Fluvoxamine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

103 genes differentially expressed following the Fluvoxamine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAV2 neuron navigator 2 0.155765
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.149196
NCAM2 neural cell adhesion molecule 2 0.118113
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.11433
FMN1 formin 1 0.110697
FOXP1 forkhead box P1 0.110632
GPHN gephyrin 0.0977348
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0966754
IGF1R insulin-like growth factor 1 receptor 0.0932706
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0926179
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0915137
GOLGA4 golgin A4 0.0897811
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0880853
ZFAND3 zinc finger, AN1-type domain 3 0.0873514
MACF1 microtubule-actin crosslinking factor 1 0.0824522
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0792672
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0786126
JARID2 jumonji, AT rich interactive domain 2 0.0774388
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0772355
AKAP12 A kinase (PRKA) anchor protein 12 0.0760724
ZNF644 zinc finger protein 644 0.0744356
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0733482
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0705576
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0687688
EXT1 exostosin glycosyltransferase 1 0.068296
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0650517
IGF2 insulin-like growth factor 2 0.0632286
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0631007
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0616792
SETD5 SET domain containing 5 0.0612107
DSCAM Down syndrome cell adhesion molecule 0.0576643
SOD2 superoxide dismutase 2, mitochondrial 0.0548405
ESYT2 extended synaptotagmin-like protein 2 0.0530826
RPL32 ribosomal protein L32 0.0516543
PKM pyruvate kinase, muscle 0.0510014
BTBD9 BTB (POZ) domain containing 9 0.0496783
FNDC3B fibronectin type III domain containing 3B 0.0481223
RAB5A RAB5A, member RAS oncogene family 0.0478759
NAMPT nicotinamide phosphoribosyltransferase 0.046581
POM121 POM121 transmembrane nucleoporin 0.0455881
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0396568
TNIP1 TNFAIP3 interacting protein 1 0.0388808
TRIO trio Rho guanine nucleotide exchange factor 0.0385679
ANO6 anoctamin 6 0.0385202
MYO10 myosin X 0.0366675
VMP1 vacuole membrane protein 1 0.0345507
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.026298
RBM39 RNA binding motif protein 39 0.0254643
DST dystonin 0.0224234
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0217998
CDC73 cell division cycle 73 0.0205356
ASPH aspartate beta-hydroxylase 0.0203056
LMO7 LIM domain 7 0.0145735
KMT2C lysine (K)-specific methyltransferase 2C 0.0119501
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0115149
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0114249
DIAPH2 diaphanous-related formin 2 0.0107045
TBC1D22A TBC1 domain family, member 22A 0.0102938
CNKSR3 CNKSR family member 3 0.00897298
ANKRD12 ankyrin repeat domain 12 0.00815434
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.00794716
PARD3 par-3 family cell polarity regulator 0.00760558
ZSWIM6 zinc finger, SWIM-type containing 6 0.00527356
NAP1L1 nucleosome assembly protein 1-like 1 0.00478363
CANX calnexin 8.23266E-4

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.232079
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.210459
VIM vimentin -0.18997
FN1 fibronectin 1 -0.183351
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.148504
PRRC2C proline-rich coiled-coil 2C -0.146522
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.11725
NDRG1 N-myc downstream regulated 1 -0.112958
EEF2 eukaryotic translation elongation factor 2 -0.104585
B2M beta-2-microglobulin -0.0998214
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0963431
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0929792
RPS6 ribosomal protein S6 -0.0894588
SLC38A2 solute carrier family 38, member 2 -0.0864444
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0844911
IGFBP3 insulin-like growth factor binding protein 3 -0.0829492
RNF213 ring finger protein 213 -0.074869
TMSB10 thymosin beta 10 -0.0732375
PTMA prothymosin, alpha -0.0567468
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0551502
PTPRM protein tyrosine phosphatase, receptor type, M -0.0452647
PRKCA protein kinase C, alpha -0.0437718
HDLBP high density lipoprotein binding protein -0.0435266
ZBTB20 zinc finger and BTB domain containing 20 -0.0433814
ZNF292 zinc finger protein 292 -0.0337453
PDLIM5 PDZ and LIM domain 5 -0.0331401
COL5A2 collagen, type V, alpha 2 -0.027217
GPC6 glypican 6 -0.0242187
RIGI RNA sensor RIG-I -0.0179058
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0163432
JMJD1C jumonji domain containing 1C -0.0121216
RUNX1 runt-related transcription factor 1 -0.0116943
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.00973185
TAS2R14 taste receptor, type 2, member 14 -0.00903997
ERRFI1 ERBB receptor feedback inhibitor 1 -0.00870612
NALF1 NALCN channel auxiliary factor 1 -0.00818579
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00702419
COL6A3 collagen, type VI, alpha 3 -0.00450174