Fluvoxamine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.354544
MEIS2 Meis homeobox 2 0.0929208
LPIN1 lipin 1 0.0729632
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0703947
FAM13A family with sequence similarity 13, member A 0.0657144
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0588088
PRRC2C proline-rich coiled-coil 2C 0.0559009
ZMIZ1 zinc finger, MIZ-type containing 1 0.0557672
HELZ helicase with zinc finger 0.0543713
SOS1 son of sevenless homolog 1 (Drosophila) 0.0505391
NRG1 neuregulin 1 0.0490555
RPL3 ribosomal protein L3 0.0478945
PTEN phosphatase and tensin homolog 0.0476013
NUP58 nucleoporin 58 0.0462451
TRIO trio Rho guanine nucleotide exchange factor 0.0456535
ZNF292 zinc finger protein 292 0.045003
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0445614
AOPEP aminopeptidase O (putative) 0.0425249
FHIT fragile histidine triad 0.0417836
SEPTIN9 septin 9 0.0410721
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0407716
DST dystonin 0.0386718
SSBP3 single stranded DNA binding protein 3 0.0382152
LIMCH1 LIM and calponin homology domains 1 0.0378634
SMAD3 SMAD family member 3 0.037406
TENT5A terminal nucleotidyltransferase 5A 0.0367813
FNDC3B fibronectin type III domain containing 3B 0.0367409
ZFC3H1 zinc finger, C3H1-type containing 0.0364865
CLTC clathrin, heavy chain (Hc) 0.0364137
TBX2 T-box 2 0.035853
GOLGA4 golgin A4 0.0354104
MSI2 musashi RNA-binding protein 2 0.0347374
NBAS neuroblastoma amplified sequence 0.0343385
KMT2C lysine (K)-specific methyltransferase 2C 0.0343137
CD36 CD36 molecule (thrombospondin receptor) 0.0342244
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0341813
ZNF148 zinc finger protein 148 0.0337476
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0326348
SLITRK6 SLIT and NTRK-like family, member 6 0.0318721
SRRM2 serine/arginine repetitive matrix 2 0.0318096
PGK1 phosphoglycerate kinase 1 0.0314903
ADGRG6 adhesion G protein-coupled receptor G6 0.0309773
NDRG1 N-myc downstream regulated 1 0.0308163
TLK2 tousled-like kinase 2 0.0307322
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0301219
KLHL13 kelch-like family member 13 0.0295328
USP34 ubiquitin specific peptidase 34 0.029404
PTK2 protein tyrosine kinase 2 0.0288792
ANGPT1 angiopoietin 1 0.0284649
ADAM9 ADAM metallopeptidase domain 9 0.0284094
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0283677
AUTS2 autism susceptibility candidate 2 0.0277128
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0277104
WAC WW domain containing adaptor with coiled-coil 0.0274348
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0273432
EWSR1 EWS RNA-binding protein 1 0.0273155
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0272671
USPL1 ubiquitin specific peptidase like 1 0.0272222
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0271584
SSBP2 single-stranded DNA binding protein 2 0.0269743
PTPRE protein tyrosine phosphatase, receptor type, E 0.0268795
RO60 Ro60, Y RNA binding protein 0.0259375
KDM3A lysine (K)-specific demethylase 3A 0.0258165
SETD5 SET domain containing 5 0.0257801
XPO1 exportin 1 0.0255827
CARD16 caspase recruitment domain family, member 16 0.0255697
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0255168
ZMYM2 zinc finger, MYM-type 2 0.0254904
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0253758
ARHGAP9 Rho GTPase activating protein 9 0.025288
RNF213 ring finger protein 213 0.0252223
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0252019
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.025047
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0249981
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0249835
DNMBP dynamin binding protein 0.0246716
BIRC6 baculoviral IAP repeat containing 6 0.0244959
MED13L mediator complex subunit 13-like 0.0244549
KCTD3 potassium channel tetramerization domain containing 3 0.0243451
MEF2A myocyte enhancer factor 2A 0.0243246
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0242326
FKBP1A FK506 binding protein 1A, 12kDa 0.0241127
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0240277
PARP14 poly (ADP-ribose) polymerase family, member 14 0.024002
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0239643
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0235881
C1ORF21 chromosome 1 open reading frame 21 0.023575
NRP1 neuropilin 1 0.0234314
ARRDC3 arrestin domain containing 3 0.0230566
NPEPPS aminopeptidase puromycin sensitive 0.0229485
PSME4 proteasome (prosome, macropain) activator subunit 4 0.022932
ZNF451 zinc finger protein 451 0.0226682
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0223412
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.022331
PICALM phosphatidylinositol binding clathrin assembly protein 0.0222914
ITPRID2 ITPR interacting domain containing 2 0.0222761
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0221223
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0219605
PDS5B PDS5 cohesin associated factor B 0.0219593
RET ret proto-oncogene 0.0219346

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.206006
VCL vinculin -0.2018
VIM vimentin -0.113225
PTMA prothymosin, alpha -0.0960909
IGF2 insulin-like growth factor 2 -0.0865497
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0821647
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0798302
RPS6 ribosomal protein S6 -0.0793602
RPL23 ribosomal protein L23 -0.0696557
AKAP12 A kinase (PRKA) anchor protein 12 -0.0683752
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0651929
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0631137
TPM1 tropomyosin 1 (alpha) -0.0586605
RPLP1 ribosomal protein, large, P1 -0.0524705
EIF1 eukaryotic translation initiation factor 1 -0.0520118
EGR1 early growth response 1 -0.0485538
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0476094
ACTG1 actin gamma 1 -0.0470375
MYO1E myosin IE -0.0469574
FTL ferritin, light polypeptide -0.0467401
MCL1 myeloid cell leukemia 1 -0.0442106
RPL19 ribosomal protein L19 -0.0439378
PTPRD protein tyrosine phosphatase, receptor type, D -0.0421639
S100A6 S100 calcium binding protein A6 -0.0417849
TLE4 transducin-like enhancer of split 4 -0.0415308
TMSB10 thymosin beta 10 -0.0397789
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0396735
RPL34 ribosomal protein L34 -0.0396305
IER3 immediate early response 3 -0.0390926
FERMT2 fermitin family member 2 -0.0381394
CANX calnexin -0.0379381
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0376317
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0374858
TPM4 tropomyosin 4 -0.0373602
NPAS2 neuronal PAS domain protein 2 -0.0362766
RPS19 ribosomal protein S19 -0.036203
INTS6 integrator complex subunit 6 -0.0361966
RPL36 ribosomal protein L36 -0.0349607
B2M beta-2-microglobulin -0.0345209
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0341178
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0333161
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0332873
RPS3 ribosomal protein S3 -0.0332028
RPL31 ribosomal protein L31 -0.0330926
PNRC1 proline-rich nuclear receptor coactivator 1 -0.032791
LSAMP limbic system-associated membrane protein -0.0317684
RPLP0 ribosomal protein, large, P0 -0.031134
FNDC3A fibronectin type III domain containing 3A -0.0310466
VMP1 vacuole membrane protein 1 -0.0310309
LIMA1 LIM domain and actin binding 1 -0.0310131
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0296105
GOLGB1 golgin B1 -0.0295975
TIMP2 TIMP metallopeptidase inhibitor 2 -0.029568
LMNA lamin A/C -0.0295123
RPS27A ribosomal protein S27a -0.0284461
PDLIM5 PDZ and LIM domain 5 -0.0277615
AEBP2 AE binding protein 2 -0.027644
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0275454
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0275104
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0273017
RPL38 ribosomal protein L38 -0.0270917
PDIA3 protein disulfide isomerase family A, member 3 -0.02709
TPT1 tumor protein, translationally-controlled 1 -0.0268859
CALD1 caldesmon 1 -0.0268079
MBTD1 mbt domain containing 1 -0.0267188
RPL35A ribosomal protein L35a -0.026562
MAPK10 mitogen-activated protein kinase 10 -0.0259504
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0259274
RPS15 ribosomal protein S15 -0.0255828
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.025375
ARF1 ADP-ribosylation factor 1 -0.0251467
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0248786
SLIT2 slit homolog 2 (Drosophila) -0.0246858
RPS27 ribosomal protein S27 -0.024367
BPTF bromodomain PHD finger transcription factor -0.0241442
RPL26 ribosomal protein L26 -0.0239302
STK38L serine/threonine kinase 38 like -0.0239191
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0231079
RPS25 ribosomal protein S25 -0.0229501
RPL27 ribosomal protein L27 -0.0228286
TPI1 triosephosphate isomerase 1 -0.0225347
ANGPTL4 angiopoietin-like 4 -0.0224959
EGFR epidermal growth factor receptor -0.0224709
SOD2 superoxide dismutase 2, mitochondrial -0.0224006
KAT6B K(lysine) acetyltransferase 6B -0.0220057
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0219137
AFF3 AF4/FMR2 family, member 3 -0.0218374
UBAP2 ubiquitin associated protein 2 -0.0217949
H1-0 H1.0 linker histone -0.0217588
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0217347
CCDC47 coiled-coil domain containing 47 -0.0215861
CUX1 cut-like homeobox 1 -0.021584
RPL11 ribosomal protein L11 -0.0213271
KLF6 Kruppel-like factor 6 -0.0212789
RNF150 ring finger protein 150 -0.0211683
BICD1 bicaudal D homolog 1 (Drosophila) -0.0210913
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0210523
MAML2 mastermind-like 2 (Drosophila) -0.0207899
RPL28 ribosomal protein L28 -0.020715
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0205027