Fluvoxamine_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.4849
FN1 fibronectin 1 0.372787
NDRG1 N-myc downstream regulated 1 0.21375
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.204152
COL6A3 collagen, type VI, alpha 3 0.185304
LOXL2 lysyl oxidase-like 2 0.0832639
PLEC plectin 0.0763606
VIM vimentin 0.0733628
TMSB10 thymosin beta 10 0.0709263
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0631837
MT2A metallothionein 2A 0.0607726
EEF2 eukaryotic translation elongation factor 2 0.0573503
FLNA filamin A, alpha 0.0537953
COL1A1 collagen, type I, alpha 1 0.0479574
SMAD3 SMAD family member 3 0.0462743
TPM4 tropomyosin 4 0.0402108
FTL ferritin, light polypeptide 0.0398686
TIMP3 TIMP metallopeptidase inhibitor 3 0.0372952
CALR calreticulin 0.0363063
COL5A1 collagen, type V, alpha 1 0.035035
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0342905
LOC112694756 uncharaterized LOC112694756 0.0324079
RPL35A ribosomal protein L35a 0.0319258
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0316843
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0293327
RPL3 ribosomal protein L3 0.02743
ATP13A3 ATPase type 13A3 0.0254269
CXCL8 chemokine (C-X-C motif) ligand 8 0.0254019
RACK1 receptor for activated C kinase 1 0.0252235
TUBB tubulin, beta class I 0.0248375
MYH9 myosin, heavy chain 9, non-muscle 0.0243431
FTH1 ferritin, heavy polypeptide 1 0.0235537
SHB Src homology 2 domain containing adaptor protein B 0.023016
RPS19 ribosomal protein S19 0.0226313
CYB5R3 cytochrome b5 reductase 3 0.02259
NAV1 neuron navigator 1 0.0222007
KLF7 Kruppel-like factor 7 (ubiquitous) 0.022144
F3 coagulation factor III (thromboplastin, tissue factor) 0.022133
GANAB glucosidase, alpha; neutral AB 0.0219335
CABIN1 calcineurin binding protein 1 0.0211692
LGALS1 lectin, galactoside-binding, soluble, 1 0.0211668
TAPBP TAP binding protein (tapasin) 0.0208271
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0199733
FAM20C family with sequence similarity 20, member C 0.0197047
ENO1 enolase 1, (alpha) 0.0191786
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0191364
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.0189916
RPL23 ribosomal protein L23 0.0188741
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0187977
CEMIP cell migration inducing protein, hyaluronan binding 0.0187902
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0186139
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0185362
PTPRF protein tyrosine phosphatase, receptor type, F 0.0181933
TRIO trio Rho guanine nucleotide exchange factor 0.0174677
TPI1 triosephosphate isomerase 1 0.0174382
HLA-A major histocompatibility complex, class I, A 0.0172342
TNIP1 TNFAIP3 interacting protein 1 0.0171627
INHBA inhibin, beta A 0.0170422
LDHA lactate dehydrogenase A 0.0169391
PKM pyruvate kinase, muscle 0.0166658
SREBF2 sterol regulatory element binding transcription factor 2 0.0166188
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0164041
SRRM2 serine/arginine repetitive matrix 2 0.0162607
DPYSL3 dihydropyrimidinase-like 3 0.0160807
CSF1 colony stimulating factor 1 (macrophage) 0.0158299
ADAM12 ADAM metallopeptidase domain 12 0.0157622
HLA-C major histocompatibility complex, class I, C 0.0155735
TIMP1 TIMP metallopeptidase inhibitor 1 0.0153347
ARRDC3 arrestin domain containing 3 0.0152331
EGR1 early growth response 1 0.0149668
COL4A1 collagen, type IV, alpha 1 0.0147482
RPS4X ribosomal protein S4, X-linked 0.0147086
IFITM3 interferon induced transmembrane protein 3 0.0146108
KAZN kazrin, periplakin interacting protein 0.0145749
COL6A2 collagen, type VI, alpha 2 0.0139967
DDIT4 DNA-damage-inducible transcript 4 0.0136723
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0136231
ZMIZ1 zinc finger, MIZ-type containing 1 0.0135933
GRB10 growth factor receptor-bound protein 10 0.0135689
PFKP phosphofructokinase, platelet 0.013541
RPS14 ribosomal protein S14 0.0135122
PRELID2 PRELI domain containing 2 0.0134471
AXL AXL receptor tyrosine kinase 0.0132427
FOSL1 FOS-like antigen 1 0.0132329
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0132299
RPL8 ribosomal protein L8 0.0132209
ECE1 endothelin converting enzyme 1 0.0131535
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.0131422
TNS1 tensin 1 0.0128192
NCOR2 nuclear receptor corepressor 2 0.012818
OAZ1 ornithine decarboxylase antizyme 1 0.0127633
RPL30 ribosomal protein L30 0.012748
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.0127085
MTSS1 metastasis suppressor 1 0.0125769
PLXNB2 plexin B2 0.0125383
ACTG1 actin gamma 1 0.0125248
MRPS6 mitochondrial ribosomal protein S6 0.012415
LMNA lamin A/C 0.0123694
NIBAN2 niban apoptosis regulator 2 0.0123247
BHLHE40 basic helix-loop-helix family, member e40 0.0123166

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0990871
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0567136
CANX calnexin -0.0548404
CDH13 cadherin 13 -0.052517
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.048147
IL6ST interleukin 6 signal transducer -0.0475746
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0461622
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0422211
SPAG9 sperm associated antigen 9 -0.0419635
RPS2 ribosomal protein S2 -0.0383701
CADM1 cell adhesion molecule 1 -0.0377095
GOLGB1 golgin B1 -0.0376114
NAMPT nicotinamide phosphoribosyltransferase -0.0371702
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0370875
GOLGA4 golgin A4 -0.0365014
ALCAM activated leukocyte cell adhesion molecule -0.0364043
ASPH aspartate beta-hydroxylase -0.0347506
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.034004
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0333463
DST dystonin -0.0329923
FNDC3B fibronectin type III domain containing 3B -0.0322872
PSD3 pleckstrin and Sec7 domain containing 3 -0.0318249
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0307914
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0306808
HMGA2 high mobility group AT-hook 2 -0.0270836
TTC3 tetratricopeptide repeat domain 3 -0.0267852
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0265353
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0265208
IARS1 isoleucyl-tRNA synthetase 1 -0.0263095
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0255953
TRPS1 trichorhinophalangeal syndrome I -0.0255091
TMF1 TATA element modulatory factor 1 -0.0248285
EXT1 exostosin glycosyltransferase 1 -0.024662
SLC38A2 solute carrier family 38, member 2 -0.0245718
TRAM1 translocation associated membrane protein 1 -0.0243795
LOX lysyl oxidase -0.022996
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0228519
CLTC clathrin, heavy chain (Hc) -0.0223348
ZFAND3 zinc finger, AN1-type domain 3 -0.0219699
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0216648
PICALM phosphatidylinositol binding clathrin assembly protein -0.0215256
RAB2A RAB2A, member RAS oncogene family -0.0212638
WWTR1 WW domain containing transcription regulator 1 -0.0211227
PDIA5 protein disulfide isomerase family A, member 5 -0.0210699
FNIP1 folliculin interacting protein 1 -0.0208838
MTDH metadherin -0.0207838
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0206609
USP34 ubiquitin specific peptidase 34 -0.0206186
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0205585
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0205508
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0204635
RBM39 RNA binding motif protein 39 -0.0204579
PTK2 protein tyrosine kinase 2 -0.0202587
RYBP RING1 and YY1 binding protein -0.0202466
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0201514
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0200297
MAP4 microtubule-associated protein 4 -0.0198908
TARS1 threonyl-tRNA synthetase 1 -0.0197583
KMT2E lysine (K)-specific methyltransferase 2E -0.0197488
ATM ATM serine/threonine kinase -0.0194164
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0193467
QKI QKI, KH domain containing, RNA binding -0.0193194
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0191721
NIPBL Nipped-B homolog (Drosophila) -0.0190998
NABP1 nucleic acid binding protein 1 -0.0190746
SP100 SP100 nuclear antigen -0.0190321
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0186922
FBN1 fibrillin 1 -0.0186212
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0185972
CDK13 cyclin-dependent kinase 13 -0.0184737
SAMD9 sterile alpha motif domain containing 9 -0.0182762
NAP1L1 nucleosome assembly protein 1-like 1 -0.018246
SEC24D SEC24 family member D -0.0180799
SQSTM1 sequestosome 1 -0.0180144
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0179705
AGO3 argonaute RISC catalytic component 3 -0.0177279
RAD21 RAD21 homolog (S. pombe) -0.0177212
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0176934
TSC22D2 TSC22 domain family, member 2 -0.0175067
RLF rearranged L-myc fusion -0.0172383
LTBP1 latent transforming growth factor beta binding protein 1 -0.0171247
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0169348
RND3 Rho family GTPase 3 -0.0169265
TTC17 tetratricopeptide repeat domain 17 -0.0169097
APP amyloid beta (A4) precursor protein -0.0165711
MACF1 microtubule-actin crosslinking factor 1 -0.0165168
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0161897
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0161497
SEC24A SEC24 family member A -0.016048
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0159933
ZBTB38 zinc finger and BTB domain containing 38 -0.0159759
C6ORF62 chromosome 6 open reading frame 62 -0.0159611
COPB1 coatomer protein complex, subunit beta 1 -0.0159409
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0158537
PUM2 pumilio RNA-binding family member 2 -0.0155672
ZFPM2 zinc finger protein, FOG family member 2 -0.015386
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0153374
AFF3 AF4/FMR2 family, member 3 -0.0152906
AFF4 AF4/FMR2 family, member 4 -0.0152216
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.015221