Fluvoxamine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fluvoxamine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fluvoxamine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.129563
FNDC3B fibronectin type III domain containing 3B 0.0864331
TRIO trio Rho guanine nucleotide exchange factor 0.0839036
NDRG1 N-myc downstream regulated 1 0.0725828
SMAD3 SMAD family member 3 0.0688146
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0636887
MYH9 myosin, heavy chain 9, non-muscle 0.0558247
ANKRD11 ankyrin repeat domain 11 0.0528597
CD109 CD109 molecule 0.0528232
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0517811
TXNRD1 thioredoxin reductase 1 0.0501504
SMOX spermine oxidase 0.0489201
SMYD3 SET and MYND domain containing 3 0.0487363
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0473963
PTK2 protein tyrosine kinase 2 0.0471537
MAP1B microtubule-associated protein 1B 0.0453927
NAV2 neuron navigator 2 0.0437435
ZNF292 zinc finger protein 292 0.043118
FLNA filamin A, alpha 0.042992
RUNX2 runt-related transcription factor 2 0.0426493
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0426214
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0419038
UBA6 ubiquitin-like modifier activating enzyme 6 0.0404211
FAM13A family with sequence similarity 13, member A 0.0397307
FOSL1 FOS-like antigen 1 0.0381755
PRELID2 PRELI domain containing 2 0.03629
PELO pelota homolog (Drosophila) 0.0361605
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0353262
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.035204
RUNX1 runt-related transcription factor 1 0.0333973
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0327453
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0323879
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0320652
ADAM9 ADAM metallopeptidase domain 9 0.0318253
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0317688
ZMIZ1 zinc finger, MIZ-type containing 1 0.0306937
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0304575
DNMBP dynamin binding protein 0.030299
SUCO SUN domain containing ossification factor 0.0296986
FBXL5 F-box and leucine-rich repeat protein 5 0.0294493
LOXL2 lysyl oxidase-like 2 0.0293054
CENPF centromere protein F, 350/400kDa 0.0281484
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0279592
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0279032
NRIP1 nuclear receptor interacting protein 1 0.0278935
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0277972
SSH1 slingshot protein phosphatase 1 0.0276348
NUP58 nucleoporin 58 0.0275007
DST dystonin 0.0274118
IQGAP3 IQ motif containing GTPase activating protein 3 0.0271789
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0269455
ZC3H12C zinc finger CCCH-type containing 12C 0.0266784
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0263668
ANXA5 annexin A5 0.0262787
EREG epiregulin 0.0261891
STC2 stanniocalcin 2 0.025671
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0254514
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0251839
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0249726
ACTN4 actinin, alpha 4 0.0248936
FAT1 FAT atypical cadherin 1 0.024458
RAD51B RAD51 paralog B 0.0241153
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0240324
TMEM156 transmembrane protein 156 0.0238879
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0238349
CDCP1 CUB domain containing protein 1 0.0237286
RTN4 reticulon 4 0.0237216
TP53BP2 tumor protein p53 binding protein 2 0.0236706
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0236578
PLEC plectin 0.0236287
SNX9 sorting nexin 9 0.0235097
TENT4A terminal nucleotidyltransferase 4A 0.0234351
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0233847
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0232708
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0231174
TNIP1 TNFAIP3 interacting protein 1 0.0230157
CEP170 centrosomal protein 170kDa 0.022951
CHD1L chromodomain helicase DNA binding protein 1-like 0.0227664
IRAK3 interleukin-1 receptor-associated kinase 3 0.0227592
PFKP phosphofructokinase, platelet 0.0227347
TPD52 tumor protein D52 0.0226399
ITGB5 integrin, beta 5 0.0225468
ARRDC3 arrestin domain containing 3 0.0225453
FLNB filamin B, beta 0.0224091
SRRM2 serine/arginine repetitive matrix 2 0.0223635
EEF2 eukaryotic translation elongation factor 2 0.0222918
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0221403
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0221293
FRY furry homolog (Drosophila) 0.0220935
CAB39 calcium binding protein 39 0.0219598
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0218425
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0217194
MSN moesin 0.0214298
ELL2 elongation factor, RNA polymerase II, 2 0.0212361
DOCK5 dedicator of cytokinesis 5 0.0211987
YAP1 Yes-associated protein 1 0.021059
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0207914
SEPTIN9 septin 9 0.0207564
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0204728
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0203663

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.217102
PTMA prothymosin, alpha -0.148703
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.119
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.111818
EXT1 exostosin glycosyltransferase 1 -0.0994411
HLA-B major histocompatibility complex, class I, B -0.0906603
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0826509
TPT1 tumor protein, translationally-controlled 1 -0.0674768
FN1 fibronectin 1 -0.0630219
RPL26 ribosomal protein L26 -0.0614775
TMSB10 thymosin beta 10 -0.0608998
NTN4 netrin 4 -0.0574999
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0566409
B2M beta-2-microglobulin -0.0538163
CANX calnexin -0.0535118
NRG1 neuregulin 1 -0.0530543
VCL vinculin -0.0504484
RPS12 ribosomal protein S12 -0.0500912
RPS24 ribosomal protein S24 -0.0496989
SEC31A SEC31 homolog A (S. cerevisiae) -0.0488936
TMSB4X thymosin beta 4, X-linked -0.046881
FTH1 ferritin, heavy polypeptide 1 -0.0454043
RPL11 ribosomal protein L11 -0.0438504
IFI27 interferon, alpha-inducible protein 27 -0.0422994
S100A6 S100 calcium binding protein A6 -0.0422605
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0411602
RPL37 ribosomal protein L37 -0.0406061
RPL37A ribosomal protein L37a -0.0404259
RPL31 ribosomal protein L31 -0.0389142
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0383999
KSR1 kinase suppressor of ras 1 -0.0376054
SQSTM1 sequestosome 1 -0.0371268
NCOA7 nuclear receptor coactivator 7 -0.0367858
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0367438
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.036585
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0361196
RPL34 ribosomal protein L34 -0.0354526
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0352489
LMNA lamin A/C -0.0343067
RPS21 ribosomal protein S21 -0.0338525
LOC102724023 ES1 protein homolog, mitochondrial -0.0337355
AKAP9 A kinase (PRKA) anchor protein 9 -0.033639
RPS3 ribosomal protein S3 -0.0327705
RPS29 ribosomal protein S29 -0.0327652
SYT1 synaptotagmin I -0.0325694
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0325128
RPL12 ribosomal protein L12 -0.0311926
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0307106
STAU1 staufen double-stranded RNA binding protein 1 -0.030672
RPS6 ribosomal protein S6 -0.0297132
RPS27 ribosomal protein S27 -0.0293883
RPS25 ribosomal protein S25 -0.0289201
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0288869
FTL ferritin, light polypeptide -0.0286862
WSB1 WD repeat and SOCS box containing 1 -0.0285512
ACTG1 actin gamma 1 -0.028541
RPL30 ribosomal protein L30 -0.0284823
RPS19 ribosomal protein S19 -0.0282501
ASPH aspartate beta-hydroxylase -0.0280604
CDK13 cyclin-dependent kinase 13 -0.0269788
AEBP2 AE binding protein 2 -0.0268446
RACK1 receptor for activated C kinase 1 -0.0267969
TPI1 triosephosphate isomerase 1 -0.0259008
RPS23 ribosomal protein S23 -0.0251096
RPS16 ribosomal protein S16 -0.0250063
TMEM263 transmembrane protein 263 -0.0250042
VIM vimentin -0.0249619
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0249553
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0243111
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.024183
RPL35A ribosomal protein L35a -0.02394
PALLD palladin, cytoskeletal associated protein -0.0239048
BHLHE40 basic helix-loop-helix family, member e40 -0.0239033
SOX4 SRY (sex determining region Y)-box 4 -0.0236088
GLCCI1 glucocorticoid induced 1 -0.0235398
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0235147
FNDC3A fibronectin type III domain containing 3A -0.0234266
S100A10 S100 calcium binding protein A10 -0.0231947
SOS1 son of sevenless homolog 1 (Drosophila) -0.0231425
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0231264
RPL36 ribosomal protein L36 -0.0229406
IFI16 interferon, gamma-inducible protein 16 -0.0227871
LY6E lymphocyte antigen 6 complex, locus E -0.0227782
EGR1 early growth response 1 -0.0224946
CALR calreticulin -0.0222813
CALU calumenin -0.0221492
RPL13A ribosomal protein L13a -0.0220158
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0219527
NIPBL Nipped-B homolog (Drosophila) -0.0217952
RPL18 ribosomal protein L18 -0.0217781
NAP1L1 nucleosome assembly protein 1-like 1 -0.0216755
PDLIM5 PDZ and LIM domain 5 -0.0214378
RAI14 retinoic acid induced 14 -0.0213546
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0213317
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0213023
RPL23 ribosomal protein L23 -0.0212705
RPL38 ribosomal protein L38 -0.0211487
CCDC138 coiled-coil domain containing 138 -0.0211211
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0210762
UBAP1 ubiquitin associated protein 1 -0.021059