Fluvoxamine (maleate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine (maleate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine (maleate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.108642
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0671736
DOK5 docking protein 5 0.0540041
MYOF myoferlin 0.0513375
PCDH1 protocadherin 1 0.0487273
TXNIP thioredoxin interacting protein 0.047993
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0456643
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0453111
MSN moesin 0.0443382
PLEC plectin 0.0440377
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0428678
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0424427
SLK STE20-like kinase 0.0397502
FTH1 ferritin, heavy polypeptide 1 0.0388004
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0385624
PCBP2 poly(rC) binding protein 2 0.0385538
AKAP13 A kinase (PRKA) anchor protein 13 0.0360819
KLF5 Kruppel-like factor 5 (intestinal) 0.0358932
CD44 CD44 molecule (Indian blood group) 0.0353037
ARHGAP21 Rho GTPase activating protein 21 0.0352199
MACF1 microtubule-actin crosslinking factor 1 0.0337566
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0322225
CALB1 calbindin 1, 28kDa 0.031779
BCAR3 breast cancer anti-estrogen resistance 3 0.0301834
RNF217 ring finger protein 217 0.0300907
GRAMD1B GRAM domain containing 1B 0.0300565
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0296104
ARRDC3 arrestin domain containing 3 0.0294354
DIAPH1 diaphanous-related formin 1 0.0290882
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.028785
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0280672
USP47 ubiquitin specific peptidase 47 0.0280351
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0275782
EFNB2 ephrin-B2 0.0274669
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0271951
KMT2C lysine (K)-specific methyltransferase 2C 0.026703
SRRM2 serine/arginine repetitive matrix 2 0.0263661
TPM3 tropomyosin 3 0.026083
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0260755
MED13L mediator complex subunit 13-like 0.0258131
DUSP4 dual specificity phosphatase 4 0.0249765
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0248842
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0247758
IFI44L interferon-induced protein 44-like 0.0244392
RICTOR RPTOR independent companion of MTOR, complex 2 0.0244013
ESYT2 extended synaptotagmin-like protein 2 0.0243911
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.023954
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0237695
TMSB4X thymosin beta 4, X-linked 0.0235245
MYH9 myosin, heavy chain 9, non-muscle 0.0229444
UBA6 ubiquitin-like modifier activating enzyme 6 0.0228705
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0225733
BHLHE40 basic helix-loop-helix family, member e40 0.0224434
DST dystonin 0.0222469
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0222063
DSPP dentin sialophosphoprotein 0.022192
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0221171
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0220854
MN1 meningioma (disrupted in balanced translocation) 1 0.0220244
BARX2 BARX homeobox 2 0.0219625
EEF2 eukaryotic translation elongation factor 2 0.0216599
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0216552
IRAK2 interleukin-1 receptor-associated kinase 2 0.0216328
PEAK1 pseudopodium-enriched atypical kinase 1 0.0215399
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0215288
CSNK1A1 casein kinase 1, alpha 1 0.0214454
EHBP1L1 EH domain binding protein 1-like 1 0.0211804
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0211552
ITGA6 integrin, alpha 6 0.0205263
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0203791
SMC1A structural maintenance of chromosomes 1A 0.0202107
DENND3 DENN/MADD domain containing 3 0.0200741
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.019992
SLC35F3 solute carrier family 35, member F3 0.0199633
AHNAK2 AHNAK nucleoprotein 2 0.0193865
KTN1 kinectin 1 (kinesin receptor) 0.0193196
MBNL1 muscleblind-like splicing regulator 1 0.0193164
KLF3 Kruppel-like factor 3 (basic) 0.019228
KDM1A lysine (K)-specific demethylase 1A 0.0191927
JAK2 Janus kinase 2 0.0191828
SRRM1 serine/arginine repetitive matrix 1 0.0191464
CORO1C coronin, actin binding protein, 1C 0.0190361
CDCP1 CUB domain containing protein 1 0.0188553
SMC3 structural maintenance of chromosomes 3 0.0187954
ANKH ANKH inorganic pyrophosphate transport regulator 0.0187755
PTK2 protein tyrosine kinase 2 0.0183833
WASL Wiskott-Aldrich syndrome-like 0.0181044
CHD1 chromodomain helicase DNA binding protein 1 0.0180124
FN1 fibronectin 1 0.0179311
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0179307
RNF145 ring finger protein 145 0.0179287
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0176753
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0176736
BACE2 beta-site APP-cleaving enzyme 2 0.0176567
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0176382
KAT6A K(lysine) acetyltransferase 6A 0.017618
USP12 ubiquitin specific peptidase 12 0.0175979
CTTN cortactin 0.0175737
MEGF6 multiple EGF-like-domains 6 0.0175241
KCTD12 potassium channel tetramerization domain containing 12 0.0173682

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.176725
NDRG1 N-myc downstream regulated 1 -0.159212
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147173
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.103524
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.101072
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0975347
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0828373
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0821916
LOC112694756 uncharaterized LOC112694756 -0.0767623
DPYD dihydropyrimidine dehydrogenase -0.0760762
PTMA prothymosin, alpha -0.0650939
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0617193
TMSB10 thymosin beta 10 -0.0601957
HM13 histocompatibility (minor) 13 -0.0588115
HSPG2 heparan sulfate proteoglycan 2 -0.0584212
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0576608
SEC31A SEC31 homolog A (S. cerevisiae) -0.055001
FSCN1 fascin actin-bundling protein 1 -0.0532551
NAMPT nicotinamide phosphoribosyltransferase -0.0529732
HDLBP high density lipoprotein binding protein -0.0527664
SULF1 sulfatase 1 -0.0518037
LAMA5 laminin, alpha 5 -0.047761
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0472831
GNAS GNAS complex locus -0.0466512
S100A10 S100 calcium binding protein A10 -0.0445428
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0439352
NEK7 NIMA-related kinase 7 -0.0434813
BCL2L1 BCL2-like 1 -0.0432791
PGK1 phosphoglycerate kinase 1 -0.0428731
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0421633
CLU clusterin -0.0421019
ANXA2 annexin A2 -0.0411346
TRIO trio Rho guanine nucleotide exchange factor -0.0409903
MECOM MDS1 and EVI1 complex locus -0.0407435
ITCH itchy E3 ubiquitin protein ligase -0.0405724
MORF4L2 mortality factor 4 like 2 -0.0404109
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0401761
EMP1 epithelial membrane protein 1 -0.0392187
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0389238
GARS1 glycyl-tRNA synthetase 1 -0.0379761
EGR1 early growth response 1 -0.0373998
TNS3 tensin 3 -0.0368318
LDHA lactate dehydrogenase A -0.0364934
ANKRD11 ankyrin repeat domain 11 -0.0359472
CAVIN1 caveolae associated protein 1 -0.0358409
CEMIP cell migration inducing protein, hyaluronan binding -0.0357197
HLA-B major histocompatibility complex, class I, B -0.0355699
THBD thrombomodulin -0.0347384
ANKRD33B ankyrin repeat domain 33B -0.0346009
ARF1 ADP-ribosylation factor 1 -0.0345875
IARS1 isoleucyl-tRNA synthetase 1 -0.0345774
IGF2 insulin-like growth factor 2 -0.0342403
RIN2 Ras and Rab interactor 2 -0.0342362
COPA coatomer protein complex, subunit alpha -0.0341858
ANLN anillin, actin binding protein -0.0341045
CALU calumenin -0.0340808
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0340079
SDCBP syndecan binding protein (syntenin) -0.0339569
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0338084
RAP1B RAP1B, member of RAS oncogene family -0.0336866
IER3 immediate early response 3 -0.0333982
TMEM263 transmembrane protein 263 -0.0333381
DUSP6 dual specificity phosphatase 6 -0.0329546
LMNA lamin A/C -0.0327302
ENO1 enolase 1, (alpha) -0.0325522
WASF2 WAS protein family, member 2 -0.031826
MON2 MON2 homolog (S. cerevisiae) -0.0308152
DLG1 discs, large homolog 1 (Drosophila) -0.0308042
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0306324
CMIP c-Maf inducing protein -0.0305751
RBM39 RNA binding motif protein 39 -0.0298199
ARF4 ADP-ribosylation factor 4 -0.0297569
PALLD palladin, cytoskeletal associated protein -0.0295579
ANXA1 annexin A1 -0.029379
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0292614
CD99 CD99 molecule -0.0291789
SRP54 signal recognition particle 54kDa -0.0290709
TPT1 tumor protein, translationally-controlled 1 -0.0287524
UFM1 ubiquitin-fold modifier 1 -0.0285585
COPB1 coatomer protein complex, subunit beta 1 -0.0285298
NCOA3 nuclear receptor coactivator 3 -0.0284812
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0284568
ZCCHC7 zinc finger, CCHC domain containing 7 -0.028205
PKM pyruvate kinase, muscle -0.0281041
DSG2 desmoglein 2 -0.0278949
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0278464
ANKRD10 ankyrin repeat domain 10 -0.0278261
LDLR low density lipoprotein receptor -0.0275833
RLF rearranged L-myc fusion -0.0272368
FOXO1 forkhead box O1 -0.0271651
CDK6 cyclin-dependent kinase 6 -0.0271441
RPLP1 ribosomal protein, large, P1 -0.0268988
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0268706
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0268489
GLG1 golgi glycoprotein 1 -0.0267924
NRG1 neuregulin 1 -0.0267343
RPL11 ribosomal protein L11 -0.0267073
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0265388
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0264438
SLC30A7 solute carrier family 30 (zinc transporter), member 7 -0.0263353