Fluvoxamine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.107309
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0931685
SMAD3 SMAD family member 3 0.0805897
PDE10A phosphodiesterase 10A 0.0788714
TRIO trio Rho guanine nucleotide exchange factor 0.0726391
NAMPT nicotinamide phosphoribosyltransferase 0.0673063
COL6A3 collagen, type VI, alpha 3 0.0647842
NAV2 neuron navigator 2 0.0644025
ZMIZ1 zinc finger, MIZ-type containing 1 0.041365
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0405688
SOD2 superoxide dismutase 2, mitochondrial 0.0404964
NDRG1 N-myc downstream regulated 1 0.0388681
FNDC3B fibronectin type III domain containing 3B 0.0372585
FRMD4A FERM domain containing 4A 0.0360311
FLNA filamin A, alpha 0.0350899
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.033646
AFDN afadin, adherens junction formation factor 0.032526
ARRDC3 arrestin domain containing 3 0.0301783
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.02949
FN1 fibronectin 1 0.0280172
VEGFA vascular endothelial growth factor A 0.0274747
KIF4A kinesin family member 4A 0.0268596
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0261454
MLPH melanophilin 0.0259668
CEP250 centrosomal protein 250kDa 0.0255714
MKI67 marker of proliferation Ki-67 0.0253056
YEATS2 YEATS domain containing 2 0.0243979
TNIP1 TNFAIP3 interacting protein 1 0.0234423
FLNB filamin B, beta 0.0233097
SHB Src homology 2 domain containing adaptor protein B 0.0231252
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0229152
PPARD peroxisome proliferator-activated receptor delta 0.0228753
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0227714
ATXN1 ataxin 1 0.0223133
ANLN anillin, actin binding protein 0.0220994
MYOF myoferlin 0.0215333
RPL3 ribosomal protein L3 0.0214013
THBS2 thrombospondin 2 0.0208246
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0204604
AFAP1 actin filament associated protein 1 0.0198943
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0198816
FAM219A family with sequence similarity 219, member A 0.0196689
BRWD3 bromodomain and WD repeat domain containing 3 0.0194067
NONO non-POU domain containing, octamer-binding 0.0193216
ABTB3 ankyrin repeat and BTB domain containing 3 0.0191099
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0186889
ACTN1 actinin, alpha 1 0.0185824
PFKP phosphofructokinase, platelet 0.0184938
TNS3 tensin 3 0.0183921
ANKRD36 ankyrin repeat domain 36 0.0180942
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0180679
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0180018
AMPD3 adenosine monophosphate deaminase 3 0.0179857
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0179494
BACE2 beta-site APP-cleaving enzyme 2 0.0176907
KDM3A lysine (K)-specific demethylase 3A 0.0176335
ELL2 elongation factor, RNA polymerase II, 2 0.0175145
FNIP1 folliculin interacting protein 1 0.017197
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0171126
NUMA1 nuclear mitotic apparatus protein 1 0.0170019
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0168525
COL5A1 collagen, type V, alpha 1 0.0167098
ZFC3H1 zinc finger, C3H1-type containing 0.0166811
IQGAP3 IQ motif containing GTPase activating protein 3 0.0166596
FAM20C family with sequence similarity 20, member C 0.0166131
CEP95 centrosomal protein 95kDa 0.0164693
DST dystonin 0.0163116
RASA3 RAS p21 protein activator 3 0.0162481
DENND5A DENN/MADD domain containing 5A 0.0160558
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0160359
MSN moesin 0.0158838
PLEC plectin 0.0158206
CDK19 cyclin-dependent kinase 19 0.0158168
ARFGEF3 ARFGEF family member 3 0.0157832
NEK6 NIMA-related kinase 6 0.0155084
SLC35F5 solute carrier family 35, member F5 0.0153158
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0151979
FRMPD4 FERM and PDZ domain containing 4 0.0151885
SDK1 sidekick cell adhesion molecule 1 0.0150862
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0150837
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.015019
SMYD3 SET and MYND domain containing 3 0.0149832
IL1RAP interleukin 1 receptor accessory protein 0.014888
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0148211
EGFR epidermal growth factor receptor 0.0147544
SAFB2 scaffold attachment factor B2 0.0146824
NGLY1 N-glycanase 1 0.0146709
MACF1 microtubule-actin crosslinking factor 1 0.0145891
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0145524
EEF2 eukaryotic translation elongation factor 2 0.0143853
CLMN calmin (calponin-like, transmembrane) 0.0143098
FAM120B family with sequence similarity 120B 0.0142211
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0142089
IGFBP3 insulin-like growth factor binding protein 3 0.0141989
NSD2 nuclear receptor binding SET domain protein 2 0.014143
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0140676
GAS2L3 growth arrest-specific 2 like 3 0.0139238
ZHX2 zinc fingers and homeoboxes 2 0.0138788
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0138018
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0136754

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.283506
VIM vimentin -0.271866
FTL ferritin, light polypeptide -0.166285
HLA-B major histocompatibility complex, class I, B -0.142765
RPS6 ribosomal protein S6 -0.120887
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.110783
MARCKS myristoylated alanine-rich protein kinase C substrate -0.103616
TMSB10 thymosin beta 10 -0.100056
MT2A metallothionein 2A -0.0950452
IER3 immediate early response 3 -0.0930349
TPT1 tumor protein, translationally-controlled 1 -0.0900425
FTH1 ferritin, heavy polypeptide 1 -0.0895735
B2M beta-2-microglobulin -0.0875723
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0765633
RPL23 ribosomal protein L23 -0.0757426
RPS12 ribosomal protein S12 -0.0740613
PTMA prothymosin, alpha -0.0717449
RPS8 ribosomal protein S8 -0.0679772
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0679
RPS24 ribosomal protein S24 -0.0676907
RPL35A ribosomal protein L35a -0.0650845
VCL vinculin -0.0589315
RPS23 ribosomal protein S23 -0.0568281
RPLP2 ribosomal protein, large, P2 -0.0556167
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0554165
RPLP1 ribosomal protein, large, P1 -0.0550348
RPLP0 ribosomal protein, large, P0 -0.054769
NAP1L1 nucleosome assembly protein 1-like 1 -0.0539565
RPL12 ribosomal protein L12 -0.0521804
RPL37A ribosomal protein L37a -0.0506941
CD44 CD44 molecule (Indian blood group) -0.0506856
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0499346
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0483202
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0480891
RPS3 ribosomal protein S3 -0.0473554
IFITM3 interferon induced transmembrane protein 3 -0.0445306
HLA-A major histocompatibility complex, class I, A -0.0441122
EIF1 eukaryotic translation initiation factor 1 -0.0434733
RPL9 ribosomal protein L9 -0.0432522
ASPH aspartate beta-hydroxylase -0.0430865
RPL26 ribosomal protein L26 -0.0426386
RPS14 ribosomal protein S14 -0.0411347
RPL19 ribosomal protein L19 -0.0405728
ENO1 enolase 1, (alpha) -0.0404769
RPS13 ribosomal protein S13 -0.0395676
RPS19 ribosomal protein S19 -0.0395371
ANXA2 annexin A2 -0.0390118
EGR1 early growth response 1 -0.038948
ACTG1 actin gamma 1 -0.0384796
SQSTM1 sequestosome 1 -0.037776
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0373835
RPL7A ribosomal protein L7a -0.0370985
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.036787
RPL36 ribosomal protein L36 -0.036286
S100A9 S100 calcium binding protein A9 -0.0360523
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0360081
CTSD cathepsin D -0.0356988
PDIA3 protein disulfide isomerase family A, member 3 -0.0354591
RPL36A ribosomal protein L36a -0.0351661
BICC1 BicC family RNA binding protein 1 -0.0349731
RPS25 ribosomal protein S25 -0.0348711
UBC ubiquitin C -0.03478
HMGA1 high mobility group AT-hook 1 -0.0340436
RPL5 ribosomal protein L5 -0.0340227
RPL31 ribosomal protein L31 -0.0339203
LDHA lactate dehydrogenase A -0.0337057
RPL11 ribosomal protein L11 -0.0325807
RPL27A ribosomal protein L27a -0.0322511
RPS21 ribosomal protein S21 -0.0320949
RPS27A ribosomal protein S27a -0.0314801
RACK1 receptor for activated C kinase 1 -0.0310922
ADM adrenomedullin -0.0305176
KTN1 kinectin 1 (kinesin receptor) -0.0300792
RPS10 ribosomal protein S10 -0.0300584
RPL8 ribosomal protein L8 -0.0300118
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0299698
MORF4L2 mortality factor 4 like 2 -0.0298281
CANX calnexin -0.0296229
RPL35 ribosomal protein L35 -0.0293656
PLIN2 perilipin 2 -0.0292947
HILPDA hypoxia inducible lipid droplet-associated -0.0290444
QKI QKI, KH domain containing, RNA binding -0.028888
HLA-E major histocompatibility complex, class I, E -0.028641
HDAC9 histone deacetylase 9 -0.0285564
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0284689
RAB7A RAB7A, member RAS oncogene family -0.0283332
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0282598
POTEF POTE ankyrin domain family, member F -0.0280442
RPL34 ribosomal protein L34 -0.0279776
RPS4X ribosomal protein S4, X-linked -0.0278685
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0278227
PFN1 profilin 1 -0.0277346
RPL32 ribosomal protein L32 -0.0277193
CALR calreticulin -0.0274215
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0271864
RPL37 ribosomal protein L37 -0.0271246
RPS11 ribosomal protein S11 -0.0270958
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0270511
RPL15 ribosomal protein L15 -0.0268707
HMGA2 high mobility group AT-hook 2 -0.0267452