Fluvoxamine (maleate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine (maleate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine (maleate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.131174
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.117839
SMOC1 SPARC related modular calcium binding 1 0.0841552
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0720532
COL8A1 collagen, type VIII, alpha 1 0.0641313
FMNL2 formin-like 2 0.0598727
RPS12 ribosomal protein S12 0.0583719
PDLIM5 PDZ and LIM domain 5 0.05687
RPS3 ribosomal protein S3 0.0562377
RPL37A ribosomal protein L37a 0.05445
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0523386
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0513411
KYNU kynureninase 0.0498532
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0496748
FTH1 ferritin, heavy polypeptide 1 0.0488586
SMAD2 SMAD family member 2 0.0466767
ZSWIM6 zinc finger, SWIM-type containing 6 0.0463706
RPL26 ribosomal protein L26 0.0452693
RPL12 ribosomal protein L12 0.0449366
GRAMD1B GRAM domain containing 1B 0.0446965
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0445753
SH3KBP1 SH3-domain kinase binding protein 1 0.0436254
RPL9 ribosomal protein L9 0.0434932
PDE10A phosphodiesterase 10A 0.0430312
AKAP13 A kinase (PRKA) anchor protein 13 0.042192
INTS6 integrator complex subunit 6 0.0414904
RPL31 ribosomal protein L31 0.0412988
DST dystonin 0.0411734
RPS17 ribosomal protein S17 0.040736
PCBP2 poly(rC) binding protein 2 0.0387867
VIM vimentin 0.0379275
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0346432
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0342177
CTIF CBP80/20-dependent translation initiation factor 0.034155
SRRM2 serine/arginine repetitive matrix 2 0.0340532
RPS19 ribosomal protein S19 0.0340383
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0319344
MAP7 microtubule-associated protein 7 0.0319027
EEF2 eukaryotic translation elongation factor 2 0.0318686
RPS8 ribosomal protein S8 0.0315833
PTMA prothymosin, alpha 0.0306152
RACK1 receptor for activated C kinase 1 0.030533
IRS2 insulin receptor substrate 2 0.02961
TGFBR1 transforming growth factor, beta receptor 1 0.0290407
RPS2 ribosomal protein S2 0.0288867
SFTPA2 surfactant protein A2 0.0282814
B2M beta-2-microglobulin 0.0279855
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0274698
RPL27 ribosomal protein L27 0.0263394
RAB3B RAB3B, member RAS oncogene family 0.0260962
PRELID2 PRELI domain containing 2 0.0259385
RPL11 ribosomal protein L11 0.0259266
MT2A metallothionein 2A 0.0253478
BMP6 bone morphogenetic protein 6 0.0251565
RPLP2 ribosomal protein, large, P2 0.0248309
MCL1 myeloid cell leukemia 1 0.0246485
RPL37 ribosomal protein L37 0.024369
RPL35A ribosomal protein L35a 0.0241164
RPS14 ribosomal protein S14 0.0239774
RPS4X ribosomal protein S4, X-linked 0.0236797
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0233404
COL5A2 collagen, type V, alpha 2 0.0229506
XYLT1 xylosyltransferase I 0.0225901
OXSR1 oxidative stress responsive 1 0.0224789
MYH9 myosin, heavy chain 9, non-muscle 0.0217277
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.02169
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0215896
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0215633
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0215621
MACF1 microtubule-actin crosslinking factor 1 0.0213477
ENO2 enolase 2 (gamma, neuronal) 0.0210706
FNDC3A fibronectin type III domain containing 3A 0.0207846
EXT1 exostosin glycosyltransferase 1 0.0206162
RPL36 ribosomal protein L36 0.0203395
BASP1 brain abundant, membrane attached signal protein 1 0.0202792
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0192748
RPS27A ribosomal protein S27a 0.0191295
SVIL supervillin 0.0190416
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0188645
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0188543
FAT1 FAT atypical cadherin 1 0.0187934
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0183679
WWOX WW domain containing oxidoreductase 0.0183446
ZMIZ1 zinc finger, MIZ-type containing 1 0.0179848
MAML3 mastermind-like 3 (Drosophila) 0.0179655
CHL1 cell adhesion molecule L1-like 0.0177828
SOX4 SRY (sex determining region Y)-box 4 0.0177308
NTN4 netrin 4 0.0174244
RPL23 ribosomal protein L23 0.0172651
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0172165
RPS27 ribosomal protein S27 0.0170158
CHD1 chromodomain helicase DNA binding protein 1 0.0169725
FAM107B family with sequence similarity 107, member B 0.0169637
TPI1 triosephosphate isomerase 1 0.0169339
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0169087
DSCAM Down syndrome cell adhesion molecule 0.0168916
P3H2 prolyl 3-hydroxylase 2 0.016789
RAD51B RAD51 paralog B 0.0165747
RPLP1 ribosomal protein, large, P1 0.0164094
INHBA inhibin, beta A 0.0163593

decreased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 -0.202773
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201078
NAMPT nicotinamide phosphoribosyltransferase -0.191447
FN1 fibronectin 1 -0.17454
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.145614
ASPH aspartate beta-hydroxylase -0.105197
TM4SF1 transmembrane 4 L six family member 1 -0.0887313
NRCAM neuronal cell adhesion molecule -0.0834218
TXNRD1 thioredoxin reductase 1 -0.0812145
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0772567
TFPI2 tissue factor pathway inhibitor 2 -0.0715946
TRIO trio Rho guanine nucleotide exchange factor -0.0702196
RTN4 reticulon 4 -0.0676796
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.066869
FNDC3B fibronectin type III domain containing 3B -0.062436
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0613345
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0605617
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0600406
PDE4D phosphodiesterase 4D, cAMP-specific -0.0595816
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0595492
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0582885
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0574939
SMYD3 SET and MYND domain containing 3 -0.0566634
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0551711
NEK7 NIMA-related kinase 7 -0.054368
PCBP3 poly(rC) binding protein 3 -0.0510757
LIMCH1 LIM and calponin homology domains 1 -0.0500509
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.049617
AGFG1 ArfGAP with FG repeats 1 -0.0455573
NCOA7 nuclear receptor coactivator 7 -0.0447729
TGFBI transforming growth factor, beta-induced, 68kDa -0.0437972
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0435999
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0435355
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0421494
SPAG9 sperm associated antigen 9 -0.0420608
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0408245
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0396857
PTGR1 prostaglandin reductase 1 -0.0383339
PGK1 phosphoglycerate kinase 1 -0.03825
OSMR oncostatin M receptor -0.0377268
OGA O-GlcNAcase -0.037525
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0365102
GNAS GNAS complex locus -0.0358834
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0354491
CANX calnexin -0.0352512
SOD2 superoxide dismutase 2, mitochondrial -0.0351974
BIRC6 baculoviral IAP repeat containing 6 -0.0344594
NPAS2 neuronal PAS domain protein 2 -0.0340755
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0330682
NALF1 NALCN channel auxiliary factor 1 -0.0329755
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0327863
GDA guanine deaminase -0.0325742
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0324855
TNPO1 transportin 1 -0.0319141
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0315715
PDIA3 protein disulfide isomerase family A, member 3 -0.0312762
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0311153
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0310286
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0308143
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0305308
AKR1C1 aldo-keto reductase family 1, member C1 -0.0300391
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0295758
PBX1 pre-B-cell leukemia homeobox 1 -0.0287568
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0283178
SRGN serglycin -0.0281249
ACTG1 actin gamma 1 -0.0278762
BMERB1 bMERB domain containing 1 -0.027694
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0273052
LOC112694756 uncharaterized LOC112694756 -0.0270194
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0268802
VDAC1 voltage-dependent anion channel 1 -0.0267772
GLIS3 GLIS family zinc finger 3 -0.0267281
NCKAP5 NCK-associated protein 5 -0.0266763
MFF mitochondrial fission factor -0.0265004
ENAH enabled homolog (Drosophila) -0.026151
DIAPH2 diaphanous-related formin 2 -0.0261246
BZW1 basic leucine zipper and W2 domains 1 -0.0259511
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0258658
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0257216
ADGRB3 adhesion G protein-coupled receptor B3 -0.0255272
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0253939
KPNB1 karyopherin (importin) beta 1 -0.0253
S100A10 S100 calcium binding protein A10 -0.0252198
ANKRD28 ankyrin repeat domain 28 -0.0252073
KMT2C lysine (K)-specific methyltransferase 2C -0.0251726
RBM39 RNA binding motif protein 39 -0.0248868
MAML2 mastermind-like 2 (Drosophila) -0.0248444
ANXA2 annexin A2 -0.024695
ELL2 elongation factor, RNA polymerase II, 2 -0.0246904
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0246227
ARF1 ADP-ribosylation factor 1 -0.0246111
WDR45B WD repeat domain 45B -0.0245421
PRKD3 protein kinase D3 -0.0244882
AVL9 AVL9 homolog (S. cerevisiase) -0.0244058
TPD52 tumor protein D52 -0.0241469
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0236102
LMAN1 lectin, mannose-binding, 1 -0.0235003
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0234803
PALLD palladin, cytoskeletal associated protein -0.0232615
USP3 ubiquitin specific peptidase 3 -0.0231868