Fluvoxamine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0954022
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0831117
ARHGAP26 Rho GTPase activating protein 26 0.0802041
GNPDA1 glucosamine-6-phosphate deaminase 1 0.074277
BTBD9 BTB (POZ) domain containing 9 0.0677224
MLPH melanophilin 0.0658126
TRIO trio Rho guanine nucleotide exchange factor 0.065682
SMAD3 SMAD family member 3 0.0571171
N4BP2L2 NEDD4 binding protein 2-like 2 0.0509363
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0495465
FAT1 FAT atypical cadherin 1 0.0492515
PRKCA protein kinase C, alpha 0.0490789
RAD51B RAD51 paralog B 0.0490576
KIF16B kinesin family member 16B 0.0481709
PRELID2 PRELI domain containing 2 0.0474228
SORBS1 sorbin and SH3 domain containing 1 0.0469626
FNDC3B fibronectin type III domain containing 3B 0.0468448
STS steroid sulfatase (microsomal), isozyme S 0.0466204
IGF1R insulin-like growth factor 1 receptor 0.04301
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0426201
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0414336
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0405519
CMIP c-Maf inducing protein 0.0398443
MSI2 musashi RNA-binding protein 2 0.0395972
MYH9 myosin, heavy chain 9, non-muscle 0.0391657
AFF1 AF4/FMR2 family, member 1 0.0375397
ABHD2 abhydrolase domain containing 2 0.0374507
CTNND1 catenin (cadherin-associated protein), delta 1 0.0371445
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0362885
ATXN1 ataxin 1 0.0359918
PADI1 peptidyl arginine deiminase, type I 0.0358881
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0353133
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0352898
SH3PXD2A SH3 and PX domains 2A 0.0343339
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.034033
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0323903
UBAC2 UBA domain containing 2 0.0304097
STK39 serine threonine kinase 39 0.0303749
PFKP phosphofructokinase, platelet 0.0297251
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0289355
NCOR2 nuclear receptor corepressor 2 0.0285729
PTK2 protein tyrosine kinase 2 0.0283066
TBC1D22A TBC1 domain family, member 22A 0.0280336
OARD1 O-acyl-ADP-ribose deacylase 1 0.0273397
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0272887
ESYT2 extended synaptotagmin-like protein 2 0.0272088
ZBTB20 zinc finger and BTB domain containing 20 0.0270001
SAMD12 sterile alpha motif domain containing 12 0.0258161
VMP1 vacuole membrane protein 1 0.0257746
HDAC4 histone deacetylase 4 0.0253376
LPP LIM domain containing preferred translocation partner in lipoma 0.0251825
SRRM2 serine/arginine repetitive matrix 2 0.0250454
PHF3 PHD finger protein 3 0.0248597
KDM4C lysine (K)-specific demethylase 4C 0.0248312
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0246898
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0246803
MYO10 myosin X 0.0246341
DSCAM Down syndrome cell adhesion molecule 0.0242148
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0239533
SHB Src homology 2 domain containing adaptor protein B 0.0233471
ARGLU1 arginine and glutamate rich 1 0.0232943
STYXL2 serine/threonine/tyrosine interacting like 2 0.0231211
NPSR1 neuropeptide S receptor 1 0.0229464
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0228999
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0227371
VEGFA vascular endothelial growth factor A 0.0226174
AKAP13 A kinase (PRKA) anchor protein 13 0.0224824
SCARB1 scavenger receptor class B, member 1 0.0223708
ASPH aspartate beta-hydroxylase 0.0222097
RNF213 ring finger protein 213 0.0216321
MAML2 mastermind-like 2 (Drosophila) 0.0215792
BACE2 beta-site APP-cleaving enzyme 2 0.0214438
CLMN calmin (calponin-like, transmembrane) 0.0213388
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0211924
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0211864
BICRAL BICRA like chromatin remodeling complex associated protein 0.0211372
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0210515
MINK1 misshapen-like kinase 1 0.0208592
EPSTI1 epithelial stromal interaction 1 (breast) 0.0206502
NCKAP5 NCK-associated protein 5 0.0205392
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0205322
GRK3 G protein-coupled receptor kinase 3 0.0203774
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.020127
PRKCE protein kinase C, epsilon 0.0200301
DNM2 dynamin 2 0.0199492
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0199053
TJP2 tight junction protein 2 0.0198096
ALPK1 alpha-kinase 1 0.0197424
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0197278
INTS6 integrator complex subunit 6 0.0196707
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.019513
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0194695
FNIP1 folliculin interacting protein 1 0.0191707
CCDC146 coiled-coil domain containing 146 0.0191054
GMDS GDP-mannose 4,6-dehydratase 0.0190614
TNIK TRAF2 and NCK interacting kinase 0.0188586
KDM6A lysine (K)-specific demethylase 6A 0.0188573
CORIN corin, serine peptidase 0.0188017
ZNF638 zinc finger protein 638 0.0187036
YEATS2 YEATS domain containing 2 0.018093

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.162436
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.153071
B2M beta-2-microglobulin -0.149343
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122659
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0862781
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0860623
HLA-B major histocompatibility complex, class I, B -0.0848314
LCN2 lipocalin 2 -0.0801
RPS6 ribosomal protein S6 -0.0743656
PTMA prothymosin, alpha -0.074016
PERP PERP, TP53 apoptosis effector -0.0672892
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0668247
SQSTM1 sequestosome 1 -0.062585
CANX calnexin -0.0575683
EIF1 eukaryotic translation initiation factor 1 -0.0558126
IRF1 interferon regulatory factor 1 -0.0551362
LMO7 LIM domain 7 -0.0536848
RPLP1 ribosomal protein, large, P1 -0.0530787
PDIA3 protein disulfide isomerase family A, member 3 -0.0529327
RPL35A ribosomal protein L35a -0.051787
IFI6 interferon, alpha-inducible protein 6 -0.0504428
ANXA2 annexin A2 -0.0470527
FTL ferritin, light polypeptide -0.0458573
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0432709
NAMPT nicotinamide phosphoribosyltransferase -0.0425617
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0423883
RPL34 ribosomal protein L34 -0.0407733
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0396918
FTH1 ferritin, heavy polypeptide 1 -0.0394876
RPS8 ribosomal protein S8 -0.0378371
RRBP1 ribosome binding protein 1 -0.0372947
H1-0 H1.0 linker histone -0.0367633
DSTN destrin (actin depolymerizing factor) -0.0365621
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0364475
RPL23 ribosomal protein L23 -0.0362672
SP100 SP100 nuclear antigen -0.0358351
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0353465
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.035094
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0347833
HLA-E major histocompatibility complex, class I, E -0.0347274
JUN jun proto-oncogene -0.0345514
EGR1 early growth response 1 -0.0343543
CCNL1 cyclin L1 -0.0341149
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0339061
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0335534
RPL12 ribosomal protein L12 -0.0333626
TMSB10 thymosin beta 10 -0.0325985
EZR ezrin -0.0317701
RPL11 ribosomal protein L11 -0.0313834
RPS24 ribosomal protein S24 -0.0308208
RPL19 ribosomal protein L19 -0.0307326
MYO1E myosin IE -0.0306916
RPLP0 ribosomal protein, large, P0 -0.0306244
IRS2 insulin receptor substrate 2 -0.0306012
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0305154
EPCAM epithelial cell adhesion molecule -0.0302063
S100A10 S100 calcium binding protein A10 -0.0300364
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0294499
RAD21 RAD21 homolog (S. pombe) -0.0288956
VCL vinculin -0.0284029
IFI27 interferon, alpha-inducible protein 27 -0.0282826
HLA-C major histocompatibility complex, class I, C -0.0281351
KLF6 Kruppel-like factor 6 -0.0278888
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0278453
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0268173
UBC ubiquitin C -0.0268115
HM13 histocompatibility (minor) 13 -0.0266925
LOC102724023 ES1 protein homolog, mitochondrial -0.0266372
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0264198
MORF4L2 mortality factor 4 like 2 -0.0262359
TMEM87A transmembrane protein 87A -0.0261091
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0258822
RPL26 ribosomal protein L26 -0.0257786
AREG amphiregulin -0.0257082
PLSCR1 phospholipid scramblase 1 -0.0256125
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0256085
RUNX1 runt-related transcription factor 1 -0.0251521
MX2 MX dynamin-like GTPase 2 -0.0249436
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0247981
UGDH UDP-glucose 6-dehydrogenase -0.0245672
GNAS GNAS complex locus -0.024392
S100A6 S100 calcium binding protein A6 -0.0240812
XRN1 5'-3' exoribonuclease 1 -0.0238737
GCC2 GRIP and coiled-coil domain containing 2 -0.0236755
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0235785
SPDYA speedy/RINGO cell cycle regulator family member A -0.0235148
COPB1 coatomer protein complex, subunit beta 1 -0.0234931
RAB7A RAB7A, member RAS oncogene family -0.0233559
CALR calreticulin -0.0229873
NCOA7 nuclear receptor coactivator 7 -0.022865
CALU calumenin -0.0228114
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0225481
RPS19 ribosomal protein S19 -0.0225272
HMGB1 high mobility group box 1 -0.0224628
LDHA lactate dehydrogenase A -0.0223146
AGR2 anterior gradient 2 -0.0222062
MACC1 metastasis associated in colon cancer 1 -0.0220755
VDAC1 voltage-dependent anion channel 1 -0.0220375
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0219198
SEC31A SEC31 homolog A (S. cerevisiae) -0.0218118