Flutamide_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Flutamide perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Flutamide_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.196968
FTH1 ferritin, heavy polypeptide 1 0.130106
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.113782
MT2A metallothionein 2A 0.112571
FTL ferritin, light polypeptide 0.0846661
CXCL8 chemokine (C-X-C motif) ligand 8 0.0710497
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0622941
VIM vimentin 0.0567194
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0562842
NDRG1 N-myc downstream regulated 1 0.0537502
STC2 stanniocalcin 2 0.0524134
TMSB10 thymosin beta 10 0.0520224
FN1 fibronectin 1 0.0498985
PLIN2 perilipin 2 0.0489018
LOC102724023 ES1 protein homolog, mitochondrial 0.0488459
RACK1 receptor for activated C kinase 1 0.0461737
RPS12 ribosomal protein S12 0.0459669
EXT1 exostosin glycosyltransferase 1 0.0453201
TPR translocated promoter region, nuclear basket protein 0.0414796
ENO2 enolase 2 (gamma, neuronal) 0.0373686
RPL37A ribosomal protein L37a 0.0368193
IFI27 interferon, alpha-inducible protein 27 0.0362302
ZFP36L1 ZFP36 ring finger protein-like 1 0.0350378
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.034475
S100A6 S100 calcium binding protein A6 0.0342776
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.033873
HIPK2 homeodomain interacting protein kinase 2 0.0337294
RPL35A ribosomal protein L35a 0.0331759
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0315401
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0309692
HLA-B major histocompatibility complex, class I, B 0.0301061
HMGA1 high mobility group AT-hook 1 0.0298136
FLNA filamin A, alpha 0.0288757
NPAS2 neuronal PAS domain protein 2 0.0275336
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0274721
HILPDA hypoxia inducible lipid droplet-associated 0.0274371
PFN1 profilin 1 0.0272962
RPS27 ribosomal protein S27 0.027028
LGALS1 lectin, galactoside-binding, soluble, 1 0.0268928
LOX lysyl oxidase 0.0267808
NTN4 netrin 4 0.0264926
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.026058
KSR1 kinase suppressor of ras 1 0.0259979
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0255972
PELO pelota homolog (Drosophila) 0.025309
NRP1 neuropilin 1 0.0245224
KLF10 Kruppel-like factor 10 0.024489
BIRC6 baculoviral IAP repeat containing 6 0.024218
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0240413
AKAP9 A kinase (PRKA) anchor protein 9 0.023695
GLUL glutamate-ammonia ligase 0.0228977
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0226277
TTC3 tetratricopeptide repeat domain 3 0.0222567
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0219787
SRRM2 serine/arginine repetitive matrix 2 0.0218923
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0216529
MKI67 marker of proliferation Ki-67 0.0211766
SEC23A Sec23 homolog A (S. cerevisiae) 0.0210785
RNF24 ring finger protein 24 0.0208006
RPL23 ribosomal protein L23 0.0206925
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0204354
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0203561
B2M beta-2-microglobulin 0.0199563
EEF2 eukaryotic translation elongation factor 2 0.019917
PGK1 phosphoglycerate kinase 1 0.0198839
IGFBP3 insulin-like growth factor binding protein 3 0.0194126
RAB7A RAB7A, member RAS oncogene family 0.0194123
CYB5R3 cytochrome b5 reductase 3 0.019325
RPS19 ribosomal protein S19 0.0191204
SEC31A SEC31 homolog A (S. cerevisiae) 0.0189622
HLA-A major histocompatibility complex, class I, A 0.0187898
RPL18 ribosomal protein L18 0.0186608
GNAS GNAS complex locus 0.0184567
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0181808
COPA coatomer protein complex, subunit alpha 0.0180714
LDHA lactate dehydrogenase A 0.017947
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0179459
GLIS3 GLIS family zinc finger 3 0.0179302
SOX9 SRY (sex determining region Y)-box 9 0.0178398
HMGA2 high mobility group AT-hook 2 0.017839
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0177814
SOS1 son of sevenless homolog 1 (Drosophila) 0.0176857
TIMP1 TIMP metallopeptidase inhibitor 1 0.017485
RUNX2 runt-related transcription factor 2 0.0173795
NUP58 nucleoporin 58 0.0172784
EGR1 early growth response 1 0.0171701
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0170995
SOX4 SRY (sex determining region Y)-box 4 0.0170004
CD44 CD44 molecule (Indian blood group) 0.0167762
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0167715
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0166218
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0165823
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0164258
BASP1 brain abundant, membrane attached signal protein 1 0.0164124
SLC38A2 solute carrier family 38, member 2 0.0162953
MRPS6 mitochondrial ribosomal protein S6 0.0162225
AHRR aryl-hydrocarbon receptor repressor 0.0161618
RNASEH2A ribonuclease H2, subunit A 0.0161589
ITGA1 integrin, alpha 1 0.0161198
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 0.0160794

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.0774409
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0707522
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0666264
CANX calnexin -0.0656979
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0562257
TRIO trio Rho guanine nucleotide exchange factor -0.0508662
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0505573
PTK2 protein tyrosine kinase 2 -0.0499382
SMAD3 SMAD family member 3 -0.0488708
TXNIP thioredoxin interacting protein -0.0412647
OGA O-GlcNAcase -0.040526
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0394356
AHNAK AHNAK nucleoprotein -0.0378246
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0362075
RBM39 RNA binding motif protein 39 -0.033756
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0326062
GCC2 GRIP and coiled-coil domain containing 2 -0.031814
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0316873
FNBP1 formin binding protein 1 -0.0304895
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0282922
RPL38 ribosomal protein L38 -0.027545
ASPH aspartate beta-hydroxylase -0.0266757
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0263077
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0261833
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0258609
XPO1 exportin 1 -0.0257999
KDM3A lysine (K)-specific demethylase 3A -0.0257426
JMJD1C jumonji domain containing 1C -0.0252492
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0251911
RPS21 ribosomal protein S21 -0.0247514
APP amyloid beta (A4) precursor protein -0.0246224
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0239667
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0238959
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0236373
PRRC2C proline-rich coiled-coil 2C -0.0234238
ELL2 elongation factor, RNA polymerase II, 2 -0.0232314
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.023124
SQSTM1 sequestosome 1 -0.0231
NIPBL Nipped-B homolog (Drosophila) -0.0230209
UBC ubiquitin C -0.0229193
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0225836
DENND5B DENN/MADD domain containing 5B -0.022502
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0223132
ZMYND8 zinc finger, MYND-type containing 8 -0.0221961
RLF rearranged L-myc fusion -0.0221829
PARD3 par-3 family cell polarity regulator -0.0221425
RPS24 ribosomal protein S24 -0.0220406
SDC4 syndecan 4 -0.0220175
TENT2 terminal nucleotidyltransferase 2 -0.0219754
SOD2 superoxide dismutase 2, mitochondrial -0.0219022
SMYD3 SET and MYND domain containing 3 -0.0215596
GPHN gephyrin -0.0212934
S100A10 S100 calcium binding protein A10 -0.0212538
IL6ST interleukin 6 signal transducer -0.0211739
SRPK2 SRSF protein kinase 2 -0.0210414
LCORL ligand dependent nuclear receptor corepressor-like -0.0210006
RAB1A RAB1A, member RAS oncogene family -0.02094
BICD1 bicaudal D homolog 1 (Drosophila) -0.0206555
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0203222
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.020107
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0200881
ZFAND3 zinc finger, AN1-type domain 3 -0.0200668
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0199732
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0196995
TNIP1 TNFAIP3 interacting protein 1 -0.0196332
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0196131
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0195758
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0193976
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0191876
CENPF centromere protein F, 350/400kDa -0.0191379
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0190845
SPIDR scaffolding protein involved in DNA repair -0.0190387
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0188973
TMEM165 transmembrane protein 165 -0.0187939
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0187927
LRMDA leucine rich melanocyte differentiation associated -0.0186234
TM4SF1 transmembrane 4 L six family member 1 -0.0186089
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0185065
SEPTIN10 septin 10 -0.0184953
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0184695
TFPI2 tissue factor pathway inhibitor 2 -0.0184597
RPS6 ribosomal protein S6 -0.018445
NEK7 NIMA-related kinase 7 -0.0181773
SVIL supervillin -0.0181182
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0179314
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0178561
SAMD4A sterile alpha motif domain containing 4A -0.0178151
CAPN2 calpain 2, (m/II) large subunit -0.0177825
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0176808
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0176209
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.0175802
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0175784
RPS23 ribosomal protein S23 -0.017296
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0172206
RO60 Ro60, Y RNA binding protein -0.0171467
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0171269
FNDC3B fibronectin type III domain containing 3B -0.0171187
UBE2H ubiquitin-conjugating enzyme E2H -0.0170429
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0167384
SUCO SUN domain containing ossification factor -0.0166699