Fluvoxamine_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATXN1 ataxin 1 0.0734206
PLEC plectin 0.0662716
FNDC3B fibronectin type III domain containing 3B 0.0653416
MBNL2 muscleblind-like splicing regulator 2 0.0580643
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0552542
KLHL29 kelch-like family member 29 0.0517172
HYOU1 hypoxia up-regulated 1 0.0409486
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0400408
FLNB filamin B, beta 0.0375025
CTNND1 catenin (cadherin-associated protein), delta 1 0.0355039
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0348099
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0338592
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0337413
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0336077
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.032738
SMAD3 SMAD family member 3 0.0324908
MYH9 myosin, heavy chain 9, non-muscle 0.0317824
BCL2L1 BCL2-like 1 0.031224
KDM6A lysine (K)-specific demethylase 6A 0.0301563
GCLC glutamate-cysteine ligase, catalytic subunit 0.0300484
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0296881
KIF16B kinesin family member 16B 0.029646
PRELID2 PRELI domain containing 2 0.0288954
SEPTIN9 septin 9 0.0287256
NBAS neuroblastoma amplified sequence 0.0285864
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0282497
ARHGAP32 Rho GTPase activating protein 32 0.0279668
MPRIP myosin phosphatase Rho interacting protein 0.0279536
ANXA11 annexin A11 0.0277655
SHB Src homology 2 domain containing adaptor protein B 0.0277486
BTBD9 BTB (POZ) domain containing 9 0.0277319
ZFAND3 zinc finger, AN1-type domain 3 0.0275166
LMO7 LIM domain 7 0.0274457
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0273658
SND1 staphylococcal nuclease and tudor domain containing 1 0.0269108
EXT1 exostosin glycosyltransferase 1 0.0265008
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0256783
ESRP1 epithelial splicing regulatory protein 1 0.0256393
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0251829
PMM2 phosphomannomutase 2 0.0251085
CAPN8 calpain 8 0.0247607
GRB10 growth factor receptor-bound protein 10 0.0246986
STK24 serine/threonine kinase 24 0.0245661
ATP11A ATPase, class VI, type 11A 0.0245093
NIBAN2 niban apoptosis regulator 2 0.0243653
AVL9 AVL9 homolog (S. cerevisiase) 0.0237639
MYOF myoferlin 0.0224283
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0223304
AKAP13 A kinase (PRKA) anchor protein 13 0.022001
CTBP2 C-terminal binding protein 2 0.0219898
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0219845
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0217253
CEMIP cell migration inducing protein, hyaluronan binding 0.0216954
KMT2C lysine (K)-specific methyltransferase 2C 0.0216183
ANKRD11 ankyrin repeat domain 11 0.021305
FNIP1 folliculin interacting protein 1 0.0212059
COG5 component of oligomeric golgi complex 5 0.0211744
MACF1 microtubule-actin crosslinking factor 1 0.0211149
SEC24D SEC24 family member D 0.0210901
TRIM2 tripartite motif containing 2 0.020995
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0208911
UBE2H ubiquitin-conjugating enzyme E2H 0.020772
TNRC18 trinucleotide repeat containing 18 0.020752
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0206413
SNX13 sorting nexin 13 0.0205659
CEMIP2 cell migration inducing hyaluronidase 2 0.0205563
NDRG1 N-myc downstream regulated 1 0.0202272
VMP1 vacuole membrane protein 1 0.0202083
PHC3 polyhomeotic homolog 3 (Drosophila) 0.020088
CMIP c-Maf inducing protein 0.0200094
MAML2 mastermind-like 2 (Drosophila) 0.019963
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0197164
NCOR2 nuclear receptor corepressor 2 0.0196602
PGM3 phosphoglucomutase 3 0.0192221
FLNA filamin A, alpha 0.0191456
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0191189
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0189832
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0187843
HELZ helicase with zinc finger 0.0185351
ALPK1 alpha-kinase 1 0.0185145
COG6 component of oligomeric golgi complex 6 0.0184827
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0183683
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0182709
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0181809
PICALM phosphatidylinositol binding clathrin assembly protein 0.0179879
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0179779
EXOC6B exocyst complex component 6B 0.0178906
SEC31A SEC31 homolog A (S. cerevisiae) 0.0178487
SEC23B Sec23 homolog B (S. cerevisiae) 0.0178277
COPG1 coatomer protein complex, subunit gamma 1 0.0178164
YEATS2 YEATS domain containing 2 0.0177431
DOCK5 dedicator of cytokinesis 5 0.0177232
ZNF292 zinc finger protein 292 0.0176277
BIRC6 baculoviral IAP repeat containing 6 0.0175186
EIF4H eukaryotic translation initiation factor 4H 0.0174477
NDEL1 nudE neurodevelopment protein 1-like 1 0.017405
TMEM39A transmembrane protein 39A 0.0173927
AFDN afadin, adherens junction formation factor 0.017327
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.0172488
YAP1 Yes-associated protein 1 0.0169598

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.157135
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.155473
PTMA prothymosin, alpha -0.1275
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119059
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117242
FGFR2 fibroblast growth factor receptor 2 -0.115508
B2M beta-2-microglobulin -0.109309
TPT1 tumor protein, translationally-controlled 1 -0.0871795
S100A6 S100 calcium binding protein A6 -0.0831319
FTL ferritin, light polypeptide -0.0744711
RPS6 ribosomal protein S6 -0.074054
EIF1 eukaryotic translation initiation factor 1 -0.0733774
RPL35A ribosomal protein L35a -0.0727886
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0707292
NPSR1 neuropeptide S receptor 1 -0.0704114
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0695772
RPS3 ribosomal protein S3 -0.0691945
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0664423
S100A10 S100 calcium binding protein A10 -0.0650999
EPCAM epithelial cell adhesion molecule -0.0619911
RPS19 ribosomal protein S19 -0.0590153
PDIA3 protein disulfide isomerase family A, member 3 -0.0585015
RPL23 ribosomal protein L23 -0.0576729
KRT18 keratin 18, type I -0.0567079
RPLP1 ribosomal protein, large, P1 -0.056299
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0558133
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0557636
HLA-A major histocompatibility complex, class I, A -0.0536279
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0528672
EMP1 epithelial membrane protein 1 -0.047998
S100P S100 calcium binding protein P -0.0465753
IFI27 interferon, alpha-inducible protein 27 -0.0447024
CALR calreticulin -0.0446277
RPL26 ribosomal protein L26 -0.0432109
RPS8 ribosomal protein S8 -0.0431332
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0429415
AREG amphiregulin -0.0424085
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0420852
AGR2 anterior gradient 2 -0.0417021
RPL19 ribosomal protein L19 -0.0415828
H1-0 H1.0 linker histone -0.0413024
PGK1 phosphoglycerate kinase 1 -0.0412915
RPS25 ribosomal protein S25 -0.0409195
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0407012
RPL12 ribosomal protein L12 -0.0406389
LOC102724023 ES1 protein homolog, mitochondrial -0.0399654
GMDS GDP-mannose 4,6-dehydratase -0.0399638
S100A11 S100 calcium binding protein A11 -0.0395667
RPL11 ribosomal protein L11 -0.0391892
S100A9 S100 calcium binding protein A9 -0.037813
ENO1 enolase 1, (alpha) -0.0373819
HLA-B major histocompatibility complex, class I, B -0.0373277
ATF5 activating transcription factor 5 -0.0369227
RPL8 ribosomal protein L8 -0.036819
HLA-E major histocompatibility complex, class I, E -0.0363633
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0362841
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0361714
ACTG1 actin gamma 1 -0.0356579
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0356578
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0353736
AGR3 anterior gradient 3 -0.0342778
CBX3 chromobox homolog 3 -0.0341818
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0341735
RPS21 ribosomal protein S21 -0.0341583
MKI67 marker of proliferation Ki-67 -0.0340868
DSTN destrin (actin depolymerizing factor) -0.0338872
RPS24 ribosomal protein S24 -0.033848
MYL12B myosin, light chain 12B, regulatory -0.0335631
KRT19 keratin 19, type I -0.0334115
INSIG1 insulin induced gene 1 -0.0333372
ACACA acetyl-CoA carboxylase alpha -0.0328232
RPL18 ribosomal protein L18 -0.0323975
TMSB4X thymosin beta 4, X-linked -0.0320414
RPL34 ribosomal protein L34 -0.0320053
RPL37A ribosomal protein L37a -0.0317194
H3-3B H3.3 histone B -0.0315522
RRBP1 ribosome binding protein 1 -0.0311599
RPS16 ribosomal protein S16 -0.0308196
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0301035
GSTP1 glutathione S-transferase pi 1 -0.0299832
RPL28 ribosomal protein L28 -0.0299801
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0296914
IFITM3 interferon induced transmembrane protein 3 -0.0294652
RPL36A ribosomal protein L36a -0.0292865
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0290006
DEK DEK proto-oncogene -0.0289995
PKM pyruvate kinase, muscle -0.0289987
SLC38A1 solute carrier family 38, member 1 -0.0284642
PDIA4 protein disulfide isomerase family A, member 4 -0.0282505
HMGA1 high mobility group AT-hook 1 -0.028186
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0281263
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0280933
RPLP0 ribosomal protein, large, P0 -0.0278823
RPS27A ribosomal protein S27a -0.0278486
IFI6 interferon, alpha-inducible protein 6 -0.0278126
RPS12 ribosomal protein S12 -0.0276992
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0276956
GNAS GNAS complex locus -0.0275783
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0275267
CANX calnexin -0.0271103