Folic acid_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERBB4 erb-b2 receptor tyrosine kinase 4 0.192123
COL5A2 collagen, type V, alpha 2 0.166254
TOX thymocyte selection-associated high mobility group box 0.109653
ADGRG6 adhesion G protein-coupled receptor G6 0.0988563
SOX5 SRY (sex determining region Y)-box 5 0.0821362
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0819103
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0785746
RERE arginine-glutamic acid dipeptide (RE) repeats 0.073451
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.072807
JMJD1C jumonji domain containing 1C 0.0647181
NALF1 NALCN channel auxiliary factor 1 0.0567484
USP9X ubiquitin specific peptidase 9, X-linked 0.056387
DST dystonin 0.0538892
VMP1 vacuole membrane protein 1 0.0518467
CDH18 cadherin 18, type 2 0.0510696
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.048675
KDM6A lysine (K)-specific demethylase 6A 0.0481762
RAD51B RAD51 paralog B 0.0462884
SFPQ splicing factor proline/glutamine-rich 0.0462321
PCBP2 poly(rC) binding protein 2 0.0378653
RPL3 ribosomal protein L3 0.0373499
YAP1 Yes-associated protein 1 0.0370488
GRID2 glutamate receptor, ionotropic, delta 2 0.0364462
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0358438
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0356045
CARD18 caspase recruitment domain family, member 18 0.032102
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0306287
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0303912
MCL1 myeloid cell leukemia 1 0.0301774
RCOR1 REST corepressor 1 0.0301127
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0289603
TBC1D5 TBC1 domain family, member 5 0.0289143
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0280377
CABIN1 calcineurin binding protein 1 0.0268194
EEF2 eukaryotic translation elongation factor 2 0.0267883
SSBP2 single-stranded DNA binding protein 2 0.0260563
NFIA nuclear factor I/A 0.0260054
EGR1 early growth response 1 0.025807
ZNF608 zinc finger protein 608 0.025788
POTEF POTE ankyrin domain family, member F 0.0257159
NUP58 nucleoporin 58 0.0255086
BNC2 basonuclin 2 0.024997
VCL vinculin 0.0245152
BCAS3 breast carcinoma amplified sequence 3 0.0244989
VEGFC vascular endothelial growth factor C 0.0240928
ANK2 ankyrin 2, neuronal 0.023789
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0236528
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0228714
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0226896
PHF21A PHD finger protein 21A 0.0226707
NFIB nuclear factor I/B 0.0221836
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0217985
CCNL1 cyclin L1 0.0216898
ADAM9 ADAM metallopeptidase domain 9 0.0215175
UBA6 ubiquitin-like modifier activating enzyme 6 0.021492
TMEM41B transmembrane protein 41B 0.0212495
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0212149
KMT2C lysine (K)-specific methyltransferase 2C 0.0211832
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0210781
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0208635
TENM3 teneurin transmembrane protein 3 0.0205868
CXXC4 CXXC finger protein 4 0.020504
SNX3 sorting nexin 3 0.020497
KMT2E lysine (K)-specific methyltransferase 2E 0.0203186
PDE8A phosphodiesterase 8A 0.0201773
ELF2 E74-like factor 2 (ets domain transcription factor) 0.020086
AUTS2 autism susceptibility candidate 2 0.0200431
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0198707
USP34 ubiquitin specific peptidase 34 0.0197472
EXOC6B exocyst complex component 6B 0.0196868
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0195727
MAML3 mastermind-like 3 (Drosophila) 0.019357
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0192622
PDE4D phosphodiesterase 4D, cAMP-specific 0.0192275
SPRED2 sprouty-related, EVH1 domain containing 2 0.018949
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0187968
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0186418
CEP112 centrosomal protein 112kDa 0.0185742
TSC22D2 TSC22 domain family, member 2 0.0185287
FOXP1 forkhead box P1 0.0182329
TRAPPC9 trafficking protein particle complex 9 0.0178792
STIM2 stromal interaction molecule 2 0.0178645
SP3 Sp3 transcription factor 0.0177888
ANKRD36 ankyrin repeat domain 36 0.0177588
SCAF8 SR-related CTD-associated factor 8 0.0177153
MARCHF7 membrane associated ring-CH-type finger 7 0.0176869
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.017469
USP47 ubiquitin specific peptidase 47 0.0172806
CCDC14 coiled-coil domain containing 14 0.017247
GPHN gephyrin 0.0171654
TBK1 TANK-binding kinase 1 0.0169339
WDFY3 WD repeat and FYVE domain containing 3 0.0169193
PARD3B par-3 family cell polarity regulator beta 0.0168842
TTC28 tetratricopeptide repeat domain 28 0.0168487
TRIP12 thyroid hormone receptor interactor 12 0.0168085
RNF145 ring finger protein 145 0.0167689
SMAD4 SMAD family member 4 0.0166717
ADAM17 ADAM metallopeptidase domain 17 0.0166045
PCM1 pericentriolar material 1 0.0163556
HOMER1 homer scaffolding protein 1 0.0162186

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.12824
PTMA prothymosin, alpha -0.119528
NEBL nebulette -0.100771
TMSB10 thymosin beta 10 -0.100286
ACTG1 actin gamma 1 -0.0965767
RPS6 ribosomal protein S6 -0.0911918
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0848709
RPS8 ribosomal protein S8 -0.0791871
RPS24 ribosomal protein S24 -0.0724674
RPL11 ribosomal protein L11 -0.0700635
RPLP1 ribosomal protein, large, P1 -0.0690834
SOX4 SRY (sex determining region Y)-box 4 -0.0690393
TRIO trio Rho guanine nucleotide exchange factor -0.0635492
RPS21 ribosomal protein S21 -0.0601158
RPL12 ribosomal protein L12 -0.0562718
LDHA lactate dehydrogenase A -0.0553961
RPL26 ribosomal protein L26 -0.0545907
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0543921
RPS19 ribosomal protein S19 -0.0541013
TPT1 tumor protein, translationally-controlled 1 -0.0540623
RPL37A ribosomal protein L37a -0.0538476
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0514183
RPL34 ribosomal protein L34 -0.0504582
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.050242
RPL23 ribosomal protein L23 -0.0496527
RPL35A ribosomal protein L35a -0.0483661
GNAS GNAS complex locus -0.0481447
RPLP2 ribosomal protein, large, P2 -0.0472984
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0463938
RSL1D1 ribosomal L1 domain containing 1 -0.0458093
RPS11 ribosomal protein S11 -0.0455796
HMGB1 high mobility group box 1 -0.0453958
RPS27A ribosomal protein S27a -0.0448592
RPL38 ribosomal protein L38 -0.0431034
KPNB1 karyopherin (importin) beta 1 -0.0430572
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0423663
DEK DEK proto-oncogene -0.0422928
RPL31 ribosomal protein L31 -0.0421108
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0421038
RPL19 ribosomal protein L19 -0.0417377
PGK1 phosphoglycerate kinase 1 -0.040239
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0397918
RACK1 receptor for activated C kinase 1 -0.0395081
RPS3 ribosomal protein S3 -0.0393554
VDAC1 voltage-dependent anion channel 1 -0.0379522
RPS5 ribosomal protein S5 -0.0378677
NAP1L1 nucleosome assembly protein 1-like 1 -0.0371215
RPLP0 ribosomal protein, large, P0 -0.0369675
LOC112694756 uncharaterized LOC112694756 -0.0366581
GJA1 gap junction protein, alpha 1, 43kDa -0.0365455
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.036005
RPS13 ribosomal protein S13 -0.0359327
CANX calnexin -0.0359255
RPL28 ribosomal protein L28 -0.0357606
ACACA acetyl-CoA carboxylase alpha -0.0356159
RPS28 ribosomal protein S28 -0.0349108
CAVIN1 caveolae associated protein 1 -0.0348055
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0334497
HMGA1 high mobility group AT-hook 1 -0.032858
RPL32 ribosomal protein L32 -0.0326077
RPL36A ribosomal protein L36a -0.032591
RPL13A ribosomal protein L13a -0.0325727
NARS1 asparaginyl-tRNA synthetase 1 -0.0324976
RPL8 ribosomal protein L8 -0.0315184
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0313833
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0312041
LARS1 leucyl-tRNA synthetase 1 -0.031012
RPL18 ribosomal protein L18 -0.0309042
ZNF33A zinc finger protein 33A -0.030886
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.030885
NF1 neurofibromin 1 -0.0308359
SERBP1 SERPINE1 mRNA binding protein 1 -0.0302667
RPS29 ribosomal protein S29 -0.0301438
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0299931
S100A9 S100 calcium binding protein A9 -0.0299287
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0296655
BLTP2 bridge-like lipid transfer protein family member 2 -0.0294334
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0293576
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0292295
WSB1 WD repeat and SOCS box containing 1 -0.0291228
EIF5B eukaryotic translation initiation factor 5B -0.028975
RPL4 ribosomal protein L4 -0.0288318
RPS14 ribosomal protein S14 -0.0287859
TUBB tubulin, beta class I -0.0286452
CCDC47 coiled-coil domain containing 47 -0.0283871
KDM3A lysine (K)-specific demethylase 3A -0.0281761
RPS16 ribosomal protein S16 -0.0280575
MAP4 microtubule-associated protein 4 -0.027872
RPL36 ribosomal protein L36 -0.0278485
HMGB2 high mobility group box 2 -0.0275814
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0274183
EMP1 epithelial membrane protein 1 -0.027291
IARS1 isoleucyl-tRNA synthetase 1 -0.0268123
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0263905
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.026349
NT5C2 5'-nucleotidase, cytosolic II -0.0259813
RPL37 ribosomal protein L37 -0.0258312
IFI6 interferon, alpha-inducible protein 6 -0.0256275
ZNF217 zinc finger protein 217 -0.0255586
RPL7L1 ribosomal protein L7-like 1 -0.0255582