Fluvoxamine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Fluvoxamine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.213444
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.15642
NAV1 neuron navigator 1 0.14677
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.138708
COL5A1 collagen, type V, alpha 1 0.0939722
FBN1 fibrillin 1 0.0936432
THBS2 thrombospondin 2 0.0929323
LOXL2 lysyl oxidase-like 2 0.0877271
CDH13 cadherin 13 0.0827449
DST dystonin 0.0724975
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0722878
AHNAK AHNAK nucleoprotein 0.0680249
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0657907
PODXL podocalyxin-like 0.0627966
AUTS2 autism susceptibility candidate 2 0.0624407
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0601836
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0590324
FNDC3B fibronectin type III domain containing 3B 0.0584496
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0569766
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0543829
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.054188
RUNX1 runt-related transcription factor 1 0.0527528
SLC39A11 solute carrier family 39, member 11 0.0524147
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0520249
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0495539
XPO1 exportin 1 0.0453638
MYOF myoferlin 0.0453047
FLNB filamin B, beta 0.045239
ATP13A3 ATPase type 13A3 0.0450669
RNF213 ring finger protein 213 0.0439386
COL5A2 collagen, type V, alpha 2 0.0424418
MSI2 musashi RNA-binding protein 2 0.0422654
NAV2 neuron navigator 2 0.0420945
COL8A1 collagen, type VIII, alpha 1 0.0411226
FLNA filamin A, alpha 0.041012
CUX1 cut-like homeobox 1 0.0403191
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0400257
SOD2 superoxide dismutase 2, mitochondrial 0.0399667
SEPTIN9 septin 9 0.0397702
FN1 fibronectin 1 0.0396821
COL3A1 collagen, type III, alpha 1 0.0383288
SP3 Sp3 transcription factor 0.0379263
PLAT plasminogen activator, tissue 0.0369493
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0367565
ZMIZ1 zinc finger, MIZ-type containing 1 0.0363634
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0362137
DCLK2 doublecortin-like kinase 2 0.0362008
PLEC plectin 0.0361677
PRSS23 protease, serine, 23 0.0360087
ANKRD10 ankyrin repeat domain 10 0.0358015
MACF1 microtubule-actin crosslinking factor 1 0.0357747
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0348968
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0345416
APP amyloid beta (A4) precursor protein 0.033684
TENM3 teneurin transmembrane protein 3 0.0335834
MYH9 myosin, heavy chain 9, non-muscle 0.0334727
ADAM9 ADAM metallopeptidase domain 9 0.0332991
ABI3BP ABI family, member 3 (NESH) binding protein 0.0331321
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0330744
CEP170 centrosomal protein 170kDa 0.0328298
FSTL1 follistatin-like 1 0.0327866
NCOR2 nuclear receptor corepressor 2 0.0324829
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0323102
CD44 CD44 molecule (Indian blood group) 0.0322821
MEIS2 Meis homeobox 2 0.0312546
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0312087
ANKRD11 ankyrin repeat domain 11 0.0308834
GPC6 glypican 6 0.030784
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0305503
SUCNR1 succinate receptor 1 0.0290691
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0284946
RSAD2 radical S-adenosyl methionine domain containing 2 0.0282905
MPRIP myosin phosphatase Rho interacting protein 0.0279704
ZEB1 zinc finger E-box binding homeobox 1 0.0274439
CAPN2 calpain 2, (m/II) large subunit 0.0272756
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0272712
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0270529
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0270289
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0270016
IGFBP3 insulin-like growth factor binding protein 3 0.0266598
KDM6A lysine (K)-specific demethylase 6A 0.0266401
TNIP1 TNFAIP3 interacting protein 1 0.0262482
PDE10A phosphodiesterase 10A 0.0262245
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0261841
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0260793
ANXA6 annexin A6 0.0259025
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.025665
SBF2 SET binding factor 2 0.025519
JAZF1 JAZF zinc finger 1 0.0253395
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0252772
IQSEC1 IQ motif and Sec7 domain 1 0.0251989
AHNAK2 AHNAK nucleoprotein 2 0.0250936
KDM3A lysine (K)-specific demethylase 3A 0.0245949
NCKAP1 NCK-associated protein 1 0.0244826
CDC73 cell division cycle 73 0.0243178
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.024312
LHFPL2 lipoma HMGIC fusion partner-like 2 0.02411
SDK1 sidekick cell adhesion molecule 1 0.0240133
AFAP1 actin filament associated protein 1 0.0238227
PICALM phosphatidylinositol binding clathrin assembly protein 0.0234865

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18206
VIM vimentin -0.154506
TMSB10 thymosin beta 10 -0.142011
MT2A metallothionein 2A -0.13877
AKAP12 A kinase (PRKA) anchor protein 12 -0.125344
B2M beta-2-microglobulin -0.0676439
CSTB cystatin B (stefin B) -0.0607408
MYADM myeloid-associated differentiation marker -0.0582395
PTMA prothymosin, alpha -0.0529941
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0522545
SQSTM1 sequestosome 1 -0.0416652
S100A6 S100 calcium binding protein A6 -0.0406599
EIF1 eukaryotic translation initiation factor 1 -0.0400799
STC1 stanniocalcin 1 -0.0383099
IFITM3 interferon induced transmembrane protein 3 -0.0379831
FTL ferritin, light polypeptide -0.0372188
RPS6 ribosomal protein S6 -0.0344423
LOX lysyl oxidase -0.0330822
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0324458
RPS8 ribosomal protein S8 -0.0321542
LOC112694756 uncharaterized LOC112694756 -0.031226
FTH1 ferritin, heavy polypeptide 1 -0.030755
RPS3 ribosomal protein S3 -0.0306992
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0305847
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0304521
LDHA lactate dehydrogenase A -0.0290987
RPL37A ribosomal protein L37a -0.0280634
GOLGA4 golgin A4 -0.0277493
RPL26 ribosomal protein L26 -0.0276229
HLA-B major histocompatibility complex, class I, B -0.0273123
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0265659
TPT1 tumor protein, translationally-controlled 1 -0.0265606
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0262455
RPL31 ribosomal protein L31 -0.0261891
RPL12 ribosomal protein L12 -0.0257446
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.025655
S100A10 S100 calcium binding protein A10 -0.025632
RPL37 ribosomal protein L37 -0.0256293
RPL23 ribosomal protein L23 -0.0255801
RACK1 receptor for activated C kinase 1 -0.0255751
VDAC1 voltage-dependent anion channel 1 -0.0250595
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0243204
RAB7A RAB7A, member RAS oncogene family -0.0242582
RPLP2 ribosomal protein, large, P2 -0.0233602
RPL28 ribosomal protein L28 -0.0231957
RPLP1 ribosomal protein, large, P1 -0.0228568
RPL34 ribosomal protein L34 -0.0225746
TPM4 tropomyosin 4 -0.0223313
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0219327
S100A11 S100 calcium binding protein A11 -0.0217578
RPL32 ribosomal protein L32 -0.0217398
RPL36 ribosomal protein L36 -0.0214789
RPL35A ribosomal protein L35a -0.0214082
RPS27A ribosomal protein S27a -0.0210293
RPS24 ribosomal protein S24 -0.0206207
ADM adrenomedullin -0.0206055
TM4SF1 transmembrane 4 L six family member 1 -0.0202111
RPL11 ribosomal protein L11 -0.0201157
RPS23 ribosomal protein S23 -0.0201063
UBC ubiquitin C -0.0197936
AKAP9 A kinase (PRKA) anchor protein 9 -0.019284
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0192491
RPL19 ribosomal protein L19 -0.0190462
PLAUR plasminogen activator, urokinase receptor -0.0185152
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0183788
IFI6 interferon, alpha-inducible protein 6 -0.0181674
RPS19 ribosomal protein S19 -0.0179466
SEPTIN2 septin 2 -0.0175115
RPS12 ribosomal protein S12 -0.0175073
RPS27 ribosomal protein S27 -0.0174878
RND3 Rho family GTPase 3 -0.0173531
PFN1 profilin 1 -0.0173461
HSPB1 heat shock 27kDa protein 1 -0.0172309
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0172088
OPTN optineurin -0.0170224
RPS5 ribosomal protein S5 -0.017014
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0169414
RPL9 ribosomal protein L9 -0.0166007
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0165484
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0164523
ACTG1 actin gamma 1 -0.0163947
RPS14 ribosomal protein S14 -0.016348
SRSF11 serine/arginine-rich splicing factor 11 -0.0160908
HLA-C major histocompatibility complex, class I, C -0.0160244
PEA15 phosphoprotein enriched in astrocytes 15 -0.0159214
RPS11 ribosomal protein S11 -0.0157035
RPL27 ribosomal protein L27 -0.0156963
IARS1 isoleucyl-tRNA synthetase 1 -0.0156414
MTDH metadherin -0.0156395
MNT MAX network transcriptional repressor -0.0155291
RPS16 ribosomal protein S16 -0.0154548
BRD2 bromodomain containing 2 -0.0153831
FOSL1 FOS-like antigen 1 -0.0149917
RPL35 ribosomal protein L35 -0.0148832
RPS15 ribosomal protein S15 -0.0148282
TP53 tumor protein p53 -0.0148178
RPL30 ribosomal protein L30 -0.0147708
JMJD1C jumonji domain containing 1C -0.0147212
GOLGB1 golgin B1 -0.0145898
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0145111