Folic acid_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.15584
POTEF POTE ankyrin domain family, member F 0.0966174
TXNRD1 thioredoxin reductase 1 0.0650992
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0642667
ITGB8 integrin, beta 8 0.0593914
ANLN anillin, actin binding protein 0.0584476
WWOX WW domain containing oxidoreductase 0.0549827
MACROD2 MACRO domain containing 2 0.0530476
DIAPH1 diaphanous-related formin 1 0.05152
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0510204
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0503476
FLNA filamin A, alpha 0.0501568
PTMA prothymosin, alpha 0.0496794
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0472988
SMAD3 SMAD family member 3 0.0463637
PRELID2 PRELI domain containing 2 0.045879
PDE4D phosphodiesterase 4D, cAMP-specific 0.04318
FTH1 ferritin, heavy polypeptide 1 0.0428456
MKI67 marker of proliferation Ki-67 0.0423321
TBC1D5 TBC1 domain family, member 5 0.0417589
PCBP2 poly(rC) binding protein 2 0.0415291
MYEOV myeloma overexpressed 0.0401959
PKM pyruvate kinase, muscle 0.0392496
BCL2L1 BCL2-like 1 0.0390341
RNF145 ring finger protein 145 0.0385676
ADAM9 ADAM metallopeptidase domain 9 0.0379023
EZR ezrin 0.0358564
PCLO piccolo presynaptic cytomatrix protein 0.0352399
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0351809
CORO1C coronin, actin binding protein, 1C 0.0351734
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0349721
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0347869
DIAPH3 diaphanous-related formin 3 0.0346986
SRRM2 serine/arginine repetitive matrix 2 0.0344169
SNX9 sorting nexin 9 0.0337389
PAX8 paired box 8 0.0335634
PDGFC platelet derived growth factor C 0.0333376
SETD5 SET domain containing 5 0.032652
BARD1 BRCA1 associated RING domain 1 0.0326372
RPS29 ribosomal protein S29 0.0325845
XPO1 exportin 1 0.0324538
RPL35A ribosomal protein L35a 0.0323265
FAT1 FAT atypical cadherin 1 0.0322458
RAD51B RAD51 paralog B 0.032062
TRIO trio Rho guanine nucleotide exchange factor 0.0318176
BICC1 BicC family RNA binding protein 1 0.0313104
TRA2B transformer 2 beta homolog (Drosophila) 0.0309123
CCNL1 cyclin L1 0.030876
AXL AXL receptor tyrosine kinase 0.0308645
MATR3 matrin 3 0.0306533
RTN4 reticulon 4 0.0304118
OXR1 oxidation resistance 1 0.0294231
FAF1 Fas (TNFRSF6) associated factor 1 0.0293678
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0292458
UTRN utrophin 0.0292342
RPLP1 ribosomal protein, large, P1 0.029176
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0288217
ANKRD36 ankyrin repeat domain 36 0.0283267
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0280593
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0279894
UPP1 uridine phosphorylase 1 0.027633
FOSL1 FOS-like antigen 1 0.0274788
NRIP1 nuclear receptor interacting protein 1 0.0273732
BBS9 Bardet-Biedl syndrome 9 0.0272659
HELZ helicase with zinc finger 0.0270637
SFPQ splicing factor proline/glutamine-rich 0.0268807
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0263607
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0262986
WWC1 WW and C2 domain containing 1 0.0262915
PRRC2C proline-rich coiled-coil 2C 0.0262495
CBX5 chromobox homolog 5 0.0262384
PARD3B par-3 family cell polarity regulator beta 0.0260737
MACROH2A1 macroH2A.1 histone 0.0260133
ECT2 epithelial cell transforming 2 0.0260098
SUMF1 sulfatase modifying factor 1 0.0257758
UBA6 ubiquitin-like modifier activating enzyme 6 0.0257482
NKTR natural killer cell triggering receptor 0.0257009
ATP13A3 ATPase type 13A3 0.0255486
VIM vimentin 0.0253405
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.025275
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0249765
ANXA11 annexin A11 0.0248748
SCAF8 SR-related CTD-associated factor 8 0.0248324
KDM4C lysine (K)-specific demethylase 4C 0.0246971
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0246329
KPNB1 karyopherin (importin) beta 1 0.0245222
RHEX regulator of hemoglobinization and erythroid cell expansion 0.024229
OGA O-GlcNAcase 0.024131
ZSWIM5 zinc finger, SWIM-type containing 5 0.0240931
EGR1 early growth response 1 0.0238455
WNK1 WNK lysine deficient protein kinase 1 0.0237675
TFDP1 transcription factor Dp-1 0.0236775
PHIP pleckstrin homology domain interacting protein 0.0235602
PICALM phosphatidylinositol binding clathrin assembly protein 0.0234673
RPLP2 ribosomal protein, large, P2 0.0234533
RABGAP1L RAB GTPase activating protein 1-like 0.0232951
PLS3 plastin 3 0.0232151
NFIB nuclear factor I/B 0.023205
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0228208
CKAP5 cytoskeleton associated protein 5 0.0224653

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.157995
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.132951
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103957
TMSB4X thymosin beta 4, X-linked -0.0931254
TPT1 tumor protein, translationally-controlled 1 -0.0915127
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.081957
LAMB3 laminin, beta 3 -0.0819218
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0763245
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0737702
ALCAM activated leukocyte cell adhesion molecule -0.0732398
AHNAK AHNAK nucleoprotein -0.0658711
CANX calnexin -0.0594084
IGFBP3 insulin-like growth factor binding protein 3 -0.056814
GOLGA4 golgin A4 -0.0558086
KRT7 keratin 7, type II -0.0534734
DSG2 desmoglein 2 -0.0528313
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.052548
LDHA lactate dehydrogenase A -0.0513721
RPLP0 ribosomal protein, large, P0 -0.0493502
VCAN versican -0.0492194
IARS1 isoleucyl-tRNA synthetase 1 -0.0478095
CD44 CD44 molecule (Indian blood group) -0.0461657
EGFR epidermal growth factor receptor -0.0438963
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0433069
GNAS GNAS complex locus -0.0430108
ANKRD10 ankyrin repeat domain 10 -0.0416529
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0414382
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0413438
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.041164
AHNAK2 AHNAK nucleoprotein 2 -0.0411296
LOC112694756 uncharaterized LOC112694756 -0.039951
APP amyloid beta (A4) precursor protein -0.0397842
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0396756
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0390536
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0384514
RACK1 receptor for activated C kinase 1 -0.038383
RTN3 reticulon 3 -0.0380242
SQSTM1 sequestosome 1 -0.0378598
RSL1D1 ribosomal L1 domain containing 1 -0.0366352
CAPN2 calpain 2, (m/II) large subunit -0.0365329
EIF1 eukaryotic translation initiation factor 1 -0.0359388
ADAM32 ADAM metallopeptidase domain 32 -0.0358188
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0357404
S100A10 S100 calcium binding protein A10 -0.0355412
ACTG1 actin gamma 1 -0.0354126
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0352067
KRT19 keratin 19, type I -0.0350194
HMGA2 high mobility group AT-hook 2 -0.0350034
ZBTB20 zinc finger and BTB domain containing 20 -0.0348489
ANXA2 annexin A2 -0.0346756
RPL23 ribosomal protein L23 -0.0346506
RPS6 ribosomal protein S6 -0.0345479
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0344695
EREG epiregulin -0.0340771
LAMC2 laminin, gamma 2 -0.0336878
RPL12 ribosomal protein L12 -0.033592
SH3KBP1 SH3-domain kinase binding protein 1 -0.033391
RPL32 ribosomal protein L32 -0.0331729
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0327108
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0325134
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0324198
SPAG9 sperm associated antigen 9 -0.0320842
MYOF myoferlin -0.0319856
CCDC138 coiled-coil domain containing 138 -0.0319609
TOP2A topoisomerase (DNA) II alpha 170kDa -0.031755
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.031499
SPDYA speedy/RINGO cell cycle regulator family member A -0.0313796
NABP1 nucleic acid binding protein 1 -0.0311573
SERBP1 SERPINE1 mRNA binding protein 1 -0.0310897
RPL34 ribosomal protein L34 -0.0309505
GARS1 glycyl-tRNA synthetase 1 -0.0303189
LAMA4 laminin, alpha 4 -0.0302432
NAP1L1 nucleosome assembly protein 1-like 1 -0.0301694
PDIA5 protein disulfide isomerase family A, member 5 -0.0298986
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0295116
DLC1 DLC1 Rho GTPase activating protein -0.0295108
AEBP2 AE binding protein 2 -0.0292119
TFRC transferrin receptor -0.0288651
WWTR1 WW domain containing transcription regulator 1 -0.0287007
RPS24 ribosomal protein S24 -0.0284815
TTC3 tetratricopeptide repeat domain 3 -0.0284422
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0283947
MBNL2 muscleblind-like splicing regulator 2 -0.0278551
EMP1 epithelial membrane protein 1 -0.0278252
MAP4 microtubule-associated protein 4 -0.0278178
BZW1 basic leucine zipper and W2 domains 1 -0.0276173
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0272478
LPP LIM domain containing preferred translocation partner in lipoma -0.0271727
RPL9 ribosomal protein L9 -0.0269063
KRT18 keratin 18, type I -0.0268883
KRT86 keratin 86, type II -0.0267846
RAB7A RAB7A, member RAS oncogene family -0.0266537
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.0262561
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.026141
RAB10 RAB10, member RAS oncogene family -0.0258968
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0258104
TPM4 tropomyosin 4 -0.0257876
RPS2 ribosomal protein S2 -0.0257385
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0255063
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0254867