Fluvoxamine (maleate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine (maleate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine (maleate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.116227
EXT1 exostosin glycosyltransferase 1 0.106991
ASPH aspartate beta-hydroxylase 0.0965821
TRIO trio Rho guanine nucleotide exchange factor 0.0731295
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0695857
SAMD4A sterile alpha motif domain containing 4A 0.0677829
PRKG1 protein kinase, cGMP-dependent, type I 0.0639361
DST dystonin 0.0561478
HMGA2 high mobility group AT-hook 2 0.055213
AHNAK AHNAK nucleoprotein 0.0535472
AKAP12 A kinase (PRKA) anchor protein 12 0.0525956
DTNA dystrobrevin, alpha 0.0511643
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0496531
PBX3 pre-B-cell leukemia homeobox 3 0.0488702
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0477965
SDCCAG8 serologically defined colon cancer antigen 8 0.0473854
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0454718
PTPRG protein tyrosine phosphatase, receptor type, G 0.0454588
SAMD3 sterile alpha motif domain containing 3 0.0453093
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0439961
MACF1 microtubule-actin crosslinking factor 1 0.0438555
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0408463
INTS6 integrator complex subunit 6 0.0396009
MYO10 myosin X 0.0384708
MYH9 myosin, heavy chain 9, non-muscle 0.0375781
MARCHF4 membrane associated ring-CH-type finger 4 0.0374693
NALF1 NALCN channel auxiliary factor 1 0.0366846
HSPA8 heat shock 70kDa protein 8 0.0363248
HDAC9 histone deacetylase 9 0.0362379
FLNA filamin A, alpha 0.0359067
ANO6 anoctamin 6 0.0356124
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0345295
PRKCE protein kinase C, epsilon 0.0344856
KIAA1549L KIAA1549-like 0.0339495
KIAA1217 KIAA1217 0.0339382
NAV1 neuron navigator 1 0.033317
RUNX1 runt-related transcription factor 1 0.0329671
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0324422
DOCK4 dedicator of cytokinesis 4 0.0322875
LIMCH1 LIM and calponin homology domains 1 0.0320645
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0312532
EEF2 eukaryotic translation elongation factor 2 0.031137
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0303383
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0300629
ERRFI1 ERBB receptor feedback inhibitor 1 0.0299819
DOCK1 dedicator of cytokinesis 1 0.0289483
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.028728
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0272915
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0270797
NTM neurotrimin 0.0268152
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0264473
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0259353
CD163L1 CD163 molecule-like 1 0.0257015
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0249757
PRELID2 PRELI domain containing 2 0.0249368
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0248476
ZNF638 zinc finger protein 638 0.0245651
EIF4B eukaryotic translation initiation factor 4B 0.0235322
PHACTR1 phosphatase and actin regulator 1 0.0234962
ZSWIM6 zinc finger, SWIM-type containing 6 0.0230756
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0227383
KDM4C lysine (K)-specific demethylase 4C 0.0223317
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0222957
AEBP2 AE binding protein 2 0.0220946
PTPRD protein tyrosine phosphatase, receptor type, D 0.0220241
ITGA6 integrin, alpha 6 0.02177
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0216766
SMYD3 SET and MYND domain containing 3 0.0215852
FMNL2 formin-like 2 0.021474
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.020918
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0207907
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.020771
CORO1C coronin, actin binding protein, 1C 0.0204518
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0203808
SATB2 SATB homeobox 2 0.0203108
RABGAP1L RAB GTPase activating protein 1-like 0.0202178
CDK14 cyclin-dependent kinase 14 0.019975
PLEC plectin 0.0199053
NAV3 neuron navigator 3 0.0197525
EGFR epidermal growth factor receptor 0.0196611
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0195417
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0191194
RAD51B RAD51 paralog B 0.0190932
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.018928
ZEB1 zinc finger E-box binding homeobox 1 0.0188407
CTBP2 C-terminal binding protein 2 0.0188254
CDH13 cadherin 13 0.0187324
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0186644
DSCAM Down syndrome cell adhesion molecule 0.0183954
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0180539
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0180022
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0177744
RPS18 ribosomal protein S18 0.0174203
LPP LIM domain containing preferred translocation partner in lipoma 0.0171789
RNF213 ring finger protein 213 0.0171679
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0171577
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0168417
DOCK5 dedicator of cytokinesis 5 0.0167318
SON SON DNA binding protein 0.0165021
TMPRSS15 transmembrane protease, serine 15 0.0163152

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.561008
FTL ferritin, light polypeptide -0.125373
TMSB10 thymosin beta 10 -0.0991555
VIM vimentin -0.0923197
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0918353
RPS6 ribosomal protein S6 -0.0890644
PTMA prothymosin, alpha -0.0805176
MT2A metallothionein 2A -0.079758
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0790184
ACTG1 actin gamma 1 -0.0749344
EIF1 eukaryotic translation initiation factor 1 -0.0592426
POTEF POTE ankyrin domain family, member F -0.0578935
RPLP1 ribosomal protein, large, P1 -0.049948
RPS19 ribosomal protein S19 -0.0497388
RPL23 ribosomal protein L23 -0.0495039
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0494987
UGCG UDP-glucose ceramide glucosyltransferase -0.0478951
RPS13 ribosomal protein S13 -0.0465283
PKM pyruvate kinase, muscle -0.04359
RPS8 ribosomal protein S8 -0.0428787
RPLP0 ribosomal protein, large, P0 -0.0404611
HMGA1 high mobility group AT-hook 1 -0.0394072
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0389851
RPL35A ribosomal protein L35a -0.0382271
RPL8 ribosomal protein L8 -0.0371026
RPS23 ribosomal protein S23 -0.036181
RPS25 ribosomal protein S25 -0.0353009
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0342146
MMP12 matrix metallopeptidase 12 -0.0338154
RPLP2 ribosomal protein, large, P2 -0.0334013
LOC112694756 uncharaterized LOC112694756 -0.0326362
RPL19 ribosomal protein L19 -0.0323445
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0322458
RPL32 ribosomal protein L32 -0.0321577
GNAS GNAS complex locus -0.0314267
TPT1 tumor protein, translationally-controlled 1 -0.0314007
TPM4 tropomyosin 4 -0.0311746
PFN1 profilin 1 -0.0299882
YBX3 Y box binding protein 3 -0.0294644
RPL7 ribosomal protein L7 -0.0292369
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0291651
ADAM9 ADAM metallopeptidase domain 9 -0.0291508
KPNB1 karyopherin (importin) beta 1 -0.0291071
SEPTIN7 septin 7 -0.028683
RPL11 ribosomal protein L11 -0.0285791
RPS24 ribosomal protein S24 -0.0276841
RPL36 ribosomal protein L36 -0.0276598
RPL5 ribosomal protein L5 -0.0275822
ANXA2 annexin A2 -0.0274667
RPL30 ribosomal protein L30 -0.0270013
RPL31 ribosomal protein L31 -0.0269819
RPL37A ribosomal protein L37a -0.0263608
RTN4 reticulon 4 -0.0260326
RPL36A ribosomal protein L36a -0.0259709
NUP58 nucleoporin 58 -0.0259438
RPL34 ribosomal protein L34 -0.0259436
RPL13A ribosomal protein L13a -0.0251718
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0251182
RPL12 ribosomal protein L12 -0.0247907
KMT2E lysine (K)-specific methyltransferase 2E -0.0246845
ZNF292 zinc finger protein 292 -0.0245619
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0243822
RPS16 ribosomal protein S16 -0.0242905
WSB1 WD repeat and SOCS box containing 1 -0.023757
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0236101
RPS5 ribosomal protein S5 -0.0234272
PNISR PNN-interacting serine/arginine-rich protein -0.0230889
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0228371
RPS21 ribosomal protein S21 -0.022762
WDR45B WD repeat domain 45B -0.0223624
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0222328
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0222173
FOSL1 FOS-like antigen 1 -0.0219936
PTBP3 polypyrimidine tract binding protein 3 -0.0219764
NAMPT nicotinamide phosphoribosyltransferase -0.0216752
MTDH metadherin -0.0216562
RPS29 ribosomal protein S29 -0.0216098
RPL28 ribosomal protein L28 -0.0215625
RPS27A ribosomal protein S27a -0.0215382
VDAC1 voltage-dependent anion channel 1 -0.0214833
RPL37 ribosomal protein L37 -0.0214523
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0212661
RPL35 ribosomal protein L35 -0.0212143
RPL27A ribosomal protein L27a -0.0211899
RPS20 ribosomal protein S20 -0.0209135
BTG1 B-cell translocation gene 1, anti-proliferative -0.0208831
RPL38 ribosomal protein L38 -0.020824
PDIA3 protein disulfide isomerase family A, member 3 -0.0205931
ELL2 elongation factor, RNA polymerase II, 2 -0.020476
UBC ubiquitin C -0.0204447
RPL9 ribosomal protein L9 -0.0202196
RPS15 ribosomal protein S15 -0.0201338
RAB1A RAB1A, member RAS oncogene family -0.0201103
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0198306
NDRG1 N-myc downstream regulated 1 -0.019742
RPS11 ribosomal protein S11 -0.0194892
RPS10 ribosomal protein S10 -0.0193222
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0192991
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0190066
TFG TRK-fused gene -0.0186229