Fluvoxamine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.243722
NDRG1 N-myc downstream regulated 1 0.219714
PLEC plectin 0.150217
FLNA filamin A, alpha 0.0970133
LAMA5 laminin, alpha 5 0.0870382
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0814411
CEMIP cell migration inducing protein, hyaluronan binding 0.0763879
KRT6A keratin 6A, type II 0.0753757
PODXL podocalyxin-like 0.0743073
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0712157
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.066993
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.063788
NCOR2 nuclear receptor corepressor 2 0.063479
HSPG2 heparan sulfate proteoglycan 2 0.0574332
MEGF6 multiple EGF-like-domains 6 0.0530441
EPHA2 EPH receptor A2 0.0526197
TRIO trio Rho guanine nucleotide exchange factor 0.0516862
RPL3 ribosomal protein L3 0.0510586
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0502525
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0497908
LMNA lamin A/C 0.0444435
ESYT2 extended synaptotagmin-like protein 2 0.042772
LOC112694756 uncharaterized LOC112694756 0.0427586
NIBAN2 niban apoptosis regulator 2 0.0408059
EZR ezrin 0.0404587
NAV2 neuron navigator 2 0.0402538
ZMIZ1 zinc finger, MIZ-type containing 1 0.040222
SMAD3 SMAD family member 3 0.0402092
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0396596
TGM2 transglutaminase 2 0.0391954
FSCN1 fascin actin-bundling protein 1 0.0388902
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0356721
EMP1 epithelial membrane protein 1 0.0350666
ITGB4 integrin, beta 4 0.0349434
TNIP1 TNFAIP3 interacting protein 1 0.0335481
MYH9 myosin, heavy chain 9, non-muscle 0.0323336
C1D C1D nuclear receptor corepressor 0.0315322
EEF2 eukaryotic translation elongation factor 2 0.0309872
GRB10 growth factor receptor-bound protein 10 0.0308862
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.0308815
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0295425
MCL1 myeloid cell leukemia 1 0.0291218
KDM7A lysine (K)-specific demethylase 7A 0.0288821
BCL2L1 BCL2-like 1 0.0278443
SH3PXD2A SH3 and PX domains 2A 0.0277983
EFHD2 EF-hand domain family, member D2 0.0276377
TMSB10 thymosin beta 10 0.0274777
RASA3 RAS p21 protein activator 3 0.0273957
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0272969
TIMP3 TIMP metallopeptidase inhibitor 3 0.0268496
ARHGAP23 Rho GTPase activating protein 23 0.0265053
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0263939
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0258596
CAPN2 calpain 2, (m/II) large subunit 0.025516
CEP250 centrosomal protein 250kDa 0.0254316
PLXNB2 plexin B2 0.0253918
GUK1 guanylate kinase 1 0.0253915
TUBB tubulin, beta class I 0.0250493
RALGDS ral guanine nucleotide dissociation stimulator 0.0246034
PTPRF protein tyrosine phosphatase, receptor type, F 0.0245015
NECTIN1 nectin cell adhesion molecule 1 0.0244131
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0241795
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.024016
ANXA11 annexin A11 0.0237379
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0236322
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0235964
BLCAP bladder cancer associated protein 0.0233854
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.023265
DOCK5 dedicator of cytokinesis 5 0.0228386
AMOTL1 angiomotin like 1 0.0224683
CD9 CD9 molecule 0.0222672
PCDH1 protocadherin 1 0.0221958
TBC1D2 TBC1 domain family, member 2 0.0218005
RACK1 receptor for activated C kinase 1 0.0216302
CMIP c-Maf inducing protein 0.0213779
SLC35F3 solute carrier family 35, member F3 0.0210031
ZNF185 zinc finger protein 185 (LIM domain) 0.0208677
GRK5 G protein-coupled receptor kinase 5 0.0208015
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0205846
EHBP1L1 EH domain binding protein 1-like 1 0.0203736
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0203053
PFKP phosphofructokinase, platelet 0.0201802
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.019944
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.0198675
COL17A1 collagen, type XVII, alpha 1 0.0197448
RPS4X ribosomal protein S4, X-linked 0.0197063
CD59 CD59 molecule, complement regulatory protein 0.0196091
SLC45A4 solute carrier family 45, member 4 0.0194422
CALR calreticulin 0.0191816
LOXL2 lysyl oxidase-like 2 0.0191467
GANAB glucosidase, alpha; neutral AB 0.0189929
CPOX coproporphyrinogen oxidase 0.0188895
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0186658
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0185157
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0183555
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0181934
PEAR1 platelet endothelial aggregation receptor 1 0.0181562
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0178585
CD47 CD47 molecule 0.0176985
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0174803

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.231963
DPYD dihydropyrimidine dehydrogenase -0.0913453
MYOF myoferlin -0.0793843
ASPH aspartate beta-hydroxylase -0.0714417
CLU clusterin -0.0699725
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0677172
MBNL1 muscleblind-like splicing regulator 1 -0.0656201
CANX calnexin -0.0645587
PDLIM5 PDZ and LIM domain 5 -0.0618878
LMO7 LIM domain 7 -0.0614616
PDE4D phosphodiesterase 4D, cAMP-specific -0.0567324
RIGI RNA sensor RIG-I -0.054226
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0521279
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0520248
SAMD9 sterile alpha motif domain containing 9 -0.0518828
RPS2 ribosomal protein S2 -0.0498071
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.047181
TMSB4X thymosin beta 4, X-linked -0.04685
STAU1 staufen double-stranded RNA binding protein 1 -0.0464592
CUL4B cullin 4B -0.0463073
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0448393
DST dystonin -0.0441976
NIPBL Nipped-B homolog (Drosophila) -0.0439842
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0434705
RPS6 ribosomal protein S6 -0.042985
NAMPT nicotinamide phosphoribosyltransferase -0.042114
ALCAM activated leukocyte cell adhesion molecule -0.0419805
FNDC3B fibronectin type III domain containing 3B -0.041449
CAV1 caveolin 1, caveolae protein, 22kDa -0.0407049
INTS6 integrator complex subunit 6 -0.0406967
TPT1 tumor protein, translationally-controlled 1 -0.0406887
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0394251
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0394183
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0393461
NAP1L1 nucleosome assembly protein 1-like 1 -0.0392851
SLC38A2 solute carrier family 38, member 2 -0.0392638
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0390284
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.038954
SULF1 sulfatase 1 -0.0386515
POTEF POTE ankyrin domain family, member F -0.0380638
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0379645
RPS21 ribosomal protein S21 -0.0379489
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0372326
VCL vinculin -0.0371325
RASAL2 RAS protein activator like 2 -0.0371142
JMJD1C jumonji domain containing 1C -0.0363137
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0361106
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0352928
HMGA2 high mobility group AT-hook 2 -0.0348125
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0345058
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0343693
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0342114
RABGAP1L RAB GTPase activating protein 1-like -0.0338982
CDK6 cyclin-dependent kinase 6 -0.0338138
B2M beta-2-microglobulin -0.0330604
MACF1 microtubule-actin crosslinking factor 1 -0.032712
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0324319
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0322766
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0317396
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.031611
FNDC3A fibronectin type III domain containing 3A -0.0314731
RBM39 RNA binding motif protein 39 -0.0314336
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0309073
RPS24 ribosomal protein S24 -0.0307168
COPB1 coatomer protein complex, subunit beta 1 -0.0303368
CDK13 cyclin-dependent kinase 13 -0.0301606
ZNFX1 zinc finger, NFX1-type containing 1 -0.0300006
SEC31A SEC31 homolog A (S. cerevisiae) -0.0297996
ARHGAP29 Rho GTPase activating protein 29 -0.0294912
KLF5 Kruppel-like factor 5 (intestinal) -0.0293736
KTN1 kinectin 1 (kinesin receptor) -0.0293368
KMT2E lysine (K)-specific methyltransferase 2E -0.0289747
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0286652
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0284908
SPAG9 sperm associated antigen 9 -0.0284651
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0283456
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0275169
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0274501
NEK7 NIMA-related kinase 7 -0.0273715
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0268793
TXNIP thioredoxin interacting protein -0.0268063
LARS1 leucyl-tRNA synthetase 1 -0.0267385
RLF rearranged L-myc fusion -0.0266583
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0266069
IFI44 interferon-induced protein 44 -0.0265723
TXNRD1 thioredoxin reductase 1 -0.0263602
PLS3 plastin 3 -0.0263389
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0262725
BZW1 basic leucine zipper and W2 domains 1 -0.0261655
ASXL1 additional sex combs like transcriptional regulator 1 -0.0261307
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0256235
IL6ST interleukin 6 signal transducer -0.0250675
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0249088
MTAP methylthioadenosine phosphorylase -0.024813
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0247214
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0246499
CLTC clathrin, heavy chain (Hc) -0.0246235
HSPH1 heat shock 105kDa/110kDa protein 1 -0.023887
FN1 fibronectin 1 -0.0237579
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0236971