Folic acid_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.140508
RPLP1 ribosomal protein, large, P1 0.0906621
STK24 serine/threonine kinase 24 0.0774714
BCL2L1 BCL2-like 1 0.0728148
RPS19 ribosomal protein S19 0.0700403
SMAD3 SMAD family member 3 0.0645547
FAT1 FAT atypical cadherin 1 0.0643206
EZR ezrin 0.0605894
RPLP2 ribosomal protein, large, P2 0.0599999
MYH9 myosin, heavy chain 9, non-muscle 0.0502556
CTNND1 catenin (cadherin-associated protein), delta 1 0.0493426
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0471368
ADARB1 adenosine deaminase, RNA-specific, B1 0.0466521
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0440328
TXNRD1 thioredoxin reductase 1 0.0433348
MYO1E myosin IE 0.0432751
RPS16 ribosomal protein S16 0.0431854
SPRED2 sprouty-related, EVH1 domain containing 2 0.0416942
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0416174
AHNAK AHNAK nucleoprotein 0.0406472
EXT1 exostosin glycosyltransferase 1 0.0395295
PDZD8 PDZ domain containing 8 0.0391559
WWC1 WW and C2 domain containing 1 0.0386569
RPS11 ribosomal protein S11 0.0380222
ANXA11 annexin A11 0.0376046
LATS2 large tumor suppressor kinase 2 0.0375878
ACTN4 actinin, alpha 4 0.0371125
ARHGAP23 Rho GTPase activating protein 23 0.0360054
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0359977
PRR5L proline rich 5 like 0.0352738
RHPN2 rhophilin, Rho GTPase binding protein 2 0.035127
CLIC5 chloride intracellular channel 5 0.0348576
RPL28 ribosomal protein L28 0.034355
GSE1 Gse1 coiled-coil protein 0.0341039
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0338229
TRAPPC9 trafficking protein particle complex 9 0.0331834
SAMD4A sterile alpha motif domain containing 4A 0.0330105
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0315329
PPL periplakin 0.0313962
NTN4 netrin 4 0.0311701
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0308475
NIBAN2 niban apoptosis regulator 2 0.0306895
RPL23 ribosomal protein L23 0.0304484
CTBP2 C-terminal binding protein 2 0.030072
MBNL1 muscleblind-like splicing regulator 1 0.0299683
RPL21 ribosomal protein L21 0.0293164
RNF43 ring finger protein 43 0.0290511
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0279413
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0275215
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0270593
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0269442
SMYD3 SET and MYND domain containing 3 0.0265594
NCEH1 neutral cholesterol ester hydrolase 1 0.0264134
PLA2R1 phospholipase A2 receptor 1, 180kDa 0.0257859
PLK2 polo-like kinase 2 0.0243068
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0241458
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0240243
ARHGAP42 Rho GTPase activating protein 42 0.0239278
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0238544
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0237793
RPL5 ribosomal protein L5 0.0236454
FLNB filamin B, beta 0.0235908
SHROOM3 shroom family member 3 0.0226849
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.0226392
ITGB4 integrin, beta 4 0.0223879
YPEL2 yippee-like 2 (Drosophila) 0.022221
FLNA filamin A, alpha 0.0214048
RPS29 ribosomal protein S29 0.0211207
RPS21 ribosomal protein S21 0.0210991
RPL36 ribosomal protein L36 0.0210584
TGFA transforming growth factor, alpha 0.0206764
OSBPL10 oxysterol binding protein-like 10 0.020478
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0203879
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0202073
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0201371
UTRN utrophin 0.0200695
ATAD2 ATPase family, AAA domain containing 2 0.0198282
FOXO1 forkhead box O1 0.0198122
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0195419
DOCK5 dedicator of cytokinesis 5 0.0195157
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.019429
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0192565
RPL31 ribosomal protein L31 0.019015
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0189473
RPL32 ribosomal protein L32 0.0187698
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0187256
TNRC18 trinucleotide repeat containing 18 0.0185114
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0183189
AGRN agrin 0.0182595
PLEC plectin 0.0179922
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0178587
RPS15 ribosomal protein S15 0.017737
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0176685
YAP1 Yes-associated protein 1 0.0176231
DIAPH1 diaphanous-related formin 1 0.0174156
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0174077
WDPCP WD repeat containing planar cell polarity effector 0.0173111
KIAA0232 KIAA0232 0.017255
PARD3B par-3 family cell polarity regulator beta 0.0171742
PICALM phosphatidylinositol binding clathrin assembly protein 0.0171108

decreased expression

Symbol Name Standardized Value
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.164742
TPT1 tumor protein, translationally-controlled 1 -0.157443
NDRG1 N-myc downstream regulated 1 -0.147812
MYH14 myosin, heavy chain 14, non-muscle -0.122268
FRY furry homolog (Drosophila) -0.122022
PTMA prothymosin, alpha -0.121582
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103362
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0955688
KRT20 keratin 20, type I -0.0941066
PDIA3 protein disulfide isomerase family A, member 3 -0.0835587
FTH1 ferritin, heavy polypeptide 1 -0.0778441
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0761961
RAD21 RAD21 homolog (S. pombe) -0.0758045
PGK1 phosphoglycerate kinase 1 -0.0735699
LDHA lactate dehydrogenase A -0.0722861
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.072065
FNDC3B fibronectin type III domain containing 3B -0.0692412
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0690034
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0684024
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0680236
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.065431
AGR2 anterior gradient 2 -0.0609851
B2M beta-2-microglobulin -0.0609281
MMP7 matrix metallopeptidase 7 -0.0595891
LYZ lysozyme -0.0595462
HM13 histocompatibility (minor) 13 -0.0591671
INTS6 integrator complex subunit 6 -0.0588981
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0574999
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0556815
AREG amphiregulin -0.0542961
FTL ferritin, light polypeptide -0.0542094
GMDS GDP-mannose 4,6-dehydratase -0.0519305
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0513563
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0500844
KRT19 keratin 19, type I -0.0500726
FAM13A family with sequence similarity 13, member A -0.049309
SQSTM1 sequestosome 1 -0.0490041
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0483523
IARS1 isoleucyl-tRNA synthetase 1 -0.0482186
GOLGA4 golgin A4 -0.0473888
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0472324
TMEM123 transmembrane protein 123 -0.0471922
ZNF292 zinc finger protein 292 -0.0459131
CD2AP CD2-associated protein -0.0447038
ENO1 enolase 1, (alpha) -0.044599
SEC31A SEC31 homolog A (S. cerevisiae) -0.0438938
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0423388
ASPH aspartate beta-hydroxylase -0.0419497
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0413535
GARS1 glycyl-tRNA synthetase 1 -0.0411813
CANX calnexin -0.0406129
EPB41 erythrocyte membrane protein band 4.1 -0.0403958
LARP1B La ribonucleoprotein domain family, member 1B -0.0401162
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0396411
DIAPH2 diaphanous-related formin 2 -0.0395055
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0390825
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0389825
RNF213 ring finger protein 213 -0.0387534
GNAS GNAS complex locus -0.0386811
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0385931
LOC102724023 ES1 protein homolog, mitochondrial -0.0385573
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0382618
GOLGB1 golgin B1 -0.0375621
EGR1 early growth response 1 -0.037293
TMEM65 transmembrane protein 65 -0.0366948
ACTG1 actin gamma 1 -0.0354059
LAMA4 laminin, alpha 4 -0.0353629
ARHGAP32 Rho GTPase activating protein 32 -0.0349731
RPS6 ribosomal protein S6 -0.0346277
SQLE squalene epoxidase -0.034391
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0342601
JUN jun proto-oncogene -0.034088
PHF3 PHD finger protein 3 -0.0338617
INSIG1 insulin induced gene 1 -0.0337489
FAM162A family with sequence similarity 162, member A -0.0337362
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0337335
RPLP0 ribosomal protein, large, P0 -0.0335415
ZFAND3 zinc finger, AN1-type domain 3 -0.0332051
HKDC1 hexokinase domain containing 1 -0.0328023
RAB1A RAB1A, member RAS oncogene family -0.0327759
BBX bobby sox homolog (Drosophila) -0.0327682
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0325726
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0325116
KDM3A lysine (K)-specific demethylase 3A -0.0324448
WDR45B WD repeat domain 45B -0.0322702
KIF5B kinesin family member 5B -0.0321605
CCNY cyclin Y -0.0314094
PDIA6 protein disulfide isomerase family A, member 6 -0.0312935
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0312285
SLC38A1 solute carrier family 38, member 1 -0.0311425
MAGT1 magnesium transporter 1 -0.0311268
RAB7A RAB7A, member RAS oncogene family -0.0311069
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0308329
NIPBL Nipped-B homolog (Drosophila) -0.0307844
KMT2C lysine (K)-specific methyltransferase 2C -0.0306748
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.030547
ACACA acetyl-CoA carboxylase alpha -0.030475
CUX1 cut-like homeobox 1 -0.0304066
CALU calumenin -0.0300211
CENPF centromere protein F, 350/400kDa -0.0298014