Folic acid_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.166979
SPTBN1 spectrin, beta, non-erythrocytic 1 0.161631
TMC5 transmembrane channel-like 5 0.095976
H1-0 H1.0 linker histone 0.0947213
POTEF POTE ankyrin domain family, member F 0.0904875
FAT1 FAT atypical cadherin 1 0.082391
AKAP13 A kinase (PRKA) anchor protein 13 0.0761145
FTH1 ferritin, heavy polypeptide 1 0.0691739
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0669309
EZR ezrin 0.0639683
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.059737
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0588132
MBNL2 muscleblind-like splicing regulator 2 0.058224
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.056609
UBE2H ubiquitin-conjugating enzyme E2H 0.0560345
PICALM phosphatidylinositol binding clathrin assembly protein 0.0552809
SEPTIN9 septin 9 0.054964
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0549209
NDRG1 N-myc downstream regulated 1 0.0525698
MYOF myoferlin 0.0519997
BCL2L1 BCL2-like 1 0.0485035
SNX9 sorting nexin 9 0.0483655
SH3RF1 SH3 domain containing ring finger 1 0.0449547
MACC1 metastasis associated in colon cancer 1 0.0447679
CEMIP2 cell migration inducing hyaluronidase 2 0.0444698
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0441319
UGCG UDP-glucose ceramide glucosyltransferase 0.0440784
SMAD3 SMAD family member 3 0.0434606
VMP1 vacuole membrane protein 1 0.0430257
ADAM9 ADAM metallopeptidase domain 9 0.0425821
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0412113
TMEM45B transmembrane protein 45B 0.0407209
USP6NL USP6 N-terminal like 0.0400028
MYH9 myosin, heavy chain 9, non-muscle 0.0394937
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.039359
ANXA11 annexin A11 0.0381961
ANXA1 annexin A1 0.0381037
LIPH lipase, member H 0.0376002
CLMN calmin (calponin-like, transmembrane) 0.0361681
EMP1 epithelial membrane protein 1 0.0357588
DSPP dentin sialophosphoprotein 0.0357514
PLS1 plastin 1 0.0356329
ARHGAP42 Rho GTPase activating protein 42 0.0356022
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0354478
TXNRD1 thioredoxin reductase 1 0.0350927
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0349541
FNDC3B fibronectin type III domain containing 3B 0.0348996
SRRM2 serine/arginine repetitive matrix 2 0.0325536
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0324715
GDA guanine deaminase 0.0317723
TNRC18 trinucleotide repeat containing 18 0.0304263
OXSR1 oxidative stress responsive 1 0.0303469
ESYT2 extended synaptotagmin-like protein 2 0.0303435
RAB7A RAB7A, member RAS oncogene family 0.0300489
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0300397
NEK7 NIMA-related kinase 7 0.0299058
AVL9 AVL9 homolog (S. cerevisiase) 0.0295312
MACF1 microtubule-actin crosslinking factor 1 0.0290553
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0283259
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0283167
ANXA2 annexin A2 0.0282763
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0282346
GARS1 glycyl-tRNA synthetase 1 0.0282306
FGFR2 fibroblast growth factor receptor 2 0.0280321
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0276968
COPA coatomer protein complex, subunit alpha 0.0276954
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0275413
LCOR ligand dependent nuclear receptor corepressor 0.0275402
RBM47 RNA binding motif protein 47 0.0275009
STK24 serine/threonine kinase 24 0.0273327
PCDH1 protocadherin 1 0.0270102
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.026979
CLDN7 claudin 7 0.0269698
IQGAP1 IQ motif containing GTPase activating protein 1 0.0267539
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0267146
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.02664
WWC1 WW and C2 domain containing 1 0.0263429
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0255741
PKM pyruvate kinase, muscle 0.0254708
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0254286
ENO1 enolase 1, (alpha) 0.0254087
N4BP2L2 NEDD4 binding protein 2-like 2 0.0249611
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0247697
ARHGAP26 Rho GTPase activating protein 26 0.0245251
COBL cordon-bleu WH2 repeat protein 0.0242716
ATP11A ATPase, class VI, type 11A 0.0242584
ESRP1 epithelial splicing regulatory protein 1 0.0242414
SIK3 SIK family kinase 3 0.0240987
DOCK5 dedicator of cytokinesis 5 0.0240108
CTNND1 catenin (cadherin-associated protein), delta 1 0.0239575
COG6 component of oligomeric golgi complex 6 0.0237742
MED13 mediator complex subunit 13 0.0237528
AKAP9 A kinase (PRKA) anchor protein 9 0.0235184
TES testin LIM domain protein 0.0234832
TFG TRK-fused gene 0.023419
AREG amphiregulin 0.0233665
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0233432
PRSS3 protease, serine, 3 0.0232816
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0229586
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0228658

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.172856
TPT1 tumor protein, translationally-controlled 1 -0.13989
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.101082
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0785104
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0668179
TRPS1 trichorhinophalangeal syndrome I -0.0665365
GMDS GDP-mannose 4,6-dehydratase -0.0639681
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.059228
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0582506
ACACA acetyl-CoA carboxylase alpha -0.056732
TFRC transferrin receptor -0.0557392
INTS6 integrator complex subunit 6 -0.0547777
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0508188
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0506705
ANO1 anoctamin 1, calcium activated chloride channel -0.0500922
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0471068
RPS24 ribosomal protein S24 -0.0453112
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0449193
HLA-C major histocompatibility complex, class I, C -0.0440056
RRBP1 ribosome binding protein 1 -0.0433064
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0429011
ACTG1 actin gamma 1 -0.0416569
TMSB10 thymosin beta 10 -0.0414415
RAD51B RAD51 paralog B -0.0399729
CANX calnexin -0.0395108
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0393537
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0383332
RPL23 ribosomal protein L23 -0.0379476
SOX4 SRY (sex determining region Y)-box 4 -0.0372893
SMC4 structural maintenance of chromosomes 4 -0.0372115
S100A10 S100 calcium binding protein A10 -0.0369861
COTL1 coactosin-like F-actin binding protein 1 -0.0367374
CALR calreticulin -0.036714
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0363789
AGR2 anterior gradient 2 -0.0360888
RUNX1 runt-related transcription factor 1 -0.0358893
AHR aryl hydrocarbon receptor -0.0354403
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0351363
EIF5B eukaryotic translation initiation factor 5B -0.0343639
SAMD12 sterile alpha motif domain containing 12 -0.0339328
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0336907
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0336533
ALCAM activated leukocyte cell adhesion molecule -0.0328956
SPDYA speedy/RINGO cell cycle regulator family member A -0.0327738
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0321552
PTMA prothymosin, alpha -0.032061
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0320572
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0320271
CBX3 chromobox homolog 3 -0.0319641
AEBP2 AE binding protein 2 -0.0315607
EPCAM epithelial cell adhesion molecule -0.0314897
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0310217
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0308942
HLA-E major histocompatibility complex, class I, E -0.0307392
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0305686
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0305211
INSIG1 insulin induced gene 1 -0.0303131
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0302904
UBAP2 ubiquitin associated protein 2 -0.0301845
ATXN1 ataxin 1 -0.0301558
RPL26 ribosomal protein L26 -0.0299227
GNAS GNAS complex locus -0.0297867
TAS2R14 taste receptor, type 2, member 14 -0.0297435
TMEM123 transmembrane protein 123 -0.0293996
RPL34 ribosomal protein L34 -0.0291269
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0290706
RTN3 reticulon 3 -0.0288802
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0288322
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0288315
TBC1D22A TBC1 domain family, member 22A -0.0287968
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0287791
ARHGAP6 Rho GTPase activating protein 6 -0.0287549
ATF5 activating transcription factor 5 -0.0285229
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0285144
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0279961
E2F3 E2F transcription factor 3 -0.0278673
DENND1A DENN/MADD domain containing 1A -0.027707
IFI6 interferon, alpha-inducible protein 6 -0.0274976
ABR active BCR-related -0.0270258
GPHN gephyrin -0.0265698
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0265309
RPS21 ribosomal protein S21 -0.0265132
ZMYM2 zinc finger, MYM-type 2 -0.0265059
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0264232
TRIM56 tripartite motif containing 56 -0.0263329
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0262769
WSB1 WD repeat and SOCS box containing 1 -0.0262603
IFRD1 interferon-related developmental regulator 1 -0.026257
NLK nemo-like kinase -0.0260265
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0260148
DEK DEK proto-oncogene -0.0259394
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0256226
ZSWIM6 zinc finger, SWIM-type containing 6 -0.025589
BZW2 basic leucine zipper and W2 domains 2 -0.0255548
CCND1 cyclin D1 -0.0255364
PALLD palladin, cytoskeletal associated protein -0.0251028
TRAPPC12 trafficking protein particle complex 12 -0.0250165
SLC25A51 solute carrier family 25, member 51 -0.0247918
POF1B premature ovarian failure, 1B -0.0247131
CDK13 cyclin-dependent kinase 13 -0.0247095