| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5311101 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Fluticasone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAH6 | dynein, axonemal, heavy chain 6 | 1.27 |
| C4BPA | complement component 4 binding protein, alpha | 1.13 |
| MT2A | metallothionein 2A | 0.87 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.68 |
| ENO1 | enolase 1, (alpha) | 0.67 |
| NPHP3 | nephronophthisis 3 (adolescent) | 0.61 |
| MT1F | metallothionein 1F | 0.61 |
| MT1E | metallothionein 1E | 0.51 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | 0.5 |
| MT1X | metallothionein 1X | 0.48 |
| ICAM1 | intercellular adhesion molecule 1 | 0.47 |
| IFFO2 | intermediate filament family orphan 2 | 0.47 |
| PIP | prolactin-induced protein | 0.46 |
| FSTL1 | follistatin-like 1 | 0.46 |
| GKAP1 | G kinase anchoring protein 1 | 0.43 |
| DPH7 | diphthamide biosynthesis 7 | 0.43 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.43 |
| CHDH | choline dehydrogenase | 0.42 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.39 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | 0.39 |
| FAM135B | family with sequence similarity 135, member B | 0.39 |
| FAM126B | family with sequence similarity 126, member B | 0.38 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | 0.38 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.37 |
| PRKCH | protein kinase C, eta | 0.37 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.37 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 0.37 |
| BEND7 | BEN domain containing 7 | 0.36 |
| TNS4 | tensin 4 | 0.36 |
| JMJD8 | jumonji domain containing 8 | 0.36 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.35 |
| PER1 | period circadian clock 1 | 0.34 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | 0.34 |
| PUM2 | pumilio RNA-binding family member 2 | 0.34 |
| SP100 | SP100 nuclear antigen | 0.33 |
| M1AP | meiosis 1 associated protein | 0.33 |
| RPL26 | ribosomal protein L26 | 0.31 |
| RNF13 | ring finger protein 13 | 0.31 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.3 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.3 |
| CCDC102A | coiled-coil domain containing 102A | 0.29 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | 0.29 |
| C19ORF47 | chromosome 19 open reading frame 47 | 0.29 |
| RNF130 | ring finger protein 130 | 0.28 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | 0.28 |
| FHOD3 | formin homology 2 domain containing 3 | 0.28 |
| LAGE3 | L antigen family, member 3 | 0.28 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.27 |
| MYORG | myogenesis regulating glycosidase (putative) | 0.27 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | 0.27 |
| TTYH3 | tweety family member 3 | 0.27 |
| SGMS2 | sphingomyelin synthase 2 | 0.27 |
| FKBP5 | FK506 binding protein 5 | 0.27 |
| WNT10B | wingless-type MMTV integration site family, member 10B | 0.27 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.26 |
| MPDZ | multiple PDZ domain protein | 0.26 |
| CNTROB | centrobin, centrosomal BRCA2 interacting protein | 0.26 |
| COL5A1 | collagen, type V, alpha 1 | 0.26 |
| COBL | cordon-bleu WH2 repeat protein | 0.26 |
| FAM162A | family with sequence similarity 162, member A | 0.26 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | 0.25 |
| RPUSD4 | RNA pseudouridylate synthase domain containing 4 | 0.25 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.25 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.25 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | 0.24 |
| DAD1 | defender against cell death 1 | 0.24 |
| RAB3D | RAB3D, member RAS oncogene family | 0.24 |
| NOP10 | NOP10 ribonucleoprotein | 0.24 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.24 |
| RTN4R | reticulon 4 receptor | 0.24 |
| CCDC138 | coiled-coil domain containing 138 | 0.24 |
| CRY2 | cryptochrome circadian clock 2 | 0.24 |
| HBA1 | hemoglobin, alpha 1 | 0.23 |
| TMEM222 | transmembrane protein 222 | 0.23 |
| MRPS24 | mitochondrial ribosomal protein S24 | 0.23 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.23 |
| BRF1 | BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit | 0.23 |
| LYST | lysosomal trafficking regulator | 0.23 |
| E2F2 | E2F transcription factor 2 | 0.23 |
| TMEM135 | transmembrane protein 135 | 0.23 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.23 |
| APOE | apolipoprotein E | 0.22 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | 0.22 |
| MYO9A | myosin IXA | 0.22 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.22 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | 0.22 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.22 |
| MED26 | mediator complex subunit 26 | 0.21 |
| RPL36AL | ribosomal protein L36a-like | 0.21 |
| SIGMAR1 | sigma non-opioid intracellular receptor 1 | 0.21 |
| PSEN2 | presenilin 2 | 0.21 |
| UROS | uroporphyrinogen III synthase | 0.21 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.21 |
| TPCN1 | two pore segment channel 1 | 0.21 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.21 |
| AARS | alanyl-tRNA synthetase | 0.21 |
| SUMO1 | small ubiquitin-like modifier 1 | 0.21 |
| EHD2 | EH-domain containing 2 | 0.21 |
| KIAA0753 | KIAA0753 | 0.21 |
| TAF8 | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VAV1 | vav 1 guanine nucleotide exchange factor | -1.3 |
| CCDC15 | coiled-coil domain containing 15 | -1.26 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.18 |
| TNIP2 | TNFAIP3 interacting protein 2 | -1.04 |
| ACTBL2 | actin, beta-like 2 | -1.01 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.98 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | -0.97 |
| TNNI3 | troponin I type 3 (cardiac) | -0.9 |
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 | -0.84 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.83 |
| ATXN1L | ataxin 1-like | -0.83 |
| ITPKB | inositol-trisphosphate 3-kinase B | -0.62 |
| NUDT12 | nudix (nucleoside diphosphate linked moiety X)-type motif 12 | -0.58 |
| ELK1 | ELK1, member of ETS oncogene family | -0.57 |
| NUDT14 | nudix (nucleoside diphosphate linked moiety X)-type motif 14 | -0.56 |
| ANKRD44 | ankyrin repeat domain 44 | -0.55 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | -0.53 |
| ERCC6 | excision repair cross-complementation group 6 | -0.53 |
| TMEM184B | transmembrane protein 184B | -0.52 |
| FAT2 | FAT atypical cadherin 2 | -0.51 |
| ICK | intestinal cell (MAK-like) kinase | -0.51 |
| LZTR1 | leucine-zipper-like transcription regulator 1 | -0.51 |
| ZBTB44 | zinc finger and BTB domain containing 44 | -0.5 |
| CES2 | carboxylesterase 2 | -0.49 |
| FBRSL1 | fibrosin-like 1 | -0.49 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.47 |
| ZBTB49 | zinc finger and BTB domain containing 49 | -0.47 |
| ZNF431 | zinc finger protein 431 | -0.46 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.44 |
| NPTN | neuroplastin | -0.43 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.43 |
| MYRF | myelin regulatory factor | -0.42 |
| MSX1 | msh homeobox 1 | -0.4 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | -0.39 |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | -0.39 |
| SMIM26 | small integral membrane protein 26 | -0.38 |
| LDHD | lactate dehydrogenase D | -0.38 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.38 |
| ZNF724 | zinc finger protein 724 | -0.38 |
| AP4S1 | adaptor-related protein complex 4, sigma 1 subunit | -0.37 |
| CCM2 | cerebral cavernous malformation 2 | -0.37 |
| TBC1D31 | TBC1 domain family, member 31 | -0.37 |
| PXN | paxillin | -0.37 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -0.36 |
| ZNF525 | zinc finger protein 525 | -0.36 |
| MFSD14B | major facilitator superfamily domain containing 14B | -0.36 |
| MAP2 | microtubule-associated protein 2 | -0.36 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | -0.36 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.35 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | -0.35 |
| SKIL | SKI-like proto-oncogene | -0.35 |
| ZNF286B | zinc finger protein 286B | -0.35 |
| DOLK | dolichol kinase | -0.35 |
| MOB3A | MOB kinase activator 3A | -0.35 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -0.34 |
| FMNL1 | formin-like 1 | -0.34 |
| HGH1 | HGH1 homolog (S. cerevisiae) | -0.34 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.34 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | -0.34 |
| DOCK11 | dedicator of cytokinesis 11 | -0.34 |
| TVP23C | trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) | -0.33 |
| MIGA2 | mitoguardin 2 | -0.33 |
| RNPEPL1 | arginyl aminopeptidase (aminopeptidase B)-like 1 | -0.33 |
| CLTA | clathrin, light chain A | -0.33 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.33 |
| TMEM104 | transmembrane protein 104 | -0.33 |
| WRB | tryptophan rich basic protein | -0.33 |
| RBAK | RB-associated KRAB zinc finger | -0.33 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | -0.33 |
| CCDC90B | coiled-coil domain containing 90B | -0.32 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.32 |
| FAM104A | family with sequence similarity 104, member A | -0.32 |
| ZNF483 | zinc finger protein 483 | -0.32 |
| FAM189B | family with sequence similarity 189, member B | -0.32 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.32 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.32 |
| ZNF551 | zinc finger protein 551 | -0.32 |
| REX1BD | required for excision 1-B domain containing | -0.32 |
| POLL | polymerase (DNA directed), lambda | -0.32 |
| DIPK1B | divergent protein kinase domain 1B | -0.31 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | -0.31 |
| DPY30 | dpy-30 homolog (C. elegans) | -0.31 |
| DCAF17 | DDB1 and CUL4 associated factor 17 | -0.31 |
| R3HDM2 | R3H domain containing 2 | -0.31 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.31 |
| ZNF503 | zinc finger protein 503 | -0.31 |
| KPTN | kaptin (actin binding protein) | -0.31 |
| NKAPD1 | NKAP domain containing 1 | -0.3 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.3 |
| CLASP2 | cytoplasmic linker associated protein 2 | -0.3 |
| MARVELD3 | MARVEL domain containing 3 | -0.3 |
| TRAK2 | trafficking protein, kinesin binding 2 | -0.3 |
| RPGRIP1L | RPGRIP1-like | -0.3 |
| ZWINT | ZW10 interacting kinetochore protein | -0.29 |
| C1ORF43 | chromosome 1 open reading frame 43 | -0.29 |
| RAB24 | RAB24, member RAS oncogene family | -0.29 |
| DTNB | dystrobrevin, beta | -0.29 |
| SRRD | SRR1 domain containing | -0.29 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.28 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.28 |
