Folic acid_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.285126
PTMA prothymosin, alpha 0.146472
POTEF POTE ankyrin domain family, member F 0.108984
EZR ezrin 0.0861535
MKI67 marker of proliferation Ki-67 0.085668
ENO1 enolase 1, (alpha) 0.0745685
TENM3 teneurin transmembrane protein 3 0.0745338
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0647214
EEF2 eukaryotic translation elongation factor 2 0.0582121
TMSB10 thymosin beta 10 0.0521134
RPL3 ribosomal protein L3 0.0495373
WWOX WW domain containing oxidoreductase 0.0468828
TOP2A topoisomerase (DNA) II alpha 170kDa 0.046168
MED13L mediator complex subunit 13-like 0.0428372
FAF1 Fas (TNFRSF6) associated factor 1 0.0426082
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0422493
SFPQ splicing factor proline/glutamine-rich 0.041223
MYH9 myosin, heavy chain 9, non-muscle 0.0408837
TUBA1B tubulin, alpha 1b 0.0400332
RRM2 ribonucleotide reductase M2 0.0399039
FLNA filamin A, alpha 0.0394508
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0390065
MACF1 microtubule-actin crosslinking factor 1 0.0359486
DIAPH3 diaphanous-related formin 3 0.0358292
SPIDR scaffolding protein involved in DNA repair 0.0354156
PKM pyruvate kinase, muscle 0.0349149
H1-2 H1.2 linker histone, cluster member 0.0347419
DST dystonin 0.0345288
NUP50 nucleoporin 50kDa 0.0338777
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0335152
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0322288
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0321713
CORO1C coronin, actin binding protein, 1C 0.031218
FTH1 ferritin, heavy polypeptide 1 0.0304342
H1-4 H1.4 linker histone, cluster member 0.0303504
CBX5 chromobox homolog 5 0.0302245
PTBP3 polypyrimidine tract binding protein 3 0.0300925
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0300848
SMC4 structural maintenance of chromosomes 4 0.0299915
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0288691
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0288004
SUMF1 sulfatase modifying factor 1 0.0286195
WWC1 WW and C2 domain containing 1 0.0285903
EGFR epidermal growth factor receptor 0.0284004
SEPTIN9 septin 9 0.0275905
FOXP1 forkhead box P1 0.0274722
FRMD5 FERM domain containing 5 0.027247
PTPRG protein tyrosine phosphatase, receptor type, G 0.0272119
TRAPPC9 trafficking protein particle complex 9 0.027099
MSI2 musashi RNA-binding protein 2 0.0269862
H1-0 H1.0 linker histone 0.026958
TXNRD1 thioredoxin reductase 1 0.0269408
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0268282
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0267967
HMGA2 high mobility group AT-hook 2 0.0267111
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0265549
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0262872
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0262344
TXNIP thioredoxin interacting protein 0.0261583
SIK3 SIK family kinase 3 0.0261378
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0259742
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0257985
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0256081
SRRM2 serine/arginine repetitive matrix 2 0.0253071
YAP1 Yes-associated protein 1 0.0252898
RNF213 ring finger protein 213 0.025288
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0251953
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0248938
PCDH7 protocadherin 7 0.0248675
ACTG1 actin gamma 1 0.0246529
ATAD2 ATPase family, AAA domain containing 2 0.0245722
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0243205
PICALM phosphatidylinositol binding clathrin assembly protein 0.0241587
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0241536
FUS FUS RNA binding protein 0.0241305
BRD4 bromodomain containing 4 0.0239587
ATXN10 ataxin 10 0.0238958
MACROH2A1 macroH2A.1 histone 0.0238798
IGF2 insulin-like growth factor 2 0.023678
XPO1 exportin 1 0.0235958
ERBIN erbb2 interacting protein 0.0235389
DIAPH1 diaphanous-related formin 1 0.0228825
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0227986
RCOR1 REST corepressor 1 0.0227977
TMPO thymopoietin 0.0226396
ACTN4 actinin, alpha 4 0.0225696
GMDS GDP-mannose 4,6-dehydratase 0.0225005
LGALS12 lectin, galactoside-binding, soluble, 12 0.022435
ENO2 enolase 2 (gamma, neuronal) 0.0221237
HELLS helicase, lymphoid-specific 0.0221233
NXN nucleoredoxin 0.0220802
ANXA2 annexin A2 0.0217923
GSE1 Gse1 coiled-coil protein 0.0217234
LPP LIM domain containing preferred translocation partner in lipoma 0.0216966
NFIB nuclear factor I/B 0.0214193
PA2G4 proliferation-associated 2G4, 38kDa 0.0213945
JUN jun proto-oncogene 0.0213147
ZNRF3 zinc and ring finger 3 0.0211489
BCL2L1 BCL2-like 1 0.0211311
SRSF3 serine/arginine-rich splicing factor 3 0.0209161

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.112225
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102224
TPT1 tumor protein, translationally-controlled 1 -0.0939646
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0934723
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0810165
AHNAK AHNAK nucleoprotein -0.0726868
GOLGA4 golgin A4 -0.0708187
DSCAM Down syndrome cell adhesion molecule -0.0707741
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0691261
CANX calnexin -0.0677693
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0609616
PGK1 phosphoglycerate kinase 1 -0.0554039
PATJ PATJ crumbs cell polarity complex component -0.0543929
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0543836
ANKRD12 ankyrin repeat domain 12 -0.0542774
COPB1 coatomer protein complex, subunit beta 1 -0.0517326
PRELID2 PRELI domain containing 2 -0.0477538
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.047682
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0451071
PHF3 PHD finger protein 3 -0.0448535
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0437495
NF1 neurofibromin 1 -0.0433615
GOLGB1 golgin B1 -0.0431411
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0421332
RPLP0 ribosomal protein, large, P0 -0.0413051
VCL vinculin -0.0405947
NAP1L1 nucleosome assembly protein 1-like 1 -0.0405408
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0399267
SEC31A SEC31 homolog A (S. cerevisiae) -0.0393633
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0390654
RPS2 ribosomal protein S2 -0.03789
FDPS farnesyl diphosphate synthase -0.0377816
BIRC6 baculoviral IAP repeat containing 6 -0.0374989
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0370302
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.036977
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0367813
TMEM263 transmembrane protein 263 -0.036461
EIF1 eukaryotic translation initiation factor 1 -0.0363586
BACE2 beta-site APP-cleaving enzyme 2 -0.035922
ARHGAP5 Rho GTPase activating protein 5 -0.0352091
RPS24 ribosomal protein S24 -0.0350562
TM9SF3 transmembrane 9 superfamily member 3 -0.0348689
LDHA lactate dehydrogenase A -0.0348667
BRWD3 bromodomain and WD repeat domain containing 3 -0.034468
HDLBP high density lipoprotein binding protein -0.0342345
KRT19 keratin 19, type I -0.0337272
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0336802
SEC24D SEC24 family member D -0.0333343
TKT transketolase -0.0327004
BTBD9 BTB (POZ) domain containing 9 -0.0326143
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0323553
CCNI cyclin I -0.032249
ARF1 ADP-ribosylation factor 1 -0.0318643
WSB1 WD repeat and SOCS box containing 1 -0.0316012
NAMPT nicotinamide phosphoribosyltransferase -0.0307035
TTC3 tetratricopeptide repeat domain 3 -0.0306911
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0304772
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0303209
RNMT RNA (guanine-7-) methyltransferase -0.0302547
HMGB2 high mobility group box 2 -0.0301989
CCDC47 coiled-coil domain containing 47 -0.0301871
RPL4 ribosomal protein L4 -0.0300486
RACK1 receptor for activated C kinase 1 -0.029831
KDM3A lysine (K)-specific demethylase 3A -0.0295681
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0295635
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.029513
BBX bobby sox homolog (Drosophila) -0.0295004
RBM39 RNA binding motif protein 39 -0.0294812
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0294182
RPL34 ribosomal protein L34 -0.0292625
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0290444
UBE2B ubiquitin-conjugating enzyme E2B -0.0290336
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.029022
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0289967
MATR3 matrin 3 -0.0289597
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0288887
GARS1 glycyl-tRNA synthetase 1 -0.0288516
SPAG9 sperm associated antigen 9 -0.0287919
AKAP9 A kinase (PRKA) anchor protein 9 -0.0284858
RLF rearranged L-myc fusion -0.0283986
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 -0.0283494
PLAUR plasminogen activator, urokinase receptor -0.0283048
RIOK3 RIO kinase 3 -0.028226
RPL7A ribosomal protein L7a -0.0281788
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0275914
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0275782
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0274761
SCARB1 scavenger receptor class B, member 1 -0.0271077
TFRC transferrin receptor -0.0269939
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.026834
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0268337
NBAS neuroblastoma amplified sequence -0.0267761
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0267652
TOR1AIP2 torsin A interacting protein 2 -0.0266567
USP37 ubiquitin specific peptidase 37 -0.0266087
RPS8 ribosomal protein S8 -0.0265944
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0260944
RPL13A ribosomal protein L13a -0.0260701
FAM114A1 family with sequence similarity 114, member A1 -0.026042
TBC1D22A TBC1 domain family, member 22A -0.0258689