Fluvoxamine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.194983
MYH9 myosin, heavy chain 9, non-muscle 0.0705247
FLNA filamin A, alpha 0.0555101
ANKRD11 ankyrin repeat domain 11 0.0533092
SMAD3 SMAD family member 3 0.0518289
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0508679
MED13L mediator complex subunit 13-like 0.0495947
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0470329
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0450858
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0400278
RNF145 ring finger protein 145 0.0381874
TENT5A terminal nucleotidyltransferase 5A 0.0357372
TRIO trio Rho guanine nucleotide exchange factor 0.035099
SHB Src homology 2 domain containing adaptor protein B 0.0341686
ERRFI1 ERBB receptor feedback inhibitor 1 0.033962
MT1X metallothionein 1X 0.0322157
LMNA lamin A/C 0.0313046
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0306849
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0299275
CSDE1 cold shock domain containing E1, RNA-binding 0.0287385
CADM1 cell adhesion molecule 1 0.0284926
CORO1C coronin, actin binding protein, 1C 0.0284534
NRXN3 neurexin 3 0.0281825
AUTS2 autism susceptibility candidate 2 0.0279991
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0279147
KDM6A lysine (K)-specific demethylase 6A 0.0277383
SMYD3 SET and MYND domain containing 3 0.0274129
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0271972
ARRDC3 arrestin domain containing 3 0.0265073
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0253673
ATP13A3 ATPase type 13A3 0.024977
GSE1 Gse1 coiled-coil protein 0.0247739
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0247274
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0245037
PLEC plectin 0.0243689
AHR aryl hydrocarbon receptor 0.0239312
MSN moesin 0.0239291
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.023872
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0237805
SP3 Sp3 transcription factor 0.0234908
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0233878
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0231558
SPRED2 sprouty-related, EVH1 domain containing 2 0.0231194
MARCHF6 membrane associated ring-CH-type finger 6 0.0229598
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0227671
JAG1 jagged 1 0.0224757
BIRC2 baculoviral IAP repeat containing 2 0.0224044
COL6A2 collagen, type VI, alpha 2 0.0222797
SMOX spermine oxidase 0.0221554
DPYD dihydropyrimidine dehydrogenase 0.0220291
NALF1 NALCN channel auxiliary factor 1 0.022014
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0219926
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0218844
MEF2A myocyte enhancer factor 2A 0.0216541
COL7A1 collagen, type VII, alpha 1 0.02156
EPAS1 endothelial PAS domain protein 1 0.0214316
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0213276
RNF111 ring finger protein 111 0.0212375
AFDN afadin, adherens junction formation factor 0.0211671
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0210475
ANKRD36C ankyrin repeat domain 36C 0.0207643
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0207402
SRRM2 serine/arginine repetitive matrix 2 0.0207242
NCOA3 nuclear receptor coactivator 3 0.020703
MB21D2 Mab-21 domain containing 2 0.0206812
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0206326
SAR1A secretion associated, Ras related GTPase 1A 0.0206218
CXXC5 CXXC finger protein 5 0.0204749
ZNF292 zinc finger protein 292 0.020464
MAP2K4 mitogen-activated protein kinase kinase 4 0.0203948
ZFPM2 zinc finger protein, FOG family member 2 0.0200691
PRDM2 PR domain containing 2, with ZNF domain 0.0200283
MAML2 mastermind-like 2 (Drosophila) 0.0199543
SUB1 SUB1 homolog (S. cerevisiae) 0.01995
ACTN1 actinin, alpha 1 0.0199442
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0199276
PRELID2 PRELI domain containing 2 0.0198471
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0196687
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0194844
CCDC14 coiled-coil domain containing 14 0.0194319
SSBP2 single-stranded DNA binding protein 2 0.0193609
TNIP1 TNFAIP3 interacting protein 1 0.0192792
DIAPH3 diaphanous-related formin 3 0.0192194
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0192134
FBXL7 F-box and leucine-rich repeat protein 7 0.0191558
SYNJ2 synaptojanin 2 0.0190889
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.019051
ANKRD33B ankyrin repeat domain 33B 0.0190298
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0189166
SRGN serglycin 0.0188512
TNS1 tensin 1 0.0188146
GRB2 growth factor receptor-bound protein 2 0.0186851
EML4 echinoderm microtubule associated protein like 4 0.0185962
FUBP1 far upstream element (FUSE) binding protein 1 0.0185183
SNAP25 synaptosomal-associated protein, 25kDa 0.0184612
KLC1 kinesin light chain 1 0.0184518
CABIN1 calcineurin binding protein 1 0.0184501
WDFY3 WD repeat and FYVE domain containing 3 0.0184444
ANKRD10 ankyrin repeat domain 10 0.0182746
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.018273

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.29438
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.242763
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.24048
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.21664
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.13425
VIM vimentin -0.133451
TMSB10 thymosin beta 10 -0.105577
FN1 fibronectin 1 -0.103528
FTL ferritin, light polypeptide -0.0921464
HLA-B major histocompatibility complex, class I, B -0.0809422
AKAP12 A kinase (PRKA) anchor protein 12 -0.0742395
STC1 stanniocalcin 1 -0.0731804
CANX calnexin -0.0715351
IL6 interleukin 6 -0.0700941
MT2A metallothionein 2A -0.0667551
TGFBI transforming growth factor, beta-induced, 68kDa -0.0644767
PDIA3 protein disulfide isomerase family A, member 3 -0.0617676
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0613534
B2M beta-2-microglobulin -0.061125
TPT1 tumor protein, translationally-controlled 1 -0.059767
FTH1 ferritin, heavy polypeptide 1 -0.0590207
CALU calumenin -0.0563512
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.05386
LMAN1 lectin, mannose-binding, 1 -0.0527546
AKAP9 A kinase (PRKA) anchor protein 9 -0.0515764
SEC31A SEC31 homolog A (S. cerevisiae) -0.0500204
PTMA prothymosin, alpha -0.0485908
EIF1 eukaryotic translation initiation factor 1 -0.0484882
LOX lysyl oxidase -0.0478283
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0439081
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0438791
GARS1 glycyl-tRNA synthetase 1 -0.041322
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0409236
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0405754
MORF4L2 mortality factor 4 like 2 -0.0404144
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0403074
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0402027
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0397237
HM13 histocompatibility (minor) 13 -0.0394243
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.038768
PDIA4 protein disulfide isomerase family A, member 4 -0.0386171
GOLGA4 golgin A4 -0.0384844
ASPH aspartate beta-hydroxylase -0.038448
CSNK1A1 casein kinase 1, alpha 1 -0.0380769
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0378446
CALR calreticulin -0.0376723
ZSWIM6 zinc finger, SWIM-type containing 6 -0.037362
EGFR epidermal growth factor receptor -0.0367449
ENO1 enolase 1, (alpha) -0.0365891
RPL34 ribosomal protein L34 -0.0364753
PDIA6 protein disulfide isomerase family A, member 6 -0.0362001
HLA-C major histocompatibility complex, class I, C -0.0354151
RPL35A ribosomal protein L35a -0.0351426
HDLBP high density lipoprotein binding protein -0.0349158
NDRG1 N-myc downstream regulated 1 -0.0339379
ZMYND8 zinc finger, MYND-type containing 8 -0.0338486
CDH13 cadherin 13 -0.0324898
CCNI cyclin I -0.0323793
IGFBP7 insulin-like growth factor binding protein 7 -0.032256
RPLP1 ribosomal protein, large, P1 -0.0322137
S100A10 S100 calcium binding protein A10 -0.0315902
TM4SF1 transmembrane 4 L six family member 1 -0.0312528
ZBTB20 zinc finger and BTB domain containing 20 -0.0308456
RPS6 ribosomal protein S6 -0.0307432
COL6A1 collagen, type VI, alpha 1 -0.0305574
RPS12 ribosomal protein S12 -0.0304648
BZW2 basic leucine zipper and W2 domains 2 -0.030184
PTGES2 prostaglandin E synthase 2 -0.0299178
LOXL2 lysyl oxidase-like 2 -0.0297464
VCL vinculin -0.0297183
MXI1 MAX interactor 1, dimerization protein -0.0293723
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0292817
VDAC1 voltage-dependent anion channel 1 -0.0291591
ACTG1 actin gamma 1 -0.0291481
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0288575
IARS1 isoleucyl-tRNA synthetase 1 -0.0286397
COL1A2 collagen, type I, alpha 2 -0.0285846
AHNAK AHNAK nucleoprotein -0.0284856
MTDH metadherin -0.0284414
CALD1 caldesmon 1 -0.0280587
RAB2A RAB2A, member RAS oncogene family -0.0280263
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0279378
MAP4 microtubule-associated protein 4 -0.0278903
OXR1 oxidation resistance 1 -0.0278891
FNIP1 folliculin interacting protein 1 -0.0277126
UBC ubiquitin C -0.0274836
RPS8 ribosomal protein S8 -0.0271993
SCFD1 sec1 family domain containing 1 -0.0267656
TPM4 tropomyosin 4 -0.0267167
CLINT1 clathrin interactor 1 -0.0266845
CAVIN1 caveolae associated protein 1 -0.0262856
NOP58 NOP58 ribonucleoprotein -0.0261571
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.02572
RPS14 ribosomal protein S14 -0.025589
S100A9 S100 calcium binding protein A9 -0.0248538
CDK13 cyclin-dependent kinase 13 -0.0248532
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0247507
TTC3 tetratricopeptide repeat domain 3 -0.0246496
FGFR1 fibroblast growth factor receptor 1 -0.0246209
RPS16 ribosomal protein S16 -0.0244803