Fluvoxamine (maleate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine (maleate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine (maleate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.205511
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.195674
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.162546
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.131528
EEF2 eukaryotic translation elongation factor 2 0.103205
MYH9 myosin, heavy chain 9, non-muscle 0.098576
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0984193
FTL ferritin, light polypeptide 0.0934088
VEGFA vascular endothelial growth factor A 0.0882919
IGFBP3 insulin-like growth factor binding protein 3 0.0827065
DSPP dentin sialophosphoprotein 0.0718981
ZSWIM6 zinc finger, SWIM-type containing 6 0.0681273
MSN moesin 0.0618663
SAMD4A sterile alpha motif domain containing 4A 0.0617722
PCBP2 poly(rC) binding protein 2 0.0586868
RPS3 ribosomal protein S3 0.0582836
APLP2 amyloid beta (A4) precursor-like protein 2 0.0571482
BRD2 bromodomain containing 2 0.0539005
CTSB cathepsin B 0.0537346
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0529473
PRRC2C proline-rich coiled-coil 2C 0.0526468
RPS12 ribosomal protein S12 0.0499861
ARRDC3 arrestin domain containing 3 0.0469851
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0466891
HSPA8 heat shock 70kDa protein 8 0.0466695
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0462778
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.046251
TPM3 tropomyosin 3 0.0433675
TMSB4X thymosin beta 4, X-linked 0.0422685
RACK1 receptor for activated C kinase 1 0.0410811
RPL3 ribosomal protein L3 0.0394161
RPL37A ribosomal protein L37a 0.0381172
PLEC plectin 0.0369734
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0366643
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0365976
GOLGB1 golgin B1 0.0363068
MX1 MX dynamin-like GTPase 1 0.0360706
EXT1 exostosin glycosyltransferase 1 0.0356055
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0345144
CANX calnexin 0.0340242
RPS2 ribosomal protein S2 0.0337456
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0335055
RPS17 ribosomal protein S17 0.0334445
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.033343
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0333026
TMF1 TATA element modulatory factor 1 0.0329408
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0321277
SON SON DNA binding protein 0.0315757
YBX1 Y box binding protein 1 0.0311693
EIF5 eukaryotic translation initiation factor 5 0.0309778
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0308893
GLS2 glutaminase 2 (liver, mitochondrial) 0.029832
AHNAK2 AHNAK nucleoprotein 2 0.0297558
PGBD5 piggyBac transposable element derived 5 0.0296701
BHLHE40 basic helix-loop-helix family, member e40 0.0295907
SFTPA2 surfactant protein A2 0.029526
EEF1G eukaryotic translation elongation factor 1 gamma 0.0294222
AKAP13 A kinase (PRKA) anchor protein 13 0.0293324
TXNIP thioredoxin interacting protein 0.0288298
EIF4B eukaryotic translation initiation factor 4B 0.0287538
ATF4 activating transcription factor 4 0.0286496
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0284175
RPL12 ribosomal protein L12 0.02836
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.02791
TJP1 tight junction protein 1 0.0277947
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.027619
RPS6 ribosomal protein S6 0.0272047
SRRM2 serine/arginine repetitive matrix 2 0.0270825
RPS18 ribosomal protein S18 0.0269599
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0266666
ADM adrenomedullin 0.0266272
INTS6 integrator complex subunit 6 0.0266169
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0263289
RPLP2 ribosomal protein, large, P2 0.0256136
EIF1 eukaryotic translation initiation factor 1 0.0253645
GPX4 glutathione peroxidase 4 0.0253408
HDGF hepatoma-derived growth factor 0.0245728
DUSP10 dual specificity phosphatase 10 0.0244774
LAMB3 laminin, beta 3 0.0240028
RPL23 ribosomal protein L23 0.0239914
FLNA filamin A, alpha 0.0233385
ENO1 enolase 1, (alpha) 0.0232159
RPS27 ribosomal protein S27 0.0230868
RPS3A ribosomal protein S3A 0.0228132
RPS19 ribosomal protein S19 0.0222675
RPS14 ribosomal protein S14 0.0222069
CTBP2 C-terminal binding protein 2 0.0220575
RPL37 ribosomal protein L37 0.0217601
MCL1 myeloid cell leukemia 1 0.0216035
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0215835
RNF213 ring finger protein 213 0.0215108
RPS27A ribosomal protein S27a 0.0214552
RB1CC1 RB1-inducible coiled-coil 1 0.0211479
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0210229
NFE2L1 nuclear factor, erythroid 2-like 1 0.0209239
ERRFI1 ERBB receptor feedback inhibitor 1 0.0208293
SFPQ splicing factor proline/glutamine-rich 0.0208074
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0206838
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0200061
MACF1 microtubule-actin crosslinking factor 1 0.0196623

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.238727
FN1 fibronectin 1 -0.155702
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.125373
NPEPPS aminopeptidase puromycin sensitive -0.113294
ASPH aspartate beta-hydroxylase -0.11283
ACTG1 actin gamma 1 -0.111411
FNDC3B fibronectin type III domain containing 3B -0.0791332
CD2AP CD2-associated protein -0.0745406
TM4SF1 transmembrane 4 L six family member 1 -0.0737027
S100A6 S100 calcium binding protein A6 -0.0735995
MARCHF6 membrane associated ring-CH-type finger 6 -0.0727121
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0697384
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0638871
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0595224
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0588952
S100A10 S100 calcium binding protein A10 -0.0588207
TMEM123 transmembrane protein 123 -0.057182
CCND1 cyclin D1 -0.0568123
TPT1 tumor protein, translationally-controlled 1 -0.056253
TMEM263 transmembrane protein 263 -0.0559422
GNAS GNAS complex locus -0.0554762
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0540843
NAMPT nicotinamide phosphoribosyltransferase -0.0524034
ITCH itchy E3 ubiquitin protein ligase -0.0513758
KMT2E lysine (K)-specific methyltransferase 2E -0.0504586
RAD21 RAD21 homolog (S. pombe) -0.0503228
HMGA1 high mobility group AT-hook 1 -0.0499302
LPP LIM domain containing preferred translocation partner in lipoma -0.0492549
PTK2 protein tyrosine kinase 2 -0.0473534
RAB1A RAB1A, member RAS oncogene family -0.0471608
FAM3C family with sequence similarity 3, member C -0.0470702
TFG TRK-fused gene -0.0463824
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0452888
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0451453
ARHGAP29 Rho GTPase activating protein 29 -0.0448328
F3 coagulation factor III (thromboplastin, tissue factor) -0.0444614
TMSB10 thymosin beta 10 -0.0438409
OSBPL3 oxysterol binding protein-like 3 -0.0420811
CDK17 cyclin-dependent kinase 17 -0.0416608
ADAM9 ADAM metallopeptidase domain 9 -0.0414699
PGK1 phosphoglycerate kinase 1 -0.0414362
TSC22D2 TSC22 domain family, member 2 -0.0405803
LMO7 LIM domain 7 -0.0405041
PLAU plasminogen activator, urokinase -0.0400267
FAM162A family with sequence similarity 162, member A -0.0391604
PRRC1 proline-rich coiled-coil 1 -0.0388226
KDM5B lysine (K)-specific demethylase 5B -0.038717
ZFAND3 zinc finger, AN1-type domain 3 -0.0384681
RPL34 ribosomal protein L34 -0.0382566
USP3 ubiquitin specific peptidase 3 -0.0380659
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0379295
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0377265
STRN3 striatin, calmodulin binding protein 3 -0.0373956
RPS24 ribosomal protein S24 -0.0371996
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0368431
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0366607
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0366308
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0364194
CDC73 cell division cycle 73 -0.0360632
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0357827
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0355047
TPM4 tropomyosin 4 -0.0347888
ZNF292 zinc finger protein 292 -0.0347334
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.034469
RLF rearranged L-myc fusion -0.0335568
ARF1 ADP-ribosylation factor 1 -0.0335057
DEK DEK proto-oncogene -0.0333538
NDFIP1 Nedd4 family interacting protein 1 -0.0333374
ZFAND6 zinc finger, AN1-type domain 6 -0.0332882
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0326531
CAPN2 calpain 2, (m/II) large subunit -0.0325673
TRIO trio Rho guanine nucleotide exchange factor -0.032485
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0324504
SDC4 syndecan 4 -0.0324425
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.032349
SLC38A1 solute carrier family 38, member 1 -0.0322836
ANXA2 annexin A2 -0.0319902
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0317271
MXD1 MAX dimerization protein 1 -0.0317255
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0311126
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0310672
GARS1 glycyl-tRNA synthetase 1 -0.0308599
LY6E lymphocyte antigen 6 complex, locus E -0.0308067
KPNB1 karyopherin (importin) beta 1 -0.0307551
SLMAP sarcolemma associated protein -0.0304876
GRB10 growth factor receptor-bound protein 10 -0.0302729
PARD3 par-3 family cell polarity regulator -0.0302095
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0292601
CCNI cyclin I -0.0291172
DSG2 desmoglein 2 -0.0281311
MORF4L1 mortality factor 4 like 1 -0.0270095
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0269776
QKI QKI, KH domain containing, RNA binding -0.026613
VEZT vezatin, adherens junctions transmembrane protein -0.0265568
CTSD cathepsin D -0.0263525
LAMC2 laminin, gamma 2 -0.0256801
UBE2H ubiquitin-conjugating enzyme E2H -0.0256591
RHEB Ras homolog enriched in brain -0.0256486
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0255619
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0255039