Fluvoxamine (maleate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine (maleate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine (maleate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.152088
MT2A metallothionein 2A 0.140596
RPS12 ribosomal protein S12 0.076049
ERRFI1 ERBB receptor feedback inhibitor 1 0.0708203
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0667228
TXNIP thioredoxin interacting protein 0.0664769
RPL12 ribosomal protein L12 0.059053
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.058321
ZFP36L1 ZFP36 ring finger protein-like 1 0.0566695
RPL36 ribosomal protein L36 0.0530642
B2M beta-2-microglobulin 0.0520898
RPS19 ribosomal protein S19 0.0513445
SDK1 sidekick cell adhesion molecule 1 0.0461401
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0459032
RPS6 ribosomal protein S6 0.0451615
RPL26 ribosomal protein L26 0.0442809
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0440951
EEF2 eukaryotic translation elongation factor 2 0.0428538
SRRM2 serine/arginine repetitive matrix 2 0.0414289
CAPRIN2 caprin family member 2 0.0407919
DST dystonin 0.0369623
PCBP2 poly(rC) binding protein 2 0.0366945
RPS3 ribosomal protein S3 0.0362154
FTL ferritin, light polypeptide 0.0359213
RPL37A ribosomal protein L37a 0.0358074
SLK STE20-like kinase 0.0354556
ENO2 enolase 2 (gamma, neuronal) 0.0351055
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0340454
MT1X metallothionein 1X 0.0337331
PLIN2 perilipin 2 0.0332559
RPS17 ribosomal protein S17 0.0330876
RPS27 ribosomal protein S27 0.0325354
BIRC3 baculoviral IAP repeat containing 3 0.0322428
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0320802
RPL3 ribosomal protein L3 0.0307444
TPM3 tropomyosin 3 0.0305156
CCNL1 cyclin L1 0.0303997
VEGFA vascular endothelial growth factor A 0.0303446
ENO1 enolase 1, (alpha) 0.0300882
RACK1 receptor for activated C kinase 1 0.0300613
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0299738
RPL31 ribosomal protein L31 0.029572
PCDH1 protocadherin 1 0.0294356
RPL27 ribosomal protein L27 0.0294338
F2R coagulation factor II (thrombin) receptor 0.0293638
RPLP2 ribosomal protein, large, P2 0.0290302
RPS18 ribosomal protein S18 0.0288766
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0288157
ZNF638 zinc finger protein 638 0.0286046
RPL37 ribosomal protein L37 0.0280449
FMNL2 formin-like 2 0.0268853
POTEF POTE ankyrin domain family, member F 0.0266841
EIF5 eukaryotic translation initiation factor 5 0.026502
PRELID2 PRELI domain containing 2 0.0263501
RPS2 ribosomal protein S2 0.0263498
RPS14 ribosomal protein S14 0.0262646
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0261138
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0253533
SFTPA2 surfactant protein A2 0.0246239
JUN jun proto-oncogene 0.0242603
KMT2E lysine (K)-specific methyltransferase 2E 0.0240313
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0235611
BRD2 bromodomain containing 2 0.0235049
ANKRD36 ankyrin repeat domain 36 0.0231923
ANGPTL4 angiopoietin-like 4 0.0231702
EEF1G eukaryotic translation elongation factor 1 gamma 0.0229514
TPI1 triosephosphate isomerase 1 0.0224024
RPL23 ribosomal protein L23 0.0222811
MSN moesin 0.0221104
HLA-A major histocompatibility complex, class I, A 0.0219913
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0219213
RPL35A ribosomal protein L35a 0.0216268
ZMIZ1 zinc finger, MIZ-type containing 1 0.021262
HLA-B major histocompatibility complex, class I, B 0.0211765
ARRDC3 arrestin domain containing 3 0.020927
KTN1 kinectin 1 (kinesin receptor) 0.0207723
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0203463
AREG amphiregulin 0.0200151
RCOR1 REST corepressor 1 0.0200046
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0195269
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.019462
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0194574
IFITM1 interferon induced transmembrane protein 1 0.019126
SRSF11 serine/arginine-rich splicing factor 11 0.0189599
ADM adrenomedullin 0.0187742
AGTPBP1 ATP/GTP binding protein 1 0.0187393
PABPN1 poly(A) binding protein, nuclear 1 0.0187252
MYH9 myosin, heavy chain 9, non-muscle 0.0187141
PLK2 polo-like kinase 2 0.0186626
PDE10A phosphodiesterase 10A 0.0186543
RPL35 ribosomal protein L35 0.0184934
CXCL8 chemokine (C-X-C motif) ligand 8 0.0184465
MYADM myeloid-associated differentiation marker 0.018416
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0178877
LGALS3 lectin, galactoside-binding, soluble, 3 0.0177361
DIAPH1 diaphanous-related formin 1 0.0177322
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0176988
GYS1 glycogen synthase 1 (muscle) 0.0175495
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0174471
OSBPL8 oxysterol binding protein-like 8 0.0174362

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.261889
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.254955
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.148812
DLG1 discs, large homolog 1 (Drosophila) -0.135992
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0978967
TM4SF1 transmembrane 4 L six family member 1 -0.0845768
AHNAK AHNAK nucleoprotein -0.0816696
VIM vimentin -0.0752571
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0714208
CD44 CD44 molecule (Indian blood group) -0.0702994
ACTG1 actin gamma 1 -0.069182
SRGN serglycin -0.063437
EHBP1 EH domain binding protein 1 -0.0618453
TXNRD1 thioredoxin reductase 1 -0.0599165
APP amyloid beta (A4) precursor protein -0.0580832
LOC112694756 uncharaterized LOC112694756 -0.0578482
KPNB1 karyopherin (importin) beta 1 -0.0535116
RIGI RNA sensor RIG-I -0.0515736
TP63 tumor protein p63 -0.0498859
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0495728
CANX calnexin -0.0460215
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0458389
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.045794
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0451653
ANXA1 annexin A1 -0.0447328
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0428952
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0425707
ZMYND8 zinc finger, MYND-type containing 8 -0.0412656
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0408363
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0406391
HDLBP high density lipoprotein binding protein -0.0404151
SLC38A2 solute carrier family 38, member 2 -0.0387445
ADGRG6 adhesion G protein-coupled receptor G6 -0.0386601
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0379067
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0372167
PGK1 phosphoglycerate kinase 1 -0.0369769
CFAP299 cilia and flagella associated protein 299 -0.0368531
TMEM123 transmembrane protein 123 -0.0362798
RAI1 retinoic acid induced 1 -0.0360813
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0360679
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0360654
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0351772
WARS1 tryptophanyl-tRNA synthetase 1 -0.0349136
GNAS GNAS complex locus -0.0348006
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0343543
MARCHF6 membrane associated ring-CH-type finger 6 -0.0337902
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0333298
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0330395
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0329554
PSD3 pleckstrin and Sec7 domain containing 3 -0.0326418
SBF2 SET binding factor 2 -0.0326308
VCL vinculin -0.0323969
ARF1 ADP-ribosylation factor 1 -0.0322701
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.032263
FBXO11 F-box protein 11 -0.032085
PTK2 protein tyrosine kinase 2 -0.0320149
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0319587
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0319362
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0314367
PYGB phosphorylase, glycogen; brain -0.0313913
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0308572
RAB1A RAB1A, member RAS oncogene family -0.030409
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0303204
CAVIN1 caveolae associated protein 1 -0.0300497
EMP1 epithelial membrane protein 1 -0.0298584
TNS3 tensin 3 -0.0295641
MAP4 microtubule-associated protein 4 -0.0295382
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.02938
OLA1 Obg-like ATPase 1 -0.0293511
ANKRD28 ankyrin repeat domain 28 -0.029161
ANLN anillin, actin binding protein -0.0291141
STK17A serine/threonine kinase 17a -0.0285725
TAS2R14 taste receptor, type 2, member 14 -0.0285624
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0284365
RPS24 ribosomal protein S24 -0.0283182
RPLP0 ribosomal protein, large, P0 -0.028056
WDR45B WD repeat domain 45B -0.0278783
ANKRD17 ankyrin repeat domain 17 -0.0277417
ZFAND3 zinc finger, AN1-type domain 3 -0.0277061
TOP1 topoisomerase (DNA) I -0.0275825
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0271304
LDHA lactate dehydrogenase A -0.0270892
PTMA prothymosin, alpha -0.0270031
OSMR oncostatin M receptor -0.026655
FUS FUS RNA binding protein -0.0264423
BZW1 basic leucine zipper and W2 domains 1 -0.0264321
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0263594
KDM3A lysine (K)-specific demethylase 3A -0.0263308
EXOC4 exocyst complex component 4 -0.026194
RTN4 reticulon 4 -0.0260211
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0259561
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0258509
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0255733
SENP6 SUMO1/sentrin specific peptidase 6 -0.0254841
NF1 neurofibromin 1 -0.025429
ZMYM2 zinc finger, MYM-type 2 -0.0254237
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0252768
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0252068
TNPO1 transportin 1 -0.0250485
RHEB Ras homolog enriched in brain -0.0249231