Folic acid_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.367078
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.160593
PLAT plasminogen activator, tissue 0.148598
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.130187
CD44 CD44 molecule (Indian blood group) 0.11442
MT2A metallothionein 2A 0.0746247
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0723498
UBC ubiquitin C 0.0680225
TMSB10 thymosin beta 10 0.0661614
B2M beta-2-microglobulin 0.0652126
POTEF POTE ankyrin domain family, member F 0.0622313
FNDC3B fibronectin type III domain containing 3B 0.0530841
LOX lysyl oxidase 0.0510382
PODXL podocalyxin-like 0.0490946
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0480448
WWTR1 WW domain containing transcription regulator 1 0.0456359
AKAP12 A kinase (PRKA) anchor protein 12 0.0435932
GLIS3 GLIS family zinc finger 3 0.0430849
VIM vimentin 0.0430839
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0426282
PKM pyruvate kinase, muscle 0.0407821
ADAM9 ADAM metallopeptidase domain 9 0.0385585
ANXA2 annexin A2 0.0381753
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0369043
CD99 CD99 molecule 0.0349444
STC1 stanniocalcin 1 0.0344988
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0341768
MCL1 myeloid cell leukemia 1 0.0340069
ATP13A3 ATPase type 13A3 0.0333877
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.033016
MB21D2 Mab-21 domain containing 2 0.0320959
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0314424
DST dystonin 0.0305746
PICALM phosphatidylinositol binding clathrin assembly protein 0.0304389
NEK7 NIMA-related kinase 7 0.0303996
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0303124
DOCK5 dedicator of cytokinesis 5 0.030206
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0288437
APP amyloid beta (A4) precursor protein 0.0280727
NOTCH2 notch 2 0.0279095
C1D C1D nuclear receptor corepressor 0.027788
COL3A1 collagen, type III, alpha 1 0.0277627
TNIP1 TNFAIP3 interacting protein 1 0.0275644
ZNF148 zinc finger protein 148 0.0275411
VEGFC vascular endothelial growth factor C 0.0274578
PSD3 pleckstrin and Sec7 domain containing 3 0.0274377
RTN4 reticulon 4 0.0270166
TPM3 tropomyosin 3 0.0265707
MYADM myeloid-associated differentiation marker 0.026539
FBN1 fibrillin 1 0.0264442
MKI67 marker of proliferation Ki-67 0.0264326
TOP2A topoisomerase (DNA) II alpha 170kDa 0.026397
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0262255
MYH9 myosin, heavy chain 9, non-muscle 0.0261487
ANLN anillin, actin binding protein 0.0259964
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0259875
EEF2 eukaryotic translation elongation factor 2 0.0250053
RHOBTB3 Rho-related BTB domain containing 3 0.0246566
ENO1 enolase 1, (alpha) 0.0243794
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0239949
S100A6 S100 calcium binding protein A6 0.0238347
SRRM2 serine/arginine repetitive matrix 2 0.0236564
TIMP2 TIMP metallopeptidase inhibitor 2 0.0234302
MAP1B microtubule-associated protein 1B 0.0233808
MSN moesin 0.0231805
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0230057
RUNX1 runt-related transcription factor 1 0.0222697
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0222164
SVIL supervillin 0.0221038
RNF145 ring finger protein 145 0.0215549
PFN1 profilin 1 0.0214039
LAMB1 laminin, beta 1 0.0209454
SMAD3 SMAD family member 3 0.0207475
ATXN1 ataxin 1 0.0203982
VMP1 vacuole membrane protein 1 0.0198005
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0197826
ITPRID2 ITPR interacting domain containing 2 0.0197508
RAI14 retinoic acid induced 14 0.0197211
LHFPL6 LHFPL tetraspan subfamily member 6 0.0196003
ADAM19 ADAM metallopeptidase domain 19 0.019376
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0193369
VCL vinculin 0.0190689
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0189912
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0188155
PRRC2C proline-rich coiled-coil 2C 0.0187715
IQGAP1 IQ motif containing GTPase activating protein 1 0.018596
LYST lysosomal trafficking regulator 0.0183209
NFE2L1 nuclear factor, erythroid 2-like 1 0.0180901
IL6ST interleukin 6 signal transducer 0.0178292
DNMBP dynamin binding protein 0.0177945
BIRC2 baculoviral IAP repeat containing 2 0.0177629
ERBIN erbb2 interacting protein 0.0177286
FLNB filamin B, beta 0.0174044
RRM2 ribonucleotide reductase M2 0.0173744
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0171353
XPO1 exportin 1 0.0170637
DCAF6 DDB1 and CUL4 associated factor 6 0.016902
GDI2 GDP dissociation inhibitor 2 0.0165746
IFITM3 interferon induced transmembrane protein 3 0.0163828
EZR ezrin 0.0163531

decreased expression

Symbol Name Standardized Value
ABI3BP ABI family, member 3 (NESH) binding protein -0.117066
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.108033
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0951789
AHNAK AHNAK nucleoprotein -0.0709449
RIGI RNA sensor RIG-I -0.0582011
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0487199
CANX calnexin -0.0479039
FN1 fibronectin 1 -0.046622
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0457558
SAMD9 sterile alpha motif domain containing 9 -0.0446572
COL5A1 collagen, type V, alpha 1 -0.0411892
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0409916
MSI2 musashi RNA-binding protein 2 -0.0407916
SLC39A11 solute carrier family 39, member 11 -0.0406816
ZBTB20 zinc finger and BTB domain containing 20 -0.0399341
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0370915
TRIO trio Rho guanine nucleotide exchange factor -0.0342054
BHLHE40 basic helix-loop-helix family, member e40 -0.0328305
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0320982
CCND1 cyclin D1 -0.0320883
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0311015
FSTL1 follistatin-like 1 -0.0309162
CAVIN1 caveolae associated protein 1 -0.0299308
CDH13 cadherin 13 -0.0297623
LMNA lamin A/C -0.0297413
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0291163
KDM4B lysine (K)-specific demethylase 4B -0.0284583
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0281391
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0277135
TMSB4X thymosin beta 4, X-linked -0.027219
EGFR epidermal growth factor receptor -0.0266848
THBS2 thrombospondin 2 -0.025592
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0251263
AEBP2 AE binding protein 2 -0.0245107
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0236248
SQSTM1 sequestosome 1 -0.0233696
TTC3 tetratricopeptide repeat domain 3 -0.0226064
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0222643
SORBS2 sorbin and SH3 domain containing 2 -0.0222634
IARS1 isoleucyl-tRNA synthetase 1 -0.0221929
IL7R interleukin 7 receptor -0.0219066
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0217786
RRBP1 ribosome binding protein 1 -0.0199409
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0196312
TPT1 tumor protein, translationally-controlled 1 -0.0195701
SOD2 superoxide dismutase 2, mitochondrial -0.0195569
DDR2 discoidin domain receptor tyrosine kinase 2 -0.019532
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0192855
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0192099
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0191921
IFIH1 interferon induced with helicase C domain 1 -0.0190536
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0181656
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0176965
CD109 CD109 molecule -0.0176934
TOX thymocyte selection-associated high mobility group box -0.0176681
ZEB1 zinc finger E-box binding homeobox 1 -0.0174693
INSIG1 insulin induced gene 1 -0.0173962
LARP1B La ribonucleoprotein domain family, member 1B -0.0168681
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0168151
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0167786
TNS3 tensin 3 -0.0166637
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0165407
FLT1 fms-related tyrosine kinase 1 -0.0164736
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.016421
MRPS6 mitochondrial ribosomal protein S6 -0.0162009
NDRG1 N-myc downstream regulated 1 -0.0160418
OASL 2'-5'-oligoadenylate synthetase-like -0.0159409
BZW1 basic leucine zipper and W2 domains 1 -0.0159362
CAPN2 calpain 2, (m/II) large subunit -0.0158717
RPTOR regulatory associated protein of MTOR, complex 1 -0.0156176
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0153901
ARF1 ADP-ribosylation factor 1 -0.0152034
MMP12 matrix metallopeptidase 12 -0.0150959
ADAM32 ADAM metallopeptidase domain 32 -0.0150112
IFI16 interferon, gamma-inducible protein 16 -0.0149509
GOLGB1 golgin B1 -0.0149426
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0148093
CDK13 cyclin-dependent kinase 13 -0.014771
ANKRD10 ankyrin repeat domain 10 -0.0146882
HM13 histocompatibility (minor) 13 -0.0146475
CMIP c-Maf inducing protein -0.0143146
ACTG1 actin gamma 1 -0.0142887
SLFN5 schlafen family member 5 -0.0141323
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0140557
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.013931
SEC24D SEC24 family member D -0.0137717
MAML2 mastermind-like 2 (Drosophila) -0.0137264
LMAN1 lectin, mannose-binding, 1 -0.0136865
MX2 MX dynamin-like GTPase 2 -0.0136288
DENND1A DENN/MADD domain containing 1A -0.013332
LRRC17 leucine rich repeat containing 17 -0.0131371
MYOF myoferlin -0.0129887
RND3 Rho family GTPase 3 -0.0129187
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0128536
EFNA5 ephrin-A5 -0.0128234
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0126932
TENM3 teneurin transmembrane protein 3 -0.0124917
IGFBP3 insulin-like growth factor binding protein 3 -0.0124689
FGFR1 fibroblast growth factor receptor 1 -0.0123161
BIRC6 baculoviral IAP repeat containing 6 -0.0119911