Focal Glomerulosclerosis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0017668
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Genes

256 genes associated with the disease Focal Glomerulosclerosis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACE angiotensin I converting enzyme
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTB actin, beta
ACTN4 actinin, alpha 4
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADA2 adenosine deaminase 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ALB albumin
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANGPT2 angiopoietin 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANLN anillin, actin binding protein
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
ARHGAP24 Rho GTPase activating protein 24
ATL1 atlastin GTPase 1
B2M beta-2-microglobulin
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BMS1 BMS1 ribosome biogenesis factor
BSG basigin (Ok blood group)
C1QL1 complement component 1, q subcomponent-like 1
C3AR1 complement component 3a receptor 1
CALB2 calbindin 2
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCN2 cellular communication network factor 2
CCR2 chemokine (C-C motif) receptor 2
CD2AP CD2-associated protein
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD80 CD80 molecule
CD9 CD9 molecule
CDC42 cell division cycle 42
CFH complement factor H
CHP1 calcineurin-like EF-hand protein 1
CLCN5 chloride channel, voltage-sensitive 5
CLCNKB chloride channel, voltage-sensitive Kb
CNKSR3 CNKSR family member 3
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COL8A1 collagen, type VIII, alpha 1
COL8A2 collagen, type VIII, alpha 2
COQ6 coenzyme Q6 monooxygenase
COQ8B coenzyme Q8B
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
CP ceruloplasmin (ferroxidase)
CRB2 crumbs family member 2
CRH corticotropin releasing hormone
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCR4 chemokine (C-X-C motif) receptor 4
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
DDN dendrin
DERL2 derlin 2
DMPK dystrophia myotonica-protein kinase
E2F3 E2F transcription factor 3
ECT2 epithelial cell transforming 2
EDN1 endothelin 1
EGF epidermal growth factor
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPHB2 EPH receptor B2
EYA1 EYA transcriptional coactivator and phosphatase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASLG Fas ligand (TNF superfamily, member 6)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FN1 fibronectin 1
G6PC glucose-6-phosphatase, catalytic subunit
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GDF15 growth differentiation factor 15
GH1 growth hormone 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GRAP2 GRB2-related adaptor protein 2
HAVCR1 hepatitis A virus cellular receptor 1
HHIP hedgehog interacting protein
HLA-A major histocompatibility complex, class I, A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HNF1B HNF1 homeobox B
HP haptoglobin
HPSE heparanase
IL10 interleukin 10
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL22 interleukin 22
IL6 interleukin 6
ILK integrin-linked kinase
INF2 inverted formin, FH2 and WH2 domain containing
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KDM6A lysine (K)-specific demethylase 6A
KEAP1 kelch-like ECH-associated protein 1
KIRREL1 kirre like nephrin family adhesion molecule 1
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT20 keratin 20, type I
LAMA5 laminin, alpha 5
LAMB2 laminin, beta 2 (laminin S)
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LIPC lipase, hepatic
LMNA lamin A/C
LMX1B LIM homeobox transcription factor 1, beta
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MLYCD malonyl-CoA decarboxylase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MMRN1 multimerin 1
MPV17 MpV17 mitochondrial inner membrane protein
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYH1 myosin, heavy chain 1, skeletal muscle, adult
MYH10 myosin, heavy chain 10, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYO1E myosin IE
NAGLU N-acetylglucosaminidase, alpha
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NBAS neuroblastoma amplified sequence
NEFH neurofilament, heavy polypeptide
NES nestin
NFE2L2 nuclear factor, erythroid 2-like 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NPHP1 nephronophthisis 1 (juvenile)
NPHP4 nephronophthisis 4
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPNT nephronectin
NRP2 neuropilin 2
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP160 nucleoporin 160kDa
NUP205 nucleoporin 205kDa
NUP85 nucleoporin 85kDa
NUP93 nucleoporin 93kDa
PAX2 paired box 2
PAX8 paired box 8
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PIAS1 protein inhibitor of activated STAT, 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLAU plasminogen activator, urokinase
PLB1 phospholipase B1
PLCE1 phospholipase C, epsilon 1
PLCG1 phospholipase C, gamma 1
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
PLG plasminogen
PLXNA3 plexin A3
PODXL podocalyxin-like
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POMC proopiomelanocortin
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRO protein tyrosine phosphatase, receptor type, O
PTPRU protein tyrosine phosphatase, receptor type, U
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1GAP RAP1 GTPase activating protein
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARA retinoic acid receptor, alpha
REN renin
RHOV ras homolog family member V
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL10A ribosomal protein L10a
RPL17 ribosomal protein L17
RPL23 ribosomal protein L23
S100A4 S100 calcium binding protein A4
SCARB2 scavenger receptor class B, member 2
SCN7A sodium channel, voltage gated, type VII alpha subunit
SDK1 sidekick cell adhesion molecule 1
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGPL1 sphingosine-1-phosphate lyase 1
SIRPA signal-regulatory protein alpha
SIRT1 sirtuin 1
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMAD7 SMAD family member 7
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNX9 sorting nexin 9
SPP1 secreted phosphoprotein 1
STRIP1 striatin interacting protein 1
SYNPO synaptopodin
TAGLN transgelin
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TBPL1 TBP-like 1
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THSD7A thrombospondin, type I, domain containing 7A
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMEM63C transmembrane protein 63C
TNF tumor necrosis factor
TRIM8 tripartite motif containing 8
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TTC21B tetratricopeptide repeat domain 21B
TYRO3 TYRO3 protein tyrosine kinase
TYRP1 tyrosinase-related protein 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBD ubiquitin D
VANGL2 VANGL planar cell polarity protein 2
VASP vasodilator-stimulated phosphoprotein
VCAN versican
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR73 WD repeat domain 73
WT1 Wilms tumor 1
YAP1 Yes-associated protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZDHHC2 zinc finger, DHHC-type containing 2
ZMPSTE24 zinc metallopeptidase STE24