Folic acid_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 0.159414
SRCIN1 SRC kinase signaling inhibitor 1 0.0751743
NCOA3 nuclear receptor coactivator 3 0.0694055
THSD4 thrombospondin, type I, domain containing 4 0.0594331
CATSPERB catsper channel auxiliary subunit beta 0.0549374
ITCH itchy E3 ubiquitin protein ligase 0.0526063
FBXL20 F-box and leucine-rich repeat protein 20 0.051805
FNDC3A fibronectin type III domain containing 3A 0.0495344
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0495101
SMYD3 SET and MYND domain containing 3 0.0467002
CEMIP cell migration inducing protein, hyaluronan binding 0.041867
YAP1 Yes-associated protein 1 0.0411738
ASPH aspartate beta-hydroxylase 0.0379499
ADARB1 adenosine deaminase, RNA-specific, B1 0.037456
INTS6 integrator complex subunit 6 0.0361827
EXT1 exostosin glycosyltransferase 1 0.0361459
FNDC3B fibronectin type III domain containing 3B 0.0354738
DTNA dystrobrevin, alpha 0.0344156
PDLIM5 PDZ and LIM domain 5 0.0341793
RAB22A RAB22A, member RAS oncogene family 0.0334723
MCL1 myeloid cell leukemia 1 0.0332957
STRN3 striatin, calmodulin binding protein 3 0.0332599
ZSWIM6 zinc finger, SWIM-type containing 6 0.0331136
CLTC clathrin, heavy chain (Hc) 0.0331019
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0330787
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0329244
ZFAND3 zinc finger, AN1-type domain 3 0.0313366
LIMCH1 LIM and calponin homology domains 1 0.0303733
ANKRD36C ankyrin repeat domain 36C 0.0301315
RCOR1 REST corepressor 1 0.0292724
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0286593
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0286301
RIMS2 regulating synaptic membrane exocytosis 2 0.0284529
ENAH enabled homolog (Drosophila) 0.0284242
DIAPH1 diaphanous-related formin 1 0.0283556
FAM219A family with sequence similarity 219, member A 0.0280828
UBE2H ubiquitin-conjugating enzyme E2H 0.0271645
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0268141
RABGAP1 RAB GTPase activating protein 1 0.0259839
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0258689
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0256319
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0256215
CDK12 cyclin-dependent kinase 12 0.0254754
GATAD2B GATA zinc finger domain containing 2B 0.0253516
SRPK2 SRSF protein kinase 2 0.0252686
SAMD12 sterile alpha motif domain containing 12 0.024897
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0246329
KMT2C lysine (K)-specific methyltransferase 2C 0.0245102
PTK2 protein tyrosine kinase 2 0.0242193
AHCTF1 AT hook containing transcription factor 1 0.0240178
SFPQ splicing factor proline/glutamine-rich 0.0237852
MYH9 myosin, heavy chain 9, non-muscle 0.0237469
TMCC1 transmembrane and coiled-coil domain family 1 0.0237061
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0234874
SBF2 SET binding factor 2 0.023477
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0231108
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.0230611
GRB10 growth factor receptor-bound protein 10 0.0228689
LPP LIM domain containing preferred translocation partner in lipoma 0.0228015
POTEF POTE ankyrin domain family, member F 0.0227692
SGMS1 sphingomyelin synthase 1 0.0225561
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0223465
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0223448
SOS2 son of sevenless homolog 2 (Drosophila) 0.0222792
RBM4 RNA binding motif protein 4 0.0219631
ARHGAP26 Rho GTPase activating protein 26 0.0219163
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0218525
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0218256
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0217379
GSK3B glycogen synthase kinase 3 beta 0.0216268
STXBP4 syntaxin binding protein 4 0.0213732
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0213648
ADGRG6 adhesion G protein-coupled receptor G6 0.0212311
ANKRD17 ankyrin repeat domain 17 0.0211824
KIAA1217 KIAA1217 0.0211749
NRIP1 nuclear receptor interacting protein 1 0.0210777
ZC3H11A zinc finger CCCH-type containing 11A 0.0209352
BCAS3 breast carcinoma amplified sequence 3 0.0207128
ANKRD11 ankyrin repeat domain 11 0.020702
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0206923
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0206841
PATJ PATJ crumbs cell polarity complex component 0.0206716
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0206703
KDM6A lysine (K)-specific demethylase 6A 0.0205594
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0204029
FAM168A family with sequence similarity 168, member A 0.0203689
ATXN1 ataxin 1 0.020354
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0202708
PARD3 par-3 family cell polarity regulator 0.0202646
USP32 ubiquitin specific peptidase 32 0.0202356
USP9X ubiquitin specific peptidase 9, X-linked 0.0198966
NEBL nebulette 0.0195691
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0195321
TRPS1 trichorhinophalangeal syndrome I 0.01942
AHR aryl hydrocarbon receptor 0.0194182
DOCK5 dedicator of cytokinesis 5 0.019416
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0191902
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.019053
TOM1L1 target of myb1 (chicken)-like 1 0.0190216
WNK1 WNK lysine deficient protein kinase 1 0.0189564

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.197318
RPL19 ribosomal protein L19 -0.165071
ZMYND8 zinc finger, MYND-type containing 8 -0.160808
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.109178
PTMA prothymosin, alpha -0.104276
ACTG1 actin gamma 1 -0.0810155
TPT1 tumor protein, translationally-controlled 1 -0.0801937
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0800893
SLC38A1 solute carrier family 38, member 1 -0.0704551
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.066732
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0626745
RPS3 ribosomal protein S3 -0.0622446
TMSB4X thymosin beta 4, X-linked -0.0607716
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0567064
RPL12 ribosomal protein L12 -0.0553313
LASP1 LIM and SH3 protein 1 -0.0538526
BZW1 basic leucine zipper and W2 domains 1 -0.051255
RPS8 ribosomal protein S8 -0.0476427
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0463307
RPS24 ribosomal protein S24 -0.0452984
IGFBP5 insulin-like growth factor binding protein 5 -0.0441463
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0433051
GRB7 growth factor receptor-bound protein 7 -0.0432304
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0411643
RPL35A ribosomal protein L35a -0.040928
B2M beta-2-microglobulin -0.0402958
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0398929
WSB1 WD repeat and SOCS box containing 1 -0.0376468
RPL34 ribosomal protein L34 -0.0375994
MYL12B myosin, light chain 12B, regulatory -0.0365897
CCND1 cyclin D1 -0.035654
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0353229
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.034292
NAMPT nicotinamide phosphoribosyltransferase -0.0336687
PFDN4 prefoldin subunit 4 -0.0331442
IFI6 interferon, alpha-inducible protein 6 -0.0328777
RPL37 ribosomal protein L37 -0.0324962
HLA-B major histocompatibility complex, class I, B -0.0323832
RPL11 ribosomal protein L11 -0.0323772
EIF1 eukaryotic translation initiation factor 1 -0.0322182
KRT19 keratin 19, type I -0.0318265
RPS12 ribosomal protein S12 -0.0314576
RSL1D1 ribosomal L1 domain containing 1 -0.0309673
LDHA lactate dehydrogenase A -0.0302743
RPL9 ribosomal protein L9 -0.0298109
KDM3A lysine (K)-specific demethylase 3A -0.0298064
RPS6 ribosomal protein S6 -0.0295549
RPL26 ribosomal protein L26 -0.0293272
RPS27A ribosomal protein S27a -0.0289533
GNAS GNAS complex locus -0.0287621
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0285021
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0282612
MT2A metallothionein 2A -0.0277313
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0277121
RRBP1 ribosome binding protein 1 -0.0272506
FTL ferritin, light polypeptide -0.0271323
RPLP0 ribosomal protein, large, P0 -0.0264293
HLA-C major histocompatibility complex, class I, C -0.0263676
VDAC1 voltage-dependent anion channel 1 -0.0263394
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0260941
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0258261
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0256749
CANX calnexin -0.0254275
IER3 immediate early response 3 -0.0253947
RPL7A ribosomal protein L7a -0.0253689
TMSB10 thymosin beta 10 -0.0252364
CCNI cyclin I -0.025105
RPL27A ribosomal protein L27a -0.0250234
RPL37A ribosomal protein L37a -0.0242924
RPS29 ribosomal protein S29 -0.0241301
TPM4 tropomyosin 4 -0.0237521
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.023566
IFIH1 interferon induced with helicase C domain 1 -0.0234045
RPLP1 ribosomal protein, large, P1 -0.0228226
SEPTIN7 septin 7 -0.022697
EPCAM epithelial cell adhesion molecule -0.02235
RACK1 receptor for activated C kinase 1 -0.0223267
RPS13 ribosomal protein S13 -0.0221572
LMAN1 lectin, mannose-binding, 1 -0.0219831
HMGB1 high mobility group box 1 -0.0218876
LMNA lamin A/C -0.021703
S100A10 S100 calcium binding protein A10 -0.0214758
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0214169
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0212638
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0211441
PGK1 phosphoglycerate kinase 1 -0.0209713
FDPS farnesyl diphosphate synthase -0.0208806
RAD21 RAD21 homolog (S. pombe) -0.0207392
TMEM123 transmembrane protein 123 -0.0206631
SQSTM1 sequestosome 1 -0.0198016
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0197352
RPL36 ribosomal protein L36 -0.0197044
DSTN destrin (actin depolymerizing factor) -0.0196882
VIM vimentin -0.0196786
RPS25 ribosomal protein S25 -0.0196434
NAP1L1 nucleosome assembly protein 1-like 1 -0.0194794
DICER1 dicer 1, ribonuclease type III -0.0194122
KDM5B lysine (K)-specific demethylase 5B -0.0194116
SET SET nuclear proto-oncogene -0.0192553
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0191798