Folic acid_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in J82 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Folic acid_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.184497
TRIO trio Rho guanine nucleotide exchange factor 0.141757
NALF1 NALCN channel auxiliary factor 1 0.138986
EXT1 exostosin glycosyltransferase 1 0.113691
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.10497
IGFBP3 insulin-like growth factor binding protein 3 0.0875915
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0829446
FN1 fibronectin 1 0.0744721
DST dystonin 0.0667002
ANXA2 annexin A2 0.06651
CD44 CD44 molecule (Indian blood group) 0.0642489
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.06405
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0630351
ELL2 elongation factor, RNA polymerase II, 2 0.0615288
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.06092
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0604533
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0593921
FNDC3B fibronectin type III domain containing 3B 0.0593349
ERBIN erbb2 interacting protein 0.0556394
PTK2 protein tyrosine kinase 2 0.0531837
AHNAK AHNAK nucleoprotein 0.0496824
TXNRD1 thioredoxin reductase 1 0.0490444
OSMR oncostatin M receptor 0.0446944
ATP13A3 ATPase type 13A3 0.0440585
NAMPT nicotinamide phosphoribosyltransferase 0.0435284
SMYD3 SET and MYND domain containing 3 0.0422324
FLNB filamin B, beta 0.0422226
UBA6 ubiquitin-like modifier activating enzyme 6 0.0407532
PODXL podocalyxin-like 0.0384362
DLG1 discs, large homolog 1 (Drosophila) 0.037658
ZEB2 zinc finger E-box binding homeobox 2 0.0370209
CCBE1 collagen and calcium binding EGF domains 1 0.0352634
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0352208
PHACTR1 phosphatase and actin regulator 1 0.0352027
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0346235
PTPRG protein tyrosine phosphatase, receptor type, G 0.0339921
LIMCH1 LIM and calponin homology domains 1 0.0339763
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0336716
ASPH aspartate beta-hydroxylase 0.033489
RAI14 retinoic acid induced 14 0.0329469
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0329395
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0319387
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0312517
COL5A1 collagen, type V, alpha 1 0.0309415
GLIS3 GLIS family zinc finger 3 0.0303355
AFAP1 actin filament associated protein 1 0.0303022
SLC12A8 solute carrier family 12, member 8 0.0298575
MACF1 microtubule-actin crosslinking factor 1 0.0297083
HEG1 heart development protein with EGF-like domains 1 0.0296583
VEGFC vascular endothelial growth factor C 0.0294306
PLCB4 phospholipase C, beta 4 0.0293288
ADARB1 adenosine deaminase, RNA-specific, B1 0.0288019
FRMD6 FERM domain containing 6 0.0283671
PPME1 protein phosphatase methylesterase 1 0.0282898
YEATS2 YEATS domain containing 2 0.0282841
WNT5B wingless-type MMTV integration site family, member 5B 0.0275874
NEK7 NIMA-related kinase 7 0.0269971
COL4A2 collagen, type IV, alpha 2 0.0269482
MYH9 myosin, heavy chain 9, non-muscle 0.0266072
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0260771
TPD52 tumor protein D52 0.025521
ZNF841 zinc finger protein 841 0.0253389
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0250818
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0247653
NAV2 neuron navigator 2 0.0246489
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0245535
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.024342
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.024254
MKI67 marker of proliferation Ki-67 0.0240673
PICALM phosphatidylinositol binding clathrin assembly protein 0.0238349
ZNF432 zinc finger protein 432 0.0238158
RUNX1 runt-related transcription factor 1 0.0234636
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0234562
PTPRM protein tyrosine phosphatase, receptor type, M 0.0232206
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0231136
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0229126
ZNF804A zinc finger protein 804A 0.0228738
IL6ST interleukin 6 signal transducer 0.0226912
CDK17 cyclin-dependent kinase 17 0.0225061
SMAD3 SMAD family member 3 0.0221416
TENM3 teneurin transmembrane protein 3 0.0219625
THSD4 thrombospondin, type I, domain containing 4 0.0219281
DPYD dihydropyrimidine dehydrogenase 0.0219201
RAD51B RAD51 paralog B 0.0218464
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0217452
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0214569
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0213526
PRRC2B proline-rich coiled-coil 2B 0.021213
NSD2 nuclear receptor binding SET domain protein 2 0.021058
CEP170 centrosomal protein 170kDa 0.0206575
FSTL1 follistatin-like 1 0.0203416
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0201845
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0200073
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0199136
ANO6 anoctamin 6 0.0198668
TPM1 tropomyosin 1 (alpha) 0.0198618
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0198245
EGFR epidermal growth factor receptor 0.0198189
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0192678
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0191864

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.12542
HLA-B major histocompatibility complex, class I, B -0.111184
FTL ferritin, light polypeptide -0.0909767
B2M beta-2-microglobulin -0.0593424
MT1X metallothionein 1X -0.0559007
INTS6 integrator complex subunit 6 -0.0511382
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0449519
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0445599
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0400714
UBC ubiquitin C -0.0389315
TMSB10 thymosin beta 10 -0.0381446
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0345718
RPL23 ribosomal protein L23 -0.0287139
IFI6 interferon, alpha-inducible protein 6 -0.0279856
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0275689
VIM vimentin -0.0273485
RPLP2 ribosomal protein, large, P2 -0.0266643
PFN1 profilin 1 -0.0257573
GOLGA4 golgin A4 -0.0251553
TPT1 tumor protein, translationally-controlled 1 -0.0246247
SLIT2 slit homolog 2 (Drosophila) -0.0226651
CALR calreticulin -0.022585
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0224189
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0213854
RPS8 ribosomal protein S8 -0.020897
RPS6 ribosomal protein S6 -0.0207903
C6ORF62 chromosome 6 open reading frame 62 -0.0199935
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0197294
HMGB1 high mobility group box 1 -0.0195773
TLE4 transducin-like enhancer of split 4 -0.0187636
TOP2A topoisomerase (DNA) II alpha 170kDa -0.01867
ENO1 enolase 1, (alpha) -0.0183786
RPS12 ribosomal protein S12 -0.0183662
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0180437
RAB7A RAB7A, member RAS oncogene family -0.0173619
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0167901
RPL12 ribosomal protein L12 -0.0167579
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0164879
GOLGB1 golgin B1 -0.0163583
PDIA3 protein disulfide isomerase family A, member 3 -0.0160787
POTEF POTE ankyrin domain family, member F -0.0160004
PTMA prothymosin, alpha -0.0159251
SQSTM1 sequestosome 1 -0.0159206
RPS3 ribosomal protein S3 -0.015695
DEK DEK proto-oncogene -0.0153475
RPS13 ribosomal protein S13 -0.0150485
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0149403
RPL37A ribosomal protein L37a -0.0147927
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0147757
EIF5B eukaryotic translation initiation factor 5B -0.01476
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0146253
ADAM32 ADAM metallopeptidase domain 32 -0.0144367
HMGA1 high mobility group AT-hook 1 -0.0143969
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0142894
HLA-A major histocompatibility complex, class I, A -0.0141276
SPDYA speedy/RINGO cell cycle regulator family member A -0.0140963
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0140418
PCBP2 poly(rC) binding protein 2 -0.0138012
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.013753
EIF1 eukaryotic translation initiation factor 1 -0.0136867
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0136804
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0136454
RPL9 ribosomal protein L9 -0.0135931
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0133698
RPS27A ribosomal protein S27a -0.0132279
CTSD cathepsin D -0.0132054
SON SON DNA binding protein -0.0129995
POMP proteasome maturation protein -0.0126391
MYADM myeloid-associated differentiation marker -0.0125535
ATP5F1E ATP synthase F1 subunit epsilon -0.0124293
ANKRD12 ankyrin repeat domain 12 -0.0123151
UBAP2 ubiquitin associated protein 2 -0.012272
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0122355
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0122315
MYL12B myosin, light chain 12B, regulatory -0.0122019
DSTN destrin (actin depolymerizing factor) -0.0120198
S100A10 S100 calcium binding protein A10 -0.0119224
S100A6 S100 calcium binding protein A6 -0.0118481
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0117963
LOC102724023 ES1 protein homolog, mitochondrial -0.0117646
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0117402
RPS17 ribosomal protein S17 -0.0116987
SEC31A SEC31 homolog A (S. cerevisiae) -0.0116309
RPS21 ribosomal protein S21 -0.011599
RPL11 ribosomal protein L11 -0.0115927
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0115094
ACBD3 acyl-CoA binding domain containing 3 -0.0114758
LOC112694756 uncharaterized LOC112694756 -0.0114626
UQCRB ubiquinol-cytochrome c reductase binding protein -0.011344
HDAC9 histone deacetylase 9 -0.0112554
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.011199
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0109718
NUCB2 nucleobindin 2 -0.0109551
YBX3 Y box binding protein 3 -0.0109017
RPL19 ribosomal protein L19 -0.0107722
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0107066
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0106151
AEBP2 AE binding protein 2 -0.0105618
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0105324
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0104176