Fluvoxamine (maleate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine (maleate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine (maleate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSPP dentin sialophosphoprotein 0.156412
ERRFI1 ERBB receptor feedback inhibitor 1 0.13827
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.132164
C3 complement component 3 0.129767
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.108147
SAMD4A sterile alpha motif domain containing 4A 0.104909
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0999995
SVIL supervillin 0.0870534
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0746509
VEGFA vascular endothelial growth factor A 0.0666914
PCBP2 poly(rC) binding protein 2 0.0615107
IGFBP1 insulin-like growth factor binding protein 1 0.0611703
MYH9 myosin, heavy chain 9, non-muscle 0.0592712
AKAP12 A kinase (PRKA) anchor protein 12 0.053986
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0481214
CCL20 chemokine (C-C motif) ligand 20 0.0479687
TNS1 tensin 1 0.0478856
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0468783
EEF2 eukaryotic translation elongation factor 2 0.0464027
DIAPH1 diaphanous-related formin 1 0.0450367
FAT1 FAT atypical cadherin 1 0.0427261
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0421148
ITGAV integrin, alpha V 0.0414861
LCOR ligand dependent nuclear receptor corepressor 0.0405398
APLP2 amyloid beta (A4) precursor-like protein 2 0.0396759
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0386931
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0383725
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0380593
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0375565
EIF4B eukaryotic translation initiation factor 4B 0.0371342
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0368768
RPL3 ribosomal protein L3 0.0365917
FTH1 ferritin, heavy polypeptide 1 0.0359193
LIMS1 LIM and senescent cell antigen-like domains 1 0.034917
BCL2L1 BCL2-like 1 0.0334438
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0328998
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0323359
MACF1 microtubule-actin crosslinking factor 1 0.0319549
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0319109
ANXA5 annexin A5 0.0313743
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0313593
CTNND1 catenin (cadherin-associated protein), delta 1 0.0310596
VCL vinculin 0.0305474
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0302905
FAM13A family with sequence similarity 13, member A 0.029057
RUNX1 runt-related transcription factor 1 0.0287042
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0268322
ARHGAP9 Rho GTPase activating protein 9 0.0267828
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0263391
PICALM phosphatidylinositol binding clathrin assembly protein 0.0261832
FKTN fukutin 0.0261566
CTSB cathepsin B 0.0253717
GLS2 glutaminase 2 (liver, mitochondrial) 0.0252149
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0251573
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0247931
FAM107B family with sequence similarity 107, member B 0.024675
TPM1 tropomyosin 1 (alpha) 0.0246131
EXT1 exostosin glycosyltransferase 1 0.0245467
FHL2 four and a half LIM domains 2 0.0244942
BRD2 bromodomain containing 2 0.024316
SHB Src homology 2 domain containing adaptor protein B 0.0240351
FERMT2 fermitin family member 2 0.0237079
MYO1E myosin IE 0.0235249
EIF5 eukaryotic translation initiation factor 5 0.0233462
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0230858
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0227605
TOP1 topoisomerase (DNA) I 0.0227438
DTNA dystrobrevin, alpha 0.0224679
USP47 ubiquitin specific peptidase 47 0.022159
HSPH1 heat shock 105kDa/110kDa protein 1 0.0220583
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0219342
ADAM9 ADAM metallopeptidase domain 9 0.0218894
IGFBP3 insulin-like growth factor binding protein 3 0.0217122
LMCD1 LIM and cysteine-rich domains 1 0.0216135
ZBTB38 zinc finger and BTB domain containing 38 0.0215285
KYNU kynureninase 0.0215133
CORO1C coronin, actin binding protein, 1C 0.0211217
AFDN afadin, adherens junction formation factor 0.0209416
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0209307
PAWR PRKC, apoptosis, WT1, regulator 0.0208352
RNMT RNA (guanine-7-) methyltransferase 0.0206697
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0206603
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0205949
SFPQ splicing factor proline/glutamine-rich 0.0205464
KDM6A lysine (K)-specific demethylase 6A 0.0203093
RPS18 ribosomal protein S18 0.0203004
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0202768
CHIC2 cysteine-rich hydrophobic domain 2 0.0199031
DUSP16 dual specificity phosphatase 16 0.0197982
DNAH17 dynein, axonemal, heavy chain 17 0.0196482
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0194253
BIRC3 baculoviral IAP repeat containing 3 0.0192082
MYO1B myosin IB 0.0191866
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0191304
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0188212
TPM3 tropomyosin 3 0.0188198
RAD51B RAD51 paralog B 0.0187467
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0187268
SRSF4 serine/arginine-rich splicing factor 4 0.0186881
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0184765

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.274794
TPT1 tumor protein, translationally-controlled 1 -0.204339
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194227
APOA2 apolipoprotein A-II -0.130662
GPC3 glypican 3 -0.114073
MT2A metallothionein 2A -0.110918
RPS24 ribosomal protein S24 -0.0919246
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0910903
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0887861
CP ceruloplasmin (ferroxidase) -0.0832301
FTL ferritin, light polypeptide -0.0821236
RPLP1 ribosomal protein, large, P1 -0.0794938
TM4SF1 transmembrane 4 L six family member 1 -0.0742216
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0728117
RPL34 ribosomal protein L34 -0.0706049
ZMYND8 zinc finger, MYND-type containing 8 -0.0696667
RPLP0 ribosomal protein, large, P0 -0.0646604
GNAS GNAS complex locus -0.0627635
LOC112694756 uncharaterized LOC112694756 -0.0595633
FNDC3B fibronectin type III domain containing 3B -0.0570875
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0569384
EML4 echinoderm microtubule associated protein like 4 -0.0557295
RPL35A ribosomal protein L35a -0.0541657
AHSG alpha-2-HS-glycoprotein -0.053873
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.053099
HMGA1 high mobility group AT-hook 1 -0.0526254
TMSB10 thymosin beta 10 -0.0509539
FN1 fibronectin 1 -0.0504177
FBF1 Fas (TNFRSF6) binding factor 1 -0.0501553
RPL11 ribosomal protein L11 -0.0477478
RPS8 ribosomal protein S8 -0.0471427
TRIM26 tripartite motif containing 26 -0.0451178
RPS21 ribosomal protein S21 -0.0450316
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0447036
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.044485
TMEM123 transmembrane protein 123 -0.0443541
IER3 immediate early response 3 -0.043443
SDC4 syndecan 4 -0.0429556
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0428049
SLC38A2 solute carrier family 38, member 2 -0.0422307
NPR2 natriuretic peptide receptor 2 -0.0406929
RPS27A ribosomal protein S27a -0.0404496
RPL37A ribosomal protein L37a -0.0396141
RPL38 ribosomal protein L38 -0.0392907
A2M alpha-2-macroglobulin -0.0386184
RPL28 ribosomal protein L28 -0.0374311
ZBTB20 zinc finger and BTB domain containing 20 -0.037068
RPS19 ribosomal protein S19 -0.0370496
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.036941
RPL9 ribosomal protein L9 -0.0359409
ENO1 enolase 1, (alpha) -0.0355368
ACTG1 actin gamma 1 -0.0354902
APOA1 apolipoprotein A-I -0.035267
RPL32 ribosomal protein L32 -0.0343788
RPS6 ribosomal protein S6 -0.0342839
WDR45B WD repeat domain 45B -0.0340702
RPS5 ribosomal protein S5 -0.0336145
APOE apolipoprotein E -0.0334216
RPL31 ribosomal protein L31 -0.0334188
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0330529
ITGA1 integrin, alpha 1 -0.0327019
RPS29 ribosomal protein S29 -0.0317982
KPNB1 karyopherin (importin) beta 1 -0.0317038
APOB apolipoprotein B -0.0315198
PTPRM protein tyrosine phosphatase, receptor type, M -0.0313627
AMBP alpha-1-microglobulin/bikunin precursor -0.0311179
RPS13 ribosomal protein S13 -0.0307779
MBNL3 muscleblind-like splicing regulator 3 -0.0307095
NPAS2 neuronal PAS domain protein 2 -0.0304914
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0303943
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0302445
DLC1 DLC1 Rho GTPase activating protein -0.0298813
STK17A serine/threonine kinase 17a -0.0295436
ANGPTL8 angiopoietin like 8 -0.0293661
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0290826
RPS16 ribosomal protein S16 -0.0287125
RPL27A ribosomal protein L27a -0.028711
EGR1 early growth response 1 -0.0284675
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0284392
KDM3A lysine (K)-specific demethylase 3A -0.0283654
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0275992
NDRG1 N-myc downstream regulated 1 -0.0275189
GCC2 GRIP and coiled-coil domain containing 2 -0.0274597
RPS23 ribosomal protein S23 -0.0273931
ARFGEF3 ARFGEF family member 3 -0.0272823
RPL12 ribosomal protein L12 -0.0272321
PTPRF protein tyrosine phosphatase, receptor type, F -0.0268928
RPL23 ribosomal protein L23 -0.0267565
OSMR oncostatin M receptor -0.0266919
RPLP2 ribosomal protein, large, P2 -0.0265249
RPL37 ribosomal protein L37 -0.0264028
RPS12 ribosomal protein S12 -0.0262622
EHBP1 EH domain binding protein 1 -0.0258481
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0257517
PDGFB platelet-derived growth factor beta polypeptide -0.0256373
PTMA prothymosin, alpha -0.0256221
SLC38A1 solute carrier family 38, member 1 -0.0255956
RAB1A RAB1A, member RAS oncogene family -0.0255751
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0252579
MALT1 MALT1 paracaspase -0.0252566