714
COL1A2 collagen, type I, alpha 2 0.0319378
ZEB2 zinc finger E-box binding homeobox 2 0.0314204
NCKAP1 NCK-associated protein 1 0.031028
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0308844
NUP58 nucleoporin 58 0.0297555
ZFP36L1 ZFP36 ring finger protein-like 1 0.0295283
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0295215
PFN1 profilin 1 0.029028
STRN3 striatin, calmodulin binding protein 3 0.0289702
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0287138
MED13L mediator complex subunit 13-like 0.0286786
PGK1 phosphoglycerate kinase 1 0.0283422
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0281901
ANKRD33B ankyrin repeat domain 33B 0.0279056
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0278901
WSB1 WD repeat and SOCS box containing 1 0.0274175
ENAH enabled homolog (Drosophila) 0.0262617
EMP1 epithelial membrane protein 1 0.0261064
SRP54 signal recognition particle 54kDa 0.0256026
ADGRL2 adhesion G protein-coupled receptor L2 0.0248991
TSC22D2 TSC22 domain family, member 2 0.0248075
ITGAV integrin, alpha V 0.0247438
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0246146
LDHA lactate dehydrogenase A 0.024525
SOX2 SRY (sex determining region Y)-box 2 0.0243934
USP9X ubiquitin specific peptidase 9, X-linked 0.0243044
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0240057
EEF2 eukaryotic translation elongation factor 2 0.0239794
CHD1 chromodomain helicase DNA binding protein 1 0.0236696
BMPR1A bone morphogenetic protein receptor, type IA 0.0235656
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0231266
PGAP1 post-GPI attachment to proteins 1 0.0229095
NAP1L1 nucleosome assembly protein 1-like 1 0.0226125
PUM1 pumilio RNA-binding family member 1 0.0225648
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0223044
PDIA3 protein disulfide isomerase family A, member 3 0.0219874
DDIT4 DNA-damage-inducible transcript 4 0.0216234
SLIT2 slit homolog 2 (Drosophila) 0.0215911
CDC73 cell division cycle 73 0.0214608
CALCR calcitonin receptor 0.0212658
CFL2 cofilin 2 (muscle) 0.0212421
LYST lysosomal trafficking regulator 0.0211545
PRPF8 pre-mRNA processing factor 8 0.0209531
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0206669
JUN jun proto-oncogene 0.0204345
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0202917
UPP1 uridine phosphorylase 1 0.0201991
TM7SF3 transmembrane 7 superfamily member 3 0.0199514
BRD4 bromodomain containing 4 0.0198621
MKI67 marker of proliferation Ki-67 0.0198106
MACF1 microtubule-actin crosslinking factor 1 0.0196765
CALU calumenin 0.019342
KLF10 Kruppel-like factor 10 0.0192306
PCBP2 poly(rC) binding protein 2 0.0191564
YY1 YY1 transcription factor 0.0190719
SRRM1 serine/arginine repetitive matrix 1 0.0190442
NFE2L1 nuclear factor, erythroid 2-like 1 0.0190384
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0189569
FBXO11 F-box protein 11 0.0186993
ANXA2 annexin A2 0.018679
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0184622
IPO7 importin 7 0.0180861
TRIO trio Rho guanine nucleotide exchange factor 0.0180768
METAP2 methionyl aminopeptidase 2 0.0180306
ANXA1 annexin A1 0.0177664
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0176487
ADGRG6 adhesion G protein-coupled receptor G6 0.0176058
RPS2 ribosomal protein S2 0.0175724
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0174658
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0174134
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0173453
GDI1 GDP dissociation inhibitor 1 0.0173278
IWS1 IWS1 homolog (S. cerevisiae) 0.0172887
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0171976
AHCTF1 AT hook containing transcription factor 1 0.0171872
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0168193
CLTC clathrin, heavy chain (Hc) 0.0167976
CALR calreticulin 0.0167935
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0166411
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0165939
ZNF608 zinc finger protein 608 0.0165476

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0979346
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0916279
RPS16 ribosomal protein S16 -0.0586405
TPT1 tumor protein, translationally-controlled 1 -0.0527465
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0470961
VIM vimentin -0.040913
RPLP1 ribosomal protein, large, P1 -0.0402925
ATP5F1B ATP synthase F1 subunit beta -0.0382395
RPS6 ribosomal protein S6 -0.0377688
RPS21 ribosomal protein S21 -0.0357583
TMSB4X thymosin beta 4, X-linked -0.0351857
RPL38 ribosomal protein L38 -0.0323155
GPC3 glypican 3 -0.0312057
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0303256
DEK DEK proto-oncogene -0.0290688
RPS19 ribosomal protein S19 -0.0285215
RPL19 ribosomal protein L19 -0.0283345
ANKRD12 ankyrin repeat domain 12 -0.0282616
RPLP2 ribosomal protein, large, P2 -0.028261
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0273302
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0271167
CNRIP1 cannabinoid receptor interacting protein 1 -0.0271101
PARD3B par-3 family cell polarity regulator beta -0.0266836
RPL5 ribosomal protein L5 -0.0261287
RPLP0 ribosomal protein, large, P0 -0.0261125
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0259295
RPL32 ribosomal protein L32 -0.0252894
HMGB1 high mobility group box 1 -0.0247583
CALM3 calmodulin 3 (phosphorylase kinase, delta) -0.0243868
TXNRD1 thioredoxin reductase 1 -0.0235332
UBC ubiquitin C -0.023521
COTL1 coactosin-like F-actin binding protein 1 -0.0230542
RPL34 ribosomal protein L34 -0.0229203
SBF2 SET binding factor 2 -0.0228711
MDK midkine (neurite growth-promoting factor 2) -0.0227367
RAB31 RAB31, member RAS oncogene family -0.0226588
RPS8 ribosomal protein S8 -0.0223983
TOX thymocyte selection-associated high mobility group box -0.0222374
RPL31 ribosomal protein L31 -0.0221312
RPS11 ribosomal protein S11 -0.0215338
RPS29 ribosomal protein S29 -0.0213124
RPS13 ribosomal protein S13 -0.0213012
RPS27A ribosomal protein S27a -0.0210396
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0206217
RAN RAN, member RAS oncogene family -0.0202472
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0199288
LOC102724023 ES1 protein homolog, mitochondrial -0.0197856
S100A9 S100 calcium binding protein A9 -0.0193489
RPL28 ribosomal protein L28 -0.0193238
RPL12 ribosomal protein L12 -0.0192367
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0191616
RPL36A ribosomal protein L36a -0.0183487
TOP1 topoisomerase (DNA) I -0.0182805
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0182508
RB1CC1 RB1-inducible coiled-coil 1 -0.0180083
DEPDC1 DEP domain containing 1 -0.0176621
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0175772
TMEM263 transmembrane protein 263 -0.0175592
DNAH14 dynein, axonemal, heavy chain 14 -0.0171936
PALS1 protein associated with LIN7 1, MAGUK p55 family member -0.0171048
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -0.0170601
RPS5 ribosomal protein S5 -0.0168126
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0165025
H3-3B H3.3 histone B -0.0160668
TUBA1B tubulin, alpha 1b -0.0160198
RPL8 ribosomal protein L8 -0.0158185
ENO1 enolase 1, (alpha) -0.015629
KHSRP KH-type splicing regulatory protein -0.015511
SMYD3 SET and MYND domain containing 3 -0.0154286
RPS25 ribosomal protein S25 -0.0153817
RASAL2 RAS protein activator like 2 -0.0153653
CENPE centromere protein E, 312kDa -0.015339
H1-0 H1.0 linker histone -0.0152366
GARS1 glycyl-tRNA synthetase 1 -0.0151456
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0150413
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0150374
KIF20B kinesin family member 20B -0.0148172
PRRC2C proline-rich coiled-coil 2C -0.0148049
ZFR zinc finger RNA binding protein -0.0147941
EGFR epidermal growth factor receptor -0.0147506
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0144882
SQSTM1 sequestosome 1 -0.0144396
PCLO piccolo presynaptic cytomatrix protein -0.0144179
MTDH metadherin -0.0143827
CENPF centromere protein F, 350/400kDa -0.0143433
NBEAL1 neurobeachin-like 1 -0.014324
FOXP1 forkhead box P1 -0.0142827
ATP5MG ATP synthase membrane subunit g -0.014222
RPL35A ribosomal protein L35a -0.014134
TBCA tubulin folding cofactor A -0.0140578
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0140302
PDCD5 programmed cell death 5 -0.0140214
SUN3 Sad1 and UNC84 domain containing 3 -0.0139378
RPL35 ribosomal protein L35 -0.0138669
EXOC6B exocyst complex component 6B -0.0138478
STAU1 staufen double-stranded RNA binding protein 1 -0.0138094
MT2A metallothionein 2A -0.0138068
GLO1 glyoxalase I -0.0137709
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0137535
NIBAN1 niban apoptosis regulator 1 -0.0137254