Flutamide_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flutamide perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flutamide_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NUP58 nucleoporin 58 0.0772218
ZNF292 zinc finger protein 292 0.0723297
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0602596
IGFBP3 insulin-like growth factor binding protein 3 0.0598115
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0586647
FNDC3B fibronectin type III domain containing 3B 0.0551576
ATP13A3 ATPase type 13A3 0.0524693
SET SET nuclear proto-oncogene 0.0492996
ATXN1 ataxin 1 0.0444694
CD44 CD44 molecule (Indian blood group) 0.0443938
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0442352
DNER delta/notch-like EGF repeat containing 0.0439761
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0426711
MACF1 microtubule-actin crosslinking factor 1 0.0417543
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0409879
CUL5 cullin 5 0.0399693
MKI67 marker of proliferation Ki-67 0.0390849
SRRM2 serine/arginine repetitive matrix 2 0.0390698
EEF2 eukaryotic translation elongation factor 2 0.0385728
SMAD5 SMAD family member 5 0.0382006
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0372079
FLNB filamin B, beta 0.0370186
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0345986
MT2A metallothionein 2A 0.0342848
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0342661
NAV2 neuron navigator 2 0.0337351
ATP11B ATPase, class VI, type 11B 0.0324704
PDE4D phosphodiesterase 4D, cAMP-specific 0.032244
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.032199
ANKRD28 ankyrin repeat domain 28 0.0321504
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0319758
RPS2 ribosomal protein S2 0.0319082
SNX13 sorting nexin 13 0.031908
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0314114
SEPTIN2 septin 2 0.0314027
AKAP13 A kinase (PRKA) anchor protein 13 0.0311342
YBX3 Y box binding protein 3 0.031051
AFF4 AF4/FMR2 family, member 4 0.0305407
TPR translocated promoter region, nuclear basket protein 0.0300728
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0297232
CKAP5 cytoskeleton associated protein 5 0.0292151
DTNA dystrobrevin, alpha 0.0292104
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0290679
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0288418
FBXL5 F-box and leucine-rich repeat protein 5 0.0285448
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0283625
CKAP2 cytoskeleton associated protein 2 0.0278065
RNASE3 ribonuclease, RNase A family, 3 0.0267708
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0267653
CCNB1 cyclin B1 0.0267185
ZFAND3 zinc finger, AN1-type domain 3 0.0266646
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0266025
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0265599
ARRDC3 arrestin domain containing 3 0.0265415
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0265293
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0263958
DERA deoxyribose-phosphate aldolase (putative) 0.0263553
PBX3 pre-B-cell leukemia homeobox 3 0.0260763
CENPF centromere protein F, 350/400kDa 0.0258571
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0257379
CLTC clathrin, heavy chain (Hc) 0.0256306
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0253802
CSNK1A1 casein kinase 1, alpha 1 0.0252517
RAB6A RAB6A, member RAS oncogene family 0.0252446
PYGL phosphorylase, glycogen, liver 0.0250046
ITGAV integrin, alpha V 0.0248985
PREPL prolyl endopeptidase-like 0.0247977
WNK1 WNK lysine deficient protein kinase 1 0.0247934
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0247535
CCDC88A coiled-coil domain containing 88A 0.0247123
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0245935
TPX2 TPX2, microtubule-associated 0.0243775
MYH9 myosin, heavy chain 9, non-muscle 0.024039
ARHGAP21 Rho GTPase activating protein 21 0.0239808
RTN4 reticulon 4 0.023968
OSMR oncostatin M receptor 0.0239018
FOXJ3 forkhead box J3 0.023832
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.0236901
SSR1 signal sequence receptor, alpha 0.0236455
NFE2L1 nuclear factor, erythroid 2-like 1 0.0235382
GPATCH2L G patch domain containing 2-like 0.0235003
CREBRF CREB3 regulatory factor 0.0234973
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0234718
RNF145 ring finger protein 145 0.0231773
ITCH itchy E3 ubiquitin protein ligase 0.0230053
RBM33 RNA binding motif protein 33 0.0229692
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0229585
RPS12 ribosomal protein S12 0.0229435
BRD4 bromodomain containing 4 0.0228949
KIF18B kinesin family member 18B 0.0228245
CAPRIN2 caprin family member 2 0.0223285
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0223203
TMED2 transmembrane emp24 domain trafficking protein 2 0.0222041
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 0.022188
CKAP2L cytoskeleton associated protein 2-like 0.0221492
DYM dymeclin 0.0220872
RARS1 arginyl-tRNA synthetase 1 0.0220824
HP1BP3 heterochromatin protein 1, binding protein 3 0.0220729
ACTN1 actinin, alpha 1 0.0218997
MIS18BP1 MIS18 binding protein 1 0.0218474

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.297471
TPT1 tumor protein, translationally-controlled 1 -0.140777
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.127335
PTMA prothymosin, alpha -0.104525
GNAS GNAS complex locus -0.0893718
AHNAK AHNAK nucleoprotein -0.0847138
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0821167
ANXA2 annexin A2 -0.0642502
TMSB10 thymosin beta 10 -0.0614955
IER3 immediate early response 3 -0.0587123
SQSTM1 sequestosome 1 -0.0578955
GOLGA4 golgin A4 -0.0539979
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0528636
RPS23 ribosomal protein S23 -0.0471443
PARD3 par-3 family cell polarity regulator -0.0465787
UBC ubiquitin C -0.0465281
SDC4 syndecan 4 -0.0464942
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0443237
CAVIN1 caveolae associated protein 1 -0.0443012
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0432677
RPS29 ribosomal protein S29 -0.041774
CANX calnexin -0.0417683
RBM39 RNA binding motif protein 39 -0.0416629
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0411984
VIM vimentin -0.0411837
OASL 2'-5'-oligoadenylate synthetase-like -0.04072
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.039306
RPLP1 ribosomal protein, large, P1 -0.0386184
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.037836
SETX senataxin -0.0368657
CDK12 cyclin-dependent kinase 12 -0.0368611
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0368145
RPS24 ribosomal protein S24 -0.0364011
RPS13 ribosomal protein S13 -0.0360016
S100A10 S100 calcium binding protein A10 -0.0358487
RPS8 ribosomal protein S8 -0.0356903
RPL32 ribosomal protein L32 -0.035665
ZBTB38 zinc finger and BTB domain containing 38 -0.0348577
RAB1A RAB1A, member RAS oncogene family -0.034208
HMGA2 high mobility group AT-hook 2 -0.0340053
FUS FUS RNA binding protein -0.0337701
UBB ubiquitin B -0.033644
SMYD3 SET and MYND domain containing 3 -0.0330936
PTK2 protein tyrosine kinase 2 -0.0330935
RPL11 ribosomal protein L11 -0.0329961
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0327448
IFIH1 interferon induced with helicase C domain 1 -0.0326447
OXSR1 oxidative stress responsive 1 -0.032219
ZNF609 zinc finger protein 609 -0.0322129
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.031933
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0315978
RIGI RNA sensor RIG-I -0.0315766
RPS15 ribosomal protein S15 -0.0315142
SH3KBP1 SH3-domain kinase binding protein 1 -0.0311233
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.031004
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0310024
DEK DEK proto-oncogene -0.0309432
IFITM3 interferon induced transmembrane protein 3 -0.0308732
GPHN gephyrin -0.0308431
RPS21 ribosomal protein S21 -0.0306577
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0305142
RPL36 ribosomal protein L36 -0.0303801
NLK nemo-like kinase -0.0301072
H3-3B H3.3 histone B -0.0301012
RPL4 ribosomal protein L4 -0.0299934
CLIP1 CAP-GLY domain containing linker protein 1 -0.029673
S100A9 S100 calcium binding protein A9 -0.0296656
RPLP0 ribosomal protein, large, P0 -0.0296424
RPL12 ribosomal protein L12 -0.0295851
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0288843
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0287642
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0285629
FOXO3 forkhead box O3 -0.0282701
SOD2 superoxide dismutase 2, mitochondrial -0.0282139
RPS27A ribosomal protein S27a -0.0280334
ISG15 ISG15 ubiquitin-like modifier -0.0278641
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0278077
OGA O-GlcNAcase -0.027783
ARHGAP5 Rho GTPase activating protein 5 -0.0277564
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0273343
DST dystonin -0.0272541
HMGB1 high mobility group box 1 -0.0267721
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0266521
RPL31 ribosomal protein L31 -0.0266022
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0261739
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0259233
NIPBL Nipped-B homolog (Drosophila) -0.0258972
SVIL supervillin -0.025832
LMNA lamin A/C -0.0258287
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0255303
PRKCA protein kinase C, alpha -0.0254271
SSH2 slingshot protein phosphatase 2 -0.0251261
IGF1R insulin-like growth factor 1 receptor -0.0250396
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0249942
TAOK1 TAO kinase 1 -0.0249734
RPS20 ribosomal protein S20 -0.0249627
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0243053
RPL19 ribosomal protein L19 -0.0243002
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0242399
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.024135