Folic acid_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 0.0796918
FN1 fibronectin 1 0.0700241
LRMDA leucine rich melanocyte differentiation associated 0.0542033
FNDC3B fibronectin type III domain containing 3B 0.0507142
AFDN afadin, adherens junction formation factor 0.0504442
TRIO trio Rho guanine nucleotide exchange factor 0.0484688
SAMD4A sterile alpha motif domain containing 4A 0.0463595
RBM39 RNA binding motif protein 39 0.0448079
FRMD5 FERM domain containing 5 0.0440569
SPTBN1 spectrin, beta, non-erythrocytic 1 0.043488
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0415744
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.041124
TNS1 tensin 1 0.0397798
MAML2 mastermind-like 2 (Drosophila) 0.0397625
RUNX1 runt-related transcription factor 1 0.0377418
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0372641
APOB apolipoprotein B 0.0364815
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0363942
GRB10 growth factor receptor-bound protein 10 0.0358547
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0353129
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0352979
ERRFI1 ERBB receptor feedback inhibitor 1 0.0349223
JMJD1C jumonji domain containing 1C 0.0332828
DNAH17 dynein, axonemal, heavy chain 17 0.0330691
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.032899
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0326747
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0325023
ABTB3 ankyrin repeat and BTB domain containing 3 0.0323348
GPC6 glypican 6 0.0322864
TBC1D22A TBC1 domain family, member 22A 0.0319951
ATP10A ATPase, class V, type 10A 0.0318319
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0314658
IGF1R insulin-like growth factor 1 receptor 0.0313318
SMAD3 SMAD family member 3 0.0313283
ANO6 anoctamin 6 0.030938
MACF1 microtubule-actin crosslinking factor 1 0.03063
MYH9 myosin, heavy chain 9, non-muscle 0.0293511
VMP1 vacuole membrane protein 1 0.0290053
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0289064
FAT1 FAT atypical cadherin 1 0.0277272
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0276738
EHBP1 EH domain binding protein 1 0.027013
NPAS2 neuronal PAS domain protein 2 0.0264472
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0264154
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0262888
KDM3A lysine (K)-specific demethylase 3A 0.0260646
DOCK4 dedicator of cytokinesis 4 0.0255138
FAM13A family with sequence similarity 13, member A 0.0253897
MTUS1 microtubule associated tumor suppressor 1 0.0250372
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0246969
FLNB filamin B, beta 0.0246389
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.024538
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0245055
KDM7A lysine (K)-specific demethylase 7A 0.0242301
NKD1 naked cuticle homolog 1 (Drosophila) 0.0238904
ESYT2 extended synaptotagmin-like protein 2 0.0238175
SVIL supervillin 0.0235488
RAI14 retinoic acid induced 14 0.0230911
KIAA1217 KIAA1217 0.0230617
TMEM181 transmembrane protein 181 0.0229746
PTK2 protein tyrosine kinase 2 0.0228846
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0227188
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0222562
CRLS1 cardiolipin synthase 1 0.0222252
MSI2 musashi RNA-binding protein 2 0.0215573
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0214726
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0209922
FCHSD2 FCH and double SH3 domains 2 0.0208732
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0207908
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0207678
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0207405
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0206919
ARHGAP9 Rho GTPase activating protein 9 0.0206637
FERMT1 fermitin family member 1 0.0205926
HELZ helicase with zinc finger 0.0203776
OSMR oncostatin M receptor 0.0202071
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0201343
BHLHE40 basic helix-loop-helix family, member e40 0.0200929
PEG3 paternally expressed 3 0.0200709
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.019765
LCOR ligand dependent nuclear receptor corepressor 0.0195296
ZNF292 zinc finger protein 292 0.0195115
FBXO42 F-box protein 42 0.0194508
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.0193985
ARHGAP21 Rho GTPase activating protein 21 0.0192405
FMNL2 formin-like 2 0.0192295
ZMYND8 zinc finger, MYND-type containing 8 0.0190744
MAPK14 mitogen-activated protein kinase 14 0.0190075
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0188146
YAP1 Yes-associated protein 1 0.0186676
UBASH3B ubiquitin associated and SH3 domain containing B 0.0182004
ATRN attractin 0.018197
NEK7 NIMA-related kinase 7 0.0181198
CCNY cyclin Y 0.0178975
MRTFA myocardin related transcription factor A 0.0177679
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.017742
SLC35F5 solute carrier family 35, member F5 0.0176983
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0176386
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0176036
NRIP1 nuclear receptor interacting protein 1 0.0175337

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.138838
MT2A metallothionein 2A -0.138442
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.120052
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113952
TPT1 tumor protein, translationally-controlled 1 -0.108037
APOA2 apolipoprotein A-II -0.0993233
IGF2 insulin-like growth factor 2 -0.0887862
RPS6 ribosomal protein S6 -0.0883797
RPS12 ribosomal protein S12 -0.0861664
RPS8 ribosomal protein S8 -0.0813607
RPL37A ribosomal protein L37a -0.0805694
AKAP12 A kinase (PRKA) anchor protein 12 -0.0799747
TMSB10 thymosin beta 10 -0.0792515
HMGA1 high mobility group AT-hook 1 -0.0779843
RPL11 ribosomal protein L11 -0.0778956
FTL ferritin, light polypeptide -0.072088
RPL23 ribosomal protein L23 -0.0690529
RPS24 ribosomal protein S24 -0.0663513
ENO1 enolase 1, (alpha) -0.0612859
AHSG alpha-2-HS-glycoprotein -0.0611894
SLC38A2 solute carrier family 38, member 2 -0.0602036
RPS19 ribosomal protein S19 -0.0589575
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0582408
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0517134
INTS6 integrator complex subunit 6 -0.0508694
RPS3 ribosomal protein S3 -0.049491
PLIN2 perilipin 2 -0.0489988
RPL35A ribosomal protein L35a -0.0487535
RPS27A ribosomal protein S27a -0.0480293
RPL34 ribosomal protein L34 -0.0478404
RPL9 ribosomal protein L9 -0.0474401
RPL31 ribosomal protein L31 -0.046732
RPL26 ribosomal protein L26 -0.0464096
RPL12 ribosomal protein L12 -0.046065
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0460575
RPLP2 ribosomal protein, large, P2 -0.0457141
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.045198
RACK1 receptor for activated C kinase 1 -0.0451255
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0448698
EGR1 early growth response 1 -0.0448427
NAP1L1 nucleosome assembly protein 1-like 1 -0.0430984
B2M beta-2-microglobulin -0.042914
TM4SF1 transmembrane 4 L six family member 1 -0.0422725
PDLIM5 PDZ and LIM domain 5 -0.0416647
RPS21 ribosomal protein S21 -0.0410104
RPLP0 ribosomal protein, large, P0 -0.0408561
RPLP1 ribosomal protein, large, P1 -0.0393628
RPS17 ribosomal protein S17 -0.0391777
EIF1 eukaryotic translation initiation factor 1 -0.0388441
RPS23 ribosomal protein S23 -0.0377239
RPS13 ribosomal protein S13 -0.0357252
RPL5 ribosomal protein L5 -0.0355951
RPS25 ribosomal protein S25 -0.0352831
ACTG1 actin gamma 1 -0.0349622
IGFBP1 insulin-like growth factor binding protein 1 -0.0349413
RPS14 ribosomal protein S14 -0.0335898
RPS29 ribosomal protein S29 -0.0333723
PTMA prothymosin, alpha -0.0328777
RPL37 ribosomal protein L37 -0.0326532
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.032313
CCL20 chemokine (C-C motif) ligand 20 -0.0309686
AMBP alpha-1-microglobulin/bikunin precursor -0.0307283
S100A9 S100 calcium binding protein A9 -0.0306357
GPC3 glypican 3 -0.0305487
KIF21A kinesin family member 21A -0.0302712
IFITM1 interferon induced transmembrane protein 1 -0.0301388
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0300299
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0298412
CPE carboxypeptidase E -0.0296919
RPL19 ribosomal protein L19 -0.0296675
ISG15 ISG15 ubiquitin-like modifier -0.0296577
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0289567
RPS10 ribosomal protein S10 -0.0284611
IFI6 interferon, alpha-inducible protein 6 -0.0281904
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0281408
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0280282
RPL36 ribosomal protein L36 -0.0274742
GNAS GNAS complex locus -0.027326
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0270956
RPS5 ribosomal protein S5 -0.0270295
DSTN destrin (actin depolymerizing factor) -0.0264856
MYO1E myosin IE -0.0263128
RPL32 ribosomal protein L32 -0.0262141
APOE apolipoprotein E -0.025513
APOA1 apolipoprotein A-I -0.0252496
RPL30 ribosomal protein L30 -0.024823
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0244946
RPL27 ribosomal protein L27 -0.0242852
RPS16 ribosomal protein S16 -0.0242323
TLE4 transducin-like enhancer of split 4 -0.0241083
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0240687
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.02379
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0237788
RPL18 ribosomal protein L18 -0.0235244
TRIM26 tripartite motif containing 26 -0.0232607
STK17A serine/threonine kinase 17a -0.0229797
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0226722
RPL28 ribosomal protein L28 -0.0226309
ATF4 activating transcription factor 4 -0.0225683
ATP5F1E ATP synthase F1 subunit epsilon -0.0223559