Folic acid_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.166991
EFNA5 ephrin-A5 0.11354
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0873413
IGFBP3 insulin-like growth factor binding protein 3 0.0688729
NRG3 neuregulin 3 0.068528
DST dystonin 0.0681965
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0582592
MAML2 mastermind-like 2 (Drosophila) 0.0577975
SMAD3 SMAD family member 3 0.0511878
RAD51B RAD51 paralog B 0.0485137
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.045808
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0448269
NAMPT nicotinamide phosphoribosyltransferase 0.0443788
BICC1 BicC family RNA binding protein 1 0.0440746
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0416603
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0413744
EXT1 exostosin glycosyltransferase 1 0.0405745
RUNX1 runt-related transcription factor 1 0.0391693
PARD3 par-3 family cell polarity regulator 0.0389857
SMYD3 SET and MYND domain containing 3 0.038179
PCDH7 protocadherin 7 0.0376616
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0346431
ELL2 elongation factor, RNA polymerase II, 2 0.0342382
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0340732
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0328087
NDRG1 N-myc downstream regulated 1 0.032271
PDZD8 PDZ domain containing 8 0.0322613
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0316273
TRIO trio Rho guanine nucleotide exchange factor 0.0315602
OSMR oncostatin M receptor 0.0311099
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0311048
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0309758
ARHGAP26 Rho GTPase activating protein 26 0.0304019
HMGA2 high mobility group AT-hook 2 0.0296996
TGM2 transglutaminase 2 0.0296588
NRP1 neuropilin 1 0.0293438
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0283992
PICALM phosphatidylinositol binding clathrin assembly protein 0.0281917
FAM13A family with sequence similarity 13, member A 0.0280526
TSC22D2 TSC22 domain family, member 2 0.0279519
LAMC2 laminin, gamma 2 0.0277406
KIAA1217 KIAA1217 0.0269236
NALF1 NALCN channel auxiliary factor 1 0.0267905
ERRFI1 ERBB receptor feedback inhibitor 1 0.0264934
LPP LIM domain containing preferred translocation partner in lipoma 0.026201
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0260034
ITGA1 integrin, alpha 1 0.0258926
GLIS3 GLIS family zinc finger 3 0.0257099
ATXN1 ataxin 1 0.0257047
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0254704
KMT2E lysine (K)-specific methyltransferase 2E 0.0254451
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0249323
ESYT2 extended synaptotagmin-like protein 2 0.0248239
PDGFC platelet derived growth factor C 0.0243389
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0242718
LMO7 LIM domain 7 0.0241095
HPCAL1 hippocalcin-like 1 0.0237646
DNAH11 dynein, axonemal, heavy chain 11 0.0235296
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0224872
KYNU kynureninase 0.0224704
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.022427
GRB10 growth factor receptor-bound protein 10 0.0222451
MACF1 microtubule-actin crosslinking factor 1 0.0221307
MYO1B myosin IB 0.0220547
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0220184
JAG1 jagged 1 0.0220046
IRAK3 interleukin-1 receptor-associated kinase 3 0.0219174
PRELID2 PRELI domain containing 2 0.021753
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.0215764
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0215127
CLMN calmin (calponin-like, transmembrane) 0.0213474
TGFB2 transforming growth factor, beta 2 0.0212251
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.021207
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0211697
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0211424
AHR aryl hydrocarbon receptor 0.0211336
ZFAND3 zinc finger, AN1-type domain 3 0.020943
ADAM28 ADAM metallopeptidase domain 28 0.0208946
ZBTB20 zinc finger and BTB domain containing 20 0.0206327
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0205223
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.020397
MEF2A myocyte enhancer factor 2A 0.0202623
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0202047
ARHGAP32 Rho GTPase activating protein 32 0.0201891
RIN2 Ras and Rab interactor 2 0.020043
TBC1D22A TBC1 domain family, member 22A 0.0199559
RTN4 reticulon 4 0.0198374
NCKAP5 NCK-associated protein 5 0.0196941
BCAR3 breast cancer anti-estrogen resistance 3 0.0196501
FAT1 FAT atypical cadherin 1 0.0195153
WWC1 WW and C2 domain containing 1 0.0193333
NUMB numb homolog (Drosophila) 0.0192806
SLTM SAFB-like, transcription modulator 0.019246
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0191786
LARP4B La ribonucleoprotein domain family, member 4B 0.0191248
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0190617
HELZ helicase with zinc finger 0.0189053
ALCAM activated leukocyte cell adhesion molecule 0.0188832
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.018854
SLC35F5 solute carrier family 35, member F5 0.0186899

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.197487
UBC ubiquitin C -0.176336
TMSB10 thymosin beta 10 -0.124957
PTMA prothymosin, alpha -0.123362
B2M beta-2-microglobulin -0.108668
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0869975
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0848707
MT1X metallothionein 1X -0.0845737
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.082262
EIF1 eukaryotic translation initiation factor 1 -0.0752473
RPL23 ribosomal protein L23 -0.0728755
VIM vimentin -0.0722036
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0699235
ENO1 enolase 1, (alpha) -0.0672428
TMSB4X thymosin beta 4, X-linked -0.0644624
HLA-B major histocompatibility complex, class I, B -0.062301
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0600301
RPS27A ribosomal protein S27a -0.0598875
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0575348
TPT1 tumor protein, translationally-controlled 1 -0.0560369
KRT19 keratin 19, type I -0.0510781
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0486647
RPS8 ribosomal protein S8 -0.0471479
C15ORF48 chromosome 15 open reading frame 48 -0.0466717
RPS3 ribosomal protein S3 -0.0425691
S100A6 S100 calcium binding protein A6 -0.04233
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0420955
HLA-E major histocompatibility complex, class I, E -0.041426
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.040735
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0387297
RPL19 ribosomal protein L19 -0.0379335
AKAP12 A kinase (PRKA) anchor protein 12 -0.0377596
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0374206
ACTG1 actin gamma 1 -0.036511
ISG15 ISG15 ubiquitin-like modifier -0.0362012
MT1E metallothionein 1E -0.0351076
FTL ferritin, light polypeptide -0.0350135
LAMB3 laminin, beta 3 -0.0344217
PCBP2 poly(rC) binding protein 2 -0.0332952
LOC112694756 uncharaterized LOC112694756 -0.0332606
IFI27 interferon, alpha-inducible protein 27 -0.0331598
HMGA1 high mobility group AT-hook 1 -0.0329161
RPL34 ribosomal protein L34 -0.0328466
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0323285
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.031811
KTN1 kinectin 1 (kinesin receptor) -0.0298655
APOL1 apolipoprotein L, 1 -0.0292878
RPL9 ribosomal protein L9 -0.0288038
CALR calreticulin -0.0284925
JUN jun proto-oncogene -0.0282941
EIF4A1 eukaryotic translation initiation factor 4A1 -0.027965
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0274877
RACK1 receptor for activated C kinase 1 -0.0274699
PDIA3 protein disulfide isomerase family A, member 3 -0.0274
RPS12 ribosomal protein S12 -0.0269367
EPCAM epithelial cell adhesion molecule -0.0268446
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0264069
TXNIP thioredoxin interacting protein -0.0264048
IFITM1 interferon induced transmembrane protein 1 -0.026316
TM4SF1 transmembrane 4 L six family member 1 -0.0262759
CSTB cystatin B (stefin B) -0.0258301
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0251883
S100A10 S100 calcium binding protein A10 -0.0239189
AREG amphiregulin -0.0238959
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0237523
RPL12 ribosomal protein L12 -0.0237402
LDHA lactate dehydrogenase A -0.0236114
ANXA2 annexin A2 -0.0235543
RPL37A ribosomal protein L37a -0.0234155
RPLP0 ribosomal protein, large, P0 -0.0233857
PDIA4 protein disulfide isomerase family A, member 4 -0.0232341
IFI6 interferon, alpha-inducible protein 6 -0.0231621
GCC2 GRIP and coiled-coil domain containing 2 -0.0228609
RPLP1 ribosomal protein, large, P1 -0.0228002
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0226058
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0223785
DSG2 desmoglein 2 -0.0221518
PDIA6 protein disulfide isomerase family A, member 6 -0.0219578
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0219375
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0217214
HLA-A major histocompatibility complex, class I, A -0.0216497
RPL5 ribosomal protein L5 -0.0214197
RPS6 ribosomal protein S6 -0.0211997
LASP1 LIM and SH3 protein 1 -0.0208078
SLC38A1 solute carrier family 38, member 1 -0.0207187
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0205571
CANX calnexin -0.0205181
PLAU plasminogen activator, urokinase -0.0204969
AKAP9 A kinase (PRKA) anchor protein 9 -0.0196767
IFITM3 interferon induced transmembrane protein 3 -0.0193041
RPS19 ribosomal protein S19 -0.0192904
GNAS GNAS complex locus -0.0192184
EEF2 eukaryotic translation elongation factor 2 -0.019131
SP100 SP100 nuclear antigen -0.0189849
PRRC2C proline-rich coiled-coil 2C -0.0189184
RPS24 ribosomal protein S24 -0.0188747
CCNI cyclin I -0.0187196
IFI16 interferon, gamma-inducible protein 16 -0.018656
NAP1L1 nucleosome assembly protein 1-like 1 -0.0185295
SDC4 syndecan 4 -0.0182967