Flutamide_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flutamide perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flutamide_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.158316
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.139039
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.107807
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0961041
FLNB filamin B, beta 0.069783
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0677415
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0668788
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0580767
NUP58 nucleoporin 58 0.0530827
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.051673
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0483287
PFN1 profilin 1 0.047349
ENO2 enolase 2 (gamma, neuronal) 0.0452417
ADAM10 ADAM metallopeptidase domain 10 0.0429505
RPS2 ribosomal protein S2 0.0425301
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0412877
PRELID2 PRELI domain containing 2 0.0388941
ZNF292 zinc finger protein 292 0.0366205
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0364592
AKAP9 A kinase (PRKA) anchor protein 9 0.0364102
SET SET nuclear proto-oncogene 0.0344594
NCEH1 neutral cholesterol ester hydrolase 1 0.0336523
TMF1 TATA element modulatory factor 1 0.0332039
LDHA lactate dehydrogenase A 0.0329667
TMEM41B transmembrane protein 41B 0.0324462
ACTG1 actin gamma 1 0.032088
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0318791
PGK1 phosphoglycerate kinase 1 0.0317475
RPS12 ribosomal protein S12 0.0316786
PCBP2 poly(rC) binding protein 2 0.0315264
SRRM2 serine/arginine repetitive matrix 2 0.0314314
PLK2 polo-like kinase 2 0.0314306
CCND1 cyclin D1 0.0313996
ECT2 epithelial cell transforming 2 0.030157
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0300596
HDAC9 histone deacetylase 9 0.029382
ZNF608 zinc finger protein 608 0.028956
KMT2E lysine (K)-specific methyltransferase 2E 0.0281645
NCKAP1 NCK-associated protein 1 0.0276423
EZR ezrin 0.0275943
RAB6A RAB6A, member RAS oncogene family 0.026947
HMGA1 high mobility group AT-hook 1 0.0267864
DSCAM Down syndrome cell adhesion molecule 0.0266958
CENPF centromere protein F, 350/400kDa 0.0263541
DDIT4 DNA-damage-inducible transcript 4 0.0263171
HILPDA hypoxia inducible lipid droplet-associated 0.0262214
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0259105
TMEM14B transmembrane protein 14B 0.0255513
PYGB phosphorylase, glycogen; brain 0.0254077
VMP1 vacuole membrane protein 1 0.0253387
COG6 component of oligomeric golgi complex 6 0.0250992
PCBP1 poly(rC) binding protein 1 0.0244984
MXI1 MAX interactor 1, dimerization protein 0.0240894
EGFR epidermal growth factor receptor 0.024076
FAT1 FAT atypical cadherin 1 0.0238301
YEATS2 YEATS domain containing 2 0.0234818
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0232645
GOLGA4 golgin A4 0.0229806
PUM2 pumilio RNA-binding family member 2 0.0228377
ZMYM2 zinc finger, MYM-type 2 0.0227299
RNF145 ring finger protein 145 0.0226906
NBAS neuroblastoma amplified sequence 0.022381
PKM pyruvate kinase, muscle 0.0222439
ATRN attractin 0.0220955
RACK1 receptor for activated C kinase 1 0.0220562
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0219641
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0219379
PNISR PNN-interacting serine/arginine-rich protein 0.0217177
KDM4C lysine (K)-specific demethylase 4C 0.0212951
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0210103
ARRDC3 arrestin domain containing 3 0.0206766
PICALM phosphatidylinositol binding clathrin assembly protein 0.0206591
HOOK2 hook microtubule-tethering protein 2 0.0206532
NFE2L1 nuclear factor, erythroid 2-like 1 0.0203116
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.0201831
SPRY4 sprouty homolog 4 (Drosophila) 0.0201505
BIRC6 baculoviral IAP repeat containing 6 0.0201251
INSIG2 insulin induced gene 2 0.0200768
SREBF2 sterol regulatory element binding transcription factor 2 0.0200096
RPL3 ribosomal protein L3 0.0199688
TXNIP thioredoxin interacting protein 0.0199588
RAD23B RAD23 homolog B (S. cerevisiae) 0.0199586
ZBTB20 zinc finger and BTB domain containing 20 0.0196292
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0195227
WDR45B WD repeat domain 45B 0.0195097
ELOVL5 ELOVL fatty acid elongase 5 0.0194229
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0188928
ANKRD12 ankyrin repeat domain 12 0.0188898
MYOF myoferlin 0.0187852
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0185998
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0185956
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0185429
SEC24A SEC24 family member A 0.0182049
TBC1D22A TBC1 domain family, member 22A 0.0182042
GLS2 glutaminase 2 (liver, mitochondrial) 0.0181267
NAMPT nicotinamide phosphoribosyltransferase 0.0179254
FAM117B family with sequence similarity 117, member B 0.0176824
YTHDC1 YTH domain containing 1 0.0174475
EIF1 eukaryotic translation initiation factor 1 0.0174418
PSAT1 phosphoserine aminotransferase 1 0.0173243

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.146297
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.135487
PTMA prothymosin, alpha -0.128333
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.107752
VCL vinculin -0.102051
FOXP1 forkhead box P1 -0.0974552
PDE4B phosphodiesterase 4B, cAMP-specific -0.0946614
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0761654
TPT1 tumor protein, translationally-controlled 1 -0.0754359
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.070366
RPS6 ribosomal protein S6 -0.0684492
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0600922
SSBP2 single-stranded DNA binding protein 2 -0.0526227
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0520138
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0511491
BMP10 bone morphogenetic protein 10 -0.0477056
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0439625
TMSB4X thymosin beta 4, X-linked -0.0429834
CAMKMT calmodulin-lysine N-methyltransferase -0.0428769
DLG1 discs, large homolog 1 (Drosophila) -0.042052
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0417963
ZMYND8 zinc finger, MYND-type containing 8 -0.0395633
EML4 echinoderm microtubule associated protein like 4 -0.0369988
STAT1 signal transducer and activator of transcription 1, 91kDa -0.035566
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0350869
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0347569
RPLP1 ribosomal protein, large, P1 -0.0339354
RPS24 ribosomal protein S24 -0.0335424
HDLBP high density lipoprotein binding protein -0.0326479
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0320035
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0319228
ZFAND3 zinc finger, AN1-type domain 3 -0.0310133
PDE7B phosphodiesterase 7B -0.0308552
RPS23 ribosomal protein S23 -0.030618
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0298155
GLI3 GLI family zinc finger 3 -0.0296081
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0292188
NT5C2 5'-nucleotidase, cytosolic II -0.029087
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.028814
RRBP1 ribosome binding protein 1 -0.0282292
CUX1 cut-like homeobox 1 -0.0271821
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0267963
CANX calnexin -0.0267765
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0264869
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0261179
RPS21 ribosomal protein S21 -0.025944
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0259128
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0245961
RPL34 ribosomal protein L34 -0.0244331
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0243793
S100A10 S100 calcium binding protein A10 -0.0237361
RPL19 ribosomal protein L19 -0.0237183
MYO5C myosin VC -0.0236403
HMGB1 high mobility group box 1 -0.0232566
HSPB1 heat shock 27kDa protein 1 -0.0230762
BPTF bromodomain PHD finger transcription factor -0.0225893
RPLP2 ribosomal protein, large, P2 -0.0225318
RHEB Ras homolog enriched in brain -0.0223947
ANKRD11 ankyrin repeat domain 11 -0.022252
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0220266
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0218814
MLIP muscular LMNA-interacting protein -0.0216956
RPS27A ribosomal protein S27a -0.0212272
RPS25 ribosomal protein S25 -0.0212235
TM4SF1 transmembrane 4 L six family member 1 -0.0211255
COMMD10 COMM domain containing 10 -0.0211034
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0209241
GLI2 GLI family zinc finger 2 -0.0208516
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0207806
RSL1D1 ribosomal L1 domain containing 1 -0.020651
UNC13A unc-13 homolog A (C. elegans) -0.0203798
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0197119
EXOC4 exocyst complex component 4 -0.0196657
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0194586
PATJ PATJ crumbs cell polarity complex component -0.0192939
FUS FUS RNA binding protein -0.0191821
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0189795
RPL32 ribosomal protein L32 -0.0188692
RPS11 ribosomal protein S11 -0.0186997
ZNFX1 zinc finger, NFX1-type containing 1 -0.0186333
RPS5 ribosomal protein S5 -0.0186309
ZNF438 zinc finger protein 438 -0.0186295
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0184305
DPYD dihydropyrimidine dehydrogenase -0.0184215
SSH2 slingshot protein phosphatase 2 -0.0183568
RPL12 ribosomal protein L12 -0.0183483
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0181308
GCLM glutamate-cysteine ligase, modifier subunit -0.01806
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0180597
RPL9 ribosomal protein L9 -0.0180207
IFI16 interferon, gamma-inducible protein 16 -0.0179729
FNDC3B fibronectin type III domain containing 3B -0.0178975
ZMYM4 zinc finger, MYM-type 4 -0.0178373
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0177694
OGA O-GlcNAcase -0.0177097
TJP1 tight junction protein 1 -0.0177009
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0176827
DEK DEK proto-oncogene -0.0176604
TPM4 tropomyosin 4 -0.0176502
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0176389