Fluvoxamine (maleate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine (maleate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine (maleate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0767589
PLPP1 phospholipid phosphatase 1 0.0636097
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0590151
TLE4 transducin-like enhancer of split 4 0.0553741
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0506276
KLHL13 kelch-like family member 13 0.0498771
BCAS3 breast carcinoma amplified sequence 3 0.0488008
EEF2 eukaryotic translation elongation factor 2 0.0485313
FMN1 formin 1 0.0469847
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0469663
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0469359
TPST1 tyrosylprotein sulfotransferase 1 0.0465066
EIF1 eukaryotic translation initiation factor 1 0.0448839
RIGI RNA sensor RIG-I 0.0439734
HSPA8 heat shock 70kDa protein 8 0.0424529
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0420935
ZSWIM6 zinc finger, SWIM-type containing 6 0.0401094
GLCCI1 glucocorticoid induced 1 0.0397158
B2M beta-2-microglobulin 0.0381251
RPLP1 ribosomal protein, large, P1 0.0376653
SIK2 salt-inducible kinase 2 0.0354425
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0347332
LSAMP limbic system-associated membrane protein 0.0345603
SP100 SP100 nuclear antigen 0.0321764
ANTXR1 anthrax toxin receptor 1 0.030154
ADGRL2 adhesion G protein-coupled receptor L2 0.0300762
RPS12 ribosomal protein S12 0.0298499
FTH1 ferritin, heavy polypeptide 1 0.029805
DNAH14 dynein, axonemal, heavy chain 14 0.0296221
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0293896
RPS6 ribosomal protein S6 0.0292698
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0287668
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0284748
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0278068
RNF213 ring finger protein 213 0.0277699
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0272723
FN1 fibronectin 1 0.0272155
PHF3 PHD finger protein 3 0.0270746
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.026539
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0262349
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0259076
IFI44L interferon-induced protein 44-like 0.0258854
COL3A1 collagen, type III, alpha 1 0.0258464
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0256976
RPL35A ribosomal protein L35a 0.0253375
RPS2 ribosomal protein S2 0.0244828
DNMBP dynamin binding protein 0.0242021
KIF5B kinesin family member 5B 0.0240869
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0236118
MX1 MX dynamin-like GTPase 1 0.0235804
RPS23 ribosomal protein S23 0.0234336
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0229507
RPL37 ribosomal protein L37 0.0227878
ZFC3H1 zinc finger, C3H1-type containing 0.0226704
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0225552
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0224873
SENP6 SUMO1/sentrin specific peptidase 6 0.0224521
TPT1 tumor protein, translationally-controlled 1 0.0223153
OGA O-GlcNAcase 0.0222211
VIM vimentin 0.0221076
TRA2A transformer 2 alpha homolog (Drosophila) 0.0220856
MX2 MX dynamin-like GTPase 2 0.0219935
TRIM56 tripartite motif containing 56 0.0219451
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0218294
RPL7 ribosomal protein L7 0.0217698
NIPBL Nipped-B homolog (Drosophila) 0.0216331
RPL27 ribosomal protein L27 0.02158
CTSB cathepsin B 0.0210676
NKTR natural killer cell triggering receptor 0.0209004
TNRC6B trinucleotide repeat containing 6B 0.0208705
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0204538
NFIB nuclear factor I/B 0.0201767
SIK3 SIK family kinase 3 0.0201173
PCBP3 poly(rC) binding protein 3 0.0200511
TENM4 teneurin transmembrane protein 4 0.0199239
PHIP pleckstrin homology domain interacting protein 0.0198725
CENPF centromere protein F, 350/400kDa 0.0198151
YBX1 Y box binding protein 1 0.0197639
RGS4 regulator of G-protein signaling 4 0.0197488
ADAR adenosine deaminase, RNA-specific 0.0195767
RPS27 ribosomal protein S27 0.0195188
TPM4 tropomyosin 4 0.019416
BPTF bromodomain PHD finger transcription factor 0.0193808
RPL26 ribosomal protein L26 0.0193639
PLSCR1 phospholipid scramblase 1 0.0189894
SFTPA2 surfactant protein A2 0.0189751
ITGA1 integrin, alpha 1 0.0189608
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0189482
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.018922
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0188842
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.018708
RPL37A ribosomal protein L37a 0.0186515
CALD1 caldesmon 1 0.018492
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.018471
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0184422
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0182466
NRP1 neuropilin 1 0.0181957
FAM107B family with sequence similarity 107, member B 0.0180953
ACTN1 actinin, alpha 1 0.0180913
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0180332

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.144582
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.107093
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0837981
LIMCH1 LIM and calponin homology domains 1 -0.080313
SYT1 synaptotagmin I -0.0730361
CEMIP cell migration inducing protein, hyaluronan binding -0.0706559
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0638499
DPH6 diphthamine biosynthesis 6 -0.060734
IGF2 insulin-like growth factor 2 -0.0599433
PRKCA protein kinase C, alpha -0.0586856
MAP1B microtubule-associated protein 1B -0.0529265
MAML2 mastermind-like 2 (Drosophila) -0.0521248
NALF1 NALCN channel auxiliary factor 1 -0.0515299
DSCAM Down syndrome cell adhesion molecule -0.0459409
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.045588
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0443573
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0434843
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0432709
PTPRM protein tyrosine phosphatase, receptor type, M -0.0383591
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0377748
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0376035
IARS1 isoleucyl-tRNA synthetase 1 -0.0375904
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0365828
NDRG1 N-myc downstream regulated 1 -0.0363504
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0352512
SPAG9 sperm associated antigen 9 -0.0350583
DTNA dystrobrevin, alpha -0.0340237
TRIO trio Rho guanine nucleotide exchange factor -0.0337453
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0332799
USP34 ubiquitin specific peptidase 34 -0.031794
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0317802
MACF1 microtubule-actin crosslinking factor 1 -0.0316787
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0311624
PKM pyruvate kinase, muscle -0.0311101
EXOC4 exocyst complex component 4 -0.0308451
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0307531
ANKRD17 ankyrin repeat domain 17 -0.0303513
LPIN1 lipin 1 -0.0302286
MBD5 methyl-CpG binding domain protein 5 -0.0301125
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0300597
HELZ helicase with zinc finger -0.029802
COL4A5 collagen, type IV, alpha 5 -0.0294909
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0293906
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0290644
NF1 neurofibromin 1 -0.0290066
GRB2 growth factor receptor-bound protein 2 -0.0288398
DLC1 DLC1 Rho GTPase activating protein -0.0287651
ZNF804A zinc finger protein 804A -0.0281071
FNDC3B fibronectin type III domain containing 3B -0.0278755
NCAM2 neural cell adhesion molecule 2 -0.0278629
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0274844
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0271829
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0269841
RBM25 RNA binding motif protein 25 -0.0268149
THSD4 thrombospondin, type I, domain containing 4 -0.0265277
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0263667
AKAP13 A kinase (PRKA) anchor protein 13 -0.0263079
DLG1 discs, large homolog 1 (Drosophila) -0.0262176
LRRC7 leucine rich repeat containing 7 -0.0262038
NPAS3 neuronal PAS domain protein 3 -0.0261435
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0261019
TRPS1 trichorhinophalangeal syndrome I -0.0259308
GOLGA4 golgin A4 -0.0250256
WAC WW domain containing adaptor with coiled-coil -0.0248289
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0246398
HMBOX1 homeobox containing 1 -0.0239321
SEC16A SEC16 homolog A (S. cerevisiae) -0.0239233
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0238361
PTK2 protein tyrosine kinase 2 -0.0235515
TRAM1 translocation associated membrane protein 1 -0.0231927
EGFR epidermal growth factor receptor -0.0231535
BICD1 bicaudal D homolog 1 (Drosophila) -0.0226854
HMGA1 high mobility group AT-hook 1 -0.0226246
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0226244
CDH13 cadherin 13 -0.0226097
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0225975
SETD5 SET domain containing 5 -0.0224926
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0224685
CADM1 cell adhesion molecule 1 -0.0221622
RPTOR regulatory associated protein of MTOR, complex 1 -0.0220727
QKI QKI, KH domain containing, RNA binding -0.0220544
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0219906
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0219498
BIRC6 baculoviral IAP repeat containing 6 -0.0219346
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0218717
GATAD2A GATA zinc finger domain containing 2A -0.0217288
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0216721
DACH2 dachshund family transcription factor 2 -0.0212782
TRIB2 tribbles pseudokinase 2 -0.0212303
ZNF292 zinc finger protein 292 -0.0209568
GDF15 growth differentiation factor 15 -0.0209102
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0209007
RIC1 RAB6A GEF complex partner 1 -0.0206393
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0205967
GARS1 glycyl-tRNA synthetase 1 -0.0205508
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.0205208
COL4A6 collagen, type IV, alpha 6 -0.0202317
SEC31A SEC31 homolog A (S. cerevisiae) -0.0201084
RTN4 reticulon 4 -0.0200552
EFNA5 ephrin-A5 -0.0199889