Folic acid_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Folic acid perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Folic acid_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTPRG protein tyrosine phosphatase, receptor type, G 0.119993
EXT1 exostosin glycosyltransferase 1 0.118253
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0901671
ASPH aspartate beta-hydroxylase 0.0848838
NALF1 NALCN channel auxiliary factor 1 0.0810591
FTL ferritin, light polypeptide 0.0808117
PRKG1 protein kinase, cGMP-dependent, type I 0.0696133
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0667339
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0648497
RUNX1 runt-related transcription factor 1 0.0644134
EFNA5 ephrin-A5 0.0624364
EEF2 eukaryotic translation elongation factor 2 0.0617207
PTPRD protein tyrosine phosphatase, receptor type, D 0.0588898
PBX3 pre-B-cell leukemia homeobox 3 0.0585455
DOCK4 dedicator of cytokinesis 4 0.0570896
HMGA2 high mobility group AT-hook 2 0.0552258
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0527525
KIAA1549L KIAA1549-like 0.0521454
MCL1 myeloid cell leukemia 1 0.0516832
SDCCAG8 serologically defined colon cancer antigen 8 0.0516576
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0515217
SAMD3 sterile alpha motif domain containing 3 0.0503198
SAMD4A sterile alpha motif domain containing 4A 0.0497674
MACF1 microtubule-actin crosslinking factor 1 0.0492967
MSN moesin 0.0491979
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0482855
MT2A metallothionein 2A 0.0475849
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.046113
USP34 ubiquitin specific peptidase 34 0.043283
ZNF638 zinc finger protein 638 0.0416226
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0408525
BRD2 bromodomain containing 2 0.0393186
MYO10 myosin X 0.0385741
ITGA6 integrin, alpha 6 0.0374779
PKM pyruvate kinase, muscle 0.0369015
AHNAK AHNAK nucleoprotein 0.0368792
PCBP2 poly(rC) binding protein 2 0.0367288
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0362179
MARCHF4 membrane associated ring-CH-type finger 4 0.0359356
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0338187
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0332732
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0332168
CDK14 cyclin-dependent kinase 14 0.0330466
MYH9 myosin, heavy chain 9, non-muscle 0.032888
NTM neurotrimin 0.032816
DPYD dihydropyrimidine dehydrogenase 0.0324646
PTK2 protein tyrosine kinase 2 0.0323655
FMNL2 formin-like 2 0.0321451
NAV1 neuron navigator 1 0.0315957
TXNRD1 thioredoxin reductase 1 0.0312752
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0307638
KDM4C lysine (K)-specific demethylase 4C 0.0303811
SPATS2 spermatogenesis associated, serine-rich 2 0.0299787
KIAA1217 KIAA1217 0.0297778
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0294363
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0288839
RPL3 ribosomal protein L3 0.0287302
RABGAP1L RAB GTPase activating protein 1-like 0.0286832
ALCAM activated leukocyte cell adhesion molecule 0.0284215
NCOR2 nuclear receptor corepressor 2 0.0282982
DNMBP dynamin binding protein 0.0277003
CD44 CD44 molecule (Indian blood group) 0.0276897
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0275579
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0273281
ADAM19 ADAM metallopeptidase domain 19 0.0268287
ZNF804A zinc finger protein 804A 0.0267118
TBC1D5 TBC1 domain family, member 5 0.0265629
ZSWIM6 zinc finger, SWIM-type containing 6 0.0263096
NLGN1 neuroligin 1 0.0261191
FOXP1 forkhead box P1 0.0260925
LIMCH1 LIM and calponin homology domains 1 0.0254172
EMP1 epithelial membrane protein 1 0.025367
CDH13 cadherin 13 0.0244172
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0243729
RPS19 ribosomal protein S19 0.0241362
FOCAD focadhesin 0.0240748
MKI67 marker of proliferation Ki-67 0.023966
LINGO2 leucine rich repeat and Ig domain containing 2 0.0238139
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0236677
ZFYVE28 zinc finger, FYVE domain containing 28 0.0235523
SMYD3 SET and MYND domain containing 3 0.0234319
ZEB1 zinc finger E-box binding homeobox 1 0.0234269
DSCAM Down syndrome cell adhesion molecule 0.0231217
EIF4B eukaryotic translation initiation factor 4B 0.022932
POTEF POTE ankyrin domain family, member F 0.0228519
ATXN1 ataxin 1 0.0228195
MBD5 methyl-CpG binding domain protein 5 0.0227091
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.0226381
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0223721
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.0223159
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0221159
DOCK1 dedicator of cytokinesis 1 0.0220036
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0218325
ANO6 anoctamin 6 0.0216145
WNK1 WNK lysine deficient protein kinase 1 0.0215076
KLHL29 kelch-like family member 29 0.0214031
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0212142
SATB2 SATB homeobox 2 0.0208853
BMAL2 basic helix-loop-helix ARNT like 2 0.0206666
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0206664

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.152207
VIM vimentin -0.142523
DTNA dystrobrevin, alpha -0.106824
TPT1 tumor protein, translationally-controlled 1 -0.0888003
LSAMP limbic system-associated membrane protein -0.081434
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0739354
MMP12 matrix metallopeptidase 12 -0.0697692
NAP1L1 nucleosome assembly protein 1-like 1 -0.0483178
RPS24 ribosomal protein S24 -0.0481655
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0453259
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0425392
PTMA prothymosin, alpha -0.0417076
BZW1 basic leucine zipper and W2 domains 1 -0.0411536
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.040311
KDM3A lysine (K)-specific demethylase 3A -0.0399472
RAD21 RAD21 homolog (S. pombe) -0.0387425
WSB1 WD repeat and SOCS box containing 1 -0.0385369
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0377978
YBX3 Y box binding protein 3 -0.0362583
SPAG9 sperm associated antigen 9 -0.0359144
TMSB10 thymosin beta 10 -0.0358876
CD109 CD109 molecule -0.0334366
ANXA2 annexin A2 -0.0326168
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0323988
CFAP251 cilia and flagella associated protein 251 -0.0307233
LMAN1 lectin, mannose-binding, 1 -0.0289625
WDR43 WD repeat domain 43 -0.0288412
PHACTR1 phosphatase and actin regulator 1 -0.0285344
KLF6 Kruppel-like factor 6 -0.0284219
RPL23 ribosomal protein L23 -0.0280746
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0275139
MARCHF6 membrane associated ring-CH-type finger 6 -0.0272442
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0270636
RPS12 ribosomal protein S12 -0.0267362
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0265419
GNAS GNAS complex locus -0.026515
RBM39 RNA binding motif protein 39 -0.0256711
NUP58 nucleoporin 58 -0.0248529
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0243167
OSMR oncostatin M receptor -0.0243132
RPS8 ribosomal protein S8 -0.0240747
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0237588
IFI16 interferon, gamma-inducible protein 16 -0.0236774
TFRC transferrin receptor -0.0235072
RAP1B RAP1B, member of RAS oncogene family -0.023232
ARID4B AT rich interactive domain 4B (RBP1-like) -0.023056
WDR45B WD repeat domain 45B -0.0230367
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0230296
TM4SF1 transmembrane 4 L six family member 1 -0.0225641
PTCHD4 patched domain containing 4 -0.022479
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0224685
RPL26 ribosomal protein L26 -0.0224204
NAMPT nicotinamide phosphoribosyltransferase -0.0223598
FNDC3B fibronectin type III domain containing 3B -0.0223479
FGFR1 fibroblast growth factor receptor 1 -0.0220389
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0218974
LDHA lactate dehydrogenase A -0.0215259
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0214991
VDAC1 voltage-dependent anion channel 1 -0.0214752
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0214721
RPS27A ribosomal protein S27a -0.0213211
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0212709
CSTB cystatin B (stefin B) -0.0212449
ELL2 elongation factor, RNA polymerase II, 2 -0.0212343
ACTG1 actin gamma 1 -0.0211477
RPL35A ribosomal protein L35a -0.0204536
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0203091
RPL37A ribosomal protein L37a -0.0202897
TMEM263 transmembrane protein 263 -0.0201931
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.020074
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0200324
RPS3 ribosomal protein S3 -0.0198075
ATP13A3 ATPase type 13A3 -0.0197955
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0197307
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0196338
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0196321
RLF rearranged L-myc fusion -0.0196243
USP15 ubiquitin specific peptidase 15 -0.0196022
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.019225
BTG1 B-cell translocation gene 1, anti-proliferative -0.0190014
MYOF myoferlin -0.0188782
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0186529
ZNF207 zinc finger protein 207 -0.0186335
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0184712
RPLP0 ribosomal protein, large, P0 -0.0184254
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0183466
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0180439
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0178603
FN1 fibronectin 1 -0.0177948
HMGA1 high mobility group AT-hook 1 -0.0177788
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0177499
CSDE1 cold shock domain containing E1, RNA-binding -0.0176867
NACA nascent polypeptide-associated complex alpha subunit -0.0176769
SEPTIN7 septin 7 -0.0174435
TSC22D2 TSC22 domain family, member 2 -0.0173917
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0169582
RPL34 ribosomal protein L34 -0.0167708
RAB1A RAB1A, member RAS oncogene family -0.0167609
HMGB1 high mobility group box 1 -0.0165053
CAVIN1 caveolae associated protein 1 -0.0164518