Fluvoxamine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.140463
NDRG1 N-myc downstream regulated 1 0.120284
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0726801
FAM13A family with sequence similarity 13, member A 0.0601031
NGLY1 N-glycanase 1 0.0507125
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0444562
TBC1D22A TBC1 domain family, member 22A 0.0433174
PLEC plectin 0.0431408
CEMIP cell migration inducing protein, hyaluronan binding 0.0410868
CES1 carboxylesterase 1 0.040014
CAMTA1 calmodulin binding transcription activator 1 0.0387924
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0355367
ARRDC3 arrestin domain containing 3 0.0332213
GRB10 growth factor receptor-bound protein 10 0.0330309
SOD2 superoxide dismutase 2, mitochondrial 0.0298732
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0265302
AGO2 argonaute RISC catalytic component 2 0.0262195
TMEM165 transmembrane protein 165 0.0248264
RUNX1 runt-related transcription factor 1 0.0245717
MYH9 myosin, heavy chain 9, non-muscle 0.0239291
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0232788
SMAD3 SMAD family member 3 0.0227129
YEATS2 YEATS domain containing 2 0.0218286
ATP11A ATPase, class VI, type 11A 0.0215848
MCL1 myeloid cell leukemia 1 0.0215177
SAMD4A sterile alpha motif domain containing 4A 0.0214275
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0213625
ATP13A3 ATPase type 13A3 0.0210062
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0192671
HELZ helicase with zinc finger 0.0191361
BRWD3 bromodomain and WD repeat domain containing 3 0.0191002
HOOK2 hook microtubule-tethering protein 2 0.0189161
SMTN smoothelin 0.0187311
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0186566
ANO6 anoctamin 6 0.0182829
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0181808
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0178133
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0170695
C1D C1D nuclear receptor corepressor 0.0169927
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0169615
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0169388
PTPRJ protein tyrosine phosphatase, receptor type, J 0.016825
RPL3 ribosomal protein L3 0.0168124
MKI67 marker of proliferation Ki-67 0.016377
UBE2O ubiquitin-conjugating enzyme E2O 0.0163748
KMT2D lysine (K)-specific methyltransferase 2D 0.0162119
MYO1B myosin IB 0.0157889
ZNF292 zinc finger protein 292 0.015691
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0153908
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0153349
MLKL mixed lineage kinase domain-like 0.0148701
TSC22D2 TSC22 domain family, member 2 0.0147951
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0143845
PRELID2 PRELI domain containing 2 0.0142848
FNIP1 folliculin interacting protein 1 0.0142727
OGA O-GlcNAcase 0.0142636
DTNA dystrobrevin, alpha 0.0139902
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0139133
FRY furry homolog (Drosophila) 0.0136166
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0135894
BACE2 beta-site APP-cleaving enzyme 2 0.0135342
MIDEAS mitotic deacetylase associated SANT domain protein 0.0134484
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0133819
SRRM2 serine/arginine repetitive matrix 2 0.0133368
RNF149 ring finger protein 149 0.0126939
CYLD cylindromatosis (turban tumor syndrome) 0.0125657
PDE8A phosphodiesterase 8A 0.0123861
RLIM ring finger protein, LIM domain interacting 0.012316
TENT5A terminal nucleotidyltransferase 5A 0.0122968
TNIP1 TNFAIP3 interacting protein 1 0.0122697
RASA2 RAS p21 protein activator 2 0.0122603
SHB Src homology 2 domain containing adaptor protein B 0.0122553
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0120314
SREBF2 sterol regulatory element binding transcription factor 2 0.0118304
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0117427
METTL15 methyltransferase like 15 0.0117017
TMEM39A transmembrane protein 39A 0.0116677
FBXL5 F-box and leucine-rich repeat protein 5 0.0115682
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0115592
NBAS neuroblastoma amplified sequence 0.0115567
KDM7A lysine (K)-specific demethylase 7A 0.0115364
CABIN1 calcineurin binding protein 1 0.0112692
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0111958
PYGL phosphorylase, glycogen, liver 0.0111855
PFKP phosphofructokinase, platelet 0.0111696
BIRC2 baculoviral IAP repeat containing 2 0.0106952
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0105341
WDR26 WD repeat domain 26 0.0103594
SLC35F5 solute carrier family 35, member F5 0.0103223
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.0102725
ATXN1 ataxin 1 0.01026
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0102431
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.0102316
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0102255
RAD51B RAD51 paralog B 0.0102116
CCNG2 cyclin G2 0.00994322
ZBTB25 zinc finger and BTB domain containing 25 0.00990801
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.00983837
SEC24D SEC24 family member D 0.00982524
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.00982388

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.352574
TXNRD1 thioredoxin reductase 1 -0.162971
ASPH aspartate beta-hydroxylase -0.162783
TMSB10 thymosin beta 10 -0.142465
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.115347
CAV1 caveolin 1, caveolae protein, 22kDa -0.0969186
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0897403
PTMA prothymosin, alpha -0.0876144
FTL ferritin, light polypeptide -0.0822207
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0809965
TPT1 tumor protein, translationally-controlled 1 -0.0805031
S100A10 S100 calcium binding protein A10 -0.0796519
ENO1 enolase 1, (alpha) -0.0766332
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0759169
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0723201
ACTG1 actin gamma 1 -0.0722837
ANXA2 annexin A2 -0.0715239
LMO7 LIM domain 7 -0.0700665
UBC ubiquitin C -0.0626639
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0614653
PKM pyruvate kinase, muscle -0.061053
LDHA lactate dehydrogenase A -0.0599585
MYOF myoferlin -0.059063
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0568682
AKR1C1 aldo-keto reductase family 1, member C1 -0.0560785
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.055144
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0545655
RPLP1 ribosomal protein, large, P1 -0.0537174
MT2A metallothionein 2A -0.0529199
RPS3 ribosomal protein S3 -0.0512182
RPS27A ribosomal protein S27a -0.0486065
KRT18 keratin 18, type I -0.0471522
SEC61G Sec61 gamma subunit -0.0468872
RPS25 ribosomal protein S25 -0.0464288
PTPRM protein tyrosine phosphatase, receptor type, M -0.0449948
SLC38A1 solute carrier family 38, member 1 -0.0443713
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0439409
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0436468
CST3 cystatin C -0.0436415
RPL35A ribosomal protein L35a -0.0433624
RPS24 ribosomal protein S24 -0.0432836
KRT7 keratin 7, type II -0.0429035
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0422221
RPS6 ribosomal protein S6 -0.0418789
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.041562
TES testin LIM domain protein -0.0415208
B2M beta-2-microglobulin -0.0414089
RPS8 ribosomal protein S8 -0.0407189
EIF1 eukaryotic translation initiation factor 1 -0.0405149
BZW1 basic leucine zipper and W2 domains 1 -0.0397216
CCND1 cyclin D1 -0.0392442
CANX calnexin -0.0389916
PDIA3 protein disulfide isomerase family A, member 3 -0.0389876
RPLP0 ribosomal protein, large, P0 -0.0373935
EGR1 early growth response 1 -0.0368554
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0366459
RPL34 ribosomal protein L34 -0.0361668
RPL31 ribosomal protein L31 -0.0354546
CPE carboxypeptidase E -0.0352631
RPL37A ribosomal protein L37a -0.0346991
PDLIM5 PDZ and LIM domain 5 -0.0345113
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0342564
IGFBP5 insulin-like growth factor binding protein 5 -0.0338749
SCEL sciellin -0.033482
FTH1 ferritin, heavy polypeptide 1 -0.0333053
RAB10 RAB10, member RAS oncogene family -0.0333001
SLC38A2 solute carrier family 38, member 2 -0.0328948
DSPP dentin sialophosphoprotein -0.0326618
AHNAK AHNAK nucleoprotein -0.0316348
RPS12 ribosomal protein S12 -0.0315155
GRAMD1B GRAM domain containing 1B -0.0311323
LPP LIM domain containing preferred translocation partner in lipoma -0.030717
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0303929
LOC112694756 uncharaterized LOC112694756 -0.0302297
AREG amphiregulin -0.0300154
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0300121
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0299578
IFI6 interferon, alpha-inducible protein 6 -0.029887
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0298649
SP100 SP100 nuclear antigen -0.0294345
RPL12 ribosomal protein L12 -0.029341
STC1 stanniocalcin 1 -0.0292985
IER3 immediate early response 3 -0.0292319
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0291418
RPL19 ribosomal protein L19 -0.0291245
PATJ PATJ crumbs cell polarity complex component -0.0290372
TPM4 tropomyosin 4 -0.0286868
INTS6 integrator complex subunit 6 -0.0283294
TOP1 topoisomerase (DNA) I -0.0280641
S100A6 S100 calcium binding protein A6 -0.0279652
CUX1 cut-like homeobox 1 -0.0275423
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0275079
HLA-B major histocompatibility complex, class I, B -0.0272185
S100A11 S100 calcium binding protein A11 -0.027131
VCL vinculin -0.0271247
KRT8 keratin 8, type II -0.0270779
FBXO11 F-box protein 11 -0.0269255
BIRC3 baculoviral IAP repeat containing 3 -0.0264722
PDE4D phosphodiesterase 4D, cAMP-specific -0.0262083
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0261793