Fluvoxamine (maleate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine (maleate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine (maleate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.160151
SRRM2 serine/arginine repetitive matrix 2 0.0824496
FLNB filamin B, beta 0.0810648
MT2A metallothionein 2A 0.0716727
HDAC9 histone deacetylase 9 0.0704127
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0693909
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0679112
LAMB3 laminin, beta 3 0.0637618
FRMD6 FERM domain containing 6 0.0602547
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0593023
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0577012
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0574973
MCL1 myeloid cell leukemia 1 0.0560276
RPL35A ribosomal protein L35a 0.0552124
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0543062
ARHGAP22 Rho GTPase activating protein 22 0.0537065
SGMS2 sphingomyelin synthase 2 0.0498794
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0484071
RPS3 ribosomal protein S3 0.0480216
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0470942
AKAP12 A kinase (PRKA) anchor protein 12 0.047048
RPL3 ribosomal protein L3 0.0463194
RPL12 ribosomal protein L12 0.0447377
JUN jun proto-oncogene 0.0445936
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0393291
RCOR1 REST corepressor 1 0.0366992
FLNA filamin A, alpha 0.0364952
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0357056
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0356586
PCBP2 poly(rC) binding protein 2 0.0355536
CORO1C coronin, actin binding protein, 1C 0.033549
ATF4 activating transcription factor 4 0.0331314
RPS26 ribosomal protein S26 0.0330747
ELL2 elongation factor, RNA polymerase II, 2 0.0329528
SFTPA2 surfactant protein A2 0.0329278
RPS12 ribosomal protein S12 0.0328283
RACK1 receptor for activated C kinase 1 0.032645
TM4SF19 transmembrane 4 L six family member 19 0.0321252
EFNB2 ephrin-B2 0.0313641
RPS6 ribosomal protein S6 0.031302
EIF5 eukaryotic translation initiation factor 5 0.0301075
DGKI diacylglycerol kinase, iota 0.0296746
ADTRP androgen-dependent TFPI-regulating protein 0.0294874
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0286325
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0285711
FTL ferritin, light polypeptide 0.0284503
RPL26 ribosomal protein L26 0.0281769
EIF4B eukaryotic translation initiation factor 4B 0.0280166
ENO1 enolase 1, (alpha) 0.0277486
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0270538
RPL35 ribosomal protein L35 0.0269499
ZFP36L1 ZFP36 ring finger protein-like 1 0.0267398
SMC1A structural maintenance of chromosomes 1A 0.0265416
SON SON DNA binding protein 0.026421
RPS4X ribosomal protein S4, X-linked 0.0253355
IFI16 interferon, gamma-inducible protein 16 0.0250536
RPL23 ribosomal protein L23 0.0247532
RPS17 ribosomal protein S17 0.0244088
RPL37A ribosomal protein L37a 0.0243253
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0241684
RPS8 ribosomal protein S8 0.0239023
RPL27 ribosomal protein L27 0.0233691
RPS7 ribosomal protein S7 0.0233002
YBX1 Y box binding protein 1 0.0228859
ENO2 enolase 2 (gamma, neuronal) 0.0228774
RPS19 ribosomal protein S19 0.0228453
DCAF8 DDB1 and CUL4 associated factor 8 0.0222327
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0214704
FTH1 ferritin, heavy polypeptide 1 0.0214437
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0212986
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0212927
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0211912
ZBTB38 zinc finger and BTB domain containing 38 0.0210745
MYH9 myosin, heavy chain 9, non-muscle 0.0210625
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0208038
EXT1 exostosin glycosyltransferase 1 0.0206289
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0204984
GTPBP2 GTP binding protein 2 0.020065
IARS1 isoleucyl-tRNA synthetase 1 0.0200508
RPL36 ribosomal protein L36 0.0200372
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0199401
EFL1 elongation factor like GTPase 1 0.0198001
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0195765
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0195293
USO1 USO1 vesicle transport factor 0.0194896
SET SET nuclear proto-oncogene 0.0194632
IER2 immediate early response 2 0.0194355
RPS3A ribosomal protein S3A 0.0190186
EEF1G eukaryotic translation elongation factor 1 gamma 0.0189758
PGM3 phosphoglucomutase 3 0.0189031
SFPQ splicing factor proline/glutamine-rich 0.0188136
TLN1 talin 1 0.0187529
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0187308
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0185746
EGR1 early growth response 1 0.01852
CIB1 calcium and integrin binding 1 (calmyrin) 0.0184032
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0183736
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0183226
NSUN6 NOP2/Sun domain family, member 6 0.0182395
CLIC1 chloride intracellular channel 1 0.0180759

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.198667
ACTG1 actin gamma 1 -0.158156
DLC1 DLC1 Rho GTPase activating protein -0.133729
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.113269
TTR transthyretin -0.097331
PTK2 protein tyrosine kinase 2 -0.0961019
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.079568
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0794063
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0713548
RAD21 RAD21 homolog (S. pombe) -0.0687498
DIAPH3 diaphanous-related formin 3 -0.0639293
ZFAND3 zinc finger, AN1-type domain 3 -0.0606364
TRIO trio Rho guanine nucleotide exchange factor -0.0599006
LPP LIM domain containing preferred translocation partner in lipoma -0.0596993
PARD3 par-3 family cell polarity regulator -0.0595622
SBF2 SET binding factor 2 -0.0562177
MTAP methylthioadenosine phosphorylase -0.0552754
RBM39 RNA binding motif protein 39 -0.0546194
USP3 ubiquitin specific peptidase 3 -0.0500995
RLF rearranged L-myc fusion -0.0491168
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0466428
SRPK2 SRSF protein kinase 2 -0.0462897
GNAS GNAS complex locus -0.0449681
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0440805
TPD52 tumor protein D52 -0.0440136
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0438317
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0432497
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0425879
BBX bobby sox homolog (Drosophila) -0.041398
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0413926
SNX14 sorting nexin 14 -0.0408516
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.040031
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0399201
MARCHF6 membrane associated ring-CH-type finger 6 -0.0396636
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0393664
NABP1 nucleic acid binding protein 1 -0.0389328
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.038409
TPT1 tumor protein, translationally-controlled 1 -0.0382902
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0372694
NUP58 nucleoporin 58 -0.0369837
WAC WW domain containing adaptor with coiled-coil -0.0368795
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0368372
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0367932
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0365142
PCNX4 pecanex 4 -0.0364025
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0360291
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0359592
FOXJ3 forkhead box J3 -0.0359028
TRAM1 translocation associated membrane protein 1 -0.0357278
TMEM123 transmembrane protein 123 -0.0355812
ZNF292 zinc finger protein 292 -0.0349683
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0349273
RTN4 reticulon 4 -0.0347672
RPL6 ribosomal protein L6 -0.0344176
AHNAK AHNAK nucleoprotein -0.0336326
PUM2 pumilio RNA-binding family member 2 -0.0335222
TAS2R14 taste receptor, type 2, member 14 -0.0332919
RAB1A RAB1A, member RAS oncogene family -0.0329422
COG5 component of oligomeric golgi complex 5 -0.0327375
ALCAM activated leukocyte cell adhesion molecule -0.0325912
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0324063
NAMPT nicotinamide phosphoribosyltransferase -0.032132
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0318018
RPS24 ribosomal protein S24 -0.0317787
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0315838
KMT2C lysine (K)-specific methyltransferase 2C -0.0313294
SPAG9 sperm associated antigen 9 -0.031286
TM4SF1 transmembrane 4 L six family member 1 -0.0312809
SEPTIN7 septin 7 -0.0311635
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0311067
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0307838
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0305912
TCF12 transcription factor 12 -0.0303675
BIRC6 baculoviral IAP repeat containing 6 -0.0301389
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0300922
CDK17 cyclin-dependent kinase 17 -0.0300765
RPL32 ribosomal protein L32 -0.0300563
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0298799
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0296224
ADAM9 ADAM metallopeptidase domain 9 -0.0295829
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0293874
CLTC clathrin, heavy chain (Hc) -0.0293476
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0293403
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0293399
RPL7 ribosomal protein L7 -0.0293386
KMT2E lysine (K)-specific methyltransferase 2E -0.0293203
TFRC transferrin receptor -0.0291941
LCORL ligand dependent nuclear receptor corepressor-like -0.0291639
OLA1 Obg-like ATPase 1 -0.0291563
RPL38 ribosomal protein L38 -0.0289645
USP34 ubiquitin specific peptidase 34 -0.0289585
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0289053
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0288977
ATAD2 ATPase family, AAA domain containing 2 -0.0288664
TASOR2 transcription activation suppressor family member 2 -0.0285437
SETD5 SET domain containing 5 -0.0285323
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0285238
NF1 neurofibromin 1 -0.0283684
RPS15 ribosomal protein S15 -0.0283439
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0283242