Folic acid_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.126448
FLNB filamin B, beta 0.116469
BCL2L1 BCL2-like 1 0.0884025
MSN moesin 0.0821652
TGM2 transglutaminase 2 0.0711761
NDRG1 N-myc downstream regulated 1 0.0697882
FOXO1 forkhead box O1 0.068864
EZR ezrin 0.0662467
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0655874
MYOF myoferlin 0.0595234
FOSL1 FOS-like antigen 1 0.0555487
ESYT2 extended synaptotagmin-like protein 2 0.0550159
TXNRD1 thioredoxin reductase 1 0.0541614
CD44 CD44 molecule (Indian blood group) 0.0523668
PCDH1 protocadherin 1 0.052194
ITGA6 integrin, alpha 6 0.0520482
NRG1 neuregulin 1 0.0511055
TXNIP thioredoxin interacting protein 0.0482466
DOCK5 dedicator of cytokinesis 5 0.0461112
RIN2 Ras and Rab interactor 2 0.0440155
PKM pyruvate kinase, muscle 0.0436266
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.043507
IGF2 insulin-like growth factor 2 0.0432188
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.04311
MBNL1 muscleblind-like splicing regulator 1 0.0430423
MCL1 myeloid cell leukemia 1 0.0429597
BCAR3 breast cancer anti-estrogen resistance 3 0.0405511
DOK5 docking protein 5 0.0397679
PICALM phosphatidylinositol binding clathrin assembly protein 0.0396034
CYB5R3 cytochrome b5 reductase 3 0.0395913
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0393378
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0384922
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0382934
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0382032
NEK7 NIMA-related kinase 7 0.0377611
CMIP c-Maf inducing protein 0.0374145
MKI67 marker of proliferation Ki-67 0.0371128
KMT2E lysine (K)-specific methyltransferase 2E 0.0370368
MYH9 myosin, heavy chain 9, non-muscle 0.036798
EMP1 epithelial membrane protein 1 0.0366237
H1-0 H1.0 linker histone 0.0365744
TNS4 tensin 4 0.0364427
B2M beta-2-microglobulin 0.0364091
PODXL podocalyxin-like 0.035862
MBNL2 muscleblind-like splicing regulator 2 0.0355452
APLP2 amyloid beta (A4) precursor-like protein 2 0.0351506
FTH1 ferritin, heavy polypeptide 1 0.0341663
ENO1 enolase 1, (alpha) 0.034134
ITCH itchy E3 ubiquitin protein ligase 0.0338511
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0336554
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0335915
CLU clusterin 0.0330717
LAMA5 laminin, alpha 5 0.0325857
RICTOR RPTOR independent companion of MTOR, complex 2 0.0322971
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0322055
SULF1 sulfatase 1 0.0320554
SMAD3 SMAD family member 3 0.0320229
LMNA lamin A/C 0.0316564
TNRC6A trinucleotide repeat containing 6A 0.0312958
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0309373
NCOR2 nuclear receptor corepressor 2 0.030833
SLTM SAFB-like, transcription modulator 0.030494
PFN1 profilin 1 0.0304649
SRRM2 serine/arginine repetitive matrix 2 0.0303391
ACTN4 actinin, alpha 4 0.0299552
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0292034
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0287641
LNPEP leucyl/cystinyl aminopeptidase 0.028651
EEF2 eukaryotic translation elongation factor 2 0.0284753
DST dystonin 0.0283504
YBX1 Y box binding protein 1 0.0281169
UBA6 ubiquitin-like modifier activating enzyme 6 0.0279864
DIAPH3 diaphanous-related formin 3 0.0279416
EFHD2 EF-hand domain family, member D2 0.0277391
ITGB4 integrin, beta 4 0.0277291
TPM3 tropomyosin 3 0.0270313
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0270285
PDLIM1 PDZ and LIM domain 1 0.0267579
S100A9 S100 calcium binding protein A9 0.0266379
LUZP1 leucine zipper protein 1 0.0264199
LRRC8C leucine rich repeat containing 8 family, member C 0.0262765
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0261472
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0258679
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0257978
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0257485
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0256152
TSC22D1 TSC22 domain family, member 1 0.0255339
TMSB10 thymosin beta 10 0.0254889
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0250103
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0249731
FNDC3B fibronectin type III domain containing 3B 0.0248697
FOXP1 forkhead box P1 0.0244927
ARHGAP29 Rho GTPase activating protein 29 0.0244787
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0244151
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0242042
KTN1 kinectin 1 (kinesin receptor) 0.0241942
ARRDC3 arrestin domain containing 3 0.024187
C1D C1D nuclear receptor corepressor 0.0239895
NCEH1 neutral cholesterol ester hydrolase 1 0.023843
ZNF148 zinc finger protein 148 0.0237867

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.24786
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.123113
INTS6 integrator complex subunit 6 -0.110964
MTSS1 metastasis suppressor 1 -0.0988164
TPT1 tumor protein, translationally-controlled 1 -0.0977454
ABI3BP ABI family, member 3 (NESH) binding protein -0.0929956
SLC35F3 solute carrier family 35, member F3 -0.085972
AHNAK AHNAK nucleoprotein -0.0856465
PDLIM5 PDZ and LIM domain 5 -0.0817218
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0774885
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0754146
STC1 stanniocalcin 1 -0.0751345
PSD3 pleckstrin and Sec7 domain containing 3 -0.0743795
ALCAM activated leukocyte cell adhesion molecule -0.0629749
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0585776
RAI14 retinoic acid induced 14 -0.0552649
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0550575
LMO7 LIM domain 7 -0.0546121
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0525145
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0524053
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0490628
NAV2 neuron navigator 2 -0.0475759
SQSTM1 sequestosome 1 -0.047134
RPS24 ribosomal protein S24 -0.0459688
PALLD palladin, cytoskeletal associated protein -0.0452594
TMSB4X thymosin beta 4, X-linked -0.0449683
HMGA2 high mobility group AT-hook 2 -0.0427873
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0423167
ZEB1 zinc finger E-box binding homeobox 1 -0.0421406
PRSS23 protease, serine, 23 -0.0417455
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0390814
VCL vinculin -0.0388978
CDK13 cyclin-dependent kinase 13 -0.0383853
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0379251
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0376912
ANO1 anoctamin 1, calcium activated chloride channel -0.0374659
KLF5 Kruppel-like factor 5 (intestinal) -0.0369784
HM13 histocompatibility (minor) 13 -0.0364493
RIGI RNA sensor RIG-I -0.0361595
SAMD9 sterile alpha motif domain containing 9 -0.0343391
RPL34 ribosomal protein L34 -0.0340869
ARF1 ADP-ribosylation factor 1 -0.0339049
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0334073
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0331822
DENND1A DENN/MADD domain containing 1A -0.0330714
NAP1L1 nucleosome assembly protein 1-like 1 -0.0327347
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.032137
THBD thrombomodulin -0.0317819
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0316653
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0314821
SOD2 superoxide dismutase 2, mitochondrial -0.0310613
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0304893
CANX calnexin -0.0299474
RPS8 ribosomal protein S8 -0.0298453
IARS1 isoleucyl-tRNA synthetase 1 -0.0297692
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0295809
BZW1 basic leucine zipper and W2 domains 1 -0.0295454
SDCBP syndecan binding protein (syntenin) -0.0294826
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0294039
NRIP1 nuclear receptor interacting protein 1 -0.0288502
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0285191
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0281244
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0280576
HDLBP high density lipoprotein binding protein -0.0278777
CAVIN1 caveolae associated protein 1 -0.0273315
LAMC2 laminin, gamma 2 -0.0268596
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0266749
RSL1D1 ribosomal L1 domain containing 1 -0.0265129
UTRN utrophin -0.0264255
EXT1 exostosin glycosyltransferase 1 -0.0262456
MTAP methylthioadenosine phosphorylase -0.0262141
PDE4D phosphodiesterase 4D, cAMP-specific -0.0256832
TM4SF1 transmembrane 4 L six family member 1 -0.025545
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0251734
PCDH9 protocadherin 9 -0.0251731
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0247792
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0244781
FN1 fibronectin 1 -0.0241306
CTBP2 C-terminal binding protein 2 -0.0240545
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0237356
RRBP1 ribosome binding protein 1 -0.0235511
ANXA1 annexin A1 -0.023376
HLA-E major histocompatibility complex, class I, E -0.0232293
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0227025
KLF6 Kruppel-like factor 6 -0.0224687
CLIC4 chloride intracellular channel 4 -0.0224629
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0224456
TRIO trio Rho guanine nucleotide exchange factor -0.0223742
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0220714
DSCAM Down syndrome cell adhesion molecule -0.0220353
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.02186
FBXO11 F-box protein 11 -0.0216712
ACTG1 actin gamma 1 -0.0215379
RPS27A ribosomal protein S27a -0.0214732
RGS4 regulator of G-protein signaling 4 -0.0212573
RPS20 ribosomal protein S20 -0.0212128
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0209544
CORO2A coronin, actin binding protein, 2A -0.0208654
KIAA1217 KIAA1217 -0.0208315
TRA2A transformer 2 alpha homolog (Drosophila) -0.0200416