Folic acid_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase 0.120971
STS steroid sulfatase (microsomal), isozyme S 0.106447
SYNE2 spectrin repeat containing, nuclear envelope 2 0.103298
LMO7 LIM domain 7 0.0984086
ARHGAP26 Rho GTPase activating protein 26 0.0906802
EXT1 exostosin glycosyltransferase 1 0.0884533
ITGA6 integrin, alpha 6 0.0854708
MACC1 metastasis associated in colon cancer 1 0.0769686
LCN2 lipocalin 2 0.0763527
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0712314
ZMYND8 zinc finger, MYND-type containing 8 0.0711482
ERBIN erbb2 interacting protein 0.0700192
EPSTI1 epithelial stromal interaction 1 (breast) 0.0684633
LYZ lysozyme 0.0660308
MSI2 musashi RNA-binding protein 2 0.0637974
FTH1 ferritin, heavy polypeptide 1 0.0637283
PRKCA protein kinase C, alpha 0.0596131
SPATA13 spermatogenesis associated 13 0.0591834
FNDC3B fibronectin type III domain containing 3B 0.0580661
TRIO trio Rho guanine nucleotide exchange factor 0.0549937
TMC5 transmembrane channel-like 5 0.0547805
MAML2 mastermind-like 2 (Drosophila) 0.0543192
ATP10B ATPase, class V, type 10B 0.0516047
CEMIP cell migration inducing protein, hyaluronan binding 0.0510651
NPSR1 neuropeptide S receptor 1 0.0498153
ETV6 ets variant 6 0.0493993
IGFBP3 insulin-like growth factor binding protein 3 0.0492187
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0486352
EPS8 epidermal growth factor receptor pathway substrate 8 0.0450347
TSHZ2 teashirt zinc finger homeobox 2 0.0444786
PTMA prothymosin, alpha 0.0443639
SQSTM1 sequestosome 1 0.0438561
JUN jun proto-oncogene 0.0423063
AREG amphiregulin 0.0415989
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.0414458
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0412004
TRIM2 tripartite motif containing 2 0.0401691
SSH2 slingshot protein phosphatase 2 0.039892
SORBS1 sorbin and SH3 domain containing 1 0.0395798
MYO1E myosin IE 0.0392132
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0391562
EPHB2 EPH receptor B2 0.0387182
CXCL8 chemokine (C-X-C motif) ligand 8 0.0377156
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0372854
RAB7A RAB7A, member RAS oncogene family 0.0371153
LOC102724023 ES1 protein homolog, mitochondrial 0.0371042
MUC13 mucin 13, cell surface associated 0.0347429
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0345578
MX1 MX dynamin-like GTPase 1 0.0341712
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0337678
C6ORF132 chromosome 6 open reading frame 132 0.033767
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0337045
PTGR1 prostaglandin reductase 1 0.0324356
IFI27 interferon, alpha-inducible protein 27 0.0316353
HLA-B major histocompatibility complex, class I, B 0.0315705
BAIAP2L1 BAI1-associated protein 2-like 1 0.0314578
IGF1R insulin-like growth factor 1 receptor 0.0312334
BCL2L1 BCL2-like 1 0.0311632
SLC38A1 solute carrier family 38, member 1 0.0310627
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0309614
CATSPERB catsper channel auxiliary subunit beta 0.0305106
XAF1 XIAP associated factor 1 0.0301736
EZR ezrin 0.030011
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0297877
TMSB10 thymosin beta 10 0.0297456
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0295009
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0294889
SOD2 superoxide dismutase 2, mitochondrial 0.0291266
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.028664
RBM47 RNA binding motif protein 47 0.0282028
EGR1 early growth response 1 0.02795
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0277399
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0273338
MYH14 myosin, heavy chain 14, non-muscle 0.0273198
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0272948
ATP11A ATPase, class VI, type 11A 0.0270573
ZNRF3 zinc and ring finger 3 0.0269016
KYNU kynureninase 0.0268362
FHIT fragile histidine triad 0.0262489
ANXA2 annexin A2 0.0262017
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0260438
FTL ferritin, light polypeptide 0.0257003
SMAD3 SMAD family member 3 0.0253198
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0251997
AKAP13 A kinase (PRKA) anchor protein 13 0.0245469
NPAS2 neuronal PAS domain protein 2 0.024365
BACE2 beta-site APP-cleaving enzyme 2 0.0242898
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0236449
USP54 ubiquitin specific peptidase 54 0.0234944
MX2 MX dynamin-like GTPase 2 0.0234931
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0231984
POTEF POTE ankyrin domain family, member F 0.023152
CYSTM1 cysteine-rich transmembrane module containing 1 0.0229769
TM4SF1 transmembrane 4 L six family member 1 0.0228984
RASAL2 RAS protein activator like 2 0.0227694
DIAPH1 diaphanous-related formin 1 0.0226999
MCL1 myeloid cell leukemia 1 0.0225496
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0224812
JMJD1C jumonji domain containing 1C 0.0223145
B2M beta-2-microglobulin 0.0222542

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.198913
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0966245
DSCAM Down syndrome cell adhesion molecule -0.069369
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.069105
BTBD9 BTB (POZ) domain containing 9 -0.0684572
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0666239
PHF3 PHD finger protein 3 -0.0635416
TXNIP thioredoxin interacting protein -0.0599583
PDIA3 protein disulfide isomerase family A, member 3 -0.0538004
INTS6 integrator complex subunit 6 -0.0530343
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0523522
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0510799
NRIP1 nuclear receptor interacting protein 1 -0.0492997
GOLGB1 golgin B1 -0.0490415
TM9SF2 transmembrane 9 superfamily member 2 -0.0478023
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0458193
AHI1 Abelson helper integration site 1 -0.0456295
FNDC3A fibronectin type III domain containing 3A -0.0444059
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.043556
ZMYM2 zinc finger, MYM-type 2 -0.0434736
IFNGR1 interferon gamma receptor 1 -0.0424148
CANX calnexin -0.0420958
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0415568
MBNL2 muscleblind-like splicing regulator 2 -0.041236
SBF2 SET binding factor 2 -0.0396926
HDLBP high density lipoprotein binding protein -0.0388584
TPT1 tumor protein, translationally-controlled 1 -0.0379443
SUCO SUN domain containing ossification factor -0.0375943
SEC24D SEC24 family member D -0.0369249
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0367702
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0342978
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0341837
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0332373
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0329893
BCLAF1 BCL2-associated transcription factor 1 -0.0315528
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0313811
RBM39 RNA binding motif protein 39 -0.0302272
AKAP9 A kinase (PRKA) anchor protein 9 -0.029887
PLSCR2 phospholipid scramblase 2 -0.0298782
NCKAP5 NCK-associated protein 5 -0.0296967
COG6 component of oligomeric golgi complex 6 -0.0292736
USP3 ubiquitin specific peptidase 3 -0.0291871
TTC3 tetratricopeptide repeat domain 3 -0.028332
GOLGA4 golgin A4 -0.0277957
RNF43 ring finger protein 43 -0.0277721
FNIP1 folliculin interacting protein 1 -0.0275812
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0273586
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0263633
PTBP3 polypyrimidine tract binding protein 3 -0.0261672
KMT2C lysine (K)-specific methyltransferase 2C -0.0259321
PDIA4 protein disulfide isomerase family A, member 4 -0.0252726
MAP7 microtubule-associated protein 7 -0.0252341
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.025043
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0247998
SSR1 signal sequence receptor, alpha -0.024764
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0245707
OARD1 O-acyl-ADP-ribose deacylase 1 -0.0241899
COPB1 coatomer protein complex, subunit beta 1 -0.024068
PIBF1 progesterone immunomodulatory binding factor 1 -0.0239804
HELZ helicase with zinc finger -0.0236963
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0236207
ARGLU1 arginine and glutamate rich 1 -0.0235042
TBPL1 TBP-like 1 -0.0234345
MCTP2 multiple C2 domains, transmembrane 2 -0.023139
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0231127
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0229355
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0226325
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.022499
EPCAM epithelial cell adhesion molecule -0.0223853
EHF ets homologous factor -0.0223702
MATR3 matrin 3 -0.0223423
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0222719
LMAN1 lectin, mannose-binding, 1 -0.022016
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0218609
TSC22D2 TSC22 domain family, member 2 -0.021694
KDM3A lysine (K)-specific demethylase 3A -0.0216746
HBS1L HBS1-like translational GTPase -0.0215879
TMED2 transmembrane emp24 domain trafficking protein 2 -0.0215638
TMEM39A transmembrane protein 39A -0.0215103
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0214296
RRBP1 ribosome binding protein 1 -0.0211035
PRELID2 PRELI domain containing 2 -0.0210338
CLTC clathrin, heavy chain (Hc) -0.0209972
STK24 serine/threonine kinase 24 -0.0208419
PDIA5 protein disulfide isomerase family A, member 5 -0.0207786
RBM26 RNA binding motif protein 26 -0.0206585
OGA O-GlcNAcase -0.0206347
CALR calreticulin -0.0205763
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0203953
ZNF451 zinc finger protein 451 -0.0202689
EIF1 eukaryotic translation initiation factor 1 -0.0202457
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.01985
CEP350 centrosomal protein 350kDa -0.0197555
SERP1 stress-associated endoplasmic reticulum protein 1 -0.0196525
MED13L mediator complex subunit 13-like -0.0196041
ERP44 endoplasmic reticulum protein 44 -0.0194967
NUCB2 nucleobindin 2 -0.0193927
DIAPH3 diaphanous-related formin 3 -0.0193026
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0192376
WSB1 WD repeat and SOCS box containing 1 -0.019211