Folic acid_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.185058
IGFBP3 insulin-like growth factor binding protein 3 0.166162
CD44 CD44 molecule (Indian blood group) 0.146721
CXCL8 chemokine (C-X-C motif) ligand 8 0.142389
NRP2 neuropilin 2 0.128311
TXNRD1 thioredoxin reductase 1 0.122928
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.118944
CA12 carbonic anhydrase XII 0.0969759
SMAD3 SMAD family member 3 0.0905808
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0901217
NAMPT nicotinamide phosphoribosyltransferase 0.0868937
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0838227
RAI14 retinoic acid induced 14 0.0829026
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.077584
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0761528
NRIP1 nuclear receptor interacting protein 1 0.0705787
FTH1 ferritin, heavy polypeptide 1 0.0698832
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0691389
VIM vimentin 0.0670146
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0635035
PAX8 paired box 8 0.0611111
FNDC3B fibronectin type III domain containing 3B 0.0604375
JAK1 Janus kinase 1 0.058161
MAP1B microtubule-associated protein 1B 0.0563406
ANXA1 annexin A1 0.0546031
RNF213 ring finger protein 213 0.0541654
GLIS3 GLIS family zinc finger 3 0.0525055
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0514781
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0506801
MYH9 myosin, heavy chain 9, non-muscle 0.0505179
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0491748
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0484799
ANXA2 annexin A2 0.0473836
TRIO trio Rho guanine nucleotide exchange factor 0.046995
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0467332
CSF1 colony stimulating factor 1 (macrophage) 0.0464422
KYNU kynureninase 0.0463295
PKM pyruvate kinase, muscle 0.0461826
PDIA3 protein disulfide isomerase family A, member 3 0.0460859
HLA-B major histocompatibility complex, class I, B 0.0455053
ZFP36L1 ZFP36 ring finger protein-like 1 0.0433057
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0425694
ADAM9 ADAM metallopeptidase domain 9 0.0422105
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0418654
CALU calumenin 0.0406129
DDIT4 DNA-damage-inducible transcript 4 0.0393017
MBNL2 muscleblind-like splicing regulator 2 0.038991
TMSB10 thymosin beta 10 0.0389185
LOXL2 lysyl oxidase-like 2 0.0388145
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0386317
CDCP1 CUB domain containing protein 1 0.0377337
SQSTM1 sequestosome 1 0.0367639
SLTM SAFB-like, transcription modulator 0.0366833
FAT1 FAT atypical cadherin 1 0.036446
MYOF myoferlin 0.036429
UBE2H ubiquitin-conjugating enzyme E2H 0.0360366
ACTN4 actinin, alpha 4 0.0360249
HLA-A major histocompatibility complex, class I, A 0.0358535
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0351258
PLSCR1 phospholipid scramblase 1 0.0347368
UBC ubiquitin C 0.0347336
SOD2 superoxide dismutase 2, mitochondrial 0.0343552
PLK2 polo-like kinase 2 0.0343484
HSPB1 heat shock 27kDa protein 1 0.0337504
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0335201
SPATS2L spermatogenesis associated, serine-rich 2-like 0.033308
KPNB1 karyopherin (importin) beta 1 0.0330968
CANX calnexin 0.0323792
NRP1 neuropilin 1 0.0317142
SRRM2 serine/arginine repetitive matrix 2 0.0316565
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0314422
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.031209
IFI44L interferon-induced protein 44-like 0.0311873
CXXC1 CXXC finger protein 1 0.0310203
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0307459
RIPK2 receptor-interacting serine-threonine kinase 2 0.0307287
PDIA6 protein disulfide isomerase family A, member 6 0.0305884
ICAM1 intercellular adhesion molecule 1 0.0305774
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0305307
TPM4 tropomyosin 4 0.030138
MKI67 marker of proliferation Ki-67 0.0301358
PDIA4 protein disulfide isomerase family A, member 4 0.0297305
UGCG UDP-glucose ceramide glucosyltransferase 0.0296854
DGKD diacylglycerol kinase, delta 130kDa 0.0290805
IL6ST interleukin 6 signal transducer 0.0290575
LMAN1 lectin, mannose-binding, 1 0.0289517
NFE2L2 nuclear factor, erythroid 2-like 2 0.0286097
TUSC3 tumor suppressor candidate 3 0.0285099
MYO1E myosin IE 0.0284633
RPL19 ribosomal protein L19 0.0284118
RTN4 reticulon 4 0.0283383
UBA6 ubiquitin-like modifier activating enzyme 6 0.0280354
APOL1 apolipoprotein L, 1 0.0279256
PBX1 pre-B-cell leukemia homeobox 1 0.0279078
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0277616
TPM1 tropomyosin 1 (alpha) 0.0276693
RPLP1 ribosomal protein, large, P1 0.0274406
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0273229
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0272495
XPO1 exportin 1 0.02711

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.111628
GPC6 glypican 6 -0.0809016
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0655321
ALCAM activated leukocyte cell adhesion molecule -0.051576
TTC3 tetratricopeptide repeat domain 3 -0.0490751
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0417431
PDE4D phosphodiesterase 4D, cAMP-specific -0.0401789
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0362997
ANKRD11 ankyrin repeat domain 11 -0.0345464
SCFD2 sec1 family domain containing 2 -0.0343494
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0343417
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0326315
NUP98 nucleoporin 98kDa -0.0310858
TPT1 tumor protein, translationally-controlled 1 -0.031018
RPL23 ribosomal protein L23 -0.0299503
UBAP2 ubiquitin associated protein 2 -0.0291806
SORCS2 sortilin-related VPS10 domain containing receptor 2 -0.0290025
PTK2 protein tyrosine kinase 2 -0.0289915
KDM6A lysine (K)-specific demethylase 6A -0.028982
KMT2C lysine (K)-specific methyltransferase 2C -0.0284611
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0280196
KDM4C lysine (K)-specific demethylase 4C -0.0269835
INTS6 integrator complex subunit 6 -0.0264794
N4BP1 NEDD4 binding protein 1 -0.0259965
PNPLA8 patatin-like phospholipase domain containing 8 -0.0259616
ATP13A3 ATPase type 13A3 -0.0258163
GLS2 glutaminase 2 (liver, mitochondrial) -0.0257939
TSC22D2 TSC22 domain family, member 2 -0.0249164
HAPSTR1 HUWE1 associated protein modifying stress responses -0.0247261
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0242556
RPL9 ribosomal protein L9 -0.02394
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0237607
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0237238
DENND4A DENN/MADD domain containing 4A -0.023679
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0233257
NUP214 nucleoporin 214kDa -0.0233069
SPAG9 sperm associated antigen 9 -0.0232409
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0230911
OXR1 oxidation resistance 1 -0.0226814
CHD1 chromodomain helicase DNA binding protein 1 -0.0223334
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0222045
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0219794
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.0216832
PHF20L1 PHD finger protein 20-like 1 -0.0215906
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0215672
GSK3B glycogen synthase kinase 3 beta -0.0215127
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0212554
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0210429
RPS8 ribosomal protein S8 -0.0209306
BIRC6 baculoviral IAP repeat containing 6 -0.0208479
GDI2 GDP dissociation inhibitor 2 -0.0206603
BLCAP bladder cancer associated protein -0.0203283
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0203038
EIF1 eukaryotic translation initiation factor 1 -0.0200932
TRIP12 thyroid hormone receptor interactor 12 -0.0200602
CDK13 cyclin-dependent kinase 13 -0.0200177
RANBP2 RAN binding protein 2 -0.0199612
LAMA5 laminin, alpha 5 -0.0197438
RBM33 RNA binding motif protein 33 -0.0196247
CGNL1 cingulin-like 1 -0.0195253
BBS9 Bardet-Biedl syndrome 9 -0.0195106
RPL27 ribosomal protein L27 -0.0194281
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -0.0194129
CADM1 cell adhesion molecule 1 -0.0191231
THRAP3 thyroid hormone receptor associated protein 3 -0.0191224
PRRC2C proline-rich coiled-coil 2C -0.0190942
RIGI RNA sensor RIG-I -0.0190495
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0189665
ARHGAP24 Rho GTPase activating protein 24 -0.0187725
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0187132
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0185796
RPL34 ribosomal protein L34 -0.0183399
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0182984
MAPK8 mitogen-activated protein kinase 8 -0.0182556
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0181996
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -0.0181515
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0180966
COG5 component of oligomeric golgi complex 5 -0.0177897
ZMAT3 zinc finger, matrin-type 3 -0.0177821
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0175765
AHCTF1 AT hook containing transcription factor 1 -0.0175238
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0174557
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0173598
PDHX pyruvate dehydrogenase complex, component X -0.0173204
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0172454
CEP350 centrosomal protein 350kDa -0.0172115
ATP11C ATPase, class VI, type 11C -0.017136
FAM120A family with sequence similarity 120A -0.0171063
TSPAN9 tetraspanin 9 -0.0170828
PTBP3 polypyrimidine tract binding protein 3 -0.0170211
PTPRF protein tyrosine phosphatase, receptor type, F -0.0169204
NIPBL Nipped-B homolog (Drosophila) -0.0169102
RPS12 ribosomal protein S12 -0.0169047
COL5A1 collagen, type V, alpha 1 -0.0168968
LENG8 leukocyte receptor cluster (LRC) member 8 -0.0168469
KIF5B kinesin family member 5B -0.0168141
IFT74 intraflagellar transport 74 -0.016748
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0167225
MON2 MON2 homolog (S. cerevisiae) -0.0167099
BRD4 bromodomain containing 4 -0.0166912